NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2113643494|ref|XP_044161903|]
View 

WD repeat-containing protein 46 isoform X1 [Bufo gargarizans]

Protein Classification

WDR46/Utp7 family protein( domain architecture ID 13237426)

WDR46/Utp7 family protein is a WD40 repeat domain-containing protein, similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 579-657 9.52e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.17  E-value: 9.52e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494  579 PYMCLSVKAP-IHGLQFCPYEDVLGIGHGGGFTSMIVPGAGEANFDGLECNPYETKKQRQEWEVKALLEKIQPELITMDP 657
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 super family cl43672
WD40 repeat [General function prediction only];
324-533 4.17e-06

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 4.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 324 DITSASKHFNLTLNQFGPYRINYSRNGRHLLLAGQRGHVASMDWHTKKLHCEMNV-METVNDVRWLHTHAMFAAA-QKKW 401
Cdd:COG2319   190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 402 LYIYD-NLGVELHCIKKFND-VLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSVKAGRLSVMCQNPHNAVVHLGH 479
Cdd:COG2319   270 VRLWDlATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2113643494 480 HNGSVSLWSPSIKEPLVKMLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRT 533
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-569 6.40e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 6.40e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2113643494 501 HGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTSC---LLPLGAGSLCHSQRGLLAAGVGNIVQVYK 569
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghTGPVRDVAASADGTYLASGSSDKTIRLWD 79
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 579-657 9.52e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.17  E-value: 9.52e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494  579 PYMCLSVKAP-IHGLQFCPYEDVLGIGHGGGFTSMIVPGAGEANFDGLECNPYETKKQRQEWEVKALLEKIQPELITMDP 657
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 579-656 2.08e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 162.24  E-value: 2.08e-47
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113643494 579 PYMCLSVKA-PIHGLQFCPYEDVLGIGHGGGFTSMIVPGAGEANFDGLECNPYETKKQRQEWEVKALLEKIQPELITMD 656
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
324-533 4.17e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 4.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 324 DITSASKHFNLTLNQFGPYRINYSRNGRHLLLAGQRGHVASMDWHTKKLHCEMNV-METVNDVRWLHTHAMFAAA-QKKW 401
Cdd:COG2319   190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 402 LYIYD-NLGVELHCIKKFND-VLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSVKAGRLSVMCQNPHNAVVHLGH 479
Cdd:COG2319   270 VRLWDlATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2113643494 480 HNGSVSLWSPSIKEPLVKMLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRT 533
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 419-540 1.04e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 419 NDVLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSV-KAGRLSVMCQNPHNAVVhLGHHNGSVSLWSPSIKEPLVK 497
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2113643494 498 MLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTSC 540
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL 131
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-569 6.40e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 6.40e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2113643494 501 HGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTSC---LLPLGAGSLCHSQRGLLAAGVGNIVQVYK 569
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghTGPVRDVAASADGTYLASGSSDKTIRLWD 79
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 579-657 9.52e-48

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.17  E-value: 9.52e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494  579 PYMCLSVKAP-IHGLQFCPYEDVLGIGHGGGFTSMIVPGAGEANFDGLECNPYETKKQRQEWEVKALLEKIQPELITMDP 657
Cdd:smart01033   1 PYMTHGLPGSrVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 579-656 2.08e-47

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 162.24  E-value: 2.08e-47
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2113643494 579 PYMCLSVKA-PIHGLQFCPYEDVLGIGHGGGFTSMIVPGAGEANFDGLECNPYETKKQRQEWEVKALLEKIQPELITMD 656
Cdd:pfam08149   1 PYLTHLLPGsTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 COG2319
WD40 repeat [General function prediction only];
324-533 4.17e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 4.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 324 DITSASKHFNLTLNQFGPYRINYSRNGRHLLLAGQRGHVASMDWHTKKLHCEMNV-METVNDVRWLHTHAMFAAA-QKKW 401
Cdd:COG2319   190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGsADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 402 LYIYD-NLGVELHCIKKFND-VLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSVKAGRLSVMCQNPHNAVVHLGH 479
Cdd:COG2319   270 VRLWDlATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2113643494 480 HNGSVSLWSPSIKEPLVKMLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRT 533
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
320-568 7.54e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 7.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 320 AEVVDITSASKHFNLTLNQFGPYRINYSRNGRHLLLAGQRGHVASMDWHTKKLHCEMNV-METVNDVRWLHTHAMFAAA- 397
Cdd:COG2319   102 VRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGs 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 398 QKKWLYIYD-NLGVELHCIKKFND-VLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSVKAGRLSVMCQNPHNAVV 475
Cdd:COG2319   182 DDGTVRLWDlATGKLLRTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 476 HLGHHNGSVSLWSPSIKEPLVKMLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTSCLLPLGA-GSLCHSQR 554
Cdd:COG2319   262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAvRSVAFSPD 341

                         250
                  ....*....|....*.
gi 2113643494 555 G--LLAAGVGNIVQVY 568
Cdd:COG2319   342 GktLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 419-540 1.04e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 419 NDVLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSV-KAGRLSVMCQNPHNAVVhLGHHNGSVSLWSPSIKEPLVK 497
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2113643494 498 MLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTSC 540
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL 131
WD40 COG2319
WD40 repeat [General function prediction only];
324-538 1.25e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 324 DITSASKHFNLTLNQFGPYRINYSRNGRHLLLAGQRGHVASMDWHTKKLHCEMNV-METVNDVRWLHTHAMFAAA-QKKW 401
Cdd:COG2319   148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGsADGT 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 402 LYIYD-NLGVELHCIKKFND-VLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSVKAGRLSVMCQNPHNAVVHLGH 479
Cdd:COG2319   228 VRLWDlATGKLLRTLTGHSGsVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2113643494 480 HNGSVSLWSPSIKEPLVKMLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLT 538
Cdd:COG2319   308 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 426-538 1.62e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 426 FLPYHFLLATCSATGFLQYLDVSVGREI-TATSVKAGRLSVMCqNPHNAVVHLGHHNGSVSLWSPSIKEPLVKMLCHGGA 504
Cdd:cd00200    59 ASADGTYLASGSSDKTIRLWDLETGECVrTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2113643494 505 VRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLT 538
Cdd:cd00200   138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 308-569 3.03e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 308 GEDTSIItqqdiaeVVDITSASKHFNLTLNQFGPYRINYSRNGRHLLLAGQRGHVASMDWHTKKLHCEMNVME-TVNDVR 386
Cdd:cd00200    28 SGDGTIK-------VWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTsYVSSVA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 387 WLHTHAMFAAA--QKKWLyIYD-NLGVELHCIK-KFNDVLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSVKAGR 462
Cdd:cd00200   101 FSPDGRILSSSsrDKTIK-VWDvETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 463 LSVMCQNPHNAVVHLGHHNGSVSLWSPSIKEPLVKMLCHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTSCLL 542
Cdd:cd00200   180 VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                         250       260       270
                  ....*....|....*....|....*....|
gi 2113643494 543 PLGA-GSLCHSQRG--LLAAGVGNIVQVYK 569
Cdd:cd00200   260 HTNSvTSLAWSPDGkrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
420-539 7.83e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.67  E-value: 7.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2113643494 420 DVLRMEFLPYHFLLATCSATGFLQYLDVSVGREITATSVKAGRLSVMCQNPHNAVVHLGHHNGSVSLWSPSIKEPLVKML 499
Cdd:COG2319    38 AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2113643494 500 CHGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTS 539
Cdd:COG2319   118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 501-569 6.40e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 6.40e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2113643494 501 HGGAVRALSIDKTGMYMASSGTDRKLTIFDLRTYRPLTSC---LLPLGAGSLCHSQRGLLAAGVGNIVQVYK 569
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkghTGPVRDVAASADGTYLASGSSDKTIRLWD 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH