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Conserved domains on  [gi|2037037853|ref|XP_041416398|]
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uncharacterized protein UHO2_06241 [Ustilago hordei]

Protein Classification

CDC37_N and CDC37_M domain-containing protein( domain architecture ID 10660762)

protein containing domains CDC37_N, CDC37_M, and CDC37_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-180 2.26e-55

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


:

Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 182.23  E-value: 2.26e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853    2 PLNYSKWDNLELSDDSDIEVHPNIDKKSFIRWKQRDIHEKRDQRKAEKDAIKAEMDTNDALSPRLDELIGSTKKQGSAyy 81
Cdd:smart01071   1 PIDYSKWDKIELSDDSDIEVHPNVDKKSFIRWKQRDIHQARVERMEEIKNLKYELIMNDHLNKRIDKLLKGLREEELS-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853   82 srevaklsagrqqrgnmdgPNGPTTDDMILSLLLQIQQHENLKGKTGndldEALLNELQRHREKLGARQTQIQFQLEQME 161
Cdd:smart01071  79 -------------------PETPTYNEMLAELQDQLKKELEEANGDS----EGLLEELKKHRDKLKKEQKELRKKLDELE 135

                          170
                   ....*....|....*....
gi 2037037853  162 KEDSKKITSDSIRDAWNSG 180
Cdd:smart01071 136 KEEKKKIWSVDTHTGFDKS 154
CDC37_M super family cl07248
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 278-386 7.19e-26

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


The actual alignment was detected with superfamily member pfam08565:

Pssm-ID: 447285  Cd Length: 113  Bit Score: 101.89  E-value: 7.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853 278 SLNINAFETALQFLSKHKLLLhpSSNTTDSLLLEAFNAQMASKSSLARRCVEKALMIQYCNKLG--PDGVNLFFRRmVAS 355
Cdd:pfam08565   4 KIPSGDYKASEQFLLKHPEIL--SEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLDgrINGVKLFFKR-ITT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2037037853 356 KDGRASVVYLNDVLATYARIRDRSKTLAEQQ 386
Cdd:pfam08565  81 KDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQ 111
CDC37_C super family cl07247
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 440-492 3.14e-13

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


The actual alignment was detected with superfamily member pfam08564:

Pssm-ID: 447284  Cd Length: 87  Bit Score: 65.04  E-value: 3.14e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2037037853 440 QRRWDIFQSFPEDFRKALETKQLIRVNEVLASINVDQAEQIVRNLDQAGILNF 492
Cdd:pfam08564  13 QKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGV 65
 
Name Accession Description Interval E-value
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-180 2.26e-55

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 182.23  E-value: 2.26e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853    2 PLNYSKWDNLELSDDSDIEVHPNIDKKSFIRWKQRDIHEKRDQRKAEKDAIKAEMDTNDALSPRLDELIGSTKKQGSAyy 81
Cdd:smart01071   1 PIDYSKWDKIELSDDSDIEVHPNVDKKSFIRWKQRDIHQARVERMEEIKNLKYELIMNDHLNKRIDKLLKGLREEELS-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853   82 srevaklsagrqqrgnmdgPNGPTTDDMILSLLLQIQQHENLKGKTGndldEALLNELQRHREKLGARQTQIQFQLEQME 161
Cdd:smart01071  79 -------------------PETPTYNEMLAELQDQLKKELEEANGDS----EGLLEELKKHRDKLKKEQKELRKKLDELE 135

                          170
                   ....*....|....*....
gi 2037037853  162 KEDSKKITSDSIRDAWNSG 180
Cdd:smart01071 136 KEEKKKIWSVDTHTGFDKS 154
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-119 2.17e-46

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 157.39  E-value: 2.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853   7 KWDNLELSDDSDIEVHPNIDKKSFIRWKQRDIHEKRDQRKAEKDAIKAEMDTNDALSPRLDELIGSTKKQGSAY---YSR 83
Cdd:pfam03234   1 KWDALELSDDSDIEVHPNVDKRSFIRWKQRDIHEKREQRKAEIKTLKYERIMNDGLLKRIDKLLTALKKHGVESdevVFQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2037037853  84 EVAKLSAGRQQRGNMD----GPNGPTTDDMILSLLLQIQQ 119
Cdd:pfam03234  81 ALMETAGDKNEKDDGPparpEENQPTYDEMLESLLDQIKE 120
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 278-386 7.19e-26

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 101.89  E-value: 7.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853 278 SLNINAFETALQFLSKHKLLLhpSSNTTDSLLLEAFNAQMASKSSLARRCVEKALMIQYCNKLG--PDGVNLFFRRmVAS 355
Cdd:pfam08565   4 KIPSGDYKASEQFLLKHPEIL--SEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLDgrINGVKLFFKR-ITT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2037037853 356 KDGRASVVYLNDVLATYARIRDRSKTLAEQQ 386
Cdd:pfam08565  81 KDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQ 111
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 278-388 7.75e-19

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 83.20  E-value: 7.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853  278 SLNINAFETALQFLSKHKLLLhpSSNTTDSLLLEAFNAQMASKSSLARRCVEKALMIQYCNKLG-------PDGVNLFFR 350
Cdd:smart01070  38 MIPAGDYDDSQKFLSEHPHIV--SEETADALVMWAFDLELEGKEALMEQVAHQAILMQYILELAkslkvdpRNCVRLFFQ 115

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2037037853  351 RMVAsKDGRASVVYLNDVLATYARIRDRSKTLAEQQKN 388
Cdd:smart01070 116 KIKT-PSHPAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 440-492 3.14e-13

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 65.04  E-value: 3.14e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2037037853 440 QRRWDIFQSFPEDFRKALETKQLIRVNEVLASINVDQAEQIVRNLDQAGILNF 492
Cdd:pfam08564  13 QKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGV 65
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 444-491 5.18e-09

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 53.56  E-value: 5.18e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2037037853  444 DIFQSFPEDFRKALETKQLIRVNEVLASINVDQAEQIVRNLDQAGILN 491
Cdd:smart01069  12 EVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWG 59
 
Name Accession Description Interval E-value
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-180 2.26e-55

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 182.23  E-value: 2.26e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853    2 PLNYSKWDNLELSDDSDIEVHPNIDKKSFIRWKQRDIHEKRDQRKAEKDAIKAEMDTNDALSPRLDELIGSTKKQGSAyy 81
Cdd:smart01071   1 PIDYSKWDKIELSDDSDIEVHPNVDKKSFIRWKQRDIHQARVERMEEIKNLKYELIMNDHLNKRIDKLLKGLREEELS-- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853   82 srevaklsagrqqrgnmdgPNGPTTDDMILSLLLQIQQHENLKGKTGndldEALLNELQRHREKLGARQTQIQFQLEQME 161
Cdd:smart01071  79 -------------------PETPTYNEMLAELQDQLKKELEEANGDS----EGLLEELKKHRDKLKKEQKELRKKLDELE 135

                          170
                   ....*....|....*....
gi 2037037853  162 KEDSKKITSDSIRDAWNSG 180
Cdd:smart01071 136 KEEKKKIWSVDTHTGFDKS 154
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-119 2.17e-46

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 157.39  E-value: 2.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853   7 KWDNLELSDDSDIEVHPNIDKKSFIRWKQRDIHEKRDQRKAEKDAIKAEMDTNDALSPRLDELIGSTKKQGSAY---YSR 83
Cdd:pfam03234   1 KWDALELSDDSDIEVHPNVDKRSFIRWKQRDIHEKREQRKAEIKTLKYERIMNDGLLKRIDKLLTALKKHGVESdevVFQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2037037853  84 EVAKLSAGRQQRGNMD----GPNGPTTDDMILSLLLQIQQ 119
Cdd:pfam03234  81 ALMETAGDKNEKDDGPparpEENQPTYDEMLESLLDQIKE 120
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 278-386 7.19e-26

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 101.89  E-value: 7.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853 278 SLNINAFETALQFLSKHKLLLhpSSNTTDSLLLEAFNAQMASKSSLARRCVEKALMIQYCNKLG--PDGVNLFFRRmVAS 355
Cdd:pfam08565   4 KIPSGDYKASEQFLLKHPEIL--SEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLDgrINGVKLFFKR-ITT 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2037037853 356 KDGRASVVYLNDVLATYARIRDRSKTLAEQQ 386
Cdd:pfam08565  81 KDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQ 111
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 278-388 7.75e-19

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 83.20  E-value: 7.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2037037853  278 SLNINAFETALQFLSKHKLLLhpSSNTTDSLLLEAFNAQMASKSSLARRCVEKALMIQYCNKLG-------PDGVNLFFR 350
Cdd:smart01070  38 MIPAGDYDDSQKFLSEHPHIV--SEETADALVMWAFDLELEGKEALMEQVAHQAILMQYILELAkslkvdpRNCVRLFFQ 115

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2037037853  351 RMVAsKDGRASVVYLNDVLATYARIRDRSKTLAEQQKN 388
Cdd:smart01070 116 KIKT-PSHPAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 440-492 3.14e-13

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 65.04  E-value: 3.14e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2037037853 440 QRRWDIFQSFPEDFRKALETKQLIRVNEVLASINVDQAEQIVRNLDQAGILNF 492
Cdd:pfam08564  13 QKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGV 65
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 444-491 5.18e-09

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 53.56  E-value: 5.18e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2037037853  444 DIFQSFPEDFRKALETKQLIRVNEVLASINVDQAEQIVRNLDQAGILN 491
Cdd:smart01069  12 EVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWG 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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