NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2024431684|ref|XP_040511644|]
View 

adenomatous polyposis coli protein isoform X10 [Gallus gallus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 732-1022 2.74e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.11  E-value: 2.74e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  732 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 811
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  812 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 890
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  891 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 969
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431684  970 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1022
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2841 5.58e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 301.92  E-value: 5.58e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2668 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2747
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2748 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2827
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431684 2828 SPKRHSGSYLVTSV 2841
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2220-2565 6.28e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 297.17  E-value: 6.28e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2220 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2298
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2299 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2378
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2379 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2452
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2453 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2530
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431684 2531 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2565
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1039-1138 1.63e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.27  E-value: 1.63e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1039 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1118
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431684 1119 GSTLGINQKVNQSLCQVDDY 1138
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1751-1842 7.90e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.17  E-value: 7.90e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1751 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1828
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431684 1829 KLPNNEERVRGSFT 1842
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 393-466 5.76e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.76e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431684  393 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 466
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1287-1373 6.48e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.22  E-value: 6.48e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1287 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1365
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431684 1366 PSKSGAQT 1373
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1876-1943 4.44e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.48  E-value: 4.44e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431684 1876 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1943
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1667-1720 1.06e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.06e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431684 1667 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1720
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.86e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


:

Pssm-ID: 435517  Cd Length: 52  Bit Score: 91.97  E-value: 2.86e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024431684    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 1.06e-12

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  127 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431684  206 TC 207
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1642-1665 1.97e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.97e-07
                           10        20
                   ....*....|....*....|....
gi 2024431684 1642 DMPRVYCVEGTPINFSTATSLSDL 1665
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 2.44e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431684   649 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2030-2049 4.51e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.19  E-value: 4.51e-05
                           10        20
                   ....*....|....*....|
gi 2024431684 2030 DSEDDLLQECISSAMPKKKK 2049
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-553 5.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431684   512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 553
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 340-392 1.56e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.56e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431684   340 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 392
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-731 2.47e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431684  691 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 731
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1721-1742 2.61e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 2.61e-03
                           10        20
                   ....*....|....*....|..
gi 2024431684 1721 DKTEEGDILAECINSAMPKGKS 1742
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1376-1398 4.47e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|....
gi 2024431684 1376 SPPEHY-VQETPLMFSRCTSVSSL 1398
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 459-510 4.95e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.95e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431684   459 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 510
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1261-1278 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 2024431684 1261 ETIQTYCVEDTPICFSRC 1278
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 732-1022 2.74e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.11  E-value: 2.74e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  732 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 811
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  812 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 890
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  891 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 969
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431684  970 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1022
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2841 5.58e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 301.92  E-value: 5.58e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2668 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2747
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2748 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2827
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431684 2828 SPKRHSGSYLVTSV 2841
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2220-2565 6.28e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 297.17  E-value: 6.28e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2220 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2298
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2299 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2378
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2379 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2452
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2453 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2530
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431684 2531 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2565
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1039-1138 1.63e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.27  E-value: 1.63e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1039 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1118
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431684 1119 GSTLGINQKVNQSLCQVDDY 1138
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1751-1842 7.90e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.17  E-value: 7.90e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1751 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1828
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431684 1829 KLPNNEERVRGSFT 1842
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 393-466 5.76e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.76e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431684  393 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 466
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1287-1373 6.48e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.22  E-value: 6.48e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1287 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1365
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431684 1366 PSKSGAQT 1373
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1876-1943 4.44e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.48  E-value: 4.44e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431684 1876 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1943
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1667-1720 1.06e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.06e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431684 1667 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1720
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.86e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 91.97  E-value: 2.86e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024431684    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 1.06e-12

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  127 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431684  206 TC 207
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1642-1665 1.97e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.97e-07
                           10        20
                   ....*....|....*....|....
gi 2024431684 1642 DMPRVYCVEGTPINFSTATSLSDL 1665
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 2.44e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431684   649 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 3.18e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.18e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431684  649 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2030-2049 4.51e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.19  E-value: 4.51e-05
                           10        20
                   ....*....|....*....|
gi 2024431684 2030 DSEDDLLQECISSAMPKKKK 2049
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-553 5.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431684   512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 553
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-552 6.04e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431684  512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 552
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 340-392 1.56e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.56e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431684   340 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 392
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2248-2561 2.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2248 PPFKNTNSKSPSEGQSSASSPRGVKSSVKPEPAPVTRQLSGLNQGGSSK--GPSRSGSRDSTPSRPQQQPLSRPLQSPGR 2325
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2326 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNTSSIPRSESASkglnqilg 2405
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-------- 2853

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2406 sGASNKKTDLSRMSSAKSSGSESDRSERPVLVR-------QSTFIKEAPSPTLRRKLEESASFESLSPSRPDSPTRSQLQ 2478
Cdd:PHA03247  2854 -GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRlarpavsRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2479 TPvlSPSLPDMSLS-THSTAQTSGWRKLPPNLSPSVEYDGR-PAKRhdiARSHSESPSRlPINRSGTwkreHSKHSSSLP 2556
Cdd:PHA03247  2933 PP--PPPRPQPPLApTTDPAGAGEPSGAVPQPWLGALVPGRvAVPR---FRVPQPAPSR-EAPASST----PPLTGHSLS 3002


                   ....*
gi 2024431684 2557 RVSTW 2561
Cdd:PHA03247  3003 RVSSW 3007
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-731 2.47e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431684  691 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 731
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1721-1742 2.61e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 2.61e-03
                           10        20
                   ....*....|....*....|..
gi 2024431684 1721 DKTEEGDILAECINSAMPKGKS 1742
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1376-1398 4.47e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|....
gi 2024431684 1376 SPPEHY-VQETPLMFSRCTSVSSL 1398
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 459-510 4.95e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.95e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431684   459 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 510
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1261-1278 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 2024431684 1261 ETIQTYCVEDTPICFSRC 1278
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 732-1022 2.74e-179

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 551.11  E-value: 2.74e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  732 NRPAKYKDTNIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNIYGEYVLDSSRHDDGVC 811
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSVC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  812 RTESFNTGNMTVLSPYLNSTVLPGSAS-SSRGNIENCLSEKDRSLDRDRAVGLNAYHPATENSGNSSKRIGMQISTAAAQ 890
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSrDSRGNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRIGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  891 IAKVMEEVTSMHIPQEDRSSGSTSEMHCLTEDRNTTRRAATAHTHSNTY-FPKSENSSRPCPVPYTKMEYKRASNDSLNS 969
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYsFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024431684  970 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1022
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2668-2841 5.58e-94

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 301.92  E-value: 5.58e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2668 RSGRSPTGNTPPVIDSVSEKGVVNGKDSKEIQEKQNPGNGSVPVRTIGLENRLNSFFQMDSPDKKGNETKPLQTNPVPAP 2747
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2748 ENNESTVSERTPFSSSSSSKHNSPIGAVAARVTPFNYNPSRRKSSVDNSSARPSQIPTPVNNSTKKRDSKSENTDSSGTQ 2827
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 2024431684 2828 SPKRHSGSYLVTSV 2841
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2220-2565 6.28e-90

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 297.17  E-value: 6.28e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2220 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPFKNTNSKSPSEGQ-SSASSPRGVKSSVKPEPAPVTRQLSglNQGGSSKGP 2298
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQqRSRSLHRLGKPSELADLSPPKRSAT--PPARISKAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2299 SRSGSRDSTPSRPQQQPLSRPLQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTAStkssssgRMSYTSPGRQMSQQNLT 2378
Cdd:pfam05956   79 SSGSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRNKLSPLPKTKSPARASTKKSGS-------HKTQKSPVRIPFMQTPT 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2379 KQTALTKNTSSI------PRSESASKGLNqilgsGASNKKTDLSRMSSAKSSGSESDRSerpVLVRQSTFIKEAPSPTLR 2452
Cdd:pfam05956  152 KQTGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLR 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2453 RKLEESASfESLSP-SRPDSPTRSQlqtpvlsPSLPDMSLSTHSTAQTSGWRKLPPNLSPSVEY-DGRPAKRHDIARSHS 2530
Cdd:pfam05956  224 RRLELSAS-ESLSPsSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPsDRPLTRRRPPRRTSS 295

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 2024431684 2531 ESPSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2565
Cdd:pfam05956  296 ESPSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1039-1138 1.63e-56

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 191.27  E-value: 1.63e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1039 LNSGRQSPSQNERWARPKHIIDDEMKQNDQRQSRSQSATYPVYTESGDDKHMKYQSPFGQQDCVPSFRSRGSNGSDQNRV 1118
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 2024431684 1119 GSTLGINQKVNQSLCQVDDY 1138
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1751-1842 7.90e-48

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 166.17  E-value: 7.90e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1751 IMDQIQQAST--SLNNKNQPEGEKKKPTSPVKPVPQNSEYRARVRKNTESKSQINNERSYPENRDAKKQNLKNNSRDFND 1828
Cdd:pfam16635    1 IMDQIQQASAasSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 2024431684 1829 KLPNNEERVRGSFT 1842
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 393-466 5.76e-44

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 154.63  E-value: 5.76e-44
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024431684  393 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVDHQICPAVCVLMKLSFDEEHRHAM 466
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1287-1373 6.48e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 129.22  E-value: 6.48e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 1287 AEDEI-GRDQSTRVTDTNATLQISELKENSGALSAEAAVSEITSTSQHIRTKSSRLPTSSLSPSESSRHKAVEFSSGAKS 1365
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSPSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 2024431684 1366 PSKSGAQT 1373
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1876-1943 4.44e-27

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 106.48  E-value: 4.44e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024431684 1876 DLSREKAELRKGKEAKEVETKDCPNVEQPSGQQPSNRTQVCQKHPTSRSQSK-------TFCQPSKDIPDRGAAT 1943
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKpllqkqtTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1667-1720 1.06e-26

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 104.49  E-value: 1.06e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024431684 1667 IESPPNELANVDSVGAGAESGEFEKRDTIPTEGRSTDDTQRAKSITVTGPGLDD 1720
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 2.86e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 91.97  E-value: 2.86e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2024431684    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 1.06e-12

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 65.74  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684  127 SRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRAAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 2024431684  206 TC 207
Cdd:pfam11414   81 LI 82
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1642-1665 1.97e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 48.92  E-value: 1.97e-07
                           10        20
                   ....*....|....*....|....
gi 2024431684 1642 DMPRVYCVEGTPINFSTATSLSDL 1665
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 2.44e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 2.44e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024431684   649 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 3.18e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 3.18e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431684  649 NEDHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2030-2049 4.51e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.19  E-value: 4.51e-05
                           10        20
                   ....*....|....*....|
gi 2024431684 2030 DSEDDLLQECISSAMPKKKK 2049
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-553 5.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024431684   512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 553
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-552 6.04e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431684  512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 552
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 340-392 1.56e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 1.56e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024431684   340 SQDSCIAMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 392
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2248-2561 2.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2248 PPFKNTNSKSPSEGQSSASSPRGVKSSVKPEPAPVTRQLSGLNQGGSSK--GPSRSGSRDSTPSRPQQQPLSRPLQSPGR 2325
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2326 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNTSSIPRSESASkglnqilg 2405
Cdd:PHA03247  2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-------- 2853

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2406 sGASNKKTDLSRMSSAKSSGSESDRSERPVLVR-------QSTFIKEAPSPTLRRKLEESASFESLSPSRPDSPTRSQLQ 2478
Cdd:PHA03247  2854 -GSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRlarpavsRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2479 TPvlSPSLPDMSLS-THSTAQTSGWRKLPPNLSPSVEYDGR-PAKRhdiARSHSESPSRlPINRSGTwkreHSKHSSSLP 2556
Cdd:PHA03247  2933 PP--PPPRPQPPLApTTDPAGAGEPSGAVPQPWLGALVPGRvAVPR---FRVPQPAPSR-EAPASST----PPLTGHSLS 3002


                   ....*
gi 2024431684 2557 RVSTW 2561
Cdd:PHA03247  3003 RVSSW 3007
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-731 2.47e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.47e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2024431684  691 NAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 731
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1721-1742 2.61e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.19  E-value: 2.61e-03
                           10        20
                   ....*....|....*....|..
gi 2024431684 1721 DKTEEGDILAECINSAMPKGKS 1742
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2255-2563 2.76e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.52  E-value: 2.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2255 SKSPSEGQSSASSPRGVKSSvKPEPA--------PV-TRQLSGLNQGGSSKGPS--RSGSRDSTPSRPQQQP------LS 2317
Cdd:PTZ00449   540 SDEPKEGGKPGETKEGEVGK-KPGPAkehkpskiPTlSKKPEFPKDPKHPKDPEepKKPKRPRSAQRPTRPKspklpeLL 618

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2318 RPLQSPGR-NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSSSGRMSYTSPGRQMSQQNLTKQTALTKNT-SSIPRSES 2395
Cdd:PTZ00449   619 DIPKSPKRpESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETkTTVVLDES 698

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2396 ASKGLNQILGSGASNKKTD-------LSRMSSAKSSGSESDRSERP-------VLVRQSTFIKEAPSPTLRRKL------ 2455
Cdd:PTZ00449   699 FESILKETLPETPGTPFTTprplppkLPRDEEFPFEPIGDPDAEQPddiefftPPEEERTFFHETPADTPLPDIlaeefk 778

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024431684 2456 EESASFESLSPS----RPDSPTRSQLQTPVLSPSLP-------DMSLSThSTAQTSGWRKL------PPNLSPSVEYDGR 2518
Cdd:PTZ00449   779 EEDIHAETGEPDeamkRPDSPSEHEDKPPGDHPSLPkkrhrldGLALST-TDLESDAGRIAkdasgkIVKLKRSKSFDDL 857

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2024431684 2519 PAKRhdIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRR 2563
Cdd:PTZ00449   858 TTVE--EAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVRR 900
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1376-1398 4.47e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.59  E-value: 4.47e-03
                           10        20
                   ....*....|....*....|....
gi 2024431684 1376 SPPEHY-VQETPLMFSRCTSVSSL 1398
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 459-510 4.95e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 4.95e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024431684   459 DEEHRHAMNELGGLQAIAELLQvdcemygltndHYSVTLRRYAGMALTNLTF 510
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK-----------SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1261-1278 8.22e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 35.82  E-value: 8.22e-03
                           10
                   ....*....|....*...
gi 2024431684 1261 ETIQTYCVEDTPICFSRC 1278
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH