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Conserved domains on  [gi|1995109912|ref|XP_039686457|]
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pyruvate dehydrogenase (acetyl-transferring) kinase, mitochondrial isoform X2 [Medicago truncatula]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468
PubMed:  10339418|10637609

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 111-277 2.32e-77

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 232.62  E-value: 2.32e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 111 SPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADG 190
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 191 LEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPL--DEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENY 268
Cdd:cd16929    81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSldDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                  ....*....
gi 1995109912 269 GTDAYLHLS 277
Cdd:cd16929   161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 1-107 4.08e-42

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 142.26  E-value: 4.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912   1 MVRDWYLDSFRDIRSFSEIKnMNDEKEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKiinqdfvEIHQFLDRFYMSR 80
Cdd:pfam10436  56 KVYEWYLQSFEELLSFPPPI-LEDNEKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSR 127

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1995109912  81 IGIRMLIGQHVELH----SPNPPPHVVGYIH 107
Cdd:pfam10436 128 IGIRLLAEQHIALTeqsnNPSHPPDYVGIID 158
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 111-277 2.32e-77

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 232.62  E-value: 2.32e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 111 SPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADG 190
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 191 LEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPL--DEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENY 268
Cdd:cd16929    81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSldDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                  ....*....
gi 1995109912 269 GTDAYLHLS 277
Cdd:cd16929   161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 1-107 4.08e-42

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 142.26  E-value: 4.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912   1 MVRDWYLDSFRDIRSFSEIKnMNDEKEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKiinqdfvEIHQFLDRFYMSR 80
Cdd:pfam10436  56 KVYEWYLQSFEELLSFPPPI-LEDNEKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSR 127

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1995109912  81 IGIRMLIGQHVELH----SPNPPPHVVGYIH 107
Cdd:pfam10436 128 IGIRLLAEQHIALTeqsnNPSHPPDYVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 151-276 3.23e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 78.07  E-value: 3.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912  151 PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTArnpldehad 230
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG--------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD--------- 65

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1995109912  231 lgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 276
Cdd:smart00387  66 ---KRSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 150-276 2.43e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 73.17  E-value: 2.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 150 VPAHLHLMVFELVKNSLRAVEErymnsdkdPPPIRIIVADGlEDVTIKISDEGGGIPRSGLRKIFTYLYStarnpldeha 229
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAK--------AGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFST---------- 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1995109912 230 dlgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 276
Cdd:pfam02518  63 ----ADKRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
104-276 2.40e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 59.54  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 104 GYIHTRMSPV---EVARNAVDDARSICSRQYGS------APDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYM 174
Cdd:COG2205    82 GKLSLELEPVdlaELLEEAVEELRPLAEEKGIRleldlpPELPLVYADPE--------LLEQVLANLLDNAIK-----YS 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 175 NSDkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPldehadlgvgdnvTMAGYGYGLPISRLYAR 254
Cdd:COG2205   149 PPG---GTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSR-------------GEGGTGLGLAIVKRIVE 212

                         170       180
                  ....*....|....*....|..
gi 1995109912 255 YFGGDLQIISMENYGTDAYLHL 276
Cdd:COG2205   213 AHGGTIWVESEPGGGTTFTVTL 234
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 186-270 1.07e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 43.39  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 186 IVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPLDEHAdlgvgdnvtmAGYGYGLPISRLYARYFGGDLQIISM 265
Cdd:PRK11091  423 VRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPA----------TGTGIGLAVSKRLAQAMGGDITVTSE 492


                  ....*
gi 1995109912 266 ENYGT 270
Cdd:PRK11091  493 EGKGS 497
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 111-277 2.32e-77

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 232.62  E-value: 2.32e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 111 SPVEVARNAVDDARSICSRQYGSAPDVHIYGDPDFTFPYVPAHLHLMVFELVKNSLRAVEERYMNSDKDPPPIRIIVADG 190
Cdd:cd16929     1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 191 LEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPL--DEHADLGVGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENY 268
Cdd:cd16929    81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSldDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                  ....*....
gi 1995109912 269 GTDAYLHLS 277
Cdd:cd16929   161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 1-107 4.08e-42

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 142.26  E-value: 4.08e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912   1 MVRDWYLDSFRDIRSFSEIKnMNDEKEFTEVIKAIKVRHNNVVPTMALGVQQLKKDVDPKiinqdfvEIHQFLDRFYMSR 80
Cdd:pfam10436  56 KVYEWYLQSFEELLSFPPPI-LEDNEKFTELLEEILDRHNDVVPTLAQGVLELKKYLSPE-------EIQSFLDRFLRSR 127

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1995109912  81 IGIRMLIGQHVELH----SPNPPPHVVGYIH 107
Cdd:pfam10436 128 IGIRLLAEQHIALTeqsnNPSHPPDYVGIID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 151-276 3.23e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 78.07  E-value: 3.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912  151 PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTArnpldehad 230
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG--------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD--------- 65

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1995109912  231 lgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 276
Cdd:smart00387  66 ---KRSRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 150-276 2.43e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 73.17  E-value: 2.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 150 VPAHLHLMVFELVKNSLRAVEErymnsdkdPPPIRIIVADGlEDVTIKISDEGGGIPRSGLRKIFTYLYStarnpldeha 229
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAK--------AGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFST---------- 62

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1995109912 230 dlgvGDNVTMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 276
Cdd:pfam02518  63 ----ADKRGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
104-276 2.40e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 59.54  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 104 GYIHTRMSPV---EVARNAVDDARSICSRQYGS------APDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYM 174
Cdd:COG2205    82 GKLSLELEPVdlaELLEEAVEELRPLAEEKGIRleldlpPELPLVYADPE--------LLEQVLANLLDNAIK-----YS 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 175 NSDkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPldehadlgvgdnvTMAGYGYGLPISRLYAR 254
Cdd:COG2205   149 PPG---GTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSR-------------GEGGTGLGLAIVKRIVE 212

                         170       180
                  ....*....|....*....|..
gi 1995109912 255 YFGGDLQIISMENYGTDAYLHL 276
Cdd:COG2205   213 AHGGTIWVESEPGGGTTFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
107-276 3.39e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 59.92  E-value: 3.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 107 HTRMSPVEVARNAVDDARSICSRQ------YGSAPDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYMNSDKdp 180
Cdd:COG0642   179 PEPVDLAELLEEVVELFRPLAEEKgielelDLPDDLPTVRGDPD--------RLRQVLLNLLSNAIK-----YTPEGG-- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 181 pPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPLDEhadlgvgdnvtmaGYGYGLPISRLYARYFGGDL 260
Cdd:COG0642   244 -TVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGG-------------GTGLGLAIVKRIVELHGGTI 309

                         170
                  ....*....|....*.
gi 1995109912 261 QIISMENYGTDAYLHL 276
Cdd:COG0642   310 EVESEPGKGTTFTVTL 325
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 109-270 1.68e-08

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 54.80  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 109 RMSPVEVARnAVDDARSICSRQYGSAP-DVHIYGDPDFtfPYV---PAHLHLMVFELVKNSLRAVEERymnsdkDPPPIR 184
Cdd:COG4191   211 EREPVDLNE-LIDEALELLRPRLKARGiEVELDLPPDL--PPVlgdPGQLEQVLLNLLINAIDAMEEG------EGGRIT 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 185 IIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehadlgVGDnvtmaGYGYGLPISRLYARYFGGDLQIIS 264
Cdd:COG4191   282 ISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKP----------VGK-----GTGLGLSISYGIVEKHGGRIEVES 346


                  ....*.
gi 1995109912 265 MENYGT 270
Cdd:COG4191   347 EPGGGT 352
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 109-283 6.18e-08

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 53.04  E-value: 6.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 109 RMSPVEVARnAVDDARSICSRQYgSAPDVHIYGDPDFTFPYV---PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRI 185
Cdd:COG5000   272 QLEPVDLNE-LLREVLALYEPAL-KEKDIRLELDLDPDLPEVladRDQLEQVLINLLKNAIEAIEEG--------GEIEV 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 186 IVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnvtmaGYGYGLPISRLYARYFGGDLQIISM 265
Cdd:COG5000   342 STRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPK-----------------GTGLGLAIVKKIVEEHGGTIELESR 404

                         170
                  ....*....|....*...
gi 1995109912 266 ENYGTDAYLHLSRLGDSQ 283
Cdd:COG5000   405 PGGGTTFTIRLPLAEEAE 422
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 151-270 9.80e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 49.34  E-value: 9.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 151 PAHLHLMVFELVKNSLRAVEERymnsdkdpPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehad 230
Cdd:cd16943     1 PSQLNQVLLNLLVNAAQAMEGR--------GRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKP-------- 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1995109912 231 lgVGDnvtmaGYGYGLPISRLYARYFGGDLQIISMENYGT 270
Cdd:cd16943    65 --VGE-----GTGLGLSLSYRIIQKHGGTIRVASVPGGGT 97
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 136-276 5.50e-06

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 47.28  E-value: 5.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 136 DVHIYGDPDFTFPYV---PAHLHLMVFELVKNSLRAveeryMNSDKDpppirIIVADGLED---VTIKISDEGGGIPRSG 209
Cdd:COG5809   359 NVQIELELEDDIPDIlgdENQLKQVFINLLKNAIEA-----MPEGGN-----ITIETKAEDddkVVISVTDEGCGIPEER 428

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1995109912 210 LRKIFTYLYSTARNpldehadlgvgdnvtmaGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 276
Cdd:COG5809   429 LKKLGEPFYTTKEK-----------------GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 161-270 5.63e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 47.15  E-value: 5.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 161 LVKNSLRAVEErymnSDKDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnvtmA 240
Cdd:COG3290   289 LLDNAIEAVEK----LPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLG----------------E 348

                          90       100       110
                  ....*....|....*....|....*....|
gi 1995109912 241 GYGYGLPISRLYARYFGGDLQIISMENYGT 270
Cdd:COG3290   349 GRGLGLALVKQIVEKYGGTIEVESEEGEGT 378
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 161-270 3.70e-05

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 44.72  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 161 LVKNSLRAVEerymnsdkDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnvtma 240
Cdd:COG5805   403 LIKNAIEAMP--------NGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK----------------- 457

                          90       100       110
                  ....*....|....*....|....*....|
gi 1995109912 241 GYGYGLPISRLYARYFGGDLQIISMENYGT 270
Cdd:COG5805   458 GTGLGLMVSYKIIENHNGTIDIDSKVGKGT 487
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
108-276 5.91e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 44.16  E-value: 5.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 108 TRMSPVEVARNAVDDARSICSRQ------YGSAPDVHIYGDPDftfpyvpaHLHLMVFELVKNSLRaveerYMNSDKdpp 181
Cdd:COG5002   238 EPVDLAELLEEVVEELRPLAEEKgielelDLPEDPLLVLGDPD--------RLEQVLTNLLDNAIK-----YTPEGG--- 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 182 PIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLY--STARNPldehadlgvgdnvTMAGYGYGLPISRLYARYFGGD 259
Cdd:COG5002   302 TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYrvDKSRSR-------------ETGGTGLGLAIVKHIVEAHGGR 368

                         170
                  ....*....|....*..
gi 1995109912 260 LQIISMENYGTDAYLHL 276
Cdd:COG5002   369 IWVESEPGKGTTFTITL 385
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 183-262 1.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 40.52  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 183 IRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehadlgvgDNVTMAGYGYGLPISRLYARYFGGDLQI 262
Cdd:cd16945    26 IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPR------------PHSGQKSTGLGLAFVQEVAQLHGGRITL 93
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 186-270 1.07e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 43.39  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 186 IVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNPLDEHAdlgvgdnvtmAGYGYGLPISRLYARYFGGDLQIISM 265
Cdd:PRK11091  423 VRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPA----------TGTGIGLAVSKRLAQAMGGDITVTSE 492


                  ....*
gi 1995109912 266 ENYGT 270
Cdd:PRK11091  493 EGKGS 497
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 158-269 1.42e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 40.13  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 158 VFELVKNSLRAVEERymnsdkDPPPIRIIVADGLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehadlgVGDnv 237
Cdd:cd16976     5 LMNLLQNALDAMGKV------ENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKP----------VGK-- 66

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1995109912 238 tmaGYGYGLPISRLYARYFGGDLQIISMENYG 269
Cdd:cd16976    67 ---GTGLGLSISYGIVEEHGGRLSVANEEGAG 95
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 133-280 2.17e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 42.52  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 133 SAPDVHIYGDPDFtfpyvpahLHLMVFELVKNSLraveerymnsDKDPPPIRIIVADGLED--VTIKISDEGGGIPRSGL 210
Cdd:PRK11100  356 RPDDARVLGDPFL--------LRQALGNLLDNAI----------DFSPEGGTITLSAEVDGeqVALSVEDQGPGIPDYAL 417

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 211 RKIFTYLYSTARnPldehadlGVGDNVTmagyGYGLPISRLYARYFGGDLQIISMENYGTDAYLHLSRLG 280
Cdd:PRK11100  418 PRIFERFYSLPR-P-------ANGRKST----GLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 157-270 2.27e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 39.58  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 157 MVFELVKNSLRAVeerymnSDKDPPPIRIIVADGLE--DVTIKISDEGGGIPRSGLRKIFTYLYSTarNPLDEHadlgvg 234
Cdd:cd16915     4 IVGNLIDNALDAL------AATGAPNKQVEVFLRDEgdDLVIEVRDTGPGIAPELRDKVFERGVST--KGQGER------ 69

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1995109912 235 dnvtmagyGYGLPISRLYARYFGGDLQIISMENYGT 270
Cdd:cd16915    70 --------GIGLALVRQSVERLGGSITVESEPGGGT 97
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 133-257 1.06e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 38.16  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 133 SAPDVHIYGDPDFtfpyvpahLHLMVFELVKNSLRaveerYMNSDKDpppIRIIVADGLEDVtIKISDEGGGIPRSGLRK 212
Cdd:cd16940     1 SAADIQVQGDALL--------LFLLLRNLVDNAVR-----YSPQGSR---VEIKLSADDGAV-IRVEDNGPGIDEEELEA 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1995109912 213 IFTYLYSTarnpldehadlgvgDNVTMAGYGYGLPI-SRLYARYFG 257
Cdd:cd16940    64 LFERFYRS--------------DGQNYGGSGLGLSIvKRIVELHGG 95
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 158-270 1.43e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 37.38  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 158 VFELVKNSLRAVEEryMNSDKDPPPIRIIVADgLEDVTIKISDEGGGIPRSGLRKIFTYLYSTARNpldehadlgvgdnv 237
Cdd:cd16920     5 LINLVRNGIEAMSE--GGCERRELTIRTSPAD-DRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE-------------- 67

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1995109912 238 tmaGYGYGLPISRLYARYFGGDLQIISMENYGT 270
Cdd:cd16920    68 ---GLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
PRK15347 PRK15347
two component system sensor kinase;
196-287 2.47e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 39.24  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 196 IKISDEGGGIPRSGLRKIFTYLYSTarnplDEHadlgvgdnvtMAGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLH 275
Cdd:PRK15347  547 FTVEDTGCGIDIQQQQQIFTPFYQA-----DTH----------SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLV 611

                          90
                  ....*....|..
gi 1995109912 276 LSrLGDSQEPLP 287
Cdd:PRK15347  612 LP-LNEYAPPEP 622
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
83-276 3.15e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 38.67  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912  83 IRMLIGQHVELHSPNPPphvvgyihtRMSPVEVARnAVDDARSICSRQYGS--------APDV-HIYGDPDftfpyvpaH 153
Cdd:COG3852   183 LNNLVDRLLSFSRPRPP---------EREPVNLHE-VLERVLELLRAEAPKnirivrdyDPSLpEVLGDPD--------Q 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 154 LHLMVFELVKNSLRAVEE--------RYMNSDKDPPpiriiVADGLEdVTIKISDEGGGIPRSGLRKIFTYLYSTARNpl 225
Cdd:COG3852   245 LIQVLLNLVRNAAEAMPEggtitirtRVERQVTLGG-----LRPRLY-VRIEVIDNGPGIPEEILDRIFEPFFTTKEK-- 316

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1995109912 226 dehadlgvgdnvtmaGYGYGLPISRLYARYFGGDLQIISMENYGTDAYLHL 276
Cdd:COG3852   317 ---------------GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 138-264 3.47e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 38.90  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 138 HIYGDPDftfpyVPA---HLHLMVFELVKNSLRAVEErymnsdkdPPPIRIIVADGLEDVTIKISDEGGGIPRSGlrKIF 214
Cdd:COG4192   530 HIPDDLM-----VQGdqvLLEQVLVNLLVNALDAVAT--------QPQISVDLLSNAENLRVAISDNGNGWPLVD--KLF 594

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1995109912 215 TYLYSTARnpldehadlgvgdnvtmAGYGYGLPISRLYARYFGGDLQIIS 264
Cdd:COG4192   595 TPFTTTKE-----------------VGLGLGLSICRSIMQQFGGDLYLAS 627
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 161-267 4.12e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 36.36  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 161 LVKNSLRAVEERymnsDKDPPPIRIIV-ADGLEDVTIKISDEGGGIPRSGLRKIFTYlYSTARNpldehadlgvgdnvtm 239
Cdd:cd16944    12 ILKNAAEAIEGR----PSDVGEVRIRVeADQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRP---------------- 70

                          90       100
                  ....*....|....*....|....*...
gi 1995109912 240 AGYGYGLPISRLYARYFGGdlqIISMEN 267
Cdd:cd16944    71 KGTGLGLAIVKKIMEEHGG---RISLSN 95
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 158-264 4.42e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 36.54  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 158 VFELVKNSLRAVEERymnsdkdpppIRIIVADGLEDVT-IKISDEGGGIPRSGLRKIFTYLYSTARNPLDeHADLGVgdn 236
Cdd:pfam13589   5 LAELIDNSIDADATN----------IKIEVNKNRGGGTeIVIEDDGHGMSPEELINALRLATSAKEAKRG-STDLGR--- 70

                          90       100
                  ....*....|....*....|....*...
gi 1995109912 237 vtmagYGYGLpisRLYARYFGGDLQIIS 264
Cdd:pfam13589  71 -----YGIGL---KLASLSLGAKLTVTS 90
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 194-276 5.32e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 36.20  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 194 VTIKISDEGGGIPRSGLRKIFTYLYSTArnpldehadlGVGdnvtmAGYGYGLPISRLYARYFGGDLQIISMENYGTDAY 273
Cdd:cd16919    48 VCLEVSDTGSGMPAEVLRRAFEPFFTTK----------EVG-----KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVR 112


                  ...
gi 1995109912 274 LHL 276
Cdd:cd16919   113 IYL 115
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
193-278 9.89e-03

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 37.25  E-value: 9.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995109912 193 DVTIKISDEGGGIPRSGLRKIFTYLYSTARnpldehadlgvgdnvtmAGYGYGLPISRLYARYFGGDLQIISMENYGTDA 272
Cdd:PRK11360  533 QVAVSIEDNGCGIDPELLKKIFDPFFTTKA-----------------KGTGLGLALSQRIINAHGGDIEVESEPGVGTTF 595


                  ....*.
gi 1995109912 273 YLHLSR 278
Cdd:PRK11360  596 TLYLPI 601
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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