BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  29 MDRLNEQRLFQPDLCDVDIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 108
Cdd:cd18231     1 MDRLNEQRLFQPDLCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1985348691 109 VNACNVQDVLNAAAVLQMNNIASSCQELINTRSLS 143
Cdd:cd18231    81 VNSCNVQDVLNAAAVLQMNDIAASCQELIDSRSLS 115

FOG: Zn-finger [General function prediction only];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1985348691 599 KPYICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHK 648
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  29 MDRLNEQRLFQPDLCDVDIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 108
Cdd:cd18231     1 MDRLNEQRLFQPDLCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1985348691 109 VNACNVQDVLNAAAVLQMNNIASSCQELINTRSLS 143
Cdd:cd18231    81 VNSCNVQDVLNAAAVLQMNDIAASCQELIDSRSLS 115

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691   46 DIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNACNVQDVLNAAAVL 124
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1985348691  125 QMNNIASSCQELINTRS 141
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 1985348691 615 NMKRHRRTHTGEKPYPCDVCGQRF 638
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691 541 GEKPFKCE--NCNERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKR 618
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                  ....*.
gi 1985348691 619 HrRTHT 624
Cdd:COG5189   417 H-RKHS 421

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 1985348691  601 YICEICGKSFTSRPNMKRHRRTH 623
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  29 MDRLNEQRLFQPDLCDVDIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 108
Cdd:cd18231     1 MDRLNEQRLFQPDLCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1985348691 109 VNACNVQDVLNAAAVLQMNNIASSCQELINTRSLS 143
Cdd:cd18231    81 VNSCNVQDVLNAAAVLQMNDIAASCQELIDSRSLS 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  42 LCDVDIVLvqQKSIFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNACNVQDVLNA 120
Cdd:cd18186     1 LCDVTLVV--GGREFPAHRAVLAARSPYFRAMFSSGmKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAA 78

                  .
gi 1985348691 121 A 121
Cdd:cd18186    79 A 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRLfQPDLCDVdiVLVQQKSIFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFI 102
Cdd:cd18255     1 HSVTLLQGLNALRA-KGQLLDV--TLIADGQRFQAHKVVLASCSDYFRAMFTGGmRESSQDEIELKGVSAKGLKHILDFA 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1985348691 103 YTSKLLVNACNVQDVLNAAAVLQMNNIASSCQE 135
Cdd:cd18255    78 YTSELTLDLDCIQDVLGAAVHLQMLPVVELCEE 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  21 VALHFTCLMDRLNEQRLfQPDLCDVDIVLVQQksIFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALTSQGLQQI 98
Cdd:cd18329     1 ISSHQSRLLQQLDEQRK-QELFCDCSILVEGQ--VFKAHRNVLFASSGYFKMLLSQNAKetGQPTVATFDVFSPDTFTII 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1985348691  99 LNFIYTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELI 137
Cdd:cd18329    78 LDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRLfQPDLCDVdiVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQL-QRVELSLEALTSQGLQQILNFI 102
Cdd:cd18326     8 HSSDILSSLNEQRT-QGLLCDV--VILVEGREFPTHRSVLAACSQYFKKLFTSGAVVdQQNVYEIDFVSAEALTALLDFA 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1985348691 103 YTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELIN 138
Cdd:cd18326    85 YTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  42 LCDVDIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQLQRV-ELSLEALTSQGLQQILNFIYTSKLLVNACNVQDVLNA 120
Cdd:cd18239    23 LCDVTLVPGDGDETFPVHRAMMASASDYFKAMFTGGMKEQELmCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEA 102

                          90
                  ....*....|....*....
gi 1985348691 121 AAVLQMNNIASSCQELINT 139
Cdd:cd18239   103 ASFLQILPVLDFCKVLLIS 121

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691   46 DIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNACNVQDVLNAAAVL 124
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1985348691  125 QMNNIASSCQELINTRS 141
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRlfqpDLCD-VDIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNF 101
Cdd:cd18276     4 HSLTLLDQLNRMK----ELAElTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGlMECSQREVVLHDITAESVSIILNY 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1985348691 102 IYTSKLLVNACNVQDVLNAAAVLQMNNIASSCQ 134
Cdd:cd18276    80 MYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  18 VEDVALHFTCLMDRLNEQRLfQPDLCDVdIVLVQQKSiFPAHKGVLAAYSQFF-HSLFTQNKQLQRVELSlEALTSQGLQ 96
Cdd:cd18278     8 VYESTVHCTNILLCLNDQRK-QDILCDV-TLIVEGKE-FRAHRAVLAACSEYFlQALVGQTENDLVVSLP-EEVTARGFG 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1985348691  97 QILNFIYTSKLLVNACNVQDVLNAAAVLQMNNIASSC 133
Cdd:cd18278    84 PLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRlfQPD-LCDVDIVLVQQKsiFPAHKGVLAAYSQFFHSLFTQNKQlQRVELSLEALTSQGLQQILNFI 102
Cdd:cd18217     1 HCEQLLERLNKQR--EAGfLCDCTIVIGQFQ--FKAHRNVLAAFSEYFGAQYKDTED-NIVFLDQSQVSADGFQKLLEFI 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1985348691 103 YTSKLLVNACNVQDVLNAAAVLQMNNIASSCQE 135
Cdd:cd18217    76 YTGNLNLDSWNVAEIHQAASYLGMEEVVAKCKI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRlfQPDLCdVDIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQLQRVElsLEALTSQGLQQILNFIY 103
Cdd:cd18221     1 HYKVMLDRLNEQR--ELDQF-TDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVE--IEGVSNMAFRHLIEFTY 75

                          90       100
                  ....*....|....*....|....
gi 1985348691 104 TSKLLVNA-CNVQDVLNAAAVLQM 126
Cdd:cd18221    76 TAKLMVQGeEEANDVWKAAEYLQM 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  28 LMDRLNEQRLfQPDLCDVDIVLVQQksIFPAHKGVLAAYSQFFHSL--FTQNKQLQRVELS-LEALTSQGLQQILNFIYT 104
Cdd:cd18201     8 LLQELNEQRK-KGILCDVNIVVSGK--VFRAHKNILVAGSRFFKTLycFTNKESCDQTTVThLDVVAVQGFSVILDFMYS 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1985348691 105 SKLLVNACNVQDVLNAAAVLQMNNIASSCQELI 137
Cdd:cd18201    85 GNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRLfQPDLCDVDIVLVQQKsiFPAHKGVLAAYSQFFHSLFT---QNKQLQRVELSLEALTSQGLQQILN 100
Cdd:cd18196     4 HFEQIFQQLNYQRL-HGQLCDCVIVVGNRH--FKAHRSVLAACSTHFRALFTvaeGDQTMNMIQLDSEVVTAEAFAALID 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1985348691 101 FIYTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELINTRSLSLA 145
Cdd:cd18196    81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMS 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  21 VALHFTCLMDRLNEQRLFQPDLCDVdIVLVQQKSiFPAHKGVLAAYSQFFHSLFTQNKQ--LQRVELSLEALTSQGLQQI 98
Cdd:cd18207     6 VSQHSADMLHNLNQQRKSGGRFCDV-LLRVGEES-FPAHRAVLAACSEYFESVFSAQEGdgGTPRELEMHTISSKVFGDI 83

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1985348691  99 LNFIYTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELI 137
Cdd:cd18207    84 LDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVI 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  42 LCDVDIVLVQQKsiFPAHKGVLAAYSQFFHSLFTQN--KQLQRvELSLEALTSQGLQQILNFIYTSKLLVNACNVQDVLN 119
Cdd:cd18247    19 LCDVTLKVGDQK--FSAHRIVLAATIPYFHAMFTHDmvESKQD-EITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLV 95

                          90       100
                  ....*....|....*....|.
gi 1985348691 120 AAAVLQMNNIASSCQELINTR 140
Cdd:cd18247    96 GASFLQLQSVKDACCEFLKER 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  22 ALHFTCLMDRLNEQRLfQPDLCDVDIVLVQQKsiFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSLEALTSQGLQQILNF 101
Cdd:cd18277     8 SVHSTNVLLSLNDQRK-KDVLCDVTILVEGQR--FRAHRSVLAACSSYFHSRIVGQADAELNITLPEEVTVKGFEPLIQF 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1985348691 102 IYTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELI 137
Cdd:cd18277    85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  42 LCDVdiVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQLQRVE-LSLEALTSQGLQQILNFIYTSKLLVNACNVQDVLNA 120
Cdd:cd18264    28 LCDV--VLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARvIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEA 105

                          90       100
                  ....*....|....*....|...
gi 1985348691 121 AAVLQMNNIASSC-QELINTRSL 142
Cdd:cd18264   106 ASYLQVTEAIGLCsQYLINNLAP 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRLfQPDLCDVDIVLvqQKSIFPAHKGVLAAYSQFFHSLFTQNkqlQRVELSLEALTSQGLQQILNFIY 103
Cdd:cd18334     4 HAKQLLLQLNQQRA-KGFLCDVIIVV--ENALFRAHKNILAASSMYFKSLVLHD---NLINLDTDMVNPTVFRQILDFIY 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1985348691 104 TSKLLVN----ACNVQDVLNAAAVLQMNNIASSCQE 135
Cdd:cd18334    78 TGKLLTSdqpgEQNFNALLTAASYLQLHDLAALCRK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  31 RLNEQRLFQPDLCD-------VDIVLVQQKSIFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFI 102
Cdd:cd18340     7 RLYQQTLLQDGLKDlldhnkfVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDlEESKKREIVLEDVDPDVMGKILHYI 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1985348691 103 YTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELINTR-SLSLAMA 147
Cdd:cd18340    87 YTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRlCLSNCLA 132

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRLfQPDLCDVDIVLVQQKsiFPAHKGVLAAYSQFFHSLFTQNKQLQRVELSL-EALTSQGLQQILNFI 102
Cdd:cd18332     2 HSSDVLLNLNELRK-RDILTDVTLLVGGTP--LRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLpSGLEARGFQLLLDFM 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1985348691 103 YTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELI 137
Cdd:cd18332    79 YTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRLfQPDLCDVdIVLVQQKSiFPAHKGVLAAYSQFFHsLFTQNKQLQR--VELSLEALTSQGLQQILNF 101
Cdd:cd18323     6 HSRHLLQSLREQRH-QGFLCDC-TVLVGSTQ-FLAHRAVLASCSPFFH-MFYKEQLDKRdlVCINNEIVTAPAFSLLLEF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1985348691 102 IYTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELINTRSLSLA 145
Cdd:cd18323    82 MYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQARALAEA 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  28 LMDRLNEQRLfQPDLCDVdiVLVQQKSIFPAHKGVLAAYSQFFHSLFTQNKQlQRVELS--LEALTSQGLQQILNFIYTS 105
Cdd:cd18306     5 VLAKLNALRK-NRQFCDV--ILQVGGHEIPAHRAVLACASPYLFELFSSDSD-GESILTvkLDGLDPDAVEVLVNYAYTS 80

                          90       100
                  ....*....|....*....|....*...
gi 1985348691 106 KLLVNACNVQDVLNAAAVLQMNNIASSC 133
Cdd:cd18306    81 RLEVPADLVKSVYSAAKKLKMDRVKKAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1985348691  24 HFTCLMDRLNEQRLfQPDLCDVDIVLVQQKsiFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFI 102
Cdd:cd18256     3 HASLILAQLNKLRG-QHEFCDVQLQVGMEL--FSVHRLVLAASSPYFAALFAGGmSESSKDVVQIHGVEPDIFHILLDFI 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1985348691 103 YTSKLLVNACNVQDVLNAAAVLQMNNIASSCQELI 137
Cdd:cd18256    80 YTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFL 114