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Conserved domains on  [gi|1958783755|ref|XP_038968461|]
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D-glutamate cyclase, mitochondrial isoform X3 [Rattus norvegicus]

Protein Classification

DUF4392 domain-containing protein( domain architecture ID 10538093)

DUF4392 domain-containing protein similar to Thermococcus onnurineus TON_0340

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
186-497 1.23e-127

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


:

Pssm-ID: 464140  Cd Length: 291  Bit Score: 373.15  E-value: 1.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 186 LESTIATDPGNRGIGHLLLKDELLLAALS-LSHAHSVLVTTGFPTHFSHepPEETDGPPGAIALAAFLQALGKEAAMVVD 264
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPlSHAAGSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 265 RralnLHTKIVEDAVKQGVLKTPIPIlTYRGGSVEDARAFLCKDGDPKSPRF---------DHLVAVERAGRAADGNYYN 335
Cdd:pfam14336  79 E----LNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAEAQAeellekykpDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 336 ARKVNIKHLVDPIDDIFLAAQKIpGISSTGVGDGGNELGMGRVKEAVKKHIRNGDVIACDVEADFAVIAGVSNWGGYALA 415
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGIGDGGNELGMGNVKEAVKKHVPNGEKIACVVAADFLITAGVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 416 CALYILNSCPvherylrratgpsgeageqswiQALPSVAKEEKMLGILVQNQVRSGVSGIVGMEVDGLPFHgVHAEMIQK 495
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 1958783755 496 LV 497
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
2-142 2.06e-72

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


:

Pssm-ID: 462133  Cd Length: 143  Bit Score: 226.18  E-value: 2.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755   2 VTFIMDCSFSIEEALEQAGIPRRDLTGSGHAGAYKTAVPCATIAGFCCPLVVTMRPVPKDKLERLLLATHSLGGQQGQPI 81
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRNVPMYRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPAVHGAPV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958783755  82 HIGDPELLGIKPLSKPDYGSYVECRPGDVPVFWPSHLTSLEAVIGCKAPLAFASPPGCTVM 142
Cdd:pfam07286  81 HIGDPALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFV 141
 
Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
186-497 1.23e-127

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


Pssm-ID: 464140  Cd Length: 291  Bit Score: 373.15  E-value: 1.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 186 LESTIATDPGNRGIGHLLLKDELLLAALS-LSHAHSVLVTTGFPTHFSHepPEETDGPPGAIALAAFLQALGKEAAMVVD 264
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPlSHAAGSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 265 RralnLHTKIVEDAVKQGVLKTPIPIlTYRGGSVEDARAFLCKDGDPKSPRF---------DHLVAVERAGRAADGNYYN 335
Cdd:pfam14336  79 E----LNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAEAQAeellekykpDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 336 ARKVNIKHLVDPIDDIFLAAQKIpGISSTGVGDGGNELGMGRVKEAVKKHIRNGDVIACDVEADFAVIAGVSNWGGYALA 415
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGIGDGGNELGMGNVKEAVKKHVPNGEKIACVVAADFLITAGVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 416 CALYILNSCPvherylrratgpsgeageqswiQALPSVAKEEKMLGILVQNQVRSGVSGIVGMEVDGLPFHgVHAEMIQK 495
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 1958783755 496 LV 497
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
2-142 2.06e-72

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


Pssm-ID: 462133  Cd Length: 143  Bit Score: 226.18  E-value: 2.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755   2 VTFIMDCSFSIEEALEQAGIPRRDLTGSGHAGAYKTAVPCATIAGFCCPLVVTMRPVPKDKLERLLLATHSLGGQQGQPI 81
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRNVPMYRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPAVHGAPV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958783755  82 HIGDPELLGIKPLSKPDYGSYVECRPGDVPVFWPSHLTSLEAVIGCKAPLAFASPPGCTVM 142
Cdd:pfam07286  81 HIGDPALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFV 141
PRK05463 PRK05463
putative hydro-lyase;
1-139 3.31e-33

putative hydro-lyase;


Pssm-ID: 180100  Cd Length: 262  Bit Score: 126.87  E-value: 3.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755   1 MVTFIMDCSFSIEEALEQAGIPRRDLTGSGHAGAYKTAVPCATIAGFCCPLVVTMRPVPKDKLERLLLATHSLGGQQGQP 80
Cdd:PRK05463  110 LVTFLIGCSFSFEHALLEAGIPVRHIEEGRNVPMYRTNIPCRPAGRFSGPMVVSMRPIPAADAIRAVQITSRFPAVHGAP 189
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958783755  81 IHIGDPELLGIKPLSKPDYGSYVECRPGDVPVFWPSHLTSLEAVIGCKAPLAFASPPGC 139
Cdd:PRK05463  190 VHIGDPAAIGIADLARPDFGDAVEIEPGEIPVFWACGVTPQAVVMAAKPPFAITHAPGH 248
 
Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
186-497 1.23e-127

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


Pssm-ID: 464140  Cd Length: 291  Bit Score: 373.15  E-value: 1.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 186 LESTIATDPGNRGIGHLLLKDELLLAALS-LSHAHSVLVTTGFPTHFSHepPEETDGPPGAIALAAFLQALGKEAAMVVD 264
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPlSHAAGSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 265 RralnLHTKIVEDAVKQGVLKTPIPIlTYRGGSVEDARAFLCKDGDPKSPRF---------DHLVAVERAGRAADGNYYN 335
Cdd:pfam14336  79 E----LNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAEAQAeellekykpDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 336 ARKVNIKHLVDPIDDIFLAAQKIpGISSTGVGDGGNELGMGRVKEAVKKHIRNGDVIACDVEADFAVIAGVSNWGGYALA 415
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGIGDGGNELGMGNVKEAVKKHVPNGEKIACVVAADFLITAGVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755 416 CALYILNSCPvherylrratgpsgeageqswiQALPSVAKEEKMLGILVQNQVRSGVSGIVGMEVDGLPFHgVHAEMIQK 495
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 1958783755 496 LV 497
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
2-142 2.06e-72

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


Pssm-ID: 462133  Cd Length: 143  Bit Score: 226.18  E-value: 2.06e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755   2 VTFIMDCSFSIEEALEQAGIPRRDLTGSGHAGAYKTAVPCATIAGFCCPLVVTMRPVPKDKLERLLLATHSLGGQQGQPI 81
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRNVPMYRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPAVHGAPV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958783755  82 HIGDPELLGIKPLSKPDYGSYVECRPGDVPVFWPSHLTSLEAVIGCKAPLAFASPPGCTVM 142
Cdd:pfam07286  81 HIGDPALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFV 141
PRK05463 PRK05463
putative hydro-lyase;
1-139 3.31e-33

putative hydro-lyase;


Pssm-ID: 180100  Cd Length: 262  Bit Score: 126.87  E-value: 3.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958783755   1 MVTFIMDCSFSIEEALEQAGIPRRDLTGSGHAGAYKTAVPCATIAGFCCPLVVTMRPVPKDKLERLLLATHSLGGQQGQP 80
Cdd:PRK05463  110 LVTFLIGCSFSFEHALLEAGIPVRHIEEGRNVPMYRTNIPCRPAGRFSGPMVVSMRPIPAADAIRAVQITSRFPAVHGAP 189
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958783755  81 IHIGDPELLGIKPLSKPDYGSYVECRPGDVPVFWPSHLTSLEAVIGCKAPLAFASPPGC 139
Cdd:PRK05463  190 VHIGDPAAIGIADLARPDFGDAVEIEPGEIPVFWACGVTPQAVVMAAKPPFAITHAPGH 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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