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Conserved domains on  [gi|1958782004|ref|XP_038967752|]
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protein jagged-2 isoform X3 [Rattus norvegicus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11168616)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 28-196 4.45e-71

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


:

Pssm-ID: 462222  Cd Length: 157  Bit Score: 227.57  E-value: 4.45e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782004  28 GYFELQLSALRNVNGELLSGACCDGdGRTTRAGGCgRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPP 107
Cdd:pfam07657   2 GYFELQLLSFENPNGRLANGNCCDG-GRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782004 108 AGaagdrararsrtgGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTT--PDEELLIERVSHAGMINPEDRWKSLHFSG 185
Cdd:pfam07657  80 LL-------------KGSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDsgSDNPRLIERAIHQGMLNPGDEWQTLRHNG 146

                         170
                  ....*....|.
gi 1958782004 186 HVAHLELQIRV 196
Cdd:pfam07657 147 GVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
178-240 4.77e-24

delta serrate ligand;


:

Pssm-ID: 128366  Cd Length: 63  Bit Score: 95.47  E-value: 4.77e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958782004  178 WKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
Cdd:smart00051   1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 385-421 3.77e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 3.77e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782004 385 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWVGATCQ 421
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 461-496 4.46e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 4.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782004 461 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
Cdd:cd00054     1 DIDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 307-345 1.06e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958782004 307 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGYLGKNCE 345
Cdd:cd00054     1 DIDECASGNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 636-671 1.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 636 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWEGELC 671
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 423-458 1.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 423 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWKGANC 458
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 536-571 2.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 536 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDFGGKNC 571
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 502-534 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958782004 502 CAS-SPCRRGGICEDLVDGFRCHCPRGLSGPLCE 534
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 351-381 2.03e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.03e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958782004 351 CASNPCANGGSCHEVLSGFECHCPSGWSGPT 381
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 28-196 4.45e-71

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 227.57  E-value: 4.45e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782004  28 GYFELQLSALRNVNGELLSGACCDGdGRTTRAGGCgRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPP 107
Cdd:pfam07657   2 GYFELQLLSFENPNGRLANGNCCDG-GRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782004 108 AGaagdrararsrtgGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTT--PDEELLIERVSHAGMINPEDRWKSLHFSG 185
Cdd:pfam07657  80 LL-------------KGSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDsgSDNPRLIERAIHQGMLNPGDEWQTLRHNG 146

                         170
                  ....*....|.
gi 1958782004 186 HVAHLELQIRV 196
Cdd:pfam07657 147 GVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
178-240 4.77e-24

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 95.47  E-value: 4.77e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958782004  178 WKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
Cdd:smart00051   1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 198-243 1.15e-17

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 76.89  E-value: 1.15e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958782004 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 243
Cdd:pfam01414   1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 385-421 3.77e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 3.77e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782004 385 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWVGATCQ 421
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 461-496 4.46e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 4.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782004 461 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
Cdd:cd00054     1 DIDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 307-345 1.06e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958782004 307 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGYLGKNCE 345
Cdd:cd00054     1 DIDECASGNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 636-671 1.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 636 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWEGELC 671
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
461-496 4.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958782004  461 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGF-GGRHCE 496
Cdd:smart00179   1 DIDECasGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 423-458 1.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 423 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWKGANC 458
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
636-667 1.55e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 1.55e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958782004  636 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWE 667
Cdd:smart00179   1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
385-421 1.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.78e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958782004  385 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWV-GATCQ 421
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
307-345 2.09e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958782004  307 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGY-LGKNCE 345
Cdd:smart00179   1 DIDECASGNPCQNGGTCVN-TVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 536-571 2.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 536 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDFGGKNC 571
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
423-458 1.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 1.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958782004  423 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWK-GANC 458
Cdd:smart00179   1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 502-534 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958782004 502 CAS-SPCRRGGICEDLVDGFRCHCPRGLSGPLCE 534
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 351-381 2.03e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.03e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958782004 351 CASNPCANGGSCHEVLSGFECHCPSGWSGPT 381
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 351-382 2.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958782004 351 CAS-NPCANGGSCHEVLSGFECHCPSGWSGPTC 382
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 540-570 3.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 3.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958782004 540 CEPNPCLNGARCYNLEDDYYCACPEDFGGKN 570
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
536-571 4.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 4.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958782004  536 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDF-GGKNC 571
Cdd:smart00179   1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 469-490 6.71e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 34.62  E-value: 6.71e-03
                          10        20
                  ....*....|....*....|..
gi 1958782004 469 CQHGGTCKDLVNGYQCVCPRGF 490
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
 
Name Accession Description Interval E-value
MNNL pfam07657
N terminus of Notch ligand C2-like domain; This entry represents a region of conserved ...
 28-196 4.45e-71

N terminus of Notch ligand C2-like domain; This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins. The entry has been extended to correspond to the C2-like domain defined by the protein structure.


Pssm-ID: 462222  Cd Length: 157  Bit Score: 227.57  E-value: 4.45e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782004  28 GYFELQLSALRNVNGELLSGACCDGdGRTTRAGGCgRDECDTYVRVCLKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPP 107
Cdd:pfam07657   2 GYFELQLLSFENPNGRLANGNCCDG-GRSSSDGQC-RDECDTYFRVCLKEYQANVSPDGPCTFGSGSTPVLGGNSFTLPG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958782004 108 AGaagdrararsrtgGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTT--PDEELLIERVSHAGMINPEDRWKSLHFSG 185
Cdd:pfam07657  80 LL-------------KGSFRGPIVIPFQFAWPGSFTLIVEAWDEDNSTDsgSDNPRLIERAIHQGMLNPGDEWQTLRHNG 146

                         170
                  ....*....|.
gi 1958782004 186 HVAHLELQIRV 196
Cdd:pfam07657 147 GVAELEYSYRV 157
DSL smart00051
delta serrate ligand;
178-240 4.77e-24

delta serrate ligand;


Pssm-ID: 128366  Cd Length: 63  Bit Score: 95.47  E-value: 4.77e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958782004  178 WKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
Cdd:smart00051   1 WSTDLHIGGRTFLEYQIRVTCDENYYGEGCNKFCRPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
 198-243 1.15e-17

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 76.89  E-value: 1.15e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1958782004 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 243
Cdd:pfam01414   1 CDENYYGSTCSKFCRPRDDKFGHYTCDANGNKVCLPGWTGPYCDKP 46
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 385-421 3.77e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 3.77e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782004 385 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWVGATCQ 421
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 461-496 4.46e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 4.46e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958782004 461 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
Cdd:cd00054     1 DIDECasGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 307-345 1.06e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958782004 307 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGYLGKNCE 345
Cdd:cd00054     1 DIDECASGNPCQNGGTCVN-TVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 636-671 1.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 636 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWEGELC 671
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
461-496 4.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958782004  461 NINDC--HGQCQHGGTCKDLVNGYQCVCPRGF-GGRHCE 496
Cdd:smart00179   1 DIDECasGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 423-458 1.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 423 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWKGANC 458
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
636-667 1.55e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 1.55e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1958782004  636 NIDDC-MGQPCRNGGTCIDEVDSFRCFCPSGWE 667
Cdd:smart00179   1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
385-421 1.78e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 1.78e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958782004  385 DIDECAS-NPCAAGGTCVDQVDGFECICPEQWV-GATCQ 421
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
307-345 2.09e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958782004  307 DLNYCGSHHPCVNGGTCINaEPDQYLCACPDGY-LGKNCE 345
Cdd:smart00179   1 DIDECASGNPCQNGGTCVN-TVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 536-571 2.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958782004 536 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDFGGKNC 571
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
423-458 1.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 1.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958782004  423 DANECE-GKPCLNAFSCKNLIGGYYCDCLPGWK-GANC 458
Cdd:smart00179   1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 502-534 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958782004 502 CAS-SPCRRGGICEDLVDGFRCHCPRGLSGPLCE 534
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 351-381 2.03e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 2.03e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958782004 351 CASNPCANGGSCHEVLSGFECHCPSGWSGPT 381
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 351-382 2.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1958782004 351 CAS-NPCANGGSCHEVLSGFECHCPSGWSGPTC 382
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 540-570 3.51e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 3.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958782004 540 CEPNPCLNGARCYNLEDDYYCACPEDFGGKN 570
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
536-571 4.00e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 4.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1958782004  536 DVDLCE-PNPCLNGARCYNLEDDYYCACPEDF-GGKNC 571
Cdd:smart00179   1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 469-490 6.71e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 34.62  E-value: 6.71e-03
                          10        20
                  ....*....|....*....|..
gi 1958782004 469 CQHGGTCKDLVNGYQCVCPRGF 490
Cdd:pfam12661   1 CQNGGTCVDGVNGYKCQCPPGY 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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