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Conserved domains on  [gi|1958775668|ref|XP_038965573|]
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eukaryotic translation initiation factor 4 gamma 3 isoform X3 [Rattus norvegicus]

Protein Classification

MIF4G domain-containing protein( domain architecture ID 10501428)

MIF4G (middle domain of eukaryotic initiation factor 4G) domain-containing protein may contain multiple alpha-helical repeats; similar to Saccharomyces cerevisiae suppressor of glycerol defect protein 1 and Arabidopsis thaliana eukaryotic translation initiation factor isoform 4G

CATH:  1.25.40.180
Gene Ontology:  GO:0003723|GO:0005515
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 962-1190 7.82e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.82e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  962 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 1041
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668 1042 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1121
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775668 1122 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1190
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1428-1540 8.41e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 132.01  E-value: 8.41e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668 1428 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1507
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958775668 1508 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1540
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 65-491 5.35e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.43  E-value: 5.35e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   65 RALQTPAPQQIPRGPVqqpledriFPPTVSavysTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGLSQTP 144
Cdd:PHA03247  2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  145 YPSGQNAGPATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYCIFAAGPRPAHHQ- 223
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALp 2819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  224 FFQRPQ--IQPPRAAIPNSSPSLRPGAQTPTAvyqanqhimmvnhlPMPYPVPQGPqycIPQYRHSGPPYVGPPQQYPVQ 301
Cdd:PHA03247  2820 PAASPAgpLPPPTSAQPTAPPPPPGPPPPSLP--------------LGGSVAPGGD---VRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  302 PPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPP-PAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNP 380
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  381 TPPIGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqspsTVLRLVLSGEKKEQA 460
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV-----SLKQTLWPPDDTEDS 3037

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1958775668  461 GQIP-------ETAAGEPSPEPPRTSSPTTLPPLARSS 491
Cdd:PHA03247  3038 DADSlfdsdseRSDLEALDPLPPEPHDPFAHEPDPATP 3075
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 962-1190 7.82e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.82e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  962 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 1041
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668 1042 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1121
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775668 1122 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1190
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 963-1187 4.13e-51

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 179.48  E-value: 4.13e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   963 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 1042
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  1043 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 1122
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958775668  1123 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1187
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1428-1540 8.41e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 132.01  E-value: 8.41e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668 1428 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1507
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958775668 1508 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1540
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1428-1540 1.67e-33

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 125.43  E-value: 1.67e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  1428 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1507
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1958775668  1508 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1540
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
PHA03247 PHA03247
large tegument protein UL36; Provisional
 65-491 5.35e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.43  E-value: 5.35e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   65 RALQTPAPQQIPRGPVqqpledriFPPTVSavysTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGLSQTP 144
Cdd:PHA03247  2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  145 YPSGQNAGPATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYCIFAAGPRPAHHQ- 223
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALp 2819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  224 FFQRPQ--IQPPRAAIPNSSPSLRPGAQTPTAvyqanqhimmvnhlPMPYPVPQGPqycIPQYRHSGPPYVGPPQQYPVQ 301
Cdd:PHA03247  2820 PAASPAgpLPPPTSAQPTAPPPPPGPPPPSLP--------------LGGSVAPGGD---VRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  302 PPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPP-PAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNP 380
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  381 TPPIGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqspsTVLRLVLSGEKKEQA 460
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV-----SLKQTLWPPDDTEDS 3037

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1958775668  461 GQIP-------ETAAGEPSPEPPRTSSPTTLPPLARSS 491
Cdd:PHA03247  3038 DADSlfdsdseRSDLEALDPLPPEPHDPFAHEPDPATP 3075
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 62-444 1.27e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.15  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   62 PNIRALQTPAPQQIPR-GPVQQPLEDRIFPPTVSAvYSTVTQVARQPGPPTPSPYSAHEINKGHPnLAATPPGHASSPGL 140
Cdd:pfam03154  229 TLIQQTPTLHPQRLPSpHPPLQPMTQPPPPSQVSP-QPLPQPSLHGQMPPMPHSLQTGPSHMQHP-VPPQPFPLTPQSSQ 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  141 SQTP-YPSGQNAGPATlvypQAPQTMNSQPQARSP-PSRAVPV-HCPDNWKRRKVLEQTPVyRSLAGRGWIKYCIFAAGP 217
Cdd:pfam03154  307 SQVPpGPSPAAPGQSQ----QRIHTPPSQSQLQSQqPPREQPLpPAPLSMPHIKPPPTTPI-PQLPNPQSHKHPPHLSGP 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  218 RPahhqfFQRPQIQPPraaipnsSPSLRPGAQTPTavyqanqhimmvNHLPMPYPvpqGPQYCIPQYRHSGPPyvgppqq 297
Cdd:pfam03154  382 SP-----FQMNSNLPP-------PPALKPLSSLST------------HHPPSAHP---PPLQLMPQSQQLPPP------- 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  298 ypvqppgpgpfypgpgpgdfanaygtpfyPSQPvyqsaPIIVPTQQQPPPAKREKKTIRIRD-PNQggKDITEEIMSGGG 376
Cdd:pfam03154  428 -----------------------------PAQP-----PVLTQSQSLPPPAASHPPTSGLHQvPSQ--SPFPQHPFVPGG 471

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775668  377 SRNPTPPIGRPTSTPT--PPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQE-EKPKPDPVFQSP 444
Cdd:pfam03154  472 PPPITPPSGPPTSTSSamPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEpESPPPPPRSPSP 542
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 962-1190 7.82e-64

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 216.08  E-value: 7.82e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  962 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 1041
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668 1042 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 1121
Cdd:pfam02854   72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958775668 1122 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 1190
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 963-1187 4.13e-51

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 179.48  E-value: 4.13e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   963 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 1042
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  1043 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 1122
Cdd:smart00543   72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958775668  1123 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1187
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1428-1540 8.41e-36

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 132.01  E-value: 8.41e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668 1428 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1507
Cdd:pfam02847    1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958775668 1508 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1540
Cdd:pfam02847   81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1428-1540 1.67e-33

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 125.43  E-value: 1.67e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  1428 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1507
Cdd:smart00544    1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80

                            90       100       110
                    ....*....|....*....|....*....|...
gi 1958775668  1508 TLELADDMAIDIPHIWLYLAELVTPMLKEGGIS 1540
Cdd:smart00544   81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
PHA03247 PHA03247
large tegument protein UL36; Provisional
 65-491 5.35e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.43  E-value: 5.35e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   65 RALQTPAPQQIPRGPVqqpledriFPPTVSavysTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGLSQTP 144
Cdd:PHA03247  2672 RAAQASSPPQRPRRRA--------ARPTVG----SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAP 2739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  145 YPSGQNAGPATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYCIFAAGPRPAHHQ- 223
Cdd:PHA03247  2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALp 2819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  224 FFQRPQ--IQPPRAAIPNSSPSLRPGAQTPTAvyqanqhimmvnhlPMPYPVPQGPqycIPQYRHSGPPYVGPPQQYPVQ 301
Cdd:PHA03247  2820 PAASPAgpLPPPTSAQPTAPPPPPGPPPPSLP--------------LGGSVAPGGD---VRRRPPSRSPAAKPAAPARPP 2882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  302 PPGPGPFYPGPGPGDFANAYGTPFYPSQPVYQSAPIIVPTQQQPP-PAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNP 380
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  381 TPPIGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVfqspsTVLRLVLSGEKKEQA 460
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPV-----SLKQTLWPPDDTEDS 3037

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1958775668  461 GQIP-------ETAAGEPSPEPPRTSSPTTLPPLARSS 491
Cdd:PHA03247  3038 DADSlfdsdseRSDLEALDPLPPEPHDPFAHEPDPATP 3075
PHA03378 PHA03378
EBNA-3B; Provisional
 75-475 1.50e-10

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 66.63  E-value: 1.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   75 IPRGPvQQPLEDRIFP-------------PTVSAVYSTVTQVARQPGP----PTPSPYSAHeinkghpnLAATPPGHASS 137
Cdd:PHA03378   525 LPPSP-PQPRAGRRAPcvytedldiesdePASTEPVHDQLLPAPGLGPlqiqPLTSPTTSQ--------LASSAPSYAQT 595

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  138 PGLsqTPYPSGQNAGPATLVYPQApqtmNSQPQARSPPSRAVPVH------CPDNWKRRKVLEQTP-VYRSLAGRGWIKY 210
Cdd:PHA03378   596 PWP--VPHPSQTPEPPTTQSHIPE----TSAPRQWPMPLRPIPMRplrmqpITFNVLVFPTPHQPPqVEITPYKPTWTQI 669

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  211 CIFAAGPRPAHHQFFQRPQIQPPRAAIPNSSPS-LRPGAQTPTAVYQANQhimmvnhLPMPYPVPQGPQYCIpQYRHSGP 289
Cdd:PHA03378   670 GHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTpMRPPAAPPGRAQRPAA-------ATGRARPPAAAPGRA-RPPAAAP 741

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  290 PYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQ--PVYQSAPIIVPTQQQPPPAKREKKTIRIRD-PNQGG-- 364
Cdd:PHA03378   742 GRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQapPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAaPGQQGpt 821

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  365 KDITEEIMSGGGSRN-----------------PTPPIGRPTSTPT-------PPQQLPSQAPehspvvyGTVESAHLAAS 420
Cdd:PHA03378   822 KQILRQLLTGGVKRGrpslkkpaalerqaaagPTPSPGSGTSDKIvqapvfyPPVLQPIQVM-------RQLGSVRAAAA 894

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958775668  421 TPVTAASDQKQEEKPKPDPVfqSPSTVLRlvlSGEKKEQAGQIPETAAGEPSPEP 475
Cdd:PHA03378   895 STVTQAPTEYTGERRGVGPM--HPTDIPP---SKRAKTDAYVESQPPHGGQSHSF 944
PHA03247 PHA03247
large tegument protein UL36; Provisional
 65-540 4.30e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.34  E-value: 4.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   65 RALQTPAPQQIPRGPVQQPLEDRIFPPTVSAvySTVTQVA-----RQPGPPTPSPYSAHeinkghpnlAATPPGHASSPG 139
Cdd:PHA03247  2566 RSVPPPRPAPRPSEPAVTSRARRPDAPPQSA--RPRAPVDdrgdpRGPAPPSPLPPDTH---------APDPPPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  140 LSQTPypsgqnaGPATLVYPQAPqtmnsQPQARSPPSRAVPvhcpdnwKRRKVLEQTPVYRSLAGRGWIKYcifAAGPRP 219
Cdd:PHA03247  2635 ANEPD-------PHPPPTVPPPE-----RPRDDPAPGRVSR-------PRRARRLGRAAQASSPPQRPRRR---AARPTV 2692

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  220 AHHQFFQRPqiqPPRAAIPNSSP-SLRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQY 298
Cdd:PHA03247  2693 GSLTSLADP---PPPPPTPEPAPhALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAP 2769

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  299 PVQPpgpgpfypgpgpgdfANAYGTPfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQggkdiTEEIMSGGGSR 378
Cdd:PHA03247  2770 APPA---------------APAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA-----ALPPAASPAGP 2827

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  379 NPTPPIGRPTSTPTPPQQL-PSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKK 457
Cdd:PHA03247  2828 LPPPTSAQPTAPPPPPGPPpPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPER 2907

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  458 EQAGQIPE------TAAGEPSPEPPRTSSPTTLPPLARSSLPSPMSAA--LSSQQLLTAEDKCELSSSKDDAPPVRSPTS 529
Cdd:PHA03247  2908 PPQPQAPPppqpqpQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgAVPQPWLGALVPGRVAVPRFRVPQPAPSRE 2987

                          490
                   ....*....|.
gi 1958775668  530 CTAAPGPSLTD 540
Cdd:PHA03247  2988 APASSTPPLTG 2998
PHA03247 PHA03247
large tegument protein UL36; Provisional
 324-562 6.32e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 6.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  324 PFYPSQPVYQSAPIIV--PTQQQPPPAKREKKTIRIRDPNQGGKDITEEimSGGGSRNPTPPIGRPTSTPTPPQ------ 395
Cdd:PHA03247  2589 PDAPPQSARPRAPVDDrgDPRGPAPPSPLPPDTHAPDPPPPSPSPAANE--PDPHPPPTVPPPERPRDDPAPGRvsrprr 2666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  396 -QLPSQAPEHSPVVYGTVESAHLAASTPVTAASD-QKQEEKPKPDPVFQSPSTVLRLVLSGEKK---------------- 457
Cdd:PHA03247  2667 aRRLGRAAQASSPPQRPRRRAARPTVGSLTSLADpPPPPPTPEPAPHALVSATPLPPGPAAARQaspalpaapappavpa 2746

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  458 -------EQAGQIPETAAGEPSPEPPR---TSSPTTLPP-------LARSSLPSPMSAALSSQQLLTAedKCELSSSKDD 520
Cdd:PHA03247  2747 gpatpggPARPARPPTTAGPPAPAPPAapaAGPPRRLTRpavaslsESRESLPSPWDPADPPAAVLAP--AAALPPAASP 2824

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1958775668  521 APPVRSPTSCTAAPGPSLTDDIGLCKKPCGVAPPDGQLVSSP 562
Cdd:PHA03247  2825 AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRP 2866
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 233-543 9.43e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 50.85  E-value: 9.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  233 PRAAIPNSSPSLR----PGAQTPTAVYQanqhimmvnhlPMPYPVPQGPQYCIPQYRHSGP---PYVGPPQQYPVQPPGP 305
Cdd:PRK10263   347 ASVDVPPAQPTVAwqpvPGPQTGEPVIA-----------PAPEGYPQQSQYAQPAVQYNEPlqqPVQPQQPYYAPAAEQP 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  306 gpfypgpgpgdfanaygtpfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEimsggGSRNPTPPIG 385
Cdd:PRK10263   416 ---------------------AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQ-----STYQTEQTYQ 469

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  386 RPTSTPTPPQQLPSQAPEhspvvygtvesahlaastPVTAASDQKQEEKPKPDPVFQSPSTVLRlvlSGEKKEQAGQ--- 462
Cdd:PRK10263   470 QPAAQEPLYQQPQPVEQQ------------------PVVEPEPVVEETKPARPPLYYFEEVEEK---RAREREQLAAwyq 528

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  463 -IPETAAgEPSPEPPRTS--SPTTLPPLARSSLPSPMSAALSSQQLLTaedkcelSSSKDDAPPVRSPTScTAAPGPSLT 539
Cdd:PRK10263   529 pIPEPVK-EPEPIKSSLKapSVAAVPPVEAAAAVSPLASGVKKATLAT-------GAAATVAAPVFSLAN-SGGPRPQVK 599


                   ....
gi 1958775668  540 DDIG 543
Cdd:PRK10263   600 EGIG 603
PHA03247 PHA03247
large tegument protein UL36; Provisional
 90-501 1.25e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   90 PPTVSAVYSTVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHAssPGLSQTPYPSGQNAGPATLvypqAPQTmnsqP 169
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA--AQASSPPQRPRRRAARPTV----GSLT----S 2697

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  170 QARSPPSRAVPVHCPDNWKRRKVLEQTPVyrslAGRGWIKYCIFAAGPR--------PAHHQFFQRPQIQ--PPRAAIPN 239
Cdd:PHA03247  2698 LADPPPPPPTPEPAPHALVSATPLPPGPA----AARQASPALPAAPAPPavpagpatPGGPARPARPPTTagPPAPAPPA 2773

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  240 SSPSLRPGAQTPTAVYQANQHIMMVNHLPMPYPVP---QGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGD 316
Cdd:PHA03247  2774 APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPaavLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  317 FANAYGTPFYPSQPVYQSAPiiVPTQQQPPPAKREKKTIRIRDPNqggkdiTEEIMSGGGSRNPTPPIGRPTSTPTPPQQ 396
Cdd:PHA03247  2854 GSVAPGGDVRRRPPSRSPAA--KPAAPARPPVRRLARPAVSRSTE------SFALPPDQPERPPQPQAPPPPQPQPQPPP 2925

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  397 LPSQAPEHSPvvygTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPstvlrlvlsgekkeqaGQIPETAAGEPSPEPP 476
Cdd:PHA03247  2926 PPQPQPPPPP----PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP----------------GRVAVPRFRVPQPAPS 2985

                          410       420
                   ....*....|....*....|....*
gi 1958775668  477 RTSSPTTLPPLARSSLPSPMSAALS 501
Cdd:PHA03247  2986 REAPASSTPPLTGHSLSRVSSWASS 3010
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 62-444 1.27e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.15  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   62 PNIRALQTPAPQQIPR-GPVQQPLEDRIFPPTVSAvYSTVTQVARQPGPPTPSPYSAHEINKGHPnLAATPPGHASSPGL 140
Cdd:pfam03154  229 TLIQQTPTLHPQRLPSpHPPLQPMTQPPPPSQVSP-QPLPQPSLHGQMPPMPHSLQTGPSHMQHP-VPPQPFPLTPQSSQ 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  141 SQTP-YPSGQNAGPATlvypQAPQTMNSQPQARSP-PSRAVPV-HCPDNWKRRKVLEQTPVyRSLAGRGWIKYCIFAAGP 217
Cdd:pfam03154  307 SQVPpGPSPAAPGQSQ----QRIHTPPSQSQLQSQqPPREQPLpPAPLSMPHIKPPPTTPI-PQLPNPQSHKHPPHLSGP 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  218 RPahhqfFQRPQIQPPraaipnsSPSLRPGAQTPTavyqanqhimmvNHLPMPYPvpqGPQYCIPQYRHSGPPyvgppqq 297
Cdd:pfam03154  382 SP-----FQMNSNLPP-------PPALKPLSSLST------------HHPPSAHP---PPLQLMPQSQQLPPP------- 427

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  298 ypvqppgpgpfypgpgpgdfanaygtpfyPSQPvyqsaPIIVPTQQQPPPAKREKKTIRIRD-PNQggKDITEEIMSGGG 376
Cdd:pfam03154  428 -----------------------------PAQP-----PVLTQSQSLPPPAASHPPTSGLHQvPSQ--SPFPQHPFVPGG 471

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958775668  377 SRNPTPPIGRPTSTPT--PPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQE-EKPKPDPVFQSP 444
Cdd:pfam03154  472 PPPITPPSGPPTSTSSamPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEpESPPPPPRSPSP 542
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
374-537 2.05e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.46  E-value: 2.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  374 GGGSRNPTPPIGRPTSTPTPPQQLPSQA-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 452
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  453 SGEKKEQAGQIPETAAGEPSPEPPRTSSPT-----TLPPLARSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAP-PVRS 526
Cdd:PRK07003   448 PVPAKANARASADSRCDERDAQPPADSGSAsapasDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPaAAAP 527

                          170
                   ....*....|.
gi 1958775668  527 PTSCTAAPGPS 537
Cdd:PRK07003   528 PAPEARPPTPA 538
PHA03378 PHA03378
EBNA-3B; Provisional
 68-617 2.54e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 2.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   68 QTPAPQQIPRGPVQQPLEDRIFPPTVsavystvtQVARQPGPPTPSPYSAHEINKGHPNLAATPPGhaSSPGLSQTPYPS 147
Cdd:PHA03378   446 HSQAPTVVLHRPPTQPLEGPTGPLSV--------QAPLEPWQPLPHPQVTPVILHQPPAQGVQAHG--SMLDLLEKDDED 515

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  148 GQNAGPATLVYPQAPQTMNSQpqarsppsRAVPVHCPDnwkrRKVLEQTPvyrslagrgwikycifaAGPRPAHHQFFQR 227
Cdd:PHA03378   516 MEQRVMATLLPPSPPQPRAGR--------RAPCVYTED----LDIESDEP-----------------ASTEPVHDQLLPA 566

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  228 P-----QIQPPRAAIPNSSPSLRPGaqtptavyqanqhimmvnHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQP 302
Cdd:PHA03378   567 PglgplQIQPLTSPTTSQLASSAPS------------------YAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL 628

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  303 PGPGPFYPGPGPGDFaNAYGTPfYPSQPVYQSAPIIVPTQQQPPPAKREkktirirdPNQGGKDITEEIMSGGGSRNP-- 380
Cdd:PHA03378   629 RPIPMRPLRMQPITF-NVLVFP-TPHQPPQVEITPYKPTWTQIGHIPYQ--------PSPTGANTMLPIQWAPGTMQPpp 698

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  381 -TPPIGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQ 459
Cdd:PHA03378   699 rAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQP 778

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  460 AGQIPETAA----GEPSPEPPRTSSPTTLPPLARSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAPPVR-SPTSCTAAP 534
Cdd:PHA03378   779 PPQAPPAPQqrprGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERqAAAGPTPSP 858

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  535 GPSLTDDIglCKKPCGVAPpdgqlVSSPVLIneMNGVGEKLPAKENTVDMV-------RQEVLPLTLElEILehPQEERK 607
Cdd:PHA03378   859 GSGTSDKI--VQAPVFYPP-----VLQPIQV--MRQLGSVRAAAASTVTQApteytgeRRGVGPMHPT-DIP--PSKRAK 926

                          570
                   ....*....|
gi 1958775668  608 VECTPTPITP 617
Cdd:PHA03378   927 TDAYVESQPP 936
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 73-290 3.18e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 45.80  E-value: 3.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   73 QQIPRGPVQQPledRIFPPTVSAVYSTVTQVARQPGPPTPSPYSAHEINKGHPNLAA------TPPGHASSPglSQTPYP 146
Cdd:pfam09770  105 QQPAARAAQSS---AQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKEPEPIPDLQVdaslwgVAPKKAAAP--APAPQP 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  147 SGQNAGP--------------------ATLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSlagrg 206
Cdd:pfam09770  180 AAQPASLpapsrkmmsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ----- 254

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  207 wikycifaAGPRPAHH-QFFQRPQIQPPRAAIPNSSPSLRPGAQTPTAVYQANQHIM------MVNHLPMPYPVPQGPQY 279
Cdd:pfam09770  255 --------QHPGQGHPvTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILqnpnrlSAARVGYPQNPQPGVQP 326

                          250
                   ....*....|.
gi 1958775668  280 CIPQYRHSGPP 290
Cdd:pfam09770  327 APAHQAHRQQG 337
PRK11901 PRK11901
hypothetical protein; Reviewed
 327-454 4.80e-04

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 44.29  E-value: 4.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  327 PSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDP---------NQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQQL 397
Cdd:PRK11901   113 TAPPQDISAPPISPTPTQAAPPQTPNGQQRIELPgnisdalsqQQGQVNAASQNAQGNTSTLPTAPATVAPSKGAKVPAT 192

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  398 PSQAPEHSPVVYGT--VESAHLAASTPVTAASDQKQEEKPKPDPVFQS-PSTVLRLVLSG 454
Cdd:PRK11901   193 AETHPTPPQKPATKkpAVNHHKTATVAVPPATSGKPKSGAASARALSSaPASHYTLQLSS 252
PHA03378 PHA03378
EBNA-3B; Provisional
 73-408 1.20e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 1.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   73 QQIPRGPVQQPLEDRifPPTVSAVY--STVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPghasspglsqtpypsgqn 150
Cdd:PHA03378   639 QPITFNVLVFPTPHQ--PPQVEITPykPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPP------------------ 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  151 AGPATLVYPQAPQTMNSQPQArsPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYCIFAAGPRPAHHQFFQRPQI 230
Cdd:PHA03378   699 RAPTPMRPPAAPPGRAQRPAA--ATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTP 776

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  231 QPPRAAIPnsSPSLRP-GAQTPTAVYQANQHIMMVnhLPMPYPVPQGPQYCIPQYRHSGPpyVGPPQQYPVQPPGPGPFY 309
Cdd:PHA03378   777 QPPPQAPP--APQQRPrGAPTPQPPPQAGPTSMQL--MPRAAPGQQGPTKQILRQLLTGG--VKRGRPSLKKPAALERQA 850

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  310 PGPGPGDFANayGTPFYPSQpvyqsAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEI--MSGGGSRNPT--PPIG 385
Cdd:PHA03378   851 AAGPTPSPGS--GTSDKIVQ-----APVFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTgeRRGVGPMHPTdiPPSK 923

                          330       340
                   ....*....|....*....|...
gi 1958775668  386 RPTSTPTPPQQLPSQAPEHSPVV 408
Cdd:PHA03378   924 RAKTDAYVESQPPHGGQSHSFSV 946
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 100-553 1.58e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  100 VTQVARQPGPPTPSPY---------SAHEINKGHPNLAATPPGHASSPGLSQTPYPSGQNAGPAtlvyPQAPqtmnSQPQ 170
Cdd:pfam03154  137 IDQDNRSTSPSIPSPQdnesdsdssAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPT----PSAP----SVPP 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  171 ARSPPSRAVPVHCPDNWKRRKVLEQTPvyrslagrgwikycifaagprPAHHQffQRPQIQPPRAAIPNSSPslrPGAQT 250
Cdd:pfam03154  209 QGSPATSQPPNQTQSTAAPHTLIQQTP---------------------TLHPQ--RLPSPHPPLQPMTQPPP---PSQVS 262

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  251 PTAVYQANQHIMMVnhlPMPYPVPQGPqyciPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYgTPfyPSQP 330
Cdd:pfam03154  263 PQPLPQPSLHGQMP---PMPHSLQTGP----SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIH-TP--PSQS 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  331 VYQSAPiivPTQQQP-PPAKRekktirirdpnqggkditeeimsgggsrnPTPPIGRPTSTPTPPQQLPsQAPEHSPvvy 409
Cdd:pfam03154  333 QLQSQQ---PPREQPlPPAPL-----------------------------SMPHIKPPPTTPIPQLPNP-QSHKHPP--- 376

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  410 gtvesaHLAASTPVTAASDQKQEEKPKPD---PVFQSPST---VLRLVlsgekkEQAGQIPEtaagePSPEPPRTSSPTT 483
Cdd:pfam03154  377 ------HLSGPSPFQMNSNLPPPPALKPLsslSTHHPPSAhppPLQLM------PQSQQLPP-----PPAQPPVLTQSQS 439

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  484 LPPLArSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAPPVRSPTSCTAApGPSLtddiglcKKPCGVAP 553
Cdd:pfam03154  440 LPPPA-ASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSA-MPGI-------QPPSSASV 500
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
323-509 1.71e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 42.73  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  323 TPFYPSQpvyqsapiiVPTQQQPPPAKREKKTIRIRDPNQGgkditeeimSGGGSRNPTPPIGRPTSTPTPPQQLPSQAP 402
Cdd:pfam05539  186 HPTYPSQ---------VTPQSQPATQGHQTATANQRLSSTE---------PVGTQGTTTSSNPEPQTEPPPSQRGPSGSP 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  403 EHSPvvygtvesahlaaSTP----VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKeqagqiPETAAGEPSPEPPRT 478
Cdd:pfam05539  248 QHPP-------------STTsqdqSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTT------KRQETGRPTPRPTAT 308

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1958775668  479 SSPTTLPPlarSSLPSPMSAALSSQQLLTAE 509
Cdd:pfam05539  309 TQSGSSPP---HSSPPGVQANPTTQNLVDCK 336
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 83-511 3.19e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 3.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   83 PLEDRIFPPTVSAVYSTVTQ--VARQ--PGPPTPSPYSAheinkghpnlaatppghasspglsqtPYPSGqnagpatlvY 158
Cdd:PRK10263   336 PVEPVTQTPPVASVDVPPAQptVAWQpvPGPQTGEPVIA--------------------------PAPEG---------Y 380

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  159 PQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYrslagrgwikycifAAGPRPAHHQFFQRPQIQPPRAAIP 238
Cdd:PRK10263   381 PQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYY--------------APAPEQPAQQPYYAPAPEQPVAGNA 446

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  239 NSSPSLRPGAQtPTAVYQANQhimmvnhlPMPYPVPQGPQYCIPQYrhsgppyvgppqqypvqppgpgpfypgpgpgdfa 318
Cdd:PRK10263   447 WQAEEQQSTFA-PQSTYQTEQ--------TYQQPAAQEPLYQQPQP---------------------------------- 483

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  319 naygtpfYPSQPVYQSAPIIVPTQQQPPP----AKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPtPP 394
Cdd:PRK10263   484 -------VEQQPVVEPEPVVEETKPARPPlyyfEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVAAVP-PV 555

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  395 QQLPSQAPehspvVYGTVESAHLAASTPVTAASdqkqeekpkpdPVFQspstvlrLVLSGEKKEQAGQipetAAGEPSPE 474
Cdd:PRK10263   556 EAAAAVSP-----LASGVKKATLATGAAATVAA-----------PVFS-------LANSGGPRPQVKE----GIGPQLPR 608

                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1958775668  475 PPRTSSPTtlpplaRSSLPSpMSAALSSQQLltAEDK 511
Cdd:PRK10263   609 PKRIRVPT------RRELAS-YGIKLPSQRA--AEEK 636
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 343-538 4.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 4.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  343 QQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQQLPSQAPEHSPVVYGTVESAHlaASTP 422
Cdd:PHA03307    69 TGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG--SPGP 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  423 VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSgekkeqAGQIPETAAGEPSPEPPRTSSPTTLPPlaRSSLPSPMSA--AL 500
Cdd:PHA03307   147 PPAASPPAAGASPAAVASDAASSRQAALPLS------SPEETARAPSSPPAEPPPSTPPAAASP--RPPRRSSPISasAS 218

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1958775668  501 SSQQLLTAEDKCELSSSKDDAPPVRS------PTSCTAAPGPSL 538
Cdd:PHA03307   219 SPAPAPGRSAADDAGASSSDSSSSESsgcgwgPENECPLPRPAP 262
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 98-243 5.86e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.56  E-value: 5.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668   98 STVTQVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGlsQTPYPSGQNAGPATLVYPQAPQTMNSQPQARSPPSR 177
Cdd:pfam09770  210 PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQ--QPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQ 287

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958775668  178 AVPVHCPDNWKRRKVLeQTPVYRSLAGRGWIKYCIFAAGPRPAHHQffQRPQIQPPRAAIPNSSPS 243
Cdd:pfam09770  288 FHQQPPPVPVQPTQIL-QNPNRLSAARVGYPQNPQPGVQPAPAHQA--HRQQGSFGRQAPIITHPQ 350
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
327-523 5.97e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 5.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  327 PSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPigrPTSTPTPPQQLPSQAPEHSP 406
Cdd:PRK07003   467 DAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPA---AAAPPAPEARPPTPAAAAPA 543

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775668  407 vvygtvesahlAASTPVTAASDqkqeekpkpdpvfqspstVLR---LVLSGEKKEQAGQIPETAAGEPSPEPPRTSSPTT 483
Cdd:PRK07003   544 -----------ARAGGAAAALD------------------VLRnagMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAV 594

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1958775668  484 LPPLARSSLPSPMSAALSSQQLLTAEDKCELSSSKDDAPP 523
Cdd:PRK07003   595 QVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPP 634
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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