protein DBF4 homolog A isoform X1 [Rattus norvegicus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| ZnF_DBF super family | cl46924 | Zinc finger in DBF-like proteins; |
287-334 | 8.32e-19 | ||
Zinc finger in DBF-like proteins; The actual alignment was detected with superfamily member smart00586: Pssm-ID: 128854 [Multi-domain] Cd Length: 49 Bit Score: 80.21 E-value: 8.32e-19
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| BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
42-109 | 3.28e-03 | ||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. : Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 36.89 E-value: 3.28e-03
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| Name | Accession | Description | Interval | E-value | ||
| ZnF_DBF | smart00586 | Zinc finger in DBF-like proteins; |
287-334 | 8.32e-19 | ||
Zinc finger in DBF-like proteins; Pssm-ID: 128854 [Multi-domain] Cd Length: 49 Bit Score: 80.21 E-value: 8.32e-19
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| zf-DBF | pfam07535 | DBF zinc finger; This domain is predicted to bind metal ions and is often found associated ... |
292-332 | 1.15e-15 | ||
DBF zinc finger; This domain is predicted to bind metal ions and is often found associated with pfam00533 and pfam02178. It was first identified in the Drosophila chiffon gene product, and is associated with initiation of DNA replication. Pssm-ID: 462197 Cd Length: 42 Bit Score: 70.99 E-value: 1.15e-15
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| DBF4 | COG5067 | Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, ... |
284-334 | 1.05e-07 | ||
Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; Pssm-ID: 227399 [Multi-domain] Cd Length: 468 Bit Score: 54.95 E-value: 1.05e-07
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| BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
42-109 | 3.28e-03 | ||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 36.89 E-value: 3.28e-03
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| Name | Accession | Description | Interval | E-value | ||
| ZnF_DBF | smart00586 | Zinc finger in DBF-like proteins; |
287-334 | 8.32e-19 | ||
Zinc finger in DBF-like proteins; Pssm-ID: 128854 [Multi-domain] Cd Length: 49 Bit Score: 80.21 E-value: 8.32e-19
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| zf-DBF | pfam07535 | DBF zinc finger; This domain is predicted to bind metal ions and is often found associated ... |
292-332 | 1.15e-15 | ||
DBF zinc finger; This domain is predicted to bind metal ions and is often found associated with pfam00533 and pfam02178. It was first identified in the Drosophila chiffon gene product, and is associated with initiation of DNA replication. Pssm-ID: 462197 Cd Length: 42 Bit Score: 70.99 E-value: 1.15e-15
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| DBF4 | COG5067 | Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, ... |
284-334 | 1.05e-07 | ||
Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; Pssm-ID: 227399 [Multi-domain] Cd Length: 468 Bit Score: 54.95 E-value: 1.05e-07
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| BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
42-109 | 3.28e-03 | ||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 36.89 E-value: 3.28e-03
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