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Conserved domains on  [gi|1958765243|ref|XP_038962242|]
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plakophilin-4 isoform X11 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-595 5.36e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.36e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958765243  556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 595
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 4.31e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.31e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958765243   862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 4.48e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.48e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958765243   600 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 641
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-380 3.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243   72 GAESPSIASTSSTE-------KSFPWRSTDVPNTGVSKPRVSDTVHPNNylirTEPEQGalySPEQTSLHERSLGNSRSS 144
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRQREKGASDT----EEPERA---TAKKSKTQEISRPNSPSE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  145 TQMNSYSDSGYQEAGSfHNSQTVNKADSRQHPFTGS-TSNHVVRNSRAEGQTL-VQPSVANRAMRRVSSVPSRAQSPSYV 222
Cdd:pfam03154  116 GEGESSDGRSVNDEGS-SDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPPPGTTQA 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  223 TSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSTY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQTSNPNGP 299
Cdd:pfam03154  195 ATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQPSLHGQ 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  300 VPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDIYERMVP 374
Cdd:pfam03154  275 MPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPPREQPLP 346


                   ....*.
gi 1958765243  375 PRPDSL 380
Cdd:pfam03154  347 PAPLSM 352
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 845-966 1.21e-03

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  845 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 918
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958765243  919 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 966
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 946-990 3.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.70e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1958765243   946 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 990
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-595 5.36e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.36e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958765243  556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 595
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-596 7.84e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 7.84e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958765243   556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 596
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 4.31e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.31e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958765243   862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 4.48e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.48e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958765243   600 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 641
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 2.13e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 2.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958765243  600 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 641
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
523-645 1.98e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  523 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 601
Cdd:COG1413     13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958765243  602 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 645
Cdd:COG1413     75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 2.55e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958765243  862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-380 3.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243   72 GAESPSIASTSSTE-------KSFPWRSTDVPNTGVSKPRVSDTVHPNNylirTEPEQGalySPEQTSLHERSLGNSRSS 144
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRQREKGASDT----EEPERA---TAKKSKTQEISRPNSPSE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  145 TQMNSYSDSGYQEAGSfHNSQTVNKADSRQHPFTGS-TSNHVVRNSRAEGQTL-VQPSVANRAMRRVSSVPSRAQSPSYV 222
Cdd:pfam03154  116 GEGESSDGRSVNDEGS-SDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPPPGTTQA 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  223 TSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSTY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQTSNPNGP 299
Cdd:pfam03154  195 ATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQPSLHGQ 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  300 VPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDIYERMVP 374
Cdd:pfam03154  275 MPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPPREQPLP 346


                   ....*.
gi 1958765243  375 PRPDSL 380
Cdd:pfam03154  347 PAPLSM 352
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 845-966 1.21e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  845 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 918
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958765243  919 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 966
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 218-375 3.01e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.84  E-value: 3.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  218 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSTYSSSTLPA----------QRAASPY----------SQRPA 277
Cdd:PLN03209   385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  278 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 349
Cdd:PLN03209   457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1958765243  350 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 375
Cdd:PLN03209   537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 946-990 3.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.70e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1958765243   946 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 990
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 527-641 6.34e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.86  E-value: 6.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  527 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 605
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958765243  606 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 641
Cdd:PLN03200   136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-595 5.36e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 5.36e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958765243  556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 595
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 556-596 7.84e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 7.84e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1958765243   556 DNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 596
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 4.31e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.31e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1958765243   862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:smart00185    5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 4.48e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.42  E-value: 4.48e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1958765243   600 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 641
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 600-641 2.13e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 2.13e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1958765243  600 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 641
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
523-645 1.98e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  523 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevyrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 601
Cdd:COG1413     13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958765243  602 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 645
Cdd:COG1413     75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 862-897 2.55e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1958765243  862 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 897
Cdd:pfam00514    5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-380 3.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243   72 GAESPSIASTSSTE-------KSFPWRSTDVPNTGVSKPRVSDTVHPNNylirTEPEQGalySPEQTSLHERSLGNSRSS 144
Cdd:pfam03154   43 GRNSPSAASTSSNDskaesmkKSSKKIKEEAPSPLKSAKRQREKGASDT----EEPERA---TAKKSKTQEISRPNSPSE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  145 TQMNSYSDSGYQEAGSfHNSQTVNKADSRQHPFTGS-TSNHVVRNSRAEGQTL-VQPSVANRAMRRVSSVPSRAQSPSYV 222
Cdd:pfam03154  116 GEGESSDGRSVNDEGS-SDPKDIDQDNRSTSPSIPSpQDNESDSDSSAQQQILqTQPPVLQAQSGAASPPSPPPPGTTQA 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  223 TSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSTY--SSSTLPAQRAASPYSQ-RPASPTAVRRVGSVTSRQTSNPNGP 299
Cdd:pfam03154  195 ATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiqQTPTLHPQRLPSPHPPlQPMTQPPPPSQVSPQPLPQPSLHGQ 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  300 VPQYQTTTRVGSPLTLTDAQTR----VASPSQGQVG-SSSPKRSGMTAVPQHLGPSLQRTvhdmdqfgQQQYDIYERMVP 374
Cdd:pfam03154  275 MPPMPHSLQTGPSHMQHPVPPQpfplTPQSSQSQVPpGPSPAAPGQSQQRIHTPPSQSQL--------QSQQPPREQPLP 346


                   ....*.
gi 1958765243  375 PRPDSL 380
Cdd:pfam03154  347 PAPLSM 352
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 845-966 1.21e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  845 GSLQNLSA---GNWkfAAYIRAAvrkekGLPILVELLRMDNDRVVSSVATALRNMAL---DVRNKeLIGKYAMRDLVNRL 918
Cdd:PLN03200   169 GALRNLCGstdGFW--SATLEAG-----GVDILVKLLSSGNSDAQANAASLLARLMMafeSSISK-VLDAGAVKQLLKLL 240

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1958765243  919 PGGNGPSILsdetvAAICCALHEVTSKNMENAKALADSGGIEKLVNIT 966
Cdd:PLN03200   241 GQGNEVSVR-----AEAAGALEALSSQSKEAKQAIADAGGIPALINAT 283
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 218-375 3.01e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.84  E-value: 3.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  218 SPSYVTSTGVSPSRGSLRTSlgsgfgspSVTDSRPLNPSTYSSSTLPA----------QRAASPY----------SQRPA 277
Cdd:PLN03209   385 SPIPTPPSSSPASSKSVDAV--------AKPAEPDVVPSPGSASNVPEvepaqveakkTRPLSPYaryedlkpptSPSPT 456

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  278 SPTAVRRVGSVTSRQTSNPNGPVPQYQTTT--------RVGSPLTLTDAQTRVASPSQGQVGSSSPKRSGMTAVPQHLGP 349
Cdd:PLN03209   457 APTGVSPSVSSTSSVPAVPDTAPATAATDAaapppanmRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSA 536

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1958765243  350 SLQRTVHDMDQFGQQQ-----YDIYERMVPP 375
Cdd:PLN03209   537 PPTALADEQHHAQPKPrplspYTMYEDLKPP 567
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 946-990 3.70e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 3.70e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1958765243   946 NMENAKALADSGGIEKLVNITKgrgdRSSLKVVKAAAQVLNTLWQ 990
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 527-641 6.34e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.86  E-value: 6.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958765243  527 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVYrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 605
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958765243  606 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 641
Cdd:PLN03200   136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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