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Conserved domains on  [gi|1958750991|ref|XP_038958361|]
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phospholipid phosphatase-related protein type 5 isoform X4 [Rattus norvegicus]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
125-274 9.76e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 218.65  E-value: 9.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 125 RTVRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 204
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 205 LSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 274
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
125-274 9.76e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 218.65  E-value: 9.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 125 RTVRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 204
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 205 LSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 274
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
132-279 1.33e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 69.37  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 132 IYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTAlGCQQYTQFISgeeactgnpdlimrarktFPSKEAALSVYAAM 211
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPA-PSTLPGLGYS------------------FPSGHSATAFALAL 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958750991 212 YLTMYITNTIKAKgtrlaKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVN 279
Cdd:pfam01569  62 LLALLLRRLRKIV-----RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
acidPPc smart00014
Acid phosphatase homologues;
134-274 4.34e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 64.67  E-value: 4.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991  134 AFGLFATDIFVNAGQVVTGNLAPHFLALCKPnytalgcqqytqfisgeeACTGNPDLIMRARKTFPSKEAALSVYAAMYL 213
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA------------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFL 62
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958750991  214 TMYItntikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 274
Cdd:smart00014  63 LLYL-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
135-272 8.96e-13

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 67.64  E-value: 8.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 135 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqyTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 214
Cdd:PLN02250  105 FSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV-----FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLS 179
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 215 MYITNTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 272
Cdd:PLN02250  180 LYLSGKIRVFDRRGHVAKLCIVFLPLlvAALVGVSRVDDYWHHWQDVFAGALIGLTVASF 239
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
198-274 4.99e-04

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 40.41  E-value: 4.99e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958750991 198 FPSKEAALSvyAAMYLTMYItntikakgtRLAKPVLCLGLMCLAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFLV 274
Cdd:COG0671   119 FPSGHAAAA--FALALVLAL---------LLPRRWLAALLLALALLVGLSRV--YLGvHYpSDVLAGALLGLAIALLLL 184
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
125-274 9.76e-72

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 218.65  E-value: 9.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 125 RTVRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAA 204
Cdd:cd03384     1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIADCTCCTGDPDLIREARLSFPSGHAS 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 205 LSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 274
Cdd:cd03384    81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
56-272 4.82e-21

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 88.82  E-value: 4.82e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991  56 AYRKPYPgpeDSSAVPPVLLYSLAAGVPVLVIIVgetavFCLqLATRDFENQEKTILTgdccyinplvrrtvrFLGIYAF 135
Cdd:cd03390     2 SISYPFA---ESETVPTWLLVIISVGIPLLVIIL-----ISL-FFRRSLWDLHTSLLG---------------LLLSVSL 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 136 GLFATDIFVNAgqvvTGNLAPHFLALCKPNYTALGCQQYTqfisGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLTM 215
Cdd:cd03390    58 NGVITNVLKNY----AGRPRPDFLARCFPDGGTPSDTLVG----IDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSL 129
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958750991 216 YITN--TIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 272
Cdd:cd03390   130 YLAGklHIFDPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYL 188
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
132-279 1.33e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 69.37  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 132 IYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTAlGCQQYTQFISgeeactgnpdlimrarktFPSKEAALSVYAAM 211
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPA-PSTLPGLGYS------------------FPSGHSATAFALAL 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958750991 212 YLTMYITNTIKAKgtrlaKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVN 279
Cdd:pfam01569  62 LLALLLRRLRKIV-----RVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
127-274 2.07e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 68.64  E-value: 2.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 127 VRFLGIYAFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYtalgcqqytqfisgeeactgNPDLIMRARKTFPSKEAALS 206
Cdd:cd01610     2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDG--------------------DPLLLTEGGYSFPSGHAAFA 61
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958750991 207 VYAAMYLTMYItntikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 274
Cdd:cd01610    62 FALALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
acidPPc smart00014
Acid phosphatase homologues;
134-274 4.34e-13

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 64.67  E-value: 4.34e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991  134 AFGLFATDIFVNAGQVVTGNLAPHFLALCKPnytalgcqqytqfisgeeACTGNPDLIMRARKTFPSKEAALSVYAAMYL 213
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA------------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFL 62
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958750991  214 TMYItntikakGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLV 274
Cdd:smart00014  63 LLYL-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
135-272 8.96e-13

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 67.64  E-value: 8.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 135 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqyTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 214
Cdd:PLN02250  105 FSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV-----FHPVTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLS 179
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 215 MYITNTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 272
Cdd:PLN02250  180 LYLSGKIRVFDRRGHVAKLCIVFLPLlvAALVGVSRVDDYWHHWQDVFAGALIGLTVASF 239
PLN02715 PLN02715
lipid phosphate phosphatase
135-272 9.49e-13

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 67.77  E-value: 9.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 135 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNytalGCQQYTQFisGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 214
Cdd:PLN02715  130 FAVLITGVITDSIKVATGRPRPNFYWRCFPD----GKELYDAL--GGVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLS 203
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 215 MYITNTIKAKGTRLAKPVLCLGLMCL--AFLTGLNRVAEYRNHWSDVIAGFLVGISIAVF 272
Cdd:PLN02715  204 LYLSGKIKAFNGEGHVAKLCLVIFPLlaACLVGISRVDDYWHHWQDVFAGALIGILVAAF 263
PLN02731 PLN02731
Putative lipid phosphate phosphatase
135-267 5.78e-11

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 62.74  E-value: 5.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958750991 135 FGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALgcqqYTQFisGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLT 214
Cdd:PLN02731  124 YSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKAL----YDSL--GDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLS 197
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958750991 215 MYITNTIKAKGTRLAKPVLCLGLMCLAF--LTGLNRVAEYRNHWSDVIAGFLVGI 267
Cdd:PLN02731  198 LYLSGKIQAFDGKGHVAKLCIVILPLLFaaLVGISRVDDYWHHWQDVFAGGLLGL 252
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
198-273 3.62e-04

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 40.67  E-value: 3.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958750991 198 FPSKEAALSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLmclAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFL 273
Cdd:cd03392   103 FPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAIL---ILLVGLSRL--YLGvHYpSDVLAGWLLGLAWLALL 175
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
198-274 4.99e-04

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 40.41  E-value: 4.99e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958750991 198 FPSKEAALSvyAAMYLTMYItntikakgtRLAKPVLCLGLMCLAFLTGLNRVaeYRN-HW-SDVIAGFLVGISIAVFLV 274
Cdd:COG0671   119 FPSGHAAAA--FALALVLAL---------LLPRRWLAALLLALALLVGLSRV--YLGvHYpSDVLAGALLGLAIALLLL 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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