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Conserved domains on  [gi|1958690941|ref|XP_038950930|]
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anoctamin-8 isoform X5 [Rattus norvegicus]

Protein Classification

anoctamin family protein( domain architecture ID 10518511)

anoctamin family protein similar to anoctamin (anion channel with 8 transmembrane domains), which is a calcium-activated protein and may mediate the calcium-dependent exposure of phospholipids to the extracellular surface, a process called phospholipid scrambling

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
184-486 8.43e-73

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 246.73  E-value: 8.43e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  184 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 263
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  264 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLCLAcLVCVFVLmlgcfqlqelvlsvkglprlv 342
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVLL-LIALLVL--------------------- 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  343 rflpkVILALLVSVsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmdrlkelllllsl 422
Cdd:pfam04547  135 -----GVIIYLNFV----YTKLAKKLTDWENHRTQSEYENSLILKVFL-------------------------------- 173
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958690941  423 tqsleRQLRaalvplaalrfrllllslrglllvaraKMLATLLITRQLLQNVREVLQPHLYRRL 486
Cdd:pfam04547  174 -----DRLR---------------------------IQLAIIMVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
691-860 1.23e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 234.78  E-value: 1.23e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  691 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 770
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  771 CTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHAAIPD 849
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365
                          170
                   ....*....|.
gi 1958690941  850 IPGWVAEEMAK 860
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
908-1086 9.88e-07

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 9.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  908 GGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 987
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  988 FLKAPERGPSPPRPGKLFAFAAREPaangalgggarshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWgcGDNPP 1067
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPA--------------AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW--EELPP 504
                          170       180
                   ....*....|....*....|
gi 1958690941 1068 RVPADAPARP-AQPACWPTA 1086
Cdd:PRK12323   505 EFASPAPAQPdAAPAGWVAE 524
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
184-486 8.43e-73

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 246.73  E-value: 8.43e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  184 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 263
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  264 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLCLAcLVCVFVLmlgcfqlqelvlsvkglprlv 342
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVLL-LIALLVL--------------------- 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  343 rflpkVILALLVSVsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmdrlkelllllsl 422
Cdd:pfam04547  135 -----GVIIYLNFV----YTKLAKKLTDWENHRTQSEYENSLILKVFL-------------------------------- 173
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958690941  423 tqsleRQLRaalvplaalrfrllllslrglllvaraKMLATLLITRQLLQNVREVLQPHLYRRL 486
Cdd:pfam04547  174 -----DRLR---------------------------IQLAIIMVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
691-860 1.23e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 234.78  E-value: 1.23e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  691 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 770
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  771 CTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHAAIPD 849
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365
                          170
                   ....*....|.
gi 1958690941  850 IPGWVAEEMAK 860
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
908-1086 9.88e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 9.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  908 GGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 987
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  988 FLKAPERGPSPPRPGKLFAFAAREPaangalgggarshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWgcGDNPP 1067
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPA--------------AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW--EELPP 504
                          170       180
                   ....*....|....*....|
gi 1958690941 1068 RVPADAPARP-AQPACWPTA 1086
Cdd:PRK12323   505 EFASPAPAQPdAAPAGWVAE 524
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
184-486 8.43e-73

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 246.73  E-value: 8.43e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  184 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 263
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  264 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLCLAcLVCVFVLmlgcfqlqelvlsvkglprlv 342
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVLL-LIALLVL--------------------- 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  343 rflpkVILALLVSVsaegYKKLAVWLNDMENYRLESTYERHLIIKVVLfqfvnsylslfyigfylkdmdrlkelllllsl 422
Cdd:pfam04547  135 -----GVIIYLNFV----YTKLAKKLTDWENHRTQSEYENSLILKVFL-------------------------------- 173
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958690941  423 tqsleRQLRaalvplaalrfrllllslrglllvaraKMLATLLITRQLLQNVREVLQPHLYRRL 486
Cdd:pfam04547  174 -----DRLR---------------------------IQLAIIMVTKQIINNITEVVLPYLKRKR 205
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
691-860 1.23e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 234.78  E-value: 1.23e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  691 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 770
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  771 CTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHAAIPD 849
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365
                          170
                   ....*....|.
gi 1958690941  850 IPGWVAEEMAK 860
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
908-1086 9.88e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 9.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  908 GGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 987
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  988 FLKAPERGPSPPRPGKLFAFAAREPaangalgggarshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWgcGDNPP 1067
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPA--------------AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW--EELPP 504
                          170       180
                   ....*....|....*....|
gi 1958690941 1068 RVPADAPARP-AQPACWPTA 1086
Cdd:PRK12323   505 EFASPAPAQPdAAPAGWVAE 524
PHA03378 PHA03378
EBNA-3B; Provisional
918-1086 3.61e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.14  E-value: 3.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  918 PGPD--PAAERGAAKAKGSERPRRPGALLPPGP-VLRLKQIIPLQTRPPAPT-GCAPPPRSPADTRLPaflslrflkaPE 993
Cdd:PHA03378   649 PTPHqpPQVEITPYKPTWTQIGHIPYQPSPTGAnTMLPIQWAPGTMQPPPRApTPMRPPAAPPGRAQR----------PA 718
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  994 RGPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPAgcwrwDAPWGCGDNPPRVPADA 1073
Cdd:PHA03378   719 AATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTP-----QPPPQAPPAPQQRPRGA 793
                          170
                   ....*....|...
gi 1958690941 1074 PARPAQPACWPTA 1086
Cdd:PHA03378   794 PTPQPPPQAGPTS 806
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
897-1085 5.25e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 5.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  897 AEQQARRERDTGGREEARAEAPGPDPAAERGAAKakgserPRRPGALLPPGPVLRLKqiiplqTRPPAPTGCAPPPRSPA 976
Cdd:PRK12323   435 AARQASARGPGGAPAPAPAPAAAPAAAARPAAAG------PRPVAAAAAAAPARAAP------AAAPAPADDDPPPWEEL 502
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  977 DTRLPAflslrflkapergPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPagcwrw 1056
Cdd:PRK12323   503 PPEFAS-------------PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAP------ 563
                          170       180
                   ....*....|....*....|....*....
gi 1958690941 1057 dapwgcgdNPPRVPADAPArPAQPACWPT 1085
Cdd:PRK12323   564 --------RPPRASASGLP-DMFDGDWPA 583
PHA03247 PHA03247
large tegument protein UL36; Provisional
913-1086 6.24e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 6.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  913 ARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTR-------LPAFLS 985
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTApppppgpPPPSLP 2851
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  986 LRFLKAP-----ERGPSPPRPGKLfAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPAgcwrwDAPW 1060
Cdd:PHA03247  2852 LGGSVAPggdvrRRPPSRSPAAKP-AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP-----QPPP 2925
                          170       180
                   ....*....|....*....|....*.
gi 1958690941 1061 GCGDNPPRVPADAPARPAQPACWPTA 1086
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAG 2951
PHA03247 PHA03247
large tegument protein UL36; Provisional
900-1085 6.85e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 6.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  900 QARRERDTGGREEARAEAPGPDPAAERGAAKAkgSERPRRPGALLPPGPVLRlkqiiPLQTRPPAP-TGCAPPPRSPADT 978
Cdd:PHA03247  2583 TSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPS-----PAANEPDPHpPPTVPPPERPRDD 2655
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  979 RLPAFLSLrflkaPERGPSPPRPGKLFAfAAREPAANGALGGGARSHRSAGDEPAAAELEPRPE---DAGPASPPAGCWR 1055
Cdd:PHA03247  2656 PAPGRVSR-----PRRARRLGRAAQASS-PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHalvSATPLPPGPAAAR 2729
                          170       180       190
                   ....*....|....*....|....*....|
gi 1958690941 1056 WDAPWGCGDNPPRVPADAPARPAQPACWPT 1085
Cdd:PHA03247  2730 QASPALPAAPAPPAVPAGPATPGGPARPAR 2759
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
921-1081 1.47e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.00  E-value: 1.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  921 DPAAERGAAKAkGSERPRRPGALLPPGPV---LRLKQIIPLQTRPPAPTGCAPPPRSPAdtrlPAFLSLRflKAPERGPS 997
Cdd:PRK07003   359 EPAVTGGGAPG-GGVPARVAGAVPAPGARaaaAVGASAVPAVTAVTGAAGAALAPKAAA----AAAATRA--EAPPAAPA 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  998 PPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPAS--PPAGCW----RWDAPWGCGDNPPRVPA 1071
Cdd:PRK07003   432 PPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASdaPPDAAFepapRAAAPSAATPAAVPDAR 511
                          170
                   ....*....|....*...
gi 1958690941 1072 --------DAPARPAQPA 1081
Cdd:PRK07003   512 apaaasreDAPAAAAPPA 529
PHA03247 PHA03247
large tegument protein UL36; Provisional
917-1081 1.69e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  917 APGPDPAA----ERGAAKAKGSERPRRPgallPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTrlPAFLSLRFLKAP 992
Cdd:PHA03247  2628 PPSPSPAAnepdPHPPPTVPPPERPRDD----PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR--PTVGSLTSLADP 2701
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  993 ERGPSPPRPgklfafaAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASP--PAGCWRWDAPWG-CGDNPPRV 1069
Cdd:PHA03247  2702 PPPPPTPEP-------APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGpPAPAPPAA 2774
                          170
                   ....*....|..
gi 1958690941 1070 PADAPARPAQPA 1081
Cdd:PHA03247  2775 PAAGPPRRLTRP 2786
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
907-1081 1.73e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.61  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  907 TGGREEARAEAPGPDPAAeRGAAKAKGSERPRRPGALLPPGPVLRlkqiiPLQTRPPAPTGCAPPPRSPA-----DTRLP 981
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGA-RAAAAVGASAVPAVTAVTGAAGAALA-----PKAAAAAAATRAEAPPAAPAppataDRGDD 441
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  982 AFLSLRFLKAPERGPSPPRPGKlfAFAAREPAANGALGGGarshrSAGDEPAAAELEPRPEDAGP----------ASPPA 1051
Cdd:PRK07003   442 AADGDAPVPAKANARASADSRC--DERDAQPPADSGSASA-----PASDAPPDAAFEPAPRAAAPsaatpaavpdARAPA 514
                          170       180       190
                   ....*....|....*....|....*....|
gi 1958690941 1052 GCWRWDAPWGCGDNPPRVPADAPARPAQPA 1081
Cdd:PRK07003   515 AASREDAPAAAAPPAPEARPPTPAAAAPAA 544
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
897-1081 2.05e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 2.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  897 AEQQARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGpvlrlkqiiplqTRPPAPTGCAPPPRSPA 976
Cdd:PRK07764   622 AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK------------AGGAAPAAPPPAPAPAA 689
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  977 DTRLPAflslrflkAPERGPSPPRPgklfafAAREPAANGALGGGARSHRSAGDEPAAAELEPRPEDAGPASPPAGCWrw 1056
Cdd:PRK07764   690 PAAPAG--------AAPAQPAPAPA------ATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAG-- 753
                          170       180
                   ....*....|....*....|....*
gi 1958690941 1057 dAPWGCGDNPPRVPADAPARPAQPA 1081
Cdd:PRK07764   754 -APAQPPPPPAPAPAAAPAAAPPPS 777
PHA03247 PHA03247
large tegument protein UL36; Provisional
912-1088 2.90e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  912 EARAEAPGP-DPAAERGAAKAKGSERP--RRPGALLPPGPVlrlkqiiPLQTRPPAPTGCAPP---------PRSPADTR 979
Cdd:PHA03247  2793 ESRESLPSPwDPADPPAAVLAPAAALPpaASPAGPLPPPTS-------AQPTAPPPPPGPPPPslplggsvaPGGDVRRR 2865
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  980 LPAFLSLRFLKAPER-------GPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAE---LEPRPEDAGPASP 1049
Cdd:PHA03247  2866 PPSRSPAAKPAAPARppvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPqppPPPPPRPQPPLAP 2945
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958690941 1050 PAGCWRWDAPWGCGDNP--------------PRVPADAPARPAQPACWPTARH 1088
Cdd:PHA03247  2946 TTDPAGAGEPSGAVPQPwlgalvpgrvavprFRVPQPAPSREAPASSTPPLTG 2998
PHA03247 PHA03247
large tegument protein UL36; Provisional
896-1086 3.23e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  896 HAEQQARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPlqtrPPAPTGCAPPPRSP 975
Cdd:PHA03247  2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP----PPPTPEPAPHALVS 2717
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  976 ADTRLPAFLSLR-FLKAPERGPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAelePRPEDAGPASPPAGCW 1054
Cdd:PHA03247  2718 ATPLPPGPAAARqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAG---PPRRLTRPAVASLSES 2794
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1958690941 1055 RWDAP--WGCGDNPPRVPADAPA-----RPAQPACWPTA 1086
Cdd:PHA03247  2795 RESLPspWDPADPPAAVLAPAAAlppaaSPAGPLPPPTS 2833
PHA03378 PHA03378
EBNA-3B; Provisional
956-1088 7.09e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 7.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  956 IPLQTRPPAPTGCAPPPRSPADTRLPAflslrflkapeRGPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAA 1035
Cdd:PHA03378   672 IPYQPSPTGANTMLPIQWAPGTMQPPP-----------RAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAA 740
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958690941 1036 ELEPRPEDAGP--ASPPAGcwrwdAPWGCgdNPPRVPADAPARPAQPACWPTARH 1088
Cdd:PHA03378   741 PGRARPPAAAPgrARPPAA-----APGRA--RPPAAAPGAPTPQPPPQAPPAPQQ 788
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
896-1083 7.47e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 7.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  896 HAEQQARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPP-------GPVLRLKQIIPLQTRPPAPTGC 968
Cdd:PHA03307    77 TEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpspapdlSEMLRPVGSPGPPPAASPPAAG 156
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  969 APPPRSPADTRLPAFLSLrFLKAPER------GPSPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPRPE 1042
Cdd:PHA03307   157 ASPAAVASDAASSRQAAL-PLSSPEEtarapsSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGAS 235
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1958690941 1043 DAGPASPPAGCWRWDAPWGCGDNPPRvPADAPARPAQPACW 1083
Cdd:PHA03307   236 SSDSSSSESSGCGWGPENECPLPRPA-PITLPTRIWEASGW 275
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
900-1087 8.13e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 8.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  900 QARRERDTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPvlrlkqiiplQTRPPAPTGCAPPPRSPADTR 979
Cdd:PRK07003   434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPAS----------DAPPDAAFEPAPRAAAPSAAT 503
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  980 LPAFLSLRFLKAPERGPSPPRPgklfafAAREPAANGALGGGARSHRSAGDEPAAAEL---------EPRPEDAGPASPP 1050
Cdd:PRK07003   504 PAAVPDARAPAAASREDAPAAA------APPAPEARPPTPAAAAPAARAGGAAAALDVlrnagmrvsSDRGARAAAAAKP 577
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1958690941 1051 AGcwrwdapwgcgdNPPRVPADAPARPAQPACWPTAR 1087
Cdd:PRK07003   578 AA------------APAAAPKPAAPRVAVQVPTPRAR 602
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
906-1086 9.34e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 9.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  906 DTGGREEARAEAPGPDPAAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPAfls 985
Cdd:PRK12323   371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA--- 447
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  986 lrflKAPERGPSP-PRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAA------ELEPRPEDAGPASPPAGCWRWDA 1058
Cdd:PRK12323   448 ----PAPAPAPAAaPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpppweELPPEFASPAPAQPDAAPAGWVA 523
                          170       180       190
                   ....*....|....*....|....*....|..
gi 1958690941 1059 PW----GCGDNPPRVPADAPARPAQPACWPTA 1086
Cdd:PRK12323   524 ESipdpATADPDDAFETLAPAPAAAPAPRAAA 555
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
927-1087 2.07e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 2.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  927 GAAKAKGSERPRRPGALLPPGPvlrlkqiiplQTRPPAPTGCAPPPRSPADtrlpaflslrflkAPERGPSPPRPGKLFA 1006
Cdd:PRK07764   590 PAPGAAGGEGPPAPASSGPPEE----------AARPAAPAAPAAPAAPAPA-------------GAAAAPAEASAAPAPG 646
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941 1007 FAAREPAANGALGGGArshrSAGDEPAAAELEPRPEDAGPASPPAGCWRWDAPWGCGDNPPRVPADAPARPAQPAcWPTA 1086
Cdd:PRK07764   647 VAAPEHHPKHVAVPDA----SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDP-AAQP 721

                   .
gi 1958690941 1087 R 1087
Cdd:PRK07764   722 P 722
PHA03247 PHA03247
large tegument protein UL36; Provisional
920-1080 2.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  920 PDPAAERGAAKAKGSE---RPRRPGALLPPGPVLRLKQiiPLQTRPPAPTgcapPPRSPADTRLPAFLSLRFLKAPERGP 996
Cdd:PHA03247  2723 PGPAAARQASPALPAApapPAVPAGPATPGGPARPARP--PTTAGPPAPA----PPAAPAAGPPRRLTRPAVASLSESRE 2796
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  997 SPPRPGKLFAFAAREPAANGALGGGARSHRSAGDEPAAAELEPrPEDAGPASPPAGCWRWDAPWG--CGDNPPRVPADAP 1074
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPLGGSVAPGGdvRRRPPSRSPAAKP 2875

                   ....*.
gi 1958690941 1075 ARPAQP 1080
Cdd:PHA03247  2876 AAPARP 2881
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
913-1081 9.80e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 9.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  913 ARAEAPgpdpaaERGAAKAKGSERPRRPGALLPPGPvlrlkqiiplqtRPPAPTGCAPPPRSPADTRLPAFlslrflKAP 992
Cdd:PRK07764   376 ARLERL------ERRLGVAGGAGAPAAAAPSAAAAA------------PAAAPAPAAAAPAAAAAPAPAAA------PQP 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958690941  993 ERGPSPPrpgklfafAAREPAANGALGGGARSHRSAGDEPAaaelEPRPEDAGPASPPAGCWRWDAPWGCGDNPPRVPAD 1072
Cdd:PRK07764   432 APAPAPA--------PAPPSPAGNAPAGGAPSPPPAAAPSA----QPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499

                   ....*....
gi 1958690941 1073 APARPAQPA 1081
Cdd:PRK07764   500 PAAPAGADD 508
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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