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Conserved domains on  [gi|1958677243|ref|XP_038948369|]
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phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [Rattus norvegicus]

Protein Classification

phosphatidylserine decarboxylase( domain architecture ID 999)

phosphatidylserine decarboxylase catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)

EC:  4.1.1.65
Gene Ontology:  GO:0004609|GO:0006646
PubMed:  27650064|9370338
SCOP:  4007787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PS_Dcarbxylase super family cl03656
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 70-373 4.19e-82

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


The actual alignment was detected with superfamily member PLN02938:

Pssm-ID: 470849  Cd Length: 428  Bit Score: 257.06  E-value: 4.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  70 PMSRVSLYKSVPTRLLSRACGRLNQVELPSWLRRPVYSLYIWTFGVNMTEAAVEdLQHYRNLSEFFRRKLKPQARPV-CG 148
Cdd:PLN02938   84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 149 LHSVISPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRACTEDLPFPPASSCDS-----------FRN 207
Cdd:PLN02938  163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 208 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 287
Cdd:PLN02938  243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 288 GATNVGSIRIHFDQDLHTNSP-SYSKGSYNDLSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP------------- 353
Cdd:PLN02938  323 GATNIGSIELFIEPELRTNRPkKKIFNSEPPEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvldqs 402

                         330       340
                  ....*....|....*....|.
gi 1958677243 354 -KDFNFRLKAGQKILFGEALG 373
Cdd:PLN02938  403 sSDFRFCVRKGDRIRVGQALG 423
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 70-373 4.19e-82

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 257.06  E-value: 4.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  70 PMSRVSLYKSVPTRLLSRACGRLNQVELPSWLRRPVYSLYIWTFGVNMTEAAVEdLQHYRNLSEFFRRKLKPQARPV-CG 148
Cdd:PLN02938   84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 149 LHSVISPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRACTEDLPFPPASSCDS-----------FRN 207
Cdd:PLN02938  163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 208 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 287
Cdd:PLN02938  243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 288 GATNVGSIRIHFDQDLHTNSP-SYSKGSYNDLSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP------------- 353
Cdd:PLN02938  323 GATNIGSIELFIEPELRTNRPkKKIFNSEPPEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvldqs 402

                         330       340
                  ....*....|....*....|.
gi 1958677243 354 -KDFNFRLKAGQKILFGEALG 373
Cdd:PLN02938  403 sSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 131-373 4.99e-75

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 231.01  E-value: 4.99e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 131 LSEFFRRKLKPQARPVC-GLHSVISPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRActedlpfppasscdsfrnql 209
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 210 vTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 289
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 290 TNVGSIRIHFdqdlhtnspsyskgsyndlsfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKILFG 369
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1958677243 370 EALG 373
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 117-373 2.95e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 227.79  E-value: 2.95e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 117 MTEAAVEDLQHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGpractEDLP 195
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 196 FPPasscdSFRNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 275
Cdd:TIGR00163  76 LSP-----YFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 276 DWKHGFFSLTAVGATNVGSIRIHFDQDLHTNSPS--YSKGSYNDLSfvthankeGIPMRKGEPLGEFNLGSTIVLIFEA- 352
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHefTQTWTYNALG--------PVKLLKGEEMGYFELGSTVILLFEAd 214

                         250       260
                  ....*....|....*....|.
gi 1958677243 353 PKDFNFRLKAGQKILFGEALG 373
Cdd:TIGR00163 215 AFQLSAHLAVGQEVKIGELLA 235
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 81-375 7.65e-58

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 188.14  E-value: 7.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  81 PTRLLSRACGRLNQVELPSWlrRPVYSLYIWTFGVNMTEAAVEdlqHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGK 159
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 160 ILTFGQVKNSEVEQVKGVTYSLESFLGPRACTEDlpfppasscdsFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 238
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEK-----------FEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 239 TVSHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFdqdlhtnspsyskgsyndl 318
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYV------------------- 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958677243 319 sfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKILFGEALGSL 375
Cdd:COG0688   194 -------KEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 70-373 4.19e-82

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 257.06  E-value: 4.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  70 PMSRVSLYKSVPTRLLSRACGRLNQVELPSWLRRPVYSLYIWTFGVNMTEAAVEdLQHYRNLSEFFRRKLKPQARPV-CG 148
Cdd:PLN02938   84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 149 LHSVISPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRACTEDLPFPPASSCDS-----------FRN 207
Cdd:PLN02938  163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 208 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 287
Cdd:PLN02938  243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 288 GATNVGSIRIHFDQDLHTNSP-SYSKGSYNDLSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP------------- 353
Cdd:PLN02938  323 GATNIGSIELFIEPELRTNRPkKKIFNSEPPEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvldqs 402

                         330       340
                  ....*....|....*....|.
gi 1958677243 354 -KDFNFRLKAGQKILFGEALG 373
Cdd:PLN02938  403 sSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 131-373 4.99e-75

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 231.01  E-value: 4.99e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 131 LSEFFRRKLKPQARPVC-GLHSVISPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRActedlpfppasscdsfrnql 209
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 210 vTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 289
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 290 TNVGSIRIHFdqdlhtnspsyskgsyndlsfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKILFG 369
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1958677243 370 EALG 373
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 117-373 2.95e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 227.79  E-value: 2.95e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 117 MTEAAVEDLQHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGpractEDLP 195
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 196 FPPasscdSFRNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 275
Cdd:TIGR00163  76 LSP-----YFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 276 DWKHGFFSLTAVGATNVGSIRIHFDQDLHTNSPS--YSKGSYNDLSfvthankeGIPMRKGEPLGEFNLGSTIVLIFEA- 352
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHefTQTWTYNALG--------PVKLLKGEEMGYFELGSTVILLFEAd 214

                         250       260
                  ....*....|....*....|.
gi 1958677243 353 PKDFNFRLKAGQKILFGEALG 373
Cdd:TIGR00163 215 AFQLSAHLAVGQEVKIGELLA 235
PRK03934 PRK03934
phosphatidylserine decarboxylase; Provisional
 81-375 8.93e-65

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 235177 [Multi-domain]  Cd Length: 265  Bit Score: 207.10  E-value: 8.93e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  81 PTRLLSRACGRLNQVELPSWLRRPVYSLYIWTFGVNMTEaaVEDLQHYRNLSEFFRRKLKPQaRPV-CGLHSVISPSDGK 159
Cdd:PRK03934    3 LSNALSRIFGKFAGYKFPKFIQKFINASYVKIFKIDMSE--FKPPENYKSLNALFTRSLKKP-REFdEDPNIFISPCDSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 160 ILTFGQVKNSEVEQVKGVTYSLESFLGPRACTEDLPFppasscdSFRNqlvtregnelyhcvIYLAPGDYHCFHSPTDWT 239
Cdd:PRK03934   80 ITECGSLEEDKALQIKGMEYSIEELLGESNSELVNGF-------DYIN--------------FYLSPKDYHRYHAPCDLE 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 240 VSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHG-FFSLTAVGATNVGSIRIHFDQDLHTNSpsyskgsynDL 318
Cdd:PRK03934  139 ILEARYIPGKLYPVNLPSLEKNKNLFVKNERVVLKCKDKKGkRLYFVFVGALNVGKMRFNFDERIQTNA---------KA 209

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958677243 319 SFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKILFGEALGSL 375
Cdd:PRK03934  210 RFIQTYEYENLKLKKGEELGNFEMGSTIVLFSQ-KGSLEFNLKAGKSVKFGESIGEI 265
PTZ00403 PTZ00403
phosphatidylserine decarboxylase; Provisional
 82-373 2.02e-61

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 173594  Cd Length: 353  Bit Score: 201.23  E-value: 2.02e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  82 TRLL-----SRACGRLNQVELPSWLRRPVYSLYIWTFGVNmTEAAVEDLQHYRNLSEFFRRKLKPQARPV--CGLHSVIS 154
Cdd:PTZ00403   57 ARLLfgrtrSRITGSIFNIEIPNTYRLPIYNFLIKYMGIN-KEEIKYPIESYKSIGDFFSRYIREETRPIgdVSDYSIVS 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 155 PSDGKILTFGQVKNSEVEQVKGVTYSLESFLGpractedLPFPPASSCDSfrnqlvtregNELYHCVIYLAPGDYHCFHS 234
Cdd:PTZ00403  136 PCDSELTDYGELSSEYLENVKGVKFNVNTFLG-------SDMQKKYNDGS----------TKFFYAIFYLSPKKYHHFHA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 235 PTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDQDLHTNSP----SY 310
Cdd:PTZ00403  199 PFNFKYKIRRHISGELFPVFQGMFKIINNLFNINERVILSGEWKGGNVYYAAISAYNVGNIKIINDEELVTNNLrtqlSY 278

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958677243 311 SKGSYNDLSFVTHANKEgipmrKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKILFGEALG 373
Cdd:PTZ00403  279 MGGDINTKIYDSYKSVE-----VGDEVGEFRMGSSIVVIFENKKNFSWNVKPNQTVSVGQRLG 336
psd PRK00044
phosphatidylserine decarboxylase; Reviewed
 80-373 7.15e-58

phosphatidylserine decarboxylase; Reviewed


Pssm-ID: 234591  Cd Length: 288  Bit Score: 189.65  E-value: 7.15e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  80 VPTRLLSRACGRLNQVELPsWLRRPVYSLYIWTFGVNMTEAAVEDLQHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDG 158
Cdd:PRK00044   13 LPKHLLTRLAGWLASSRAG-WLTTAVIRLFIKKYKVDMSEAQKPDPAAYKTFNDFFTRALKDGARPIDeDPNALVSPADG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 159 KILTFGQVKNSEVEQVKGVTYSLESFLGpraCTEDLpfppassCDSFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTD 237
Cdd:PRK00044   92 AISQLGPIEDGQIFQAKGHSYSLEALLG---GDAAL-------ADPFRNgSFAT----------IYLSPRDYHRVHMPCD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 238 WTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSI------RIhfdqdlhtnSPSYS 311
Cdd:PRK00044  152 GTLREMIYVPGDLFSVNPLTARNVPNLFARNERVVCLFDTEFGPMAQVLVGATIVGSIetvwagTV---------TPPRE 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958677243 312 KG----SYNDlsfvthANKEGIPMRKGEPLGEFNLGSTIVLIFEAPK-DFNFRLKAGQKILFGEALG 373
Cdd:PRK00044  223 GIikrwDYPE------AGDGAITLKKGAEMGRFKLGSTVINLFPPGKvQLAEQLQAGSVVRMGQPLA 283
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 81-375 7.65e-58

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 188.14  E-value: 7.65e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  81 PTRLLSRACGRLNQVELPSWlrRPVYSLYIWTFGVNMTEAAVEdlqHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGK 159
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 160 ILTFGQVKNSEVEQVKGVTYSLESFLGPRACTEDlpfppasscdsFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 238
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEK-----------FEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 239 TVSHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFdqdlhtnspsyskgsyndl 318
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYV------------------- 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958677243 319 sfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKILFGEALGSL 375
Cdd:COG0688   194 -------KEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
PRK03140 PRK03140
phosphatidylserine decarboxylase; Provisional
 99-375 8.01e-34

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179544 [Multi-domain]  Cd Length: 259  Bit Score: 125.87  E-value: 8.01e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  99 SWLRRPVYSLYIWTFGVNMTEAAvEDLQHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDGKILTFGQVKNSEVEQVKGV 177
Cdd:PRK03140   28 SRLSSILIPSYAKVYQINQDEME-KGLKEYRTLHELFTRKLKEGKRPIdTDASSIVSPVDGVFADVGPIEDDKTFDVKGK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 178 TYSLESFLGpractedlpfppasscdsfrNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSH-----RRHFPgslms 252
Cdd:PRK03140  107 RYSIAEMLG--------------------NEERAQRYAGGTYMVLYLSPSHYHRIHSPISGTVTEqfvlgRKSYP----- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 253 VNPGMARWIKELFCHNERVV--LTGDWKHgfFSLTAVGATNVGSIRIhfdqdlhtnspsyskgsyndlsfvTHANKEgip 330
Cdd:PRK03140  162 VNALGLEYGKRPLSKNYRSVteVNSDGEH--MALVKVGAMFVNSIEL------------------------THERDT--- 212

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1958677243 331 MRKGEPLGEFNLGSTIVLIFEapKD---FNFRLKAGQKILFGEALGSL 375
Cdd:PRK03140  213 VQKGEEMAYFSFGSTVVLLFE--KDmiePDQELKSGQEVRLGEKIGTR 258
PRK00723 PRK00723
phosphatidylserine decarboxylase; Provisional
 82-373 1.80e-33

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179097 [Multi-domain]  Cd Length: 297  Bit Score: 126.19  E-value: 1.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  82 TRLLSRACGRLNQVelpSWLRRPVYSlYIWTFGVNMTEAAvEDLQHYRNLSEFFRRKLKPQARPVC-GLHSVISPSDGKI 160
Cdd:PRK00723   42 KKIFSKIYGWYCDS---RLSRKKIKP-FVNDFNIDMSESE-KPLSDFKSFNDFFTRKLKPEARPIDqGENILISPGDGRL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 161 LTFGQVKNSEVEQVKGVTYSLESFLGpractedlpfppasscdsfrNQLVTREgnelYH---CVIY-LAPGDYHCFHSPT 236
Cdd:PRK00723  117 LAYENIDLNSLFQVKGKTYSLKELLG--------------------DPELAKK----YAggtCLILrLCPTDYHRFHFPD 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 237 DWTVSHRRHFPGSLMSVNPGMARWIKELFCHNER--VVLTGDwKHGFFSLTAVGATNVGSIrihfdqdLHTNSPsyskgs 314
Cdd:PRK00723  173 SGICEETRKIKGHYYSVNPIALKKIFELFCENKRewSIFKSE-NFGDILYVEVGATCVGSI-------IQTYKP------ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958677243 315 yndlsfvthankeGIPMRKGEPLGEFNL-GSTIVLIFEAPK-----DF--NFRLKAGQKILFGEALG 373
Cdd:PRK00723  239 -------------NKKVKKGDEKGYFKFgGSTVILFFEKNKikidaDIleQSKLGYETKVLMGESIG 292
PRK09629 PRK09629
bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional
 80-373 1.35e-30

bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional


Pssm-ID: 104071 [Multi-domain]  Cd Length: 610  Bit Score: 122.92  E-value: 1.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243  80 VPTRLLSRACGRLNQVELpSWLRRPVYSLYIWTFGVNMTEAAVEDLQHYRNLSEFFRRKLKPQARPV-CGLHSVISPSDG 158
Cdd:PRK09629  336 LPHHLLSRLAGCVAECRV-RWFKNAFTAWFARRYQVDMSQALVEDLTSYEHFNAFFTRALKADARPLdTTPGAILSPADG 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 159 KILTFGQVKNSEVEQVKGVTYSLESFLG--PRACTedlPFppasscdsfrnqlvtrEGNELyhCVIYLAPGDYHCFHSPT 236
Cdd:PRK09629  415 AISQLGPIDHGRIFQAKGHSFSVLELLGgdPKLSA---PF----------------MGGEF--ATVYLSPKDYHRVHMPL 473

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 237 DWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDQDLHTNSPSYSKGSYN 316
Cdd:PRK09629  474 AGTLREMVYVPGRIFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASVETVWAGLVTPPKRELKTFSYD 553

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958677243 317 DlsfvthANKEGIPMRKGEPLGEFNLGSTIVLIFeAPKDFNF--RLKAGQKILFGEALG 373
Cdd:PRK09629  554 E------AARAPIHLEKGAEMGRFKLGSTAIVLF-GPNQVKWaeQLTAGSKVQMGQALA 605
PLN02964 PLN02964
phosphatidylserine decarboxylase
 115-352 8.54e-22

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 96.85  E-value: 8.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 115 VNMTEAAvEDLQHYRNLSEFFRRKLKPQARPV-CGLHS--VISPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRACT 191
Cdd:PLN02964  401 INMDEVK-YPLEHFKTFNEFFIRELKPGARPIaCMDNDdvAVCAADCRLMAFQSVDDSTRFWIKGRKFSIKGLLGKKVHS 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 192 EDLPFPPasscdsfrnqlvtregnelyhCVIY-LAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPgMARWIK--ELFCHN 268
Cdd:PLN02964  480 DAFLDGS---------------------LVIFrLAPQDYHRFHVPVSGVIEKFVDVPGSLYTVNP-IAVNSKycNVFTEN 537

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958677243 269 ERVV-LTGDWKHGFFSLTAVGATNVGSIrihfdqdlhtnspsyskgsyndlsfvTHANKEGIPMRKGEPLGEFNLG-STI 346
Cdd:PLN02964  538 KRAVcIISTAEFGKVAFVAIGATMVGSI--------------------------TFVKKEGDHVKKGDELGYFSFGgSTV 591


                  ....*.
gi 1958677243 347 VLIFEA 352
Cdd:PLN02964  592 ICVFEK 597
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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