|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
257-896 |
9.76e-42 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 165.42 E-value: 9.76e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 257 FQDYLLMD-TVYPAIAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPFMNLTALIILvGIGADD 334
Cdd:COG1033 212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 335 A-FVLCDVWNYTKSDKPRAEtseAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWL 413
Cdd:COG1033 289 GiHLLNRYREERRKGLDKRE---ALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLL 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 414 PAVIVLheryllniftcFRKPqpqayhkscwtvlcRKGRKALFAISEASRIFfeKVLPCIVIKFRYLWLVWFLALTVGGA 493
Cdd:COG1033 366 PALLSL-----------LPRP--------------KPKTRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 494 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEFkklfmFERVHHGEelhMPITVIwgvspedsgdplnpkskgeLTLD 573
Cdd:COG1033 419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 574 STFNIASPASQAWILHFCQKLRNQTFFHQTeqQDFTScFIETFKQWMENQDCDEPALypccshcsfPYKQEVfelcIKKA 653
Cdd:COG1033 465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESREL----LAQL 528
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 654 IMELDRSTGYHLNNktpgprFdINDTIRAVVLefqSTFLFTLAYEKMQQFYKEVDSWISHELssAPEGLShgWFVS--NL 731
Cdd:COG1033 529 LLLLSSPPGDDLSR------F-VDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgsAV 594
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 732 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVD 811
Cdd:COG1033 595 LFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVD 674
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 812 FAVHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQC 889
Cdd:COG1033 675 YTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPA 754
|
....*..
gi 1958672000 890 LCRCLGP 896
Cdd:COG1033 755 LLLLLDP 761
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
196-876 |
2.04e-22 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 104.36 E-value: 2.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 196 DFMTSKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGITTVTGIEFGIKHSLFQDYLLM---DTVYPAIAI 272
Cdd:pfam02460 144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 273 AIVLLIM-----CVYTKSVFITLMT------MFAIISSL--IVSYFLYRVVFNFEFFPFMNLTALIILvGIGADDAFVLC 339
Cdd:pfam02460 222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 340 DVW-NYTKSDKPRaetsEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIV 418
Cdd:pfam02460 301 AAWqRTTATLSVK----KRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMA 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 419 LHERYLLNIFTCFRKPqPQAYHKSCWTVLCRKgRKALFAISEASRIFFEKVLPCI----VIKFRYLWLVWFLALTVGGay 494
Cdd:pfam02460 377 ICAKPEAEGRHCLFVW-ATSSPQRIDSEGSEP-DKSHNIEQLKSRFFLDIYCPFLlnpsVRVCMLVLFVVYIAIAIYG-- 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 495 ivCINPKMklpslELSEFQVFRSSHPFERYDAEFKKLFMfervHHGEELHMPItviwgvspEDSGDPLNPKSKGEL---- 570
Cdd:pfam02460 453 --CVNIKE-----GLEPDKLVLEDSPLVEYLSLREKHFW----PEGLQIQVAV--------NNPPNLTIPESRDRMnemv 513
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 571 -TLDSTFNIASP-ASQAWILHFCQKLRNQTFFhqtEQQDF-TSCFIETFKQWMEnqdcdepalYPCCSHCSfpykqevfe 647
Cdd:pfam02460 514 dEFENTPYSLGPnSTLFWLREYENFLSTLNME---EEEDEeKEWSYGNLPSFLK---------APGNSHWA--------- 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 648 lcikkaimeldrstGYHLNNKTpGPRFdindtiravvlefqSTFLFTLAYEKMQQFYKEVDS---W--ISHELSSapegL 722
Cdd:pfam02460 573 --------------GDLVWDDN-TTMV--------------TKFRFTLAGKGLSTWNDRTRAlqeWrsIADQYPE----F 619
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 723 SHGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTI 802
Cdd:pfam02460 620 NVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITI 699
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958672000 803 SVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLGRMGSAIAVAALTTFVagAMMMPSTVLAYTQLGTF--MMLVM 876
Cdd:pfam02460 700 IMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVV 773
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
269-423 |
5.48e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 83.37 E-value: 5.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 269 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSY-FLYrvVFNFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKS 347
Cdd:COG1033 612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958672000 348 DKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 423
Cdd:COG1033 687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
734-887 |
5.57e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 83.37 E-value: 5.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 734 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 813
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958672000 814 VHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTTFVA-GAMM-MPSTVLAytQLGTFMMLVMCVSWAFATFFF 887
Cdd:COG1033 290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
268-432 |
7.10e-15 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 73.39 E-value: 7.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 268 PAIAIAIVLLIMCVYTKSVfiTLMTMFAIISSLIVSyflyrvvfnfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKS 347
Cdd:pfam12349 6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 348 DKPraeTSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHER----Y 423
Cdd:pfam12349 67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143
|
....*....
gi 1958672000 424 LLNIFTCFR 432
Cdd:pfam12349 144 RLDVACCIR 152
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
216-843 |
1.22e-10 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 66.47 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 216 FSPTEKGESMM---NIYLDNFENWNSSDGITTVTgieFGIKHSLfQDYLLMDTVYPAIAIAIVLLIMCVYT--------- 283
Cdd:TIGR00917 522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 284 -KSVFITLMTMFAIISSLIVsyfLYRVVFNFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNY-------TKS 347
Cdd:TIGR00917 598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYleyfyrqVGV 674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 348 DKPRAETSE-AVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HER 422
Cdd:TIGR00917 675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 423 YLLNIFTCFRkpqpqayhkscwtvLCRKGRKALFAISEAS----RIFFEKVLPCIVIK--FRYLWLVWFLALTVGG-AYI 495
Cdd:TIGR00917 755 KRVDCFPCIK--------------TSKSSISAEKGSGQRKagllTRYFKEVYAPVLLHwiVKIVVIAFFVGLLMAGiALS 820
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 496 VCINP----KMKLPSleLSEFQVFRSShpferydaefkklfMFERVHHGEELHMPI------TVIWGVSPEDSGDPLNPK 565
Cdd:TIGR00917 821 TRVEIgldqQIVLPQ--DSYLQIYFAS--------------LTPLLEVGPPFYIVIkgdynyTDFESQNKLCTMGGCDKD 884
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 566 SKGELTLDSTFnIASPASqAWILHF-----------CQKLRNQTFFHQTEQQDFtSCFIET-----------FKQWMENQ 623
Cdd:TIGR00917 885 SIVNVFNNLSY-IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWF 961
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 624 DCDEPAlyPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHlnnktpgprfdindtiraVVLEFQSTFLFTLayEKMQQF 703
Cdd:TIGR00917 962 LNALPS--ADCAKGGHAAYSSAVDLQGYATIIQASSFRTYH------------------TPLNTQVDFINAM--RAAQEF 1019
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 704 YKEVDSwishelSSAPEGLSHGWFVSnleFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTCNIIISLYAIASIAGTIFV 782
Cdd:TIGR00917 1020 AAKVSR------SSKMEVYPYSVFYV---FFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVF 1090
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958672000 783 TVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLGRMGSAI 843
Cdd:TIGR00917 1091 CVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
739-916 |
1.29e-09 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 62.71 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 739 SLSDGTLIAMGLSVaVAFSVMLLttcniiISLYAIASIAGtIFVT--VGSLVLLGWELNVLESVT-ISVA-----VGLSV 810
Cdd:TIGR03480 266 TVSEGATVAGLLSF-VLVLVLLW------LALRSPRLVFA-VLVTliVGLILTAAFATLAVGHLNlISVAfavlfIGLGV 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 811 DFAVHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWaFATF-FF 887
Cdd:TIGR03480 338 DFAIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTLtVL 416
|
170 180
....*....|....*....|....*....
gi 1958672000 888 QCLCRCLGPQGTCGQIPLPKKLQCSAFSH 916
Cdd:TIGR03480 417 PALLRLLRPPRRRKPPGYATLAPLDAFLR 445
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
213-419 |
2.00e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 62.16 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 213 SMLFSPTEKgESMMNIYLDNFENWNSSDGIT-TVTG--IEFGIKHSLFQDYLLMDTVYPAIAIAIVLLImcVY---TKSV 286
Cdd:TIGR00921 519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 287 FiTLMTMFAIISSLIVSYFLYRVVFnfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKSDKPRAETS--EAVSVTLQ 363
Cdd:TIGR00921 596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1958672000 364 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 419
Cdd:TIGR00921 664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
732-870 |
5.77e-09 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 60.55 E-value: 5.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 732 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLV--------LLGWELNVLESVT-- 801
Cdd:COG2409 507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 802 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLGRMGSAIAVAAL---TTFVAgamMMPSTVLAYTQL 868
Cdd:COG2409 587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRVITSAALimaAVFAA---FATSPLVFLKQI 657
|
..
gi 1958672000 869 GT 870
Cdd:COG2409 658 GF 659
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
735-871 |
1.82e-08 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 57.69 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 735 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 810
Cdd:pfam03176 135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958672000 811 --DFAVHYGVAYR--LAPDPDREGKVIFSLGRMGSAIAVAALTtfVAGAMMmpstVLAYTQLGTF 871
Cdd:pfam03176 214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
290-442 |
1.96e-07 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 55.66 E-value: 1.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 290 LMTMFAIISSLIVSYFLyRVVFN---FEFFPFMNLtaliilvGIGADDAFVLCDVwnYTKSDkPRAETSEAVSVTLQHAA 366
Cdd:TIGR00918 435 LLVALSVAAGLGLCALL-GISFNaatTQVLPFLAL-------GVGVDDVFLLAHA--FSETG-QNIPFEERTGECLKRTG 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 367 LSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL----HERYLLNIFTCFRKP-------- 434
Cdd:TIGR00918 504 ASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSPcsarviqi 583
|
....*...
gi 1958672000 435 QPQAYHKS 442
Cdd:TIGR00918 584 EPQAYADG 591
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
269-419 |
1.48e-06 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 52.69 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 269 AIAIAIVLLIMCVYTKS---VFITLMTMFAiisSLIVSyflyrvvfnFEFFPFM----NL--TALIIL-VGIGADDA--F 336
Cdd:TIGR03480 276 LLSFVLVLVLLWLALRSprlVFAVLVTLIV---GLILT---------AAFATLAvghlNLisVAFAVLfIGLGVDFAiqF 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 337 VLcdvwNYTKSDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAV 416
Cdd:TIGR03480 344 SL----RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPAL 419
|
...
gi 1958672000 417 IVL 419
Cdd:TIGR03480 420 LRL 422
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
269-421 |
1.87e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 52.53 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 269 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSlivsyflyrVVFNFEFFPFM-------NLTALIILVGIGAD-DAFVLCD 340
Cdd:TIGR00921 200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTLNR 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 341 VwnYTKSDKPRAeTSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLH 420
Cdd:TIGR00921 271 Y--EEERDIGRA-KGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSI 347
|
.
gi 1958672000 421 E 421
Cdd:TIGR00921 348 D 348
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
269-436 |
6.34e-06 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 50.74 E-value: 6.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 269 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSYFLYRVVFNFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 343
Cdd:TIGR00833 180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 344 YTKSDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERY 423
Cdd:TIGR00833 256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335
|
170
....*....|...
gi 1958672000 424 LLniftcFRKPQP 436
Cdd:TIGR00833 336 GL-----MKPGRK 343
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
269-419 |
1.29e-05 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 48.83 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 269 AIAIAIVLLIMCVYTKSVFITLMTMFAIISSL-----IVSYFLYRVVFNFEFFPFMNLTalIILVGIGADDAFVLcdVWN 343
Cdd:pfam03176 149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLgaaqgLVAILAHILGIGLSTFALNLLV--VLLIAVGTDYALFL--VSR 224
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958672000 344 YTKSDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVL 419
Cdd:pfam03176 225 YREELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
803-887 |
5.85e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.54 E-value: 5.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 803 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLGRMGSAIAVAALTTFVAGAMMM--PSTVLAytQLGTFMMLVMCVSW 880
Cdd:COG4258 310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383
|
....*..
gi 1958672000 881 AFATFFF 887
Cdd:COG4258 384 LTTLLWL 390
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
733-871 |
1.42e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 46.30 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 733 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 808
Cdd:COG2409 160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958672000 809 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLGRMGSAIAVAALTtfVAGAMMmpstVLAYTQLGTF 871
Cdd:COG2409 239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
733-885 |
1.78e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 45.98 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 733 FYDLQDSLSDGtlIAMGLSVAVAFSVMLLTTC--NIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSV 810
Cdd:TIGR00921 558 FAEMHELVNEG--MRRMTIAGAILVLMILLAVfrNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGM 635
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958672000 811 DFAVHygVAYRLAPDPDREGKV---IFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGtFMMLVMCVSWAFATF 885
Cdd:TIGR00921 636 DYSIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
252-419 |
6.20e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 43.99 E-value: 6.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 252 IKHSLFQDYLLMdtVypAIAIAIVLLIMCVYTKSVFI----TLMTMFAIISSLIVSYFLY---RVVFNFE------FFPF 318
Cdd:COG2409 511 ISDALADDLPLV--I--PVVLGLIFLLLLLLFRSVVAplkaVLTNLLSLGAALGVLVLVFqhgWLLLGFTpgpldsFVPL 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 319 MnltALIILVGIGAD-DAFVLCDVW-NYTKSDKPRaetsEAVSVTLQH-------AALSMFVTsFttaAAFyanYVSNIT 389
Cdd:COG2409 587 L---LFVILFGLGMDyEVFLVSRIReEYDRGGGTR----EAVIRGLARtgrvitsAALIMAAV-F---AAF---ATSPLV 652
|
170 180 190
....*....|....*....|....*....|.
gi 1958672000 390 AIRCFGVYAGTAILVNYVLMVTWL-PAVIVL 419
Cdd:COG2409 653 FLKQIGFGLAVGVLLDAFVVRMLLvPALMAL 683
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
734-886 |
1.54e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 42.90 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 734 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 813
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958672000 814 VHYGVAYRlapDPDREGK-----VIFSLGRMGSAIAVAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFF 886
Cdd:TIGR00921 265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLV 339
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
748-850 |
1.66e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 42.92 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 748 MGLSVAVAFSVMLLTTCNIIISLYAIASIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 827
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718
|
90 100
....*....|....*....|...
gi 1958672000 828 REGkvifSLGRMGSAIAVAALTT 850
Cdd:COG4258 719 DKG----ELARTLLSILLAALTT 737
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
270-350 |
6.29e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 41.16 E-value: 6.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958672000 270 IAIAIVLLIMCVYTKSVFITLMTMFAIISSLIVSyFLYRVVFNFEfFPFMNLTALIILVGIGADDAF-VLCDVWNYTKSD 348
Cdd:NF033617 338 EAVALVILVVFLFLRNLRATLIPAVTVPLSLIGT-FAVMYLFGFS-INLLTLMALVLAIGLVVDDAIvVVENIHRHIEEG 415
|
..
gi 1958672000 349 KP 350
Cdd:NF033617 416 ES 417
|
|
| |
