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Conserved domains on  [gi|1958668161|ref|XP_038945128|]
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N-acetylserotonin O-methyltransferase-like protein isoform X3 [Rattus norvegicus]

Protein Classification

Maf family protein( domain architecture ID 2046)

multicopy associated filamentation (Maf) family protein is a nucleotide binding protein involved in septum formation and may also have a role as a house-cleaning NTP pyrophosphatase

Gene Ontology:  GO:0047429

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Maf_Ham1 super family cl00276
Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum ...
 1-117 1.33e-40

Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, such as hypoxanthine/xanthine NTP, but not standard nucleotides.


The actual alignment was detected with superfamily member cd00555:

Pssm-ID: 469702  Cd Length: 180  Bit Score: 133.37  E-value: 1.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagtRDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:cd00555    72 LDGRILGKPKDREEAREMLKRLSGRTHEVYTGVALI-------DPGGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDK 144

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958668161  81 AGGYGLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:cd00555   145 AGAYGIQGLGGALI-ERIEGDYSNVVGLPLPELLKLL 180
 
Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 1-117 1.33e-40

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


Pssm-ID: 238310  Cd Length: 180  Bit Score: 133.37  E-value: 1.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagtRDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:cd00555    72 LDGRILGKPKDREEAREMLKRLSGRTHEVYTGVALI-------DPGGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDK 144

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958668161  81 AGGYGLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:cd00555   145 AGAYGIQGLGGALI-ERIEGDYSNVVGLPLPELLKLL 180
Maf pfam02545
Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and ...
 5-117 3.09e-39

Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.


Pssm-ID: 460586  Cd Length: 174  Bit Score: 129.83  E-value: 3.09e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   5 IMGKPCDREDALRMLTRLNGREHSVITGVAIILTGGAGTRdaevvVVFHEETLVTFSKLSDELVQEHVEGGEPWDKAGGY 84
Cdd:pfam02545  65 ILGKPKDEEEARAMLKRLSGRTHEVYTGVALINPGGGTGG-----VSFVETTRVTFRPLSDEEIEAYVATGEPLDKAGAY 139

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958668161  85 GLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:pfam02545 140 GIQGLGAALV-ERIEGDYSNVVGLPLIELLRLL 171
Maf COG0424
7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary ...
 2-117 8.97e-38

7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440193  Cd Length: 189  Bit Score: 126.31  E-value: 8.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagtRDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDKA 81
Cdd:COG0424    74 DGRILGKPADAEEARAMLRRLSGRTHRVHTGVALI-------DPGGRLWTRVVTTRVTFRPLSDAEIEAYLATGEPLDKA 146

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958668161  82 GGYGLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:COG0424   147 GAYGIQGLGAALV-ERIEGSYSNVVGLPLIELLELL 181
PRK00648 PRK00648
Maf-like protein; Reviewed
 2-117 5.54e-34

Maf-like protein; Reviewed


Pssm-ID: 234807  Cd Length: 191  Bit Score: 116.93  E-value: 5.54e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagTRDAEVVvvFHEETLVTFSKLSDELVQEHVEGGEPWDKA 81
Cdd:PRK00648   78 DGKVLGKPKDEEEAVEMLRTLSGKTHEVITGVCLL------HNGKLLS--GSETTQVTFRELSDEEIEYYIDTYKPLDKA 149

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958668161  82 GGYGLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:PRK00648  150 GAYGIQEWGGLIV-KKIEGSYYNVMGLPIQTLYEEL 184
maf TIGR00172
MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A ...
 3-117 1.75e-27

MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A member of the family is found in the Archaeon Pyrococcus horikoshii and another in the round worm Caenorhabditis elegans. [Cellular processes, Cell division]


Pssm-ID: 129276  Cd Length: 183  Bit Score: 100.16  E-value: 1.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   3 GQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagtrDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDKAG 82
Cdd:TIGR00172  77 GEIYGKPKDKEEAAEFLRKLSGQEHEVYTAVALI--------DSVHLLTFLDVTKVHFRALDPEEIEKYVESGEPLEKAG 148

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958668161  83 GYGLQARGGaIMAEAVRGDPLNAAGLPLNRLCREL 117
Cdd:TIGR00172 149 AFGIEGFGA-PLIKKIDGDYSNVVGLPLEKLLGAL 182
 
Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 1-117 1.33e-40

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


Pssm-ID: 238310  Cd Length: 180  Bit Score: 133.37  E-value: 1.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagtRDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:cd00555    72 LDGRILGKPKDREEAREMLKRLSGRTHEVYTGVALI-------DPGGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDK 144

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1958668161  81 AGGYGLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:cd00555   145 AGAYGIQGLGGALI-ERIEGDYSNVVGLPLPELLKLL 180
Maf pfam02545
Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and ...
 5-117 3.09e-39

Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.


Pssm-ID: 460586  Cd Length: 174  Bit Score: 129.83  E-value: 3.09e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   5 IMGKPCDREDALRMLTRLNGREHSVITGVAIILTGGAGTRdaevvVVFHEETLVTFSKLSDELVQEHVEGGEPWDKAGGY 84
Cdd:pfam02545  65 ILGKPKDEEEARAMLKRLSGRTHEVYTGVALINPGGGTGG-----VSFVETTRVTFRPLSDEEIEAYVATGEPLDKAGAY 139

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958668161  85 GLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:pfam02545 140 GIQGLGAALV-ERIEGDYSNVVGLPLIELLRLL 171
Maf COG0424
7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary ...
 2-117 8.97e-38

7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440193  Cd Length: 189  Bit Score: 126.31  E-value: 8.97e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagtRDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDKA 81
Cdd:COG0424    74 DGRILGKPADAEEARAMLRRLSGRTHRVHTGVALI-------DPGGRLWTRVVTTRVTFRPLSDAEIEAYLATGEPLDKA 146

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958668161  82 GGYGLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:COG0424   147 GAYGIQGLGAALV-ERIEGSYSNVVGLPLIELLELL 181
PRK00648 PRK00648
Maf-like protein; Reviewed
 2-117 5.54e-34

Maf-like protein; Reviewed


Pssm-ID: 234807  Cd Length: 191  Bit Score: 116.93  E-value: 5.54e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagTRDAEVVvvFHEETLVTFSKLSDELVQEHVEGGEPWDKA 81
Cdd:PRK00648   78 DGKVLGKPKDEEEAVEMLRTLSGKTHEVITGVCLL------HNGKLLS--GSETTQVTFRELSDEEIEYYIDTYKPLDKA 149

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1958668161  82 GGYGLQARGGAIMaEAVRGDPLNAAGLPLNRLCREL 117
Cdd:PRK00648  150 GAYGIQEWGGLIV-KKIEGSYYNVMGLPIQTLYEEL 184
PRK00078 PRK00078
Maf-like protein; Reviewed
 3-113 4.68e-29

Maf-like protein; Reviewed


Pssm-ID: 234618  Cd Length: 192  Bit Score: 104.42  E-value: 4.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   3 GQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggaGTRDAEVVVVFhEETLVTFSKLSDELVQEHVEGGEPWDKAG 82
Cdd:PRK00078   78 GKVLGKPKDEEDAFEMLKALSGNEHEVYSGIAIL-----DTKSNKIIKDF-VCTEVKFSKLTDRQIRKYINTGEPMDKAG 151

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1958668161  83 GYGLQARGGaIMAEAVRGDPLNAAGLPLNRL 113
Cdd:PRK00078  152 AYGIQGKGG-VFVEEINGCYYNVVGLPLNKL 181
maf TIGR00172
MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A ...
 3-117 1.75e-27

MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A member of the family is found in the Archaeon Pyrococcus horikoshii and another in the round worm Caenorhabditis elegans. [Cellular processes, Cell division]


Pssm-ID: 129276  Cd Length: 183  Bit Score: 100.16  E-value: 1.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   3 GQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagtrDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDKAG 82
Cdd:TIGR00172  77 GEIYGKPKDKEEAAEFLRKLSGQEHEVYTAVALI--------DSVHLLTFLDVTKVHFRALDPEEIEKYVESGEPLEKAG 148

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1958668161  83 GYGLQARGGaIMAEAVRGDPLNAAGLPLNRLCREL 117
Cdd:TIGR00172 149 AFGIEGFGA-PLIKKIDGDYSNVVGLPLEKLLGAL 182
PRK14362 PRK14362
Maf-like protein; Provisional
 1-125 2.22e-27

Maf-like protein; Provisional


Pssm-ID: 172838  Cd Length: 207  Bit Score: 100.32  E-value: 2.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIILTGGAGtrdaevvVVFHEETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:PRK14362   85 LDGMILGKPADRADALSMLRRLAGRTHEVVSACCVVLPDGGR-------EVFHAITRVTMWDWPEAALAAYVATGEPSDK 157

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1958668161  81 AGGYGLQARgGAIMAEAVRGDPLNAAGLPLNRLCRELGRR--LLPSG 125
Cdd:PRK14362  158 AGAYGIQGI-GAFLVRSIEGSWSNVVGLPVAELTALLLRRgvILPVG 203
PRK14368 PRK14368
Maf-like protein; Provisional
 2-119 4.68e-24

Maf-like protein; Provisional


Pssm-ID: 237693  Cd Length: 193  Bit Score: 91.38  E-value: 4.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltggagTRDAEVVVVFHEETLVTFSKLSDELVQEHVEGGEPWDKA 81
Cdd:PRK14368   78 DGEIMGKPKDEADAVRMLKKLSGVPHEVITGFAVY------DRERDGCVTKAVRTKVFFKPLRDEEIRDYIATGCPMDKA 151

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958668161  82 GGYGLQArGGAIMAEAVRGDPLNAAGLPLNRLCRELGR 119
Cdd:PRK14368  152 GAYAIQG-GAAHMVRKIDGSYTNVVGLPLCEVVEALRT 188
PRK14365 PRK14365
Maf-like protein; Provisional
 2-113 9.49e-22

Maf-like protein; Provisional


Pssm-ID: 237690  Cd Length: 197  Bit Score: 85.64  E-value: 9.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITGVAII-LTGGAGTRDaevvvvfHEETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:PRK14365   76 NGEVLGKPASPENAEEMLEKLSGRKFLVITGLTVLdLDSGKEISE-------IESTDVWMTELSREQILAYVRTGEPLDK 148

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1958668161  81 AGGYGLQARgGAIMAEAVRGDPLNAAGLPLNRL 113
Cdd:PRK14365  149 AGAFAIQGK-GAVLVEKIEGDFFNVVGLPLFRL 180
PRK14363 PRK14363
Maf-like protein; Provisional
 1-110 3.72e-19

Maf-like protein; Provisional


Pssm-ID: 184647  Cd Length: 204  Bit Score: 79.17  E-value: 3.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltgGAGTRDaevvvVFHEETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:PRK14363   73 LDGNILGKPESLEEAKGMLKKLSGRWHVVYTGVAFV---SSETKD-----VIVSSTKVRFRELPESVIDYYVEKYRPLDK 144

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958668161  81 AGGYGLQARgGAIMAEAVRGDPLNAAGLPL 110
Cdd:PRK14363  145 AGAYGIQDF-AAVFVEKIEGDFFTVVGFPL 173
PRK14367 PRK14367
Maf-like protein; Provisional
 2-120 2.18e-17

Maf-like protein; Provisional


Pssm-ID: 237692  Cd Length: 202  Bit Score: 74.33  E-value: 2.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITGVAIILTGGAGTRdaevvvvfHEETLVTFSKLSDELVQEHVEGGEPWDKA 81
Cdd:PRK14367   82 DGIILGKPRSQAEAIEFLNRLSGKQHTVLTAVCIHYRGKTSSR--------VQTNRVVFKPLSSEEISAYVQSGEPMDKA 153

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958668161  82 GGYGLQARGGaIMAEAVRGDPLNAAGLPLNR---LCRELGRR 120
Cdd:PRK14367  154 GAYAVQGIGG-IFIQSIEGSFSGIMGLPVYEtvsMLQDLGYR 194
PRK14361 PRK14361
Maf-like protein; Provisional
 1-119 1.34e-16

Maf-like protein; Provisional


Pssm-ID: 172837  Cd Length: 187  Bit Score: 71.89  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIIltgGAGTRDAEVvvvfhEETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:PRK14361   70 LGGVLLAKPADEAENEAFLRVLSGRTHQVYTGVAVL---SRGTEQVGV-----ERTDVTFRALTAAEISFYARSGEGLDK 141

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958668161  81 AGGYGLQARGGAIMAEaVRGDPLNAAGLPLNRLCRELGR 119
Cdd:PRK14361  142 AGGYGIQGVGMALVSR-VEGDYSNVVGFPLSLVIRLLRG 179
PRK04694 PRK04694
Maf-like protein; Reviewed
 1-110 2.28e-16

Maf-like protein; Reviewed


Pssm-ID: 179873  Cd Length: 190  Bit Score: 71.53  E-value: 2.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIILTGGAGtrdAEVVVVfheeTLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:PRK04694   76 LGERVFGKPVDVDDAIAMLRALSGRTHQVLTAVVLVCAQRAP---AQALVV----SEVTFDLLDDAQIAAYAASGEPMGK 148

                          90       100       110
                  ....*....|....*....|....*....|
gi 1958668161  81 AGGYGLQARGGAIMAEAVrGDPLNAAGLPL 110
Cdd:PRK04694  149 AGAYAIQGRAERFIRHLS-GSYSGVMGLPL 177
PRK14364 PRK14364
Maf-like protein; Provisional
 1-119 4.77e-12

Maf-like protein; Provisional


Pssm-ID: 184648  Cd Length: 181  Bit Score: 60.02  E-value: 4.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIiltggAGTRDAEVVVVfheETLVTFSKLSDELVQEHVEGGEPWDK 80
Cdd:PRK14364   69 LDGQIIGKPDSKQHAFDIWKQLSGRWHDVFSGICI-----ATQQQILSQVV---QTQVEFASLTTQDMEDYWATGEPVGK 140

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1958668161  81 AGGYGLQARGGAIMAEaVRGDPLNAAGLPLNRLCRELGR 119
Cdd:PRK14364  141 AGAYAIQGIASQYIPK-IQGSYSNVVGLPLYEFSQLFKR 178
Maf_Ham1 cd00985
Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum ...
 1-61 9.12e-11

Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, such as hypoxanthine/xanthine NTP, but not standard nucleotides.


Pssm-ID: 238485  Cd Length: 131  Bit Score: 55.59  E-value: 9.12e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958668161   1 MEGQIMGKPCDREDALRMLTRLNGREHSVITGVAIILTGGagtrdaeVVVVFHEETLVTFS 61
Cdd:cd00985    71 VDGRPGGKPARFAEALEMLRGLSGRTAEFVTAVALVDPDG-------KIITFEGETEGKIA 124
PRK01441 PRK01441
Maf-like protein; Reviewed
 4-110 2.57e-09

Maf-like protein; Reviewed


Pssm-ID: 167232  Cd Length: 207  Bit Score: 52.80  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   4 QIMGKPCDREDALRMLTRLNGREHSVITGVAIILTGGAgTRDAEVvvvfheETLVTFSKLSDELVQEHVEGGEPWDKAGG 83
Cdd:PRK01441   87 RILPKAELVDEASQCLRLLSGRNHRVYTGVCLVTPDGK-LRQKLV------ETRVRFKRLSREDIEAYLASGEWRGKAGG 159

                          90       100
                  ....*....|....*....|....*..
gi 1958668161  84 YGLQARGGAIMAEAVrGDPLNAAGLPL 110
Cdd:PRK01441  160 YAIQGIAGSFVVKLV-GSYTNVVGLPL 185
PRK02141 PRK02141
Maf-like protein; Reviewed
 2-123 7.50e-09

Maf-like protein; Reviewed


Pssm-ID: 235009  Cd Length: 207  Bit Score: 51.68  E-value: 7.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGRE---HSVITgvaiILTGGAGTRDAEVVVvfheeTLVTFSKLSDELVQEHVEGGEPW 78
Cdd:PRK02141   85 DGLQIGKPGTHERALAQLQAMRGRTvefHSALC----LYDSRTGETQSEDVV-----TRVRFRTLTDAELDAYLRAETPY 155

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958668161  79 DKAGGYGLQARGGAIMaEAVRG-DPLNAAGLPLNRLCRELGRRLLP 123
Cdd:PRK02141  156 DVAGSAKSEGLGIALL-DAIDSdDPTALVGLPLIALTRMLRAAGYP 200
PRK04056 PRK04056
septum formation inhibitor Maf;
2-96 2.30e-06

septum formation inhibitor Maf;


Pssm-ID: 179732  Cd Length: 180  Bit Score: 44.57  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958668161   2 EGQIMGKPCDREDALRMLTRLNGREHSVITgvAIILTGgagtRDAEVVVVfhEETLVTFSKLSDELVQEHVEGGEpWdka 81
Cdd:PRK04056   74 GNKILRKAKDKEEAREMLKLQSGNEISVLT--CMILKS----PEKEWLDL--SVTTYRFKKFDEDDLEKYLESGL-W--- 141

                          90
                  ....*....|....*
gi 1958668161  82 ggyglQARGGAIMAE 96
Cdd:PRK04056  142 -----QGKAGACMVE 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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