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Conserved domains on  [gi|1958658099|ref|XP_038941775|]
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zinc finger protein GLIS2 isoform X1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-328 4.54e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 4.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 234 KPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 313
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                          90
                  ....*....|....*
gi 1958658099 314 HIKAHGHFVSHEQQE 328
Cdd:COG5048   110 LSSSSSNSNDNNLLS 124
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-328 4.54e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 4.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 234 KPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 313
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                          90
                  ....*....|....*
gi 1958658099 314 HIKAHGHFVSHEQQE 328
Cdd:COG5048   110 LSSSSSNSNDNNLLS 124
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-247 2.73e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.73e-05
                          10        20
                  ....*....|....*....|..
gi 1958658099 226 HIRTHTNEKPHRCPTCNKSFSR 247
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-328 4.54e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 4.54e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 234 KPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSlrK 313
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSS--S 109

                          90
                  ....*....|....*
gi 1958658099 314 HIKAHGHFVSHEQQE 328
Cdd:COG5048   110 LSSSSSNSNDNNLLS 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-309 7.66e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 7.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 234 KPHRCPTCNKSFSRLENLKIHNRS--HTGE--KPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPS 309
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 260-320 1.32e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.87  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 260 GEKPYVCPYEGCNKRYSNS-------------------SDRFKHTRTHYVDKPYYCkmPGCHKRYTDPSSLRKHIKaHGH 320
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQnglkyhmlhghqnqklhenPSPEKMNIFSAKDKPYRC--EVCDKRYKNLNGLKYHRK-HSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
82-318 8.13e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 8.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099  82 SLSPPSGLDSPNGSSSLSPErqgngdlpPLPTAVDFQPLRYLD----GVPSSFQFFLPLGSGGALHLPASSFLTPPKDKC 157
Cdd:COG5048   208 SYSIPSSSSDQNLENSSSSL--------PLTTNSQLSPKSLLSqspsSLSSSDSSSSASESPRSSLPTASSQSSSPNESD 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 158 LSPELplAKQLVCRWAKCNQLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCarhgrGFNASRYKML-IHIRTHTNEKPH 236
Cdd:COG5048   280 SSSEK--GFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYSLC-----GKLFSRNDALkRHILLHTSISPA 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 237 RCPT--CNKSFSRLENLK-----IHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPS 309
Cdd:COG5048   353 KEKLlnSSSKFSPLLNNEppqslQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHY 432


                  ....*....
gi 1958658099 310 SLRKHIKAH 318
Cdd:COG5048   433 NLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
226-247 2.73e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.73e-05
                          10        20
                  ....*....|....*....|..
gi 1958658099 226 HIRTHTNEKPHRCPTCNKSFSR 247
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 202-291 2.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 202 YCCHWEGCARHGRGFNASRYKMLihiRTHTNEKPHRCPTCNKsfsrlenlkiHNRSHTGEKPYVCPYegCNKRYSNSSDr 281
Cdd:COG5189   350 YKCPVEGCNKKYKNQNGLKYHML---HGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEV--CDKRYKNLNG- 413

                          90
                  ....*....|
gi 1958658099 282 FKHTRTHYVD 291
Cdd:COG5189   414 LKYHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 3.67e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.67e-04
                          10        20
                  ....*....|....*....|...
gi 1958658099 236 HRCPTCNKSFSRLENLKIHNRSH 258
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-277 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958658099 250 NLKIHNRSHTGEKPYVCPYegCNKRYSN 277
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-305 1.11e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958658099 223 MLIHIRTHTNEKPHRC--PTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPG 300
Cdd:COG5048    49 LTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSL 128


                  ....*
gi 1958658099 301 CHKRY 305
Cdd:COG5048   129 PPSSR 133
zf-C2H2_6 pfam13912
C2H2-type zinc finger;
236-258 3.63e-03

C2H2-type zinc finger;


Pssm-ID: 433576  Cd Length: 27  Bit Score: 34.91  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|...
gi 1958658099 236 HRCPTCNKSFSRLENLKIHNRSH 258
Cdd:pfam13912   2 HECSECGKSFPSYQALGGHKKSH 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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