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Conserved domains on  [gi|1958656049|ref|XP_038940965|]
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protein AATF isoform X1 [Rattus norvegicus]

Protein Classification

AATF family protein( domain architecture ID 10595123)

apoptosis-antagonizing transcription factor (AATF) family protein, such as AATF, also called Che-1, which has been shown to play a crucial role in cell cycle control, apoptosis, and chromatin remodeling due to its interaction with various important components of cell survival machinery including Retinoblastoma(Rb), DAP like kinases(DLK) and histone deacetylases (HDACs)

Gene Ontology:  GO:0006357|GO:0030490|GO:0042254
PubMed:  33145763

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 184-247 1.26e-23

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


:

Pssm-ID: 463850  Cd Length: 136  Bit Score: 93.21  E-value: 1.26e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958656049 184 EVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKdKGGPEFASALKNTMAASN 247
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFL-KSDEEFSEALEEAEKALK 63
 
Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 184-247 1.26e-23

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


Pssm-ID: 463850  Cd Length: 136  Bit Score: 93.21  E-value: 1.26e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958656049 184 EVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKdKGGPEFASALKNTMAASN 247
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFL-KSDEEFSEALEEAEKALK 63
 
Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 184-247 1.26e-23

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


Pssm-ID: 463850  Cd Length: 136  Bit Score: 93.21  E-value: 1.26e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958656049 184 EVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKdKGGPEFASALKNTMAASN 247
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFL-KSDEEFSEALEEAEKALK 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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