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Conserved domains on  [gi|1958647929|ref|XP_038940236|]
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protein PAT1 homolog 1 isoform X3 [Rattus norvegicus]

Protein Classification

PAT1 family protein( domain architecture ID 1001013)

PAT1 family protein similar to Saccharomyces cerevisiae DNA topoisomerase 2-associated protein PAT1, an activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation

Gene Ontology:  GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 12-394 1.56e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 60.82  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929  12 RMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLP 91
Cdd:pfam09770 204 RAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQP 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929  92 PAPGFRaffsapppatPPPQQHPPGPGPHLQNLR---------PQAPMFRPDTTHLHPQHRR---LLHQRQLQSRNQH-- 157
Cdd:pfam09770 284 QAQQFH----------QQPPPVPVQPTQILQNPNrlsaarvgyPQNPQPGVQPAPAHQAHRQqgsFGRQAPIITHPQQla 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 158 ------RNLNGTGDRGGHRVSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQ----- 215
Cdd:pfam09770 354 qlseeeKAAYLDEEAKRAKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQvysqi 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 216 ------------NYFEK---LEKSSAAEEM--QGDGPKKERTKLiTPQVARLEHAYK--P----VQFEGSLGKLTVSSVN 272
Cdd:pfam09770 432 rggprqhpsqplSNFAQtylFQTGSRQGGMrrQGRGAENHMQRM-EQQVQRAVEAAKnkPknkqLVIEGSLGKISFSNAK 510

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 273 NPRKMI---------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPAlTDERKHKI 343
Cdd:pfam09770 511 TPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDP-ELIEKHME 589

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958647929 344 W-SMYDNLRGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 394
Cdd:pfam09770 590 WrSTLQALNAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 12-394 1.56e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 60.82  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929  12 RMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLP 91
Cdd:pfam09770 204 RAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQP 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929  92 PAPGFRaffsapppatPPPQQHPPGPGPHLQNLR---------PQAPMFRPDTTHLHPQHRR---LLHQRQLQSRNQH-- 157
Cdd:pfam09770 284 QAQQFH----------QQPPPVPVQPTQILQNPNrlsaarvgyPQNPQPGVQPAPAHQAHRQqgsFGRQAPIITHPQQla 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 158 ------RNLNGTGDRGGHRVSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQ----- 215
Cdd:pfam09770 354 qlseeeKAAYLDEEAKRAKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQvysqi 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 216 ------------NYFEK---LEKSSAAEEM--QGDGPKKERTKLiTPQVARLEHAYK--P----VQFEGSLGKLTVSSVN 272
Cdd:pfam09770 432 rggprqhpsqplSNFAQtylFQTGSRQGGMrrQGRGAENHMQRM-EQQVQRAVEAAKnkPknkqLVIEGSLGKISFSNAK 510

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 273 NPRKMI---------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPAlTDERKHKI 343
Cdd:pfam09770 511 TPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDP-ELIEKHME 589

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958647929 344 W-SMYDNLRGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 394
Cdd:pfam09770 590 WrSTLQALNAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Name Accession Description Interval E-value
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 12-394 1.56e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 60.82  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929  12 RMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLP 91
Cdd:pfam09770 204 RAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQP 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929  92 PAPGFRaffsapppatPPPQQHPPGPGPHLQNLR---------PQAPMFRPDTTHLHPQHRR---LLHQRQLQSRNQH-- 157
Cdd:pfam09770 284 QAQQFH----------QQPPPVPVQPTQILQNPNrlsaarvgyPQNPQPGVQPAPAHQAHRQqgsFGRQAPIITHPQQla 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 158 ------RNLNGTGDRGGHRVSHQDHL-RKDpyANLMLQREKDWVSKIQMMQL---------QSTDPYL-DDFYYQ----- 215
Cdd:pfam09770 354 qlseeeKAAYLDEEAKRAKRNHKIFLlSKD--NGLMTPQDKNFITRIQLQQLvsatgnpneQGTDASLsEDFYYQvysqi 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 216 ------------NYFEK---LEKSSAAEEM--QGDGPKKERTKLiTPQVARLEHAYK--P----VQFEGSLGKLTVSSVN 272
Cdd:pfam09770 432 rggprqhpsqplSNFAQtylFQTGSRQGGMrrQGRGAENHMQRM-EQQVQRAVEAAKnkPknkqLVIEGSLGKISFSNAK 510

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958647929 273 NPRKMI---------DAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPAlTDERKHKI 343
Cdd:pfam09770 511 TPKPLLnikrpessnDAHRPGSAKKQRSHSETFSLDRKTILRNIEKVYDTLMKMEDHERKMPPPPTEDSDP-ELIEKHME 589

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958647929 344 W-SMYDNLRGKL---------PGQERPsddH-FVQIMCIRKGKRMVARILPFLSTEQAADIL 394
Cdd:pfam09770 590 WrSTLQALNAKLwqelkvhepIGSTTP---HpFIAFLSHPKGKKAIPRIFRHLSQEQRTTIL 648
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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