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Conserved domains on  [gi|1958797219|ref|XP_038937774|]
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zinc finger protein 426-like isoform X3 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 18089471)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-519 9.64e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 9.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 328 KSYKCMECGKAFLRWSGLTEHIR--VHTGE--KPYECKE--CGKTFSRSTQLTEHIRTHTGIKPYECKEcgkaftqysgl 401
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL----------- 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 402 athvRIHSGEKPFACKECGKAFTRTSGLIHHVRTHTGEKPFECVHCGKTFITSSHRTKHLKihSGEKPFVCNICGKAFIY 481
Cdd:COG5048   357 ----LNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958797219 482 STSLNIHMRTHTgEKPYICKQCGKAFAVYSRLRKHSRV 519
Cdd:COG5048   431 HYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB super family cl42959
krueppel associated box;
1-28 1.64e-05

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 42.58  E-value: 1.64e-05
                           10        20
                   ....*....|....*....|....*...
gi 1958797219    1 MLENYENLTSVGCQFFIPSLTPWLKQEE 28
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGE 57
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-519 9.64e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 9.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 328 KSYKCMECGKAFLRWSGLTEHIR--VHTGE--KPYECKE--CGKTFSRSTQLTEHIRTHTGIKPYECKEcgkaftqysgl 401
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL----------- 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 402 athvRIHSGEKPFACKECGKAFTRTSGLIHHVRTHTGEKPFECVHCGKTFITSSHRTKHLKihSGEKPFVCNICGKAFIY 481
Cdd:COG5048   357 ----LNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958797219 482 STSLNIHMRTHTgEKPYICKQCGKAFAVYSRLRKHSRV 519
Cdd:COG5048   431 HYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB smart00349
krueppel associated box;
1-28 1.64e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 42.58  E-value: 1.64e-05
                           10        20
                   ....*....|....*....|....*...
gi 1958797219    1 MLENYENLTSVGCQFFIPSLTPWLKQEE 28
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGE 57
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-397 7.68e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.68e-05
                          10        20
                  ....*....|....*....|....*
gi 1958797219 373 LTEHIRTHTGIKPYECKECGKAFTQ 397
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 383-433 3.26e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 3.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958797219 383 IKPYECKECGKAFTQYSGLATHVRIHSGEKpfACKECGKAFTRTSGLIHHV 433
Cdd:PHA00733   71 VSPYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-519 9.64e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 9.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 328 KSYKCMECGKAFLRWSGLTEHIR--VHTGE--KPYECKE--CGKTFSRSTQLTEHIRTHTGIKPYECKEcgkaftqysgl 401
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL----------- 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 402 athvRIHSGEKPFACKECGKAFTRTSGLIHHVRTHTGEKPFECVHCGKTFITSSHRTKHLKihSGEKPFVCNICGKAFIY 481
Cdd:COG5048   357 ----LNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLS--FRPYNCKNPPCSKSFNR 430

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1958797219 482 STSLNIHMRTHTgEKPYICKQCGKAFAVYSRLRKHSRV 519
Cdd:COG5048   431 HYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-455 3.59e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 272 KSKVCKICGKSFANYSRLSAHVKTHNEE----KPFVCKE--CGKAFKNMSYLNDHVRIHTGIKSYKCMecgkaflrwsgL 345
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----------L 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 346 TEHIRVHTGEKPyeckecgktfSRSTQLTEHIRTHTGIKPYEC--KECGKAFTQYSGLATHVRIHSGEKP--FACKECGK 421
Cdd:COG5048   357 LNSSSKFSPLLN----------NEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1958797219 422 AFTRTSGLIHHVRTHTGEKPFECVHCGKTFITSS 455
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
KRAB smart00349
krueppel associated box;
1-28 1.64e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 42.58  E-value: 1.64e-05
                           10        20
                   ....*....|....*....|....*...
gi 1958797219    1 MLENYENLTSVGCQFFIPSLTPWLKQEE 28
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGE 57
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-397 7.68e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.68e-05
                          10        20
                  ....*....|....*....|....*
gi 1958797219 373 LTEHIRTHTGIKPYECKECGKAFTQ 397
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-369 7.83e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.83e-05
                          10        20
                  ....*....|....*....|....*
gi 1958797219 345 LTEHIRVHTGEKPYECKECGKTFSR 369
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-425 1.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.54e-04
                          10        20
                  ....*....|....*....|....*
gi 1958797219 401 LATHVRIHSGEKPFACKECGKAFTR 425
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-530 1.81e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 365 KTFSRSTQLTEHIRTHTGI-KPYECKECGKAFTQYSGLATHVR--IHSGE--KPFACKE--CGKAFTRTSGLIHHVRTHT 437
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 438 GEKPFECV--HCGKTFITSSHRTKHLKIH-----SGEKPFVC--NICGKAFI--YSTSLNIHMRTHTGEKPYICKQCGKA 506
Cdd:COG5048   348 SISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKrdSNLSLHIITHLSFRPYNCKNPPCSKS 427

                         170       180
                  ....*....|....*....|....
gi 1958797219 507 FAVYSRLRKHSRVHTEEKPYQCEG 530
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSI 451
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 410-493 2.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797219 410 GEKPFACK--ECGKAFTRTSGLIHHvRTHTgekpfecvHCGKTFITSSHRTKHLKIHSGEKPFVCNICGKAFIYSTSLNI 487
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1958797219 488 HmRTHT 493
Cdd:COG5189   417 H-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 358-380 2.61e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.61e-04
                          10        20
                  ....*....|....*....|...
gi 1958797219 358 YECKECGKTFSRSTQLTEHIRTH 380
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
328-381 3.76e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.76e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958797219 328 KSYKCMECGKAFLRWSGLTEHIRVHTGEKPYEC--KECGKTFSRSTQLTEHIRTHT 381
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
484-508 3.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.84e-04
                          10        20
                  ....*....|....*....|....*
gi 1958797219 484 SLNIHMRTHTGEKPYICKQCGKAFA 508
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-341 5.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958797219 316 YLNDHVRIHTGIKSYKCMECGKAFLR 341
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 470-492 2.09e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|...
gi 1958797219 470 FVCNICGKAFIYSTSLNIHMRTH 492
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-414 3.12e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.12e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958797219 356 KPYECKECGKTFSRSTQLTEHIRTHTGIKPYEC--KECGKAFTQYSGLATHVRIHSGEKPF 414
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD 92
PHA00733 PHA00733
hypothetical protein
 383-433 3.26e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 3.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958797219 383 IKPYECKECGKAFTQYSGLATHVRIHSGEKpfACKECGKAFTRTSGLIHHV 433
Cdd:PHA00733   71 VSPYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-453 5.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.94e-03
                          10        20
                  ....*....|....*....|..
gi 1958797219 432 HVRTHTGEKPFECVHCGKTFIT 453
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 414-436 6.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.40e-03
                          10        20
                  ....*....|....*....|...
gi 1958797219 414 FACKECGKAFTRTSGLIHHVRTH 436
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 357-405 9.27e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.39  E-value: 9.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1958797219 357 PYECKECGKTFSRSTQLTEHIR--THTGIKPYeckeCGKAFTQYSGLATHV 405
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRytEHSKVCPV----CGKEFRNTDSTLDHV 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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