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Conserved domains on  [gi|1958797188|ref|XP_038937759|]
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zinc finger protein 26 isoform X2 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003677|GO:0008270|GO:0005515|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|8183940|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
103-161 3.12e-27

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.98  E-value: 3.12e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958797188  103 VTFEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLATVGGQLFKPSLISWLERKVEL 161
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-750 2.62e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.90  E-value: 2.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 337 KKYYECKKCEKFFTHPVYLNIHVQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTREKSYEC-KECGKTFIQPSRLTE 413
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 414 HMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLGHIRTHTGEKpyeckvCGKAFSG 491
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSL------SKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 492 RSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNSSCLKTH----FRIHTGIKPYKC 566
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSlsssDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 567 NYCGKDFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KPFEC--YQCGKALAHSSSLVGHL 639
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 640 RTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPERSCLTKHIRTHTGERPYECK--E 708
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1958797188 709 CGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 750
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
590-917 6.39e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 6.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 590 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 665
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 666 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQLTVHIktHSSERPFQCKVCTKSFRNSS 745
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH--PPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 746 SLETHFrihtgvkPYKCSYCGKDFTARSGLTIHLRNHTGEKSYACQECGKAFSTS---------SGLIAHIRSHKGEKPF 816
Cdd:COG5048   189 SSNVST-------SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 817 ECDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRV 889
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340
                  ....*....|....*....|....*...
gi 1958797188 890 HMRIHTGEKPYVCQYCGKAFTEHSGLNK 917
Cdd:COG5048   342 HILLHTSISPAKEKLLNSSSKFSPLLNN 369
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
103-161 3.12e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.98  E-value: 3.12e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958797188  103 VTFEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLATVGGQLFKPSLISWLERKVEL 161
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 103-143 4.99e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 4.99e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958797188 103 VTFEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLATVG 143
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 103-140 2.73e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 2.73e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958797188 103 VTFEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLA 140
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-750 2.62e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.90  E-value: 2.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 337 KKYYECKKCEKFFTHPVYLNIHVQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTREKSYEC-KECGKTFIQPSRLTE 413
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 414 HMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLGHIRTHTGEKpyeckvCGKAFSG 491
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSL------SKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 492 RSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNSSCLKTH----FRIHTGIKPYKC 566
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSlsssDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 567 NYCGKDFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KPFEC--YQCGKALAHSSSLVGHL 639
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 640 RTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPERSCLTKHIRTHTGERPYECK--E 708
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1958797188 709 CGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 750
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
590-917 6.39e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 6.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 590 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 665
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 666 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQLTVHIktHSSERPFQCKVCTKSFRNSS 745
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH--PPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 746 SLETHFrihtgvkPYKCSYCGKDFTARSGLTIHLRNHTGEKSYACQECGKAFSTS---------SGLIAHIRSHKGEKPF 816
Cdd:COG5048   189 SSNVST-------SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 817 ECDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRV 889
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340
                  ....*....|....*....|....*...
gi 1958797188 890 HMRIHTGEKPYVCQYCGKAFTEHSGLNK 917
Cdd:COG5048   342 HILLHTSISPAKEKLLNSSSKFSPLLNN 369
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 758-811 3.42e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.93  E-value: 3.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958797188 758 KPYkCSYCGKDFTARSGLTIHLRNHTgeksYACQECGKAFSTSSGLIAHI-RSHK 811
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHK 50
zf-H2C2_2 pfam13465
Zinc-finger double domain;
886-910 3.79e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.79e-05
                          10        20
                  ....*....|....*....|....*
gi 1958797188 886 YLRVHMRIHTGEKPYVCQYCGKAFT 910
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
662-685 4.14e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.14e-05
                          10        20
                  ....*....|....*....|....
gi 1958797188 662 YLRIHMRTHTGEKPYECKECGKTF 685
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 562-610 5.26e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 5.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958797188 562 KPYkCNYCGKDFTARSGLtkhvLIHNGEKPYECKECGKAFSTSSGLVEH 610
Cdd:cd20908     1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
103-161 3.12e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.98  E-value: 3.12e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958797188  103 VTFEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLATVGGQLFKPSLISWLERKVEL 161
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 103-143 4.99e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.53  E-value: 4.99e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1958797188 103 VTFEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLATVG 143
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 103-140 2.73e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 2.73e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958797188 103 VTFEDVAVDFTQEEWTSLDPIQRTLYREVMLENYQNLA 140
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-750 2.62e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.90  E-value: 2.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 337 KKYYECKKCEKFFTHPVYLNIHVQSHTVEKPYDC--KECGKAFTERSSLIVHLRQHTREKSYEC-KECGKTFIQPSRLTE 413
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 414 HMRSHTGEKPYQCDQCGNAFASSSYLT--THLRTHTGEKPFECNIcGKAFTRSSYLLGHIRTHTGEKpyeckvCGKAFSG 491
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSL------SKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 492 RSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTH-TGEKPFRCKVCARTFRNSSCLKTH----FRIHTGIKPYKC 566
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSlsssDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 567 NYCGKDFTARSGLTKHVLIHNG-EKPYECKECGKAFSTSSGLVEHIR--IHTGE--KPFEC--YQCGKALAHSSSLVGHL 639
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 640 RTHTGEKPFEC--NQCDKTFTRSSY-----LRIHMRTHTGEKPYEC--KECGKTFPERSCLTKHIRTHTGERPYECK--E 708
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1958797188 709 CGKGFISFAQLTVHIKTHSSERPFQCKvCTKSFRNSSSLETH 750
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
450-881 9.63e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.90  E-value: 9.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 450 KPFECNICGKAFTRSSYLLGHIRTHTGEKPYECKVCGkafsgrswltihlrkhtgerpypcteCEKAFTSFAQLTEHIKT 529
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 530 HTGEKPFRC--KVCARTFRNSSCLKTHFrIHTGIKPYKCNYCGKDFTARSGLTKHVL--IHNGEKPYE-CKECGKAFSTS 604
Cdd:COG5048    86 HHNNPSDLNskSLPLSNSKASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLsiSNLRNNPLPgNNSSSVNTPQS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 605 SGLveHIRIHTGEKPFECYQCGKALAHSSslvghlrTHTGEKPFECNQCDKTFTRSSYLRIHMRTHTGEKPYECKECGKT 684
Cdd:COG5048   165 NSL--HPPLPANSLSKDPSSNLSLLISSN-------VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 685 FPERSCLTKHIRTHTGERPYECKECGKGFISFA--QLTVHIKTHSSER-----PFQCKVCTKSFRNSSSLETHFR--IHT 755
Cdd:COG5048   236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAssQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 756 G--VKPYKC--SYCGKDFTARSGLTIHLRNHTGEKSYAC--QECGKAFSTSS-----GLIAHIRSHKGEKPFECDH--CG 822
Cdd:COG5048   316 GesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnsCI 395

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958797188 823 KAFASSSYLNVHLKIHTGEKP--FQCTVCGKTFTCSSYLPVHMRTHTGEKPFQCIICGKSF 881
Cdd:COG5048   396 RNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
394-834 1.21e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 394 KSYECKECGKTFIQPSRLTEHMRSHTGEKPYQC--DQCGNAFASSSYLTTHLRTHTGEKPFECNICGK--AFTRSSYLLG 469
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 470 HIRTHTGEKPYECKvCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIKTHTGekpfrckvcARTFRNSS 549
Cdd:COG5048   112 SSSSNSNDNNLLSS-HSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA---------NSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 550 CLKTHFRIHTGIKPYKCNYCGKDFTARSGLTKHVLIHNgekpyeckecgkAFSTSSGLVEHIRIHTGEKPFECYQcgkal 629
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQN------------LENSSSSLPLTTNSQLSPKSLLSQS----- 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 630 ahSSSLVGHLRTHTGEKPFECNQCDKTFTRSSYLRIHMRTHTG-EKPYECKECGKTFPERSCLTKHIRT--HTGE--RPY 704
Cdd:COG5048   245 --PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPF 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 705 ECKE--CGKGFISFAQLTVHIKTHSSERPFQCKVCTKSFRNSSSL----ETHFRIHTGVKPYK---CSY--CGKDFTARS 773
Cdd:COG5048   323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKkseTLSnsCIRNFKRDS 402

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958797188 774 GLTIHLRNHTGEKSYACQ--ECGKAFSTSSGLIAHIRSHKGEKPFECDHCGKAFASSSYLNVH 834
Cdd:COG5048   403 NLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
590-917 6.39e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 6.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 590 KPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVG--HLRTHTGEKPFECNQ--CDKTFTRSSYLrI 665
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKslPLSNSKASSSS-L 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 666 HMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQLTVHIktHSSERPFQCKVCTKSFRNSS 745
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH--PPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 746 SLETHFrihtgvkPYKCSYCGKDFTARSGLTIHLRNHTGEKSYACQECGKAFSTS---------SGLIAHIRSHKGEKPF 816
Cdd:COG5048   189 SSNVST-------SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 817 ECDHCGKAFASSSYLNVHLKIHTG-EKPFQCTVCGKTFTCSSYLPVHMRT--HTGE--KPFQC--IICGKSFLWSSYLRV 889
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340
                  ....*....|....*....|....*...
gi 1958797188 890 HMRIHTGEKPYVCQYCGKAFTEHSGLNK 917
Cdd:COG5048   342 HILLHTSISPAKEKLLNSSSKFSPLLNN 369
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 758-811 3.42e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.93  E-value: 3.42e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1958797188 758 KPYkCSYCGKDFTARSGLTIHLRNHTgeksYACQECGKAFSTSSGLIAHI-RSHK 811
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHClQVHK 50
zf-H2C2_2 pfam13465
Zinc-finger double domain;
886-910 3.79e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 3.79e-05
                          10        20
                  ....*....|....*....|....*
gi 1958797188 886 YLRVHMRIHTGEKPYVCQYCGKAFT 910
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
662-685 4.14e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.14e-05
                          10        20
                  ....*....|....*....|....
gi 1958797188 662 YLRIHMRTHTGEKPYECKECGKTF 685
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 532-611 8.33e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 8.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 532 GEKPFRCKV--CARTFRNSSCLKTHfRIHtgikpykcNYCGKDFTARSGLTKHVLIHNGEKPYECKECGKAFSTSSGLVE 609
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1958797188 610 HI 611
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-435 1.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958797188 410 RLTEHMRSHTGEKPYQCDQCGNAFAS 435
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-463 2.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958797188 438 YLTTHLRTHTGEKPFECNICGKAFTR 463
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
830-855 3.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 1958797188 830 YLNVHLKIHTGEKPFQCTVCGKTFTC 855
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
862-881 4.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.40e-04
                          10        20
                  ....*....|....*....|
gi 1958797188 862 HMRTHTGEKPFQCIICGKSF 881
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
746-770 5.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.52e-04
                          10        20
                  ....*....|....*....|....*
gi 1958797188 746 SLETHFRIHTGVKPYKCSYCGKDFT 770
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
551-574 6.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.03e-04
                          10        20
                  ....*....|....*....|....
gi 1958797188 551 LKTHFRIHTGIKPYKCNYCGKDFT 574
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 648-670 6.43e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 6.43e-04
                          10        20
                  ....*....|....*....|...
gi 1958797188 648 FECNQCDKTFTRSSYLRIHMRTH 670
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
691-715 6.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.58e-04
                          10        20
                  ....*....|....*....|....*
gi 1958797188 691 LTKHIRTHTGERPYECKECGKGFIS 715
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 476-559 6.63e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 6.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 476 GEKPYECKV--CGKAFSGRSWLTIH-LRKHTGERPYPcTECEKAFTSFAqltehikthTGEKPFRCKVCARTFRNSSCLK 552
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGHQNQKLHE-NPSPEKMNIFS---------AKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1958797188 553 THfRIHT 559
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
470-490 7.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.05e-04
                          10        20
                  ....*....|....*....|.
gi 1958797188 470 HIRTHTGEKPYECKVCGKAFS 490
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
638-659 7.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.05e-04
                          10        20
                  ....*....|....*....|..
gi 1958797188 638 HLRTHTGEKPFECNQCDKTFTR 659
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 820-923 7.74e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 7.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958797188 820 HCGKAFASSSYLNVHLKihtGEKPFQCTV--CGKTFTCSSYLPVHMRT-HTGEKpfqciicgksfLWSSYLRVHMRIHTG 896
Cdd:COG5189   329 HGGERNIDTPSRMLKVK---DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQK-----------LHENPSPEKMNIFSA 394

                          90       100
                  ....*....|....*....|....*...
gi 1958797188 897 E-KPYVCQYCGKAFTEHSGLNKHlRKHT 923
Cdd:COG5189   395 KdKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-519 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*
gi 1958797188 495 LTIHLRKHTGERPYPCTECEKAFTS 519
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
806-827 2.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.41e-03
                          10        20
                  ....*....|....*....|..
gi 1958797188 806 HIRSHKGEKPFECDHCGKAFAS 827
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
579-603 3.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|....*
gi 1958797188 579 LTKHVLIHNGEKPYECKECGKAFST 603
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
607-628 3.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.71e-03
                          10        20
                  ....*....|....*....|..
gi 1958797188 607 LVEHIRIHTGEKPFECYQCGKA 628
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 452-474 4.90e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.90e-03
                          10        20
                  ....*....|....*....|...
gi 1958797188 452 FECNICGKAFTRSSYLLGHIRTH 474
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 676-698 4.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.95e-03
                          10        20
                  ....*....|....*....|...
gi 1958797188 676 YECKECGKTFPERSCLTKHIRTH 698
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 562-610 5.26e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 5.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1958797188 562 KPYkCNYCGKDFTARSGLtkhvLIHNGEKPYECKECGKAFSTSSGLVEH 610
Cdd:cd20908     1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 396-418 5.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.91e-03
                          10        20
                  ....*....|....*....|...
gi 1958797188 396 YECKECGKTFIQPSRLTEHMRSH 418
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
775-799 5.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.94e-03
                          10        20
                  ....*....|....*....|....*
gi 1958797188 775 LTIHLRNHTGEKSYACQECGKAFST 799
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 592-614 7.70e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.70e-03
                          10        20
                  ....*....|....*....|...
gi 1958797188 592 YECKECGKAFSTSSGLVEHIRIH 614
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-378 8.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|....*
gi 1958797188 354 YLNIHVQSHTVEKPYDCKECGKAFT 378
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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