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Conserved domains on  [gi|1952448449|ref|XP_038649319|]
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LOW QUALITY PROTEIN: lipoxygenase homology domain-containing protein 1-like [Scyliorhinus canicula]

Protein Classification

phospholipase C( domain architecture ID 10205347)

phospholipase C catayzes the hydroysis of a phosphatidylcholine to form 1,2-diacyl-sn-glycerol and phosphocholine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1394-1514 7.32e-62

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 207.41  E-value: 7.32e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1394 TTYTVRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLKaSKSNKNKFEKGNIDEFTIEAVDIGSLKKIRIGHDNRGGCAG 1473
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLK-KSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 1474 WFLDWVEIDAPSLGQVLRFPCGRWLDKAEDDGYIVRDLFPA 1514
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1247-1366 8.02e-61

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 204.33  E-value: 8.02e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1247 NSYTVHVITGNVMGAGTDANVFINIFGETTDTGERYLKMSNHLNKFERGQEDIFLIKAIDLGVLRKLRIRHDNAGGNAAW 1326
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 1327 FLDRVEIVDEKDDTTYFFPCERWLAVDEDDGQIARELVPV 1366
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
2381-2499 4.02e-59

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 199.32  E-value: 4.02e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2381 VKYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKHK-FRNLFERGNTDRFILEMLDLGELNKVKIEHDNSNSNAGW 2459
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 2460 MLERVEITNTATGVTTIFPCGKWLDRKKGDGQIFRELYPK 2499
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
453-570 8.60e-58

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 195.85  E-value: 8.60e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  453 NKYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLD--NDKDNFERGNEDKFTIESPNLGRLKKITIGHNSKGSSAGW 530
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449  531 FLDKVIIDDIGNKIVHQFPVNRWFALDEDDGKIQRDILVG 570
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
2109-2229 8.51e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 190.07  E-value: 8.51e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2109 TTYIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSNNSNKFERKSTDIFKFaDMLSLGDLAKVRVWHDNKGPGAG 2188
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 2189 WHLDYIEVKDEAMEETFRFPCDRWLAKSEDDGQIIRELPCA 2229
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
834-955 2.42e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.53  E-value: 2.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  834 VKYRAIIYTGSVSGSGTDANVFICLIGLKGDTGERVLyDSKNNVNKFEKGNADEFIIEAVSLKKVTRVRIGHDGRGGSCG 913
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKL-KKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449  914 WYLDKVIVKEEGapESQSVEFPCYRWLDKGEDDGQIVRELVP 955
Cdd:cd01756     80 WFLDKVEIREPG--TGDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1679-1799 3.39e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 3.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1679 HTYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSEsHSNKFERNQVDTFTMEAVDLGEVFKIKIRHDNTMASPD 1758
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSN-NKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 1759 WYLEKVEVVDVDLEENYLFVCERWLSKTKEDKRIERTLFVK 1799
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
965-1086 1.86e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.14  E-value: 1.86e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  965 IRYHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKHSLAISDNdlGNYFEQGRVDVFIIDTMDIGKLNRLLIGHDNVGLRA 1044
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449 1045 GWFLDSVQVKVPVHGKEYMFPAHRWLCKDEADGKTEIEIYPS 1086
Cdd:cd01756     79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
324-443 1.68e-50

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 174.67  E-value: 1.68e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  324 TVYEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHL-TSKSRTAFEKNKTDVFRIKTNNVGPIKKIRIEHDNTGMSASW 402
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449  403 FLDRLVITDMNRpHL*FYFPCNQWLSKEEGDGLYVRDLLGS 443
Cdd:cd01756     81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
577-695 2.83e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 171.20  E-value: 2.83e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  577 IVYNVSVITGNIRGAGTNSKVHIILHGSKGvkNSGKIFLE----GGHFERGITDIFNVElAALLSPLSRVTIGHDNGGVS 652
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENG--DTGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1952448449  653 SGWFCEKVIVYCPFTGIEQTFPCRKWLDEDEGDGLIERELYEM 695
Cdd:cd01756     78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1525-1651 6.32e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 170.43  E-value: 6.32e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1525 VPYEITVSTSDIYGAGTDADVFIVLYGRNGiCTHQKPLCvnKRERKMFFRRGAVNKFVIELEDVGEcIEKIRIGHDGRGF 1604
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENG-DTGKRKLK--KSNNKNKFERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1952448449 1605 NSGWHLDSVEIRRLLQKgkgsETTIFPCERWLAKSEDDGEIIRELVP 1651
Cdd:cd01756     77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
706-823 9.41e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 169.66  E-value: 9.41e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  706 NPWSLWIWTSDIKNAGSDANVFLQLYGDKRKSDEMCLD--NNSDNFETGQTDKLMIELPELGTIYKLRIWHEKRHPFAGW 783
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449  784 HLNKVTLMKSLTKEKYSFKCGRWLDVNEDDNEIIRELPAE 823
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1095-1239 2.25e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.89  E-value: 2.25e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1095 VNYEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLRS--RSDNFVRGATEMFKIEALDVGKLIKLRIGHDGSGLGPGW 1172
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKsnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952448449 1173 FLGSVIINRLnfrtveddrkkkkkkkkaegpvdglqeEMMETYTFNCQRWLAKDEGDRQLVVELLPE 1239
Cdd:cd01756     81 FLDKVEIREP---------------------------GTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1981-2099 1.94e-38

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 140.38  E-value: 1.94e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1981 IPYEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKC--GDRFERGQEDTFNMVIADIAPLRKIRIRTDIKGYRPDW 2058
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 2059 FLDKVIMLNQSTMEVTTFTYNDWLSKTRGTKRsTICELAAV 2099
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQ-IVRELYPS 120
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1850-1967 1.88e-29

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01756:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 114.57  E-value: 1.88e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1850 IPYHITITTGQERDAGTNSRVYIIIMGpMKIHTSRLWLELSGGKNAFLPGSMEKFQVMGLDVGEIKKIELGHDGATPESC 1929
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1952448449 1930 WLVEELEISVPTTGTMYVFKCKCWLAKDRGDGLTARVF 1967
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVREL 117
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
189-313 4.40e-24

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01756:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 99.17  E-value: 4.40e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  189 ILYEVTVKTGQKREAGTNAKVSLQMKGSKGKINKKRLCKklvsriSDMPVAFQfaKGSSHTFKVYGPEIGELQNIVLEHD 268
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKK------SNNKNKFE--RGQTDKFTVEAVDLGKLKKIRIGHD 72
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1952448449  269 GLEKGQAWYVEEVSIVNTARNKTWNIPCKSWLSLFHTDCQLSRTF 313
Cdd:cd01756     73 NSGLGAGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVREL 117
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
2242-2347 2.54e-09

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


:

Pssm-ID: 396180  Cd Length: 115  Bit Score: 57.06  E-value: 2.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2242 YEIVTETSDRDDAETKENVWVLFEGKKGKSKEfvLENSSKKKRFLRGAKDKFEFSSK-NVGDIATIcvghcprdgkKFTS 2320
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQ--LEITLDNPDFERGAEDSFEIDTDwDVGAILKI----------NLHW 68
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449 2321 KNAV---EWHVKEIIVT-EKELGNKYIFKCN 2347
Cdd:pfam01477   69 DNNGlsdEWFLKSITVEvPGETGGKYTFPCN 99
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1394-1514 7.32e-62

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 207.41  E-value: 7.32e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1394 TTYTVRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLKaSKSNKNKFEKGNIDEFTIEAVDIGSLKKIRIGHDNRGGCAG 1473
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLK-KSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 1474 WFLDWVEIDAPSLGQVLRFPCGRWLDKAEDDGYIVRDLFPA 1514
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1247-1366 8.02e-61

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 204.33  E-value: 8.02e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1247 NSYTVHVITGNVMGAGTDANVFINIFGETTDTGERYLKMSNHLNKFERGQEDIFLIKAIDLGVLRKLRIRHDNAGGNAAW 1326
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 1327 FLDRVEIVDEKDDTTYFFPCERWLAVDEDDGQIARELVPV 1366
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
2381-2499 4.02e-59

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 199.32  E-value: 4.02e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2381 VKYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKHK-FRNLFERGNTDRFILEMLDLGELNKVKIEHDNSNSNAGW 2459
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 2460 MLERVEITNTATGVTTIFPCGKWLDRKKGDGQIFRELYPK 2499
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
453-570 8.60e-58

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 195.85  E-value: 8.60e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  453 NKYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLD--NDKDNFERGNEDKFTIESPNLGRLKKITIGHNSKGSSAGW 530
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449  531 FLDKVIIDDIGNKIVHQFPVNRWFALDEDDGKIQRDILVG 570
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
2109-2229 8.51e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 190.07  E-value: 8.51e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2109 TTYIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSNNSNKFERKSTDIFKFaDMLSLGDLAKVRVWHDNKGPGAG 2188
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 2189 WHLDYIEVKDEAMEETFRFPCDRWLAKSEDDGQIIRELPCA 2229
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
834-955 2.42e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.53  E-value: 2.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  834 VKYRAIIYTGSVSGSGTDANVFICLIGLKGDTGERVLyDSKNNVNKFEKGNADEFIIEAVSLKKVTRVRIGHDGRGGSCG 913
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKL-KKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449  914 WYLDKVIVKEEGapESQSVEFPCYRWLDKGEDDGQIVRELVP 955
Cdd:cd01756     80 WFLDKVEIREPG--TGDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1679-1799 3.39e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 3.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1679 HTYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSEsHSNKFERNQVDTFTMEAVDLGEVFKIKIRHDNTMASPD 1758
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSN-NKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 1759 WYLEKVEVVDVDLEENYLFVCERWLSKTKEDKRIERTLFVK 1799
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
965-1086 1.86e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.14  E-value: 1.86e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  965 IRYHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKHSLAISDNdlGNYFEQGRVDVFIIDTMDIGKLNRLLIGHDNVGLRA 1044
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449 1045 GWFLDSVQVKVPVHGKEYMFPAHRWLCKDEADGKTEIEIYPS 1086
Cdd:cd01756     79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
324-443 1.68e-50

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 174.67  E-value: 1.68e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  324 TVYEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHL-TSKSRTAFEKNKTDVFRIKTNNVGPIKKIRIEHDNTGMSASW 402
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449  403 FLDRLVITDMNRpHL*FYFPCNQWLSKEEGDGLYVRDLLGS 443
Cdd:cd01756     81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
577-695 2.83e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 171.20  E-value: 2.83e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  577 IVYNVSVITGNIRGAGTNSKVHIILHGSKGvkNSGKIFLE----GGHFERGITDIFNVElAALLSPLSRVTIGHDNGGVS 652
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENG--DTGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1952448449  653 SGWFCEKVIVYCPFTGIEQTFPCRKWLDEDEGDGLIERELYEM 695
Cdd:cd01756     78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1525-1651 6.32e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 170.43  E-value: 6.32e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1525 VPYEITVSTSDIYGAGTDADVFIVLYGRNGiCTHQKPLCvnKRERKMFFRRGAVNKFVIELEDVGEcIEKIRIGHDGRGF 1604
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENG-DTGKRKLK--KSNNKNKFERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1952448449 1605 NSGWHLDSVEIRRLLQKgkgsETTIFPCERWLAKSEDDGEIIRELVP 1651
Cdd:cd01756     77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
706-823 9.41e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 169.66  E-value: 9.41e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  706 NPWSLWIWTSDIKNAGSDANVFLQLYGDKRKSDEMCLD--NNSDNFETGQTDKLMIELPELGTIYKLRIWHEKRHPFAGW 783
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449  784 HLNKVTLMKSLTKEKYSFKCGRWLDVNEDDNEIIRELPAE 823
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1095-1239 2.25e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.89  E-value: 2.25e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1095 VNYEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLRS--RSDNFVRGATEMFKIEALDVGKLIKLRIGHDGSGLGPGW 1172
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKsnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952448449 1173 FLGSVIINRLnfrtveddrkkkkkkkkaegpvdglqeEMMETYTFNCQRWLAKDEGDRQLVVELLPE 1239
Cdd:cd01756     81 FLDKVEIREP---------------------------GTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1981-2099 1.94e-38

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 140.38  E-value: 1.94e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1981 IPYEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKC--GDRFERGQEDTFNMVIADIAPLRKIRIRTDIKGYRPDW 2058
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 2059 FLDKVIMLNQSTMEVTTFTYNDWLSKTRGTKRsTICELAAV 2099
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQ-IVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1850-1967 1.88e-29

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 114.57  E-value: 1.88e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1850 IPYHITITTGQERDAGTNSRVYIIIMGpMKIHTSRLWLELSGGKNAFLPGSMEKFQVMGLDVGEIKKIELGHDGATPESC 1929
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1952448449 1930 WLVEELEISVPTTGTMYVFKCKCWLAKDRGDGLTARVF 1967
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVREL 117
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
189-313 4.40e-24

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 99.17  E-value: 4.40e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  189 ILYEVTVKTGQKREAGTNAKVSLQMKGSKGKINKKRLCKklvsriSDMPVAFQfaKGSSHTFKVYGPEIGELQNIVLEHD 268
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKK------SNNKNKFE--RGQTDKFTVEAVDLGKLKKIRIGHD 72
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1952448449  269 GLEKGQAWYVEEVSIVNTARNKTWNIPCKSWLSLFHTDCQLSRTF 313
Cdd:cd01756     73 NSGLGAGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVREL 117
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1249-1355 2.67e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 91.34  E-value: 2.67e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1249 YTVHVITGNVMGAGTDANVFINIFGETTDTGERYLKMSNhlNKFERGQEDIFLIKA-IDLGVLRKLRIRHDNAGGNAAWF 1327
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDN--PDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWF 78
                           90       100
                   ....*....|....*....|....*....
gi 1952448449 1328 LDRVEI-VDEKDDTTYFFPCERWLAVDED 1355
Cdd:pfam01477   79 LKSITVeVPGETGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1681-1797 4.25e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 90.57  E-value: 4.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1681 YKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLsksESHSNKFERNQVDTFTM-EAVDLGEVFKIKIRHDNTMASPDW 1759
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEI---TLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1760 YLEKVEV-VDVDLEENYLFVCERWLSKTKEDKRiERTLF 1797
Cdd:pfam01477   78 FLKSITVeVPGETGGKYTFPCNSWVYGSKKYKE-TRVFF 115
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
2383-2493 8.48e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 89.80  E-value: 8.48e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2383 YEIIVITGDVKGAGTDANVSITIYGTNGDSgIHRLKHKFRNLFERGNTDRFILEM-LDLGELNKVKIEHDNSNSNAGWML 2461
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGES-AQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449 2462 ERVEIT-NTATGVTTIFPCGKWLDRKKGDGQIF 2493
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKETR 112
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
326-431 3.18e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.26  E-value: 3.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  326 YEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHLTSKSRTaFEKNKTDVFRIKT-NNVGPIKKIRIEHDNTGMSASWFL 404
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79
                           90       100
                   ....*....|....*....|....*..
gi 1952448449  405 DRLVITDMNRPHL*FYFPCNQWLSKEE 431
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
579-683 5.58e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 87.49  E-value: 5.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  579 YNVSVITGNIRGAGTNSKVHIILHGSKGVKNSGKIFLEGGHFERGITDIFNVELAALLSPLSRVTIGHDNGGVSSGWFCE 658
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100
                   ....*....|....*....|....*.
gi 1952448449  659 KVIVYCP-FTGIEQTFPCRKWLDEDE 683
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
2111-2218 6.64e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 87.10  E-value: 6.64e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2111 YIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSNNSnkFERKSTDIFKFADMLSLGDLAKVRVWHDNKGPGAGWH 2190
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD--FERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78
                           90       100
                   ....*....|....*....|....*....
gi 1952448449 2191 LDYIEVKDEAMEE-TFRFPCDRWLAKSED 2218
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1396-1506 1.27e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1396 YTVRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLkasKSNKNKFEKGNIDEFTI-EAVDIGSLKKIRIGHDNRGGCAGW 1474
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEI---TLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449 1475 FLDWVEIDAPSL-GQVLRFPCGRWLDKAEDDGY 1506
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKKYKE 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
455-554 1.44e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.44e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  455 YIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLDNDKDNFERGNEDKFTIESP-NLGRLKKITIGHNSKGSSAGWFLD 533
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100
                   ....*....|....*....|..
gi 1952448449  534 KVIIDDIG-NKIVHQFPVNRWF 554
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1097-1234 3.78e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.09  E-value: 3.78e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1097 YEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLRSRSDNFVRGATEMFKI-EALDVGKLIKLRIGHDGSGLGPGWFLG 1175
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1952448449 1176 SVIINRLNFRTVeddrkkkkkkkkaegpvdglqeemmeTYTFNCQRWLAKDEGDRQLVV 1234
Cdd:pfam01477   81 SITVEVPGETGG--------------------------KYTFPCNSWVYGSKKYKETRV 113
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
967-1070 3.08e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 79.78  E-value: 3.08e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  967 YHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKHSLAISDNDlgnyFEQGRVDVFIIDT-MDIGKLNRLLIGHDNVGLRAG 1045
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76
                           90       100
                   ....*....|....*....|....*.
gi 1952448449 1046 WFLDSVQVKVPVH-GKEYMFPAHRWL 1070
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1983-2093 1.12e-16

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 77.86  E-value: 1.12e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1983 YEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKCGDRFERGQEDTFNM-VIADIAPLRKIRIRTDIKGYRPDWFLD 2061
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449 2062 KV-IMLNQSTMEVTTFTYNDWLSKTRGTKRSTI 2093
Cdd:pfam01477   81 SItVEVPGETGGKYTFPCNSWVYGSKKYKETRV 113
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2382-2484 6.83e-16

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 75.37  E-value: 6.83e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  2382 KYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKHKFRNLFERGNTDRFILEM-LDLGELNKVKIEHDNSNSNagWM 2460
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRHPE--WF 79
                            90       100
                    ....*....|....*....|....
gi 1952448449  2461 LERVEITNTATGVTTIFPCGKWLD 2484
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1679-1786 8.00e-15

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 72.29  E-value: 8.00e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1679 HTYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSESHSnkFERNQVDTFTME-AVDLGEVFKIKIRhdNTMASP 1757
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDvDEDFGELGAVKIK--NEHRHP 76
                            90       100
                    ....*....|....*....|....*....
gi 1952448449  1758 DWYLEKVEVVDVDLEENYLFVCERWLSKT 1786
Cdd:smart00308   77 EWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1527-1644 1.01e-14

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 72.46  E-value: 1.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1527 YEITVSTSDIYGAGTDADVFIVLYGRNGiCTHQKPLCVNKRErkmfFRRGAVNKFVIELE-DVGEcIEKIRIGHDGRGFN 1605
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVG-ESAQLEITLDNPD----FERGAEDSFEIDTDwDVGA-ILKINLHWDNNGLS 74
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1606 SGWHLDSVEIRRLLQKGKgseTTIFPCERWLAKSEDDGE 1644
Cdd:pfam01477   75 DEWFLKSITVEVPGETGG---KYTFPCNSWVYGSKKYKE 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
708-815 2.39e-14

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 71.31  E-value: 2.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  708 WSLWIWTSDIKNAGSDANVFLQLYGDKRKS--DEMCLDNNSdnFETGQTDKLMIELP-ELGTIYKLRIWHEKRHPFAGWH 784
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESaqLEITLDNPD--FERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWF 78
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1952448449  785 LNKVTLMKSL-TKEKYSFKCGRWLDVNEDDNE 815
Cdd:pfam01477   79 LKSITVEVPGeTGGKYTFPCNSWVYGSKKYKE 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
836-945 4.80e-14

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 70.54  E-value: 4.80e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  836 YRAIIYTGSVSGSGTDANVFiclIGLKGDTGERVLYDSKNNVNKFEKGNADEFII-EAVSLKKVTRVRIGHDGRGGSCGW 914
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVY---ISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449  915 YLDKVIVKEEGAPEsQSVEFPCYRWLDKGED 945
Cdd:pfam01477   78 FLKSITVEVPGETG-GKYTFPCNSWVYGSKK 107
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1396-1501 3.84e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 67.67  E-value: 3.84e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1396 YTVRVKTGEKKNAGTDANVFIILFGEKDDTGtvNLKASKSNKNKFEKGNIDEFTIE-AVDIGSLKKIRIGHDNRGGcaGW 1474
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK--ESKLDYLFKGIFARGSTYEFTFDvDEDFGELGAVKIKNEHRHP--EW 78
                            90       100
                    ....*....|....*....|....*..
gi 1952448449  1475 FLDWVEIDAPSLGQVLRFPCGRWLDKA 1501
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
191-301 5.60e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 5.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  191 YEVTVKTGQKREAGTNAKVSLQMKGSKGKinkkrlcKKLVSRISDMPvafQFAKGSSHTFKVYGP-EIGELQNIVLEHDG 269
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGE-------SAQLEITLDNP---DFERGAEDSFEIDTDwDVGAILKINLHWDN 70
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449  270 LEKGQAWYVEEVSI-VNTARNKTWNIPCKSWLS 301
Cdd:pfam01477   71 NGLSDEWFLKSITVeVPGETGGKYTFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
454-553 1.40e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.13  E-value: 1.40e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   454 KYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLD-NDKDNFERGNEDKFTIESP-NLGRLKKITIgHNSKGSSAgWF 531
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDyLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79
                            90       100
                    ....*....|....*....|..
gi 1952448449   532 LDKVIIDDIGNKIVHQFPVNRW 553
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSW 101
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2111-2213 1.48e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.74  E-value: 1.48e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  2111 YIITVKTSDMSGAGTDANVSLIIFGEHGDTGsLALKHSNNSNKFERKSTDIFKFADMLSLGDLAKVRVWHDNKGPgaGWH 2190
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRHP--EWF 79
                            90       100
                    ....*....|....*....|...
gi 1952448449  2191 LDYIEVKDEAMEETFRFPCDRWL 2213
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1249-1353 1.23e-11

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 63.43  E-value: 1.23e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1249 YTVHVITGNVMGAGTDANVFINIFGETTDTGERYLkMSNHLNKFERGQEDIFLIK-AIDLGVLRKLRIRHDNAGGnaAWF 1327
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL-DYLFKGIFARGSTYEFTFDvDEDFGELGAVKIKNEHRHP--EWF 79
                            90       100
                    ....*....|....*....|....*.
gi 1952448449  1328 LDRVEIVDEKDDTTYFFPCERWLAVD 1353
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
579-682 1.35e-11

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 63.04  E-value: 1.35e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   579 YNVSVITGNIRGAGTNSKVHIILHGSKGV-KNSGKIFLEGGHFERGITDIFNVELAALLSPLSRVTIGHDNGgvSSGWFC 657
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDgKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWFL 80
                            90       100
                    ....*....|....*....|....*
gi 1952448449   658 EKVIVYCPFTGIEQTFPCRKWLDED 682
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1852-1968 1.58e-11

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 63.22  E-value: 1.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1852 YHITITTGQERDAGTNSRVYIIIMGpmkIHTSRLWLELSGGKNAFLPGSMEKFQV-MGLDVGEIKKIELGHDGATPESCW 1930
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYG---KVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1931 LVEELEISVP-TTGTMYVFKCKCWLAKDRGDGLTaRVFN 1968
Cdd:pfam01477   78 FLKSITVEVPgETGGKYTFPCNSWVYGSKKYKET-RVFF 115
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
326-430 1.11e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 60.73  E-value: 1.11e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   326 YEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHLTSKSRTAFEKNKTDVFRIKTN-NVGPIKKIRIEHDNTgmSASWFL 404
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHR--HPEWFL 80
                            90       100
                    ....*....|....*....|....*.
gi 1952448449   405 DRLVITDmNRPHL*FYFPCNQWLSKE 430
Cdd:smart00308   81 KSITVKD-LPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
714-808 2.17e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 56.88  E-value: 2.17e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   714 TSDIKNAGSDANVFLQLYGDKRKSDEMCLDNNSDN-FETGQTDKLMIELPE-LGTIYKLRIWHEKRHPfaGWHLNKVTLM 791
Cdd:smart00308    9 TGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDEdFGELGAVKIKNEHRHP--EWFLKSITVK 86
                            90
                    ....*....|....*..
gi 1952448449   792 KSLTKEKYSFKCGRWLD 808
Cdd:smart00308   87 DLPTGGKYHFPCNSWVY 103
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
2242-2347 2.54e-09

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 57.06  E-value: 2.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2242 YEIVTETSDRDDAETKENVWVLFEGKKGKSKEfvLENSSKKKRFLRGAKDKFEFSSK-NVGDIATIcvghcprdgkKFTS 2320
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQ--LEITLDNPDFERGAEDSFEIDTDwDVGAILKI----------NLHW 68
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449 2321 KNAV---EWHVKEIIVT-EKELGNKYIFKCN 2347
Cdd:pfam01477   69 DNNGlsdEWFLKSITVEvPGETGGKYTFPCN 99
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1983-2085 1.08e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.95  E-value: 1.08e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1983 YEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKCGD-RFERGQEDTFNM-VIADIAPLRKIRIRtdIKGYRPDWFL 2060
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKgIFARGSTYEFTFdVDEDFGELGAVKIK--NEHRHPEWFL 80
                            90       100
                    ....*....|....*....|....*
gi 1952448449  2061 DKVIMLNQSTMEVTTFTYNDWLSKT 2085
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
835-942 4.76e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 50.33  E-value: 4.76e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   835 KYRAIIYTGSVSGSGTDANVFICLIGLKGDTGERVLYdsKNNVNKFEKGNADEFIIE-AVSLKKVTRVRIGHDgrGGSCG 913
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLD--YLFKGIFARGSTYEFTFDvDEDFGELGAVKIKNE--HRHPE 77
                            90       100
                    ....*....|....*....|....*....
gi 1952448449   914 WYLDKVIVKeeGAPESQSVEFPCYRWLDK 942
Cdd:smart00308   78 WFLKSITVK--DLPTGGKYHFPCNSWVYP 104
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
2241-2347 1.55e-06

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 49.26  E-value: 1.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2241 RYEIVTETSDRDDAETKENVWVLFEGKKGKSKEFvlENSSKKKRFLRGAKDKFEFSSK-NVGDIATIcvghcprdgkKFT 2319
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDI--PILDGPGSFERGSTDTFQIDLKlDIGDITKV----------YLR 69
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449 2320 SKNAV---EWHVKEIIVTEKELGNKYIFKCN 2347
Cdd:cd00113     70 RDGSGlsdGWYCESITVQALGTKKVYTFPVN 100
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
966-1070 3.17e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 48.02  E-value: 3.17e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   966 RYHIIVKTGSVPGASSDSKVFIKLYGEKGDtSKHSLAISDNDLGnyFEQGRVDVFIIDT-MDIGKLNRLLIGHDNVglRA 1044
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGD-GKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEHR--HP 76
                            90       100
                    ....*....|....*....|....*.
gi 1952448449  1045 GWFLDSVQVKVPVHGKEYMFPAHRWL 1070
Cdd:smart00308   77 EWFLKSITVKDLPTGGKYHFPCNSWV 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1097-1226 4.86e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 47.25  E-value: 4.86e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1097 YEIAVHTGDVTGAGTDAKVFIQIYG---ELGKTEQIRLRSRSdnFVRGATEMFKIE-ALDVGKLIKLRIGHDGSglGPGW 1172
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGaegDGKESKLDYLFKGI--FARGSTYEFTFDvDEDFGELGAVKIKNEHR--HPEW 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1952448449  1173 FLGSVIinrlnfrtveddrkkkkkkkkaegpVDGLQEEmmETYTFNCQRWLAKD 1226
Cdd:smart00308   79 FLKSIT-------------------------VKDLPTG--GKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
191-301 9.24e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.48  E-value: 9.24e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   191 YEVTVKTGQKREAGTNAKVSLQMKGSKGkinkkrlCKKLVSRISdmpvAFQ--FAKGSSHTFKVYGPE-IGELQNIVLEH 267
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEG-------DGKESKLDY----LFKgiFARGSTYEFTFDVDEdFGELGAVKIKN 71
                            90       100       110
                    ....*....|....*....|....*....|....
gi 1952448449   268 DGleKGQAWYVEEVSIVNTARNKTWNIPCKSWLS 301
Cdd:smart00308   72 EH--RHPEWFLKSITVKDLPTGGKYHFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1527-1636 1.46e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 1.46e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1527 YEITVSTSDIYGAGTDADVFIVLYGRNGIC--THQKPLcvnkreRKMFFRRGAVNKFVIEL-EDVGEcIEKIRIGHDgrG 1603
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGkeSKLDYL------FKGIFARGSTYEFTFDVdEDFGE-LGAVKIKNE--H 73
                            90       100       110
                    ....*....|....*....|....*....|...
gi 1952448449  1604 FNSGWHLDSVEirrlLQKGKGSETTIFPCERWL 1636
Cdd:smart00308   74 RHPEWFLKSIT----VKDLPTGGKYHFPCNSWV 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1852-1957 2.52e-04

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 42.63  E-value: 2.52e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1852 YHITITTGQERDAGTNSRVYIIIMGpmKIHTSRLWLELSGGKNAFLPGSMEKFQV-MGLDVGEIKKIELGHDGATPEscW 1930
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVG--AEGDGKESKLDYLFKGIFARGSTYEFTFdVDEDFGELGAVKIKNEHRHPE--W 78
                            90       100
                    ....*....|....*....|....*..
gi 1952448449  1931 LVEELEISVPTTGTMYVFKCKCWLAKD 1957
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1394-1514 7.32e-62

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 207.41  E-value: 7.32e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1394 TTYTVRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLKaSKSNKNKFEKGNIDEFTIEAVDIGSLKKIRIGHDNRGGCAG 1473
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLK-KSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 1474 WFLDWVEIDAPSLGQVLRFPCGRWLDKAEDDGYIVRDLFPA 1514
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1247-1366 8.02e-61

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 204.33  E-value: 8.02e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1247 NSYTVHVITGNVMGAGTDANVFINIFGETTDTGERYLKMSNHLNKFERGQEDIFLIKAIDLGVLRKLRIRHDNAGGNAAW 1326
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 1327 FLDRVEIVDEKDDTTYFFPCERWLAVDEDDGQIARELVPV 1366
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
2381-2499 4.02e-59

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 199.32  E-value: 4.02e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2381 VKYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKHK-FRNLFERGNTDRFILEMLDLGELNKVKIEHDNSNSNAGW 2459
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 2460 MLERVEITNTATGVTTIFPCGKWLDRKKGDGQIFRELYPK 2499
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
453-570 8.60e-58

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 195.85  E-value: 8.60e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  453 NKYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLD--NDKDNFERGNEDKFTIESPNLGRLKKITIGHNSKGSSAGW 530
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449  531 FLDKVIIDDIGNKIVHQFPVNRWFALDEDDGKIQRDILVG 570
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
2109-2229 8.51e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 190.07  E-value: 8.51e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2109 TTYIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSNNSNKFERKSTDIFKFaDMLSLGDLAKVRVWHDNKGPGAG 2188
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 2189 WHLDYIEVKDEAMEETFRFPCDRWLAKSEDDGQIIRELPCA 2229
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
834-955 2.42e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.53  E-value: 2.42e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  834 VKYRAIIYTGSVSGSGTDANVFICLIGLKGDTGERVLyDSKNNVNKFEKGNADEFIIEAVSLKKVTRVRIGHDGRGGSCG 913
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKL-KKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449  914 WYLDKVIVKEEGapESQSVEFPCYRWLDKGEDDGQIVRELVP 955
Cdd:cd01756     80 WFLDKVEIREPG--TGDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1679-1799 3.39e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 3.39e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1679 HTYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSEsHSNKFERNQVDTFTMEAVDLGEVFKIKIRHDNTMASPD 1758
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSN-NKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 1759 WYLEKVEVVDVDLEENYLFVCERWLSKTKEDKRIERTLFVK 1799
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
965-1086 1.86e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.14  E-value: 1.86e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  965 IRYHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKHSLAISDNdlGNYFEQGRVDVFIIDTMDIGKLNRLLIGHDNVGLRA 1044
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449 1045 GWFLDSVQVKVPVHGKEYMFPAHRWLCKDEADGKTEIEIYPS 1086
Cdd:cd01756     79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
324-443 1.68e-50

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 174.67  E-value: 1.68e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  324 TVYEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHL-TSKSRTAFEKNKTDVFRIKTNNVGPIKKIRIEHDNTGMSASW 402
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449  403 FLDRLVITDMNRpHL*FYFPCNQWLSKEEGDGLYVRDLLGS 443
Cdd:cd01756     81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
577-695 2.83e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 171.20  E-value: 2.83e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  577 IVYNVSVITGNIRGAGTNSKVHIILHGSKGvkNSGKIFLE----GGHFERGITDIFNVElAALLSPLSRVTIGHDNGGVS 652
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENG--DTGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1952448449  653 SGWFCEKVIVYCPFTGIEQTFPCRKWLDEDEGDGLIERELYEM 695
Cdd:cd01756     78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1525-1651 6.32e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 170.43  E-value: 6.32e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1525 VPYEITVSTSDIYGAGTDADVFIVLYGRNGiCTHQKPLCvnKRERKMFFRRGAVNKFVIELEDVGEcIEKIRIGHDGRGF 1604
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENG-DTGKRKLK--KSNNKNKFERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1952448449 1605 NSGWHLDSVEIRRLLQKgkgsETTIFPCERWLAKSEDDGEIIRELVP 1651
Cdd:cd01756     77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
706-823 9.41e-49

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 169.66  E-value: 9.41e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  706 NPWSLWIWTSDIKNAGSDANVFLQLYGDKRKSDEMCLD--NNSDNFETGQTDKLMIELPELGTIYKLRIWHEKRHPFAGW 783
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449  784 HLNKVTLMKSLTKEKYSFKCGRWLDVNEDDNEIIRELPAE 823
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1095-1239 2.25e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.89  E-value: 2.25e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1095 VNYEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLRS--RSDNFVRGATEMFKIEALDVGKLIKLRIGHDGSGLGPGW 1172
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKsnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1952448449 1173 FLGSVIINRLnfrtveddrkkkkkkkkaegpvdglqeEMMETYTFNCQRWLAKDEGDRQLVVELLPE 1239
Cdd:cd01756     81 FLDKVEIREP---------------------------GTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1981-2099 1.94e-38

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 140.38  E-value: 1.94e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1981 IPYEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKC--GDRFERGQEDTFNMVIADIAPLRKIRIRTDIKGYRPDW 2058
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 2059 FLDKVIMLNQSTMEVTTFTYNDWLSKTRGTKRsTICELAAV 2099
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQ-IVRELYPS 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
2111-2229 2.83e-31

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 120.07  E-value: 2.83e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2111 YIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSNnSNKFERKSTDIFKFADMLSLGDLAKVRVWHDNKGPGAGWH 2190
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPE-KPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSWY 81
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 2191 LDYIEVKDEAMEETFRFPCDRWLAKSEDDGQIIRELPCA 2229
Cdd:cd01752     82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
2382-2497 3.30e-31

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 119.69  E-value: 3.30e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2382 KYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKHKFRNLFERGNTDRFILEML-DLGELNKVKIEHDNSNSNAGWM 2460
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1952448449 2461 LERVEITNTATGVTTIFPCGKWLDRKKGDGQIFRELY 2497
Cdd:cd01752     82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
1850-1967 1.88e-29

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 114.57  E-value: 1.88e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1850 IPYHITITTGQERDAGTNSRVYIIIMGpMKIHTSRLWLELSGGKNAFLPGSMEKFQVMGLDVGEIKKIELGHDGATPESC 1929
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1952448449 1930 WLVEELEISVPTTGTMYVFKCKCWLAKDRGDGLTARVF 1967
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVREL 117
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
454-569 7.64e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 112.75  E-value: 7.64e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  454 KYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLDNDKDN-FERGNEDKFTIESP-NLGRLKKITIGHNSKGSSAGWF 531
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPiFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1952448449  532 LDKVIIDDIGNKIVHQFPVNRWFALDEDDGKIQRDILV 569
Cdd:cd01752     82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPV 119
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
1248-1363 1.19e-28

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 112.37  E-value: 1.19e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1248 SYTVHVITGNVMGAGTDANVFINIFGETTDTGERYLKmSNHLNKFERGQEDIFLIK-AIDLGVLRKLRIRHDNAGGNAAW 1326
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLR-DPEKPIFERGSVDSFLLTtPFPLGELQSIRLWHDNSGLSPSW 80
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1952448449 1327 FLDRVEIVDEKDDTTYFFPCERWLAVDEDDGQIAREL 1363
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTF 117
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
326-435 6.78e-28

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 110.06  E-value: 6.78e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  326 YEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHLTSKSRTAFEKNKTDVFRIKT-NNVGPIKKIRIEHDNTGMSASWFL 404
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTpFPLGELQSIRLWHDNSGLSPSWYL 82
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449  405 DRLVITDMNRPHl*FYFPCNQWLSKEEGDGL 435
Cdd:cd01752     83 SRVIVRDLQTGK-KWFFLCNDWLSVEEGDGT 112
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
1681-1798 1.90e-27

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 108.90  E-value: 1.90e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1681 YKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSksESHSNKFERNQVDTFTME-AVDLGEVFKIKIRHDNTMASPDW 1759
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLR--DPEKPIFERGSVDSFLLTtPFPLGELQSIRLWHDNSGLSPSW 80
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1760 YLEKVEVVDVDLEENYLFVCERWLSKTKEDKRIERTLFV 1798
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPV 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
189-313 4.40e-24

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 99.17  E-value: 4.40e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  189 ILYEVTVKTGQKREAGTNAKVSLQMKGSKGKINKKRLCKklvsriSDMPVAFQfaKGSSHTFKVYGPEIGELQNIVLEHD 268
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKK------SNNKNKFE--RGQTDKFTVEAVDLGKLKKIRIGHD 72
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1952448449  269 GLEKGQAWYVEEVSIVNTARNKTWNIPCKSWLSLFHTDCQLSRTF 313
Cdd:cd01756     73 NSGLGAGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVREL 117
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
966-1084 6.46e-24

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 98.89  E-value: 6.46e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  966 RYHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKHSLAISDNDLgnyFEQGRVDVFIIDT-MDIGKLNRLLIGHDNVGLRA 1044
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI---FERGSVDSFLLTTpFPLGELQSIRLWHDNSGLSP 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 1045 GWFLDSVQVKVPVHGKEYMFPAHRWLCKDEADGKTEIEIY 1084
Cdd:cd01752     79 SWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
2382-2484 1.92e-23

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 97.41  E-value: 1.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2382 KYEIIVITGDVKGAGTDANVSITIYGTNGDSGIH-RLKHKFRnlFERGNTDRFILEM-LDLGELNKVKIEHDNSNSNAGW 2459
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIpILDGPGS--FERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79
                           90       100
                   ....*....|....*....|....*
gi 1952448449 2460 MLERVEITNTATGVTTIFPCGKWLD 2484
Cdd:cd00113     80 YCESITVQALGTKKVYTFPVNRWVL 104
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
579-693 2.87e-22

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 94.26  E-value: 2.87e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  579 YNVSVITGNIRGAGTNSKVHIILHGSKGvkNSGKIFLEGGH---FERGITDIFNVELAALLSPLSRVTIGHDNGGVSSGW 655
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEG--ESEPHHLRDPEkpiFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1952448449  656 FCEKVIVYCPFTGIEQTFPCRKWLDEDEGDGLIERELY 693
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
835-953 5.95e-22

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 93.11  E-value: 5.95e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  835 KYRAIIYTGSVSGSGTDANVFICLIGLKGDTGERVLYDSKNNVnkFEKGNADEFIIE-AVSLKKVTRVRIGHDGRGGSCG 913
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI--FERGSVDSFLLTtPFPLGELQSIRLWHDNSGLSPS 79
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449  914 WYLDKVIVKEegAPESQSVEFPCYRWLDKGEDDGQIVREL 953
Cdd:cd01752     80 WYLSRVIVRD--LQTGKKWFFLCNDWLSVEEGDGTVERTF 117
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
2111-2221 1.26e-21

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 92.02  E-value: 1.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2111 YIITVKTSDMSGAGTDANVSLIIFGEHGdTGSLALKHSNNSNkFERKSTDIFKFADMLSLGDLAKVRVWHDNKGPGAGWH 2190
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENG-NSSDIPILDGPGS-FERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWY 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449 2191 LDYIEVKDEAMEETFRFPCDRWLAKSEDDGQ 2221
Cdd:cd00113     81 CESITVQALGTKKVYTFPVNRWVLGGKWYTS 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1679-1790 1.47e-21

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 92.02  E-value: 1.47e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1679 HTYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSESHsnkFERNQVDTFTMEA-VDLGEVFKIKIRHDNTMASP 1757
Cdd:cd00113      1 CRYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGS---FERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSD 77
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449 1758 DWYLEKVEVVDVDLEENYLFVCERWLSKTKEDK 1790
Cdd:cd00113     78 GWYCESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1249-1355 2.67e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 91.34  E-value: 2.67e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1249 YTVHVITGNVMGAGTDANVFINIFGETTDTGERYLKMSNhlNKFERGQEDIFLIKA-IDLGVLRKLRIRHDNAGGNAAWF 1327
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDN--PDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWF 78
                           90       100
                   ....*....|....*....|....*....
gi 1952448449 1328 LDRVEI-VDEKDDTTYFFPCERWLAVDED 1355
Cdd:pfam01477   79 LKSITVeVPGETGGKYTFPCNSWVYGSKK 107
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1982-2086 3.53e-21

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 90.86  E-value: 3.53e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1982 PYEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKCGDRFERGQEDTFNMVIA-DIAPLRKIRIRTDIKGYRPDWFL 2060
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81
                           90       100
                   ....*....|....*....|....*.
gi 1952448449 2061 DKVIMLNQSTMEVTTFTYNDWLSKTR 2086
Cdd:cd00113     82 ESITVQALGTKKVYTFPVNRWVLGGK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1681-1797 4.25e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 90.57  E-value: 4.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1681 YKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLsksESHSNKFERNQVDTFTM-EAVDLGEVFKIKIRHDNTMASPDW 1759
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEI---TLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1760 YLEKVEV-VDVDLEENYLFVCERWLSKTKEDKRiERTLF 1797
Cdd:pfam01477   78 FLKSITVeVPGETGGKYTFPCNSWVYGSKKYKE-TRVFF 115
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
2383-2493 8.48e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 89.80  E-value: 8.48e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2383 YEIIVITGDVKGAGTDANVSITIYGTNGDSgIHRLKHKFRNLFERGNTDRFILEM-LDLGELNKVKIEHDNSNSNAGWML 2461
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGES-AQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449 2462 ERVEIT-NTATGVTTIFPCGKWLDRKKGDGQIF 2493
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKETR 112
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
1527-1649 1.05e-20

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 89.64  E-value: 1.05e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1527 YEITVSTSDIYGAGTDADVFIVLYGRNGICTHQKPLCvnkrERKMFFRRGAVNKFVIE-LEDVGEcIEKIRIGHDGRGFN 1605
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRD----PEKPIFERGSVDSFLLTtPFPLGE-LQSIRLWHDNSGLS 77
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1952448449 1606 SGWHLDSVEIRRlLQKGKGSettIFPCERWLAKSEDDGEIIREL 1649
Cdd:cd01752     78 PSWYLSRVIVRD-LQTGKKW---FFLCNDWLSVEEGDGTVERTF 117
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
454-553 1.54e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 88.94  E-value: 1.54e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  454 KYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLDNDKDNFERGNEDKFTIESP-NLGRLKKITIGHNSKGSSAGWFL 532
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81
                           90       100
                   ....*....|....*....|.
gi 1952448449  533 DKVIIDDIGNKIVHQFPVNRW 553
Cdd:cd00113     82 ESITVQALGTKKVYTFPVNRW 102
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1249-1358 2.30e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 88.55  E-value: 2.30e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1249 YTVHVITGNVMGAGTDANVFINIFGETtDTGERYLKMSNHLNkFERGQEDIFLIKA-IDLGVLRKLRIRHDNAGGNAAWF 1327
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGEN-GNSSDIPILDGPGS-FERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGWY 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449 1328 LDRVEIVDEKDDTTYFFPCERWLAVDEDDGQ 1358
Cdd:cd00113     81 CESITVQALGTKKVYTFPVNRWVLGGKWYTS 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1396-1500 3.01e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 88.16  E-value: 3.01e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1396 YTVRVKTGEKKNAGTDANVFIILFGEKddtGTVNLKASKSNKNKFEKGNIDEFTIEA-VDIGSLKKIRIGHDNRGGCAGW 1474
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGEN---GNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79
                           90       100
                   ....*....|....*....|....*.
gi 1952448449 1475 FLDWVEIDAPSLGQVLRFPCGRWLDK 1500
Cdd:cd00113     80 YCESITVQALGTKKVYTFPVNRWVLG 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
326-431 3.18e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.26  E-value: 3.18e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  326 YEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHLTSKSRTaFEKNKTDVFRIKT-NNVGPIKKIRIEHDNTGMSASWFL 404
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79
                           90       100
                   ....*....|....*....|....*..
gi 1952448449  405 DRLVITDMNRPHL*FYFPCNQWLSKEE 431
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
579-683 5.58e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 87.49  E-value: 5.58e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  579 YNVSVITGNIRGAGTNSKVHIILHGSKGVKNSGKIFLEGGHFERGITDIFNVELAALLSPLSRVTIGHDNGGVSSGWFCE 658
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100
                   ....*....|....*....|....*.
gi 1952448449  659 KVIVYCP-FTGIEQTFPCRKWLDEDE 683
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
2111-2218 6.64e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 87.10  E-value: 6.64e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2111 YIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSNNSnkFERKSTDIFKFADMLSLGDLAKVRVWHDNKGPGAGWH 2190
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD--FERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78
                           90       100
                   ....*....|....*....|....*....
gi 1952448449 2191 LDYIEVKDEAMEE-TFRFPCDRWLAKSED 2218
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1396-1506 1.27e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1396 YTVRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLkasKSNKNKFEKGNIDEFTI-EAVDIGSLKKIRIGHDNRGGCAGW 1474
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEI---TLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449 1475 FLDWVEIDAPSL-GQVLRFPCGRWLDKAEDDGY 1506
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKKYKE 110
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
707-814 1.34e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 86.24  E-value: 1.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  707 PWSLWIWTSDIKNAGSDANVFLQLYGDKRKSDEMCLDNNSDNFETGQTDKLMIELPE-LGTIYKLRIWHEKRHPFAGWHL 785
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKLdIGDITKVYLRRDGSGLSDGWYC 81
                           90       100
                   ....*....|....*....|....*....
gi 1952448449  786 NKVTLMKSLTKEKYSFKCGRWLDVNEDDN 814
Cdd:cd00113     82 ESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
455-554 1.44e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.44e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  455 YIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLDNDKDNFERGNEDKFTIESP-NLGRLKKITIGHNSKGSSAGWFLD 533
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100
                   ....*....|....*....|..
gi 1952448449  534 KVIIDDIG-NKIVHQFPVNRWF 554
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
1396-1514 2.37e-19

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 85.79  E-value: 2.37e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1396 YTVRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLkaSKSNKNKFEKGNIDEFTIE-AVDIGSLKKIRIGHDNRGGCAGW 1474
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHL--RDPEKPIFERGSVDSFLLTtPFPLGELQSIRLWHDNSGLSPSW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1952448449 1475 FLDWVEIDAPSLGQVLRFPCGRWLDKAEDDGYIVRDLFPA 1514
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
720-823 4.33e-19

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 85.02  E-value: 4.33e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  720 AGSDANVFLQLYGDKRKSDEMCL-DNNSDNFETGQTDKLMIELPE-LGTIYKLRIWHEKRHPFAGWHLNKVTLMKSLTKE 797
Cdd:cd01752     15 AGTTAKVTITLYGAEGESEPHHLrDPEKPIFERGSVDSFLLTTPFpLGELQSIRLWHDNSGLSPSWYLSRVIVRDLQTGK 94
                           90       100
                   ....*....|....*....|....*.
gi 1952448449  798 KYSFKCGRWLDVNEDDNEIIRELPAE 823
Cdd:cd01752     95 KWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
1096-1232 1.61e-18

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 83.48  E-value: 1.61e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1096 NYEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLR-SRSDNFVRGATEMFKIEAL-DVGKLIKLRIGHDGSGLGPGWF 1173
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRdPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1952448449 1174 LGSVIINRLnfrtveddrkkkkkkkkaegpvdglqeEMMETYTFNCQRWLAKDEGDRQL 1232
Cdd:cd01752     82 LSRVIVRDL---------------------------QTGKKWFFLCNDWLSVEEGDGTV 113
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1097-1234 3.78e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.09  E-value: 3.78e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1097 YEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLRSRSDNFVRGATEMFKI-EALDVGKLIKLRIGHDGSGLGPGWFLG 1175
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1952448449 1176 SVIINRLNFRTVeddrkkkkkkkkaegpvdglqeemmeTYTFNCQRWLAKDEGDRQLVV 1234
Cdd:pfam01477   81 SITVEVPGETGG--------------------------KYTFPCNSWVYGSKKYKETRV 113
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
325-435 3.83e-18

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 82.39  E-value: 3.83e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  325 VYEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHLTSKSRTaFEKNKTDVFRIKT-NNVGPIKKIRIEHDNTGMSASWF 403
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGS-FERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGWY 80
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1952448449  404 LDRLVITDMNRPHl*FYFPCNQWLSKEEGDGL 435
Cdd:cd00113     81 CESITVQALGTKK-VYTFPVNRWVLGGKWYTS 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
578-687 1.44e-17

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 80.46  E-value: 1.44e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  578 VYNVSVITGNIRGAGTNSKVHIILHGSKGVKNSGKIFLEGGHFERGITDIFNVELAALLSPLSRVTIGHDNGGVSSGWFC 657
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWYC 81
                           90       100       110
                   ....*....|....*....|....*....|
gi 1952448449  658 EKVIVYCPFTGIEQTFPCRKWLDEDEGDGL 687
Cdd:cd00113     82 ESITVQALGTKKVYTFPVNRWVLGGKWYTS 111
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
190-313 2.53e-17

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 80.01  E-value: 2.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  190 LYEVTVKTGQKREAGTNAKVSLQMKGSKGKINKKRLckklvsRISDMPVafqFAKGSSHTFKVYGPE-IGELQNIVLEHD 268
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHL------RDPEKPI---FERGSVDSFLLTTPFpLGELQSIRLWHD 72
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1952448449  269 GLEKGQAWYVEEVSIVNTARNKTWNIPCKSWLSLFHTDCQLSRTF 313
Cdd:cd01752     73 NSGLSPSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTF 117
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
967-1070 3.08e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 79.78  E-value: 3.08e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  967 YHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKHSLAISDNDlgnyFEQGRVDVFIIDT-MDIGKLNRLLIGHDNVGLRAG 1045
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76
                           90       100
                   ....*....|....*....|....*.
gi 1952448449 1046 WFLDSVQVKVPVH-GKEYMFPAHRWL 1070
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1983-2093 1.12e-16

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 77.86  E-value: 1.12e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1983 YEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKCGDRFERGQEDTFNM-VIADIAPLRKIRIRTDIKGYRPDWFLD 2061
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449 2062 KV-IMLNQSTMEVTTFTYNDWLSKTRGTKRSTI 2093
Cdd:pfam01477   81 SItVEVPGETGGKYTFPCNSWVYGSKKYKETRV 113
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1096-1234 1.15e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 78.15  E-value: 1.15e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1096 NYEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLRSRSDNFVRGATEMFKIEA-LDVGKLIKLRIGHDGSGLGPGWFL 1174
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGWYC 81
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1175 GSViinrlnfrTVEDDRKKkkkkkkaegpvdglqeemmETYTFNCQRWLAKDEGDRQLVV 1234
Cdd:cd00113     82 ESI--------TVQALGTK-------------------KVYTFPVNRWVLGGKWYTSVRS 114
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
966-1070 1.57e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 77.76  E-value: 1.57e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  966 RYHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKhslaISDNDLGNYFEQGRVDVFIIDT-MDIGKLNRLLIGHDNVGLRA 1044
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSD----IPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSD 77
                           90       100
                   ....*....|....*....|....*.
gi 1952448449 1045 GWFLDSVQVKVPVHGKEYMFPAHRWL 1070
Cdd:cd00113     78 GWYCESITVQALGTKKVYTFPVNRWV 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2382-2484 6.83e-16

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 75.37  E-value: 6.83e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  2382 KYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKHKFRNLFERGNTDRFILEM-LDLGELNKVKIEHDNSNSNagWM 2460
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRHPE--WF 79
                            90       100
                    ....*....|....*....|....
gi 1952448449  2461 LERVEITNTATGVTTIFPCGKWLD 2484
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVY 103
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
835-948 1.61e-15

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 74.68  E-value: 1.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  835 KYRAIIYTGSVSGSGTDANVFICLIGLKGDTGERVLYDsknNVNKFEKGNADEFIIEA-VSLKKVTRVRIGHDGRGGSCG 913
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILD---GPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDG 78
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1952448449  914 WYLDKVIVKEEGapESQSVEFPCYRWLDKGEDDGQ 948
Cdd:cd00113     79 WYCESITVQALG--TKKVYTFPVNRWVLGGKWYTS 111
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
1983-2083 2.38e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 74.23  E-value: 2.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1983 YEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKCGDR-FERGQEDTFNM-VIADIAPLRKIRIRTDIKGYRPDWFL 2060
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPiFERGSVDSFLLtTPFPLGELQSIRLWHDNSGLSPSWYL 82
                           90       100
                   ....*....|....*....|...
gi 1952448449 2061 DKVIMLNQSTMEVTTFTYNDWLS 2083
Cdd:cd01752     83 SRVIVRDLQTGKKWFFLCNDWLS 105
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
966-1083 3.88e-15

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 73.50  E-value: 3.88e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  966 RYHIIVKTGSVPGASSDSKVFIKLYGEKGDTSKHSLaisdNDLGNYFEQGRVDVFIID-TMDIGKLNRLLIGHDNVGLRA 1044
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLL----DRPGYDFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFD 77
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1045 GWFLDSVQVKVPvHGKEYMFPAHRWLckdeaDGKTEIEI 1083
Cdd:cd01753     78 AWFCNYITVTGP-GGDEYHFPCYRWI-----EGYGTLEL 110
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
1398-1505 6.21e-15

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 72.96  E-value: 6.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1398 VRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLKAsksnknkfekgNIDEFTIEAVDIGSLKKIRIGHDNRGGCAGWFLD 1477
Cdd:cd01757      6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIPK-----------NSLEMTFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74
                           90       100
                   ....*....|....*....|....*...
gi 1952448449 1478 WVEIDAPSLGQVLRFPCGRWLDKAEDDG 1505
Cdd:cd01757     75 YVMVRNEITGHTYKFPCGRWLGEGVDDG 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1679-1786 8.00e-15

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 72.29  E-value: 8.00e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1679 HTYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSESHSnkFERNQVDTFTME-AVDLGEVFKIKIRhdNTMASP 1757
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDvDEDFGELGAVKIK--NEHRHP 76
                            90       100
                    ....*....|....*....|....*....
gi 1952448449  1758 DWYLEKVEVVDVDLEENYLFVCERWLSKT 1786
Cdd:smart00308   77 EWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1527-1644 1.01e-14

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 72.46  E-value: 1.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1527 YEITVSTSDIYGAGTDADVFIVLYGRNGiCTHQKPLCVNKRErkmfFRRGAVNKFVIELE-DVGEcIEKIRIGHDGRGFN 1605
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVG-ESAQLEITLDNPD----FERGAEDSFEIDTDwDVGA-ILKINLHWDNNGLS 74
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1606 SGWHLDSVEIRRLLQKGKgseTTIFPCERWLAKSEDDGE 1644
Cdd:pfam01477   75 DEWFLKSITVEVPGETGG---KYTFPCNSWVYGSKKYKE 110
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
191-301 1.39e-14

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 71.99  E-value: 1.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  191 YEVTVKTGQKREAGTNAKVSLQMKGSKGKInkkrlckklvSRISDMPVAFQFAKGSSHTFKVYGPE-IGELQNIVLEHDG 269
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNS----------SDIPILDGPGSFERGSTDTFQIDLKLdIGDITKVYLRRDG 72
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1952448449  270 LEKGQAWYVEEVSIVNTARNKTWNIPCKSWLS 301
Cdd:cd00113     73 SGLSDGWYCESITVQALGTKKVYTFPVNRWVL 104
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1526-1643 1.55e-14

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 71.99  E-value: 1.55e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1526 PYEITVSTSDIYGAGTDADVFIVLYGRNGictHQKPLCVNKreRKMFFRRGAVNKFVIELE-DVGEcIEKIRIGHDGRGF 1604
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENG---NSSDIPILD--GPGSFERGSTDTFQIDLKlDIGD-ITKVYLRRDGSGL 75
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1605 NSGWHLDSVEIrrllQKGKGSETTIFPCERWLAKSEDDG 1643
Cdd:cd00113     76 SDGWYCESITV----QALGTKKVYTFPVNRWVLGGKWYT 110
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
1852-1969 1.77e-14

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 71.92  E-value: 1.77e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1852 YHITITTGQERDAGTNSRVYIIIMGpmKIHTSRLWLELSGGKNAFLPGSMEKFQV-MGLDVGEIKKIELGHDGATPESCW 1930
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYG--AEGESEPHHLRDPEKPIFERGSVDSFLLtTPFPLGELQSIRLWHDNSGLSPSW 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1952448449 1931 -----LVEELEisvptTGTMYVFKCKCWLAKDRGDGLTARVFNI 1969
Cdd:cd01752     81 ylsrvIVRDLQ-----TGKKWFFLCNDWLSVEEGDGTVERTFPV 119
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
708-815 2.39e-14

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 71.31  E-value: 2.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  708 WSLWIWTSDIKNAGSDANVFLQLYGDKRKS--DEMCLDNNSdnFETGQTDKLMIELP-ELGTIYKLRIWHEKRHPFAGWH 784
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESaqLEITLDNPD--FERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWF 78
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1952448449  785 LNKVTLMKSL-TKEKYSFKCGRWLDVNEDDNE 815
Cdd:pfam01477   79 LKSITVEVPGeTGGKYTFPCNSWVYGSKKYKE 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
836-945 4.80e-14

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 70.54  E-value: 4.80e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  836 YRAIIYTGSVSGSGTDANVFiclIGLKGDTGERVLYDSKNNVNKFEKGNADEFII-EAVSLKKVTRVRIGHDGRGGSCGW 914
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVY---ISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449  915 YLDKVIVKEEGAPEsQSVEFPCYRWLDKGED 945
Cdd:pfam01477   78 FLKSITVEVPGETG-GKYTFPCNSWVYGSKK 107
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
2383-2490 5.21e-14

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 70.26  E-value: 5.21e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2383 YEIIVITGD-VKGAGTDANVSITIYGTNGDSGIHRLKhkfRNLFErgntdrFILEMLDLGELNKVKIEHDNSNSNAGWML 2461
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIP---KNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLV 73
                           90       100
                   ....*....|....*....|....*....
gi 1952448449 2462 ERVEITNTATGVTTIFPCGKWLDRKKGDG 2490
Cdd:cd01757     74 EYVMVRNEITGHTYKFPCGRWLGEGVDDG 102
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
2381-2495 6.49e-14

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 70.03  E-value: 6.49e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2381 VKYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKHKFRNlFERGNTDRFILEM-LDLGELNKVKIEHDNSNSNAGW 2459
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-FERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAW 79
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1952448449 2460 MLERVEITnTATGVTTIFPCGKWLDrkkGDG-QIFRE 2495
Cdd:cd01753     80 FCNYITVT-GPGGDEYHFPCYRWIE---GYGtLELRE 112
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
2112-2220 6.84e-14

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 70.26  E-value: 6.84e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2112 IITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSNNSNKFERKStdifkfadmlsLGDLAKVRVWHDNKGPGAGWHL 2191
Cdd:cd01757      5 VVIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQN-----------LGKLTTVQIGHDNSGLLAKWLV 73
                           90       100
                   ....*....|....*....|....*....
gi 1952448449 2192 DYIEVKDEAMEETFRFPCDRWLAKSEDDG 2220
Cdd:cd01757     74 EYVMVRNEITGHTYKFPCGRWLGEGVDDG 102
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
836-947 7.40e-14

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 69.87  E-value: 7.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  836 YRAIIYTGS-VSGSGTDANVFICLIGLKGDTGERVLydsknnvnkfeKGNADEFIIEAVSLKKVTRVRIGHDGRGGSCGW 914
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQI-----------PKNSLEMTFDCQNLGKLTTVQIGHDNSGLLAKW 71
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449  915 YLDKVIVKEEgaPESQSVEFPCYRWLDKGEDDG 947
Cdd:cd01757     72 LVEYVMVRNE--ITGHTYKFPCGRWLGEGVDDG 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1396-1501 3.84e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 67.67  E-value: 3.84e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1396 YTVRVKTGEKKNAGTDANVFIILFGEKDDTGtvNLKASKSNKNKFEKGNIDEFTIE-AVDIGSLKKIRIGHDNRGGcaGW 1474
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK--ESKLDYLFKGIFARGSTYEFTFDvDEDFGELGAVKIKNEHRHP--EW 78
                            90       100
                    ....*....|....*....|....*..
gi 1952448449  1475 FLDWVEIDAPSLGQVLRFPCGRWLDKA 1501
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
191-301 5.60e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 5.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  191 YEVTVKTGQKREAGTNAKVSLQMKGSKGKinkkrlcKKLVSRISDMPvafQFAKGSSHTFKVYGP-EIGELQNIVLEHDG 269
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGE-------SAQLEITLDNP---DFERGAEDSFEIDTDwDVGAILKINLHWDN 70
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1952448449  270 LEKGQAWYVEEVSI-VNTARNKTWNIPCKSWLS 301
Cdd:pfam01477   71 NGLSDEWFLKSITVeVPGETGGKYTFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
454-553 1.40e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 66.13  E-value: 1.40e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   454 KYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLD-NDKDNFERGNEDKFTIESP-NLGRLKKITIgHNSKGSSAgWF 531
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDyLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79
                            90       100
                    ....*....|....*....|..
gi 1952448449   532 LDKVIIDDIGNKIVHQFPVNRW 553
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSW 101
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2111-2213 1.48e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.74  E-value: 1.48e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  2111 YIITVKTSDMSGAGTDANVSLIIFGEHGDTGsLALKHSNNSNKFERKSTDIFKFADMLSLGDLAKVRVWHDNKGPgaGWH 2190
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRHP--EWF 79
                            90       100
                    ....*....|....*....|...
gi 1952448449  2191 LDYIEVKDEAMEETFRFPCDRWL 2213
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
1248-1360 7.23e-12

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 64.25  E-value: 7.23e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1248 SYTVHVITGNVMGAGTDANVFINIFGEttdTGE-RYLKMSNHLNKFERGQEDIFLIKA-IDLGVLRKLRIRHDNAGGNAA 1325
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGT---AGEsEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDA 78
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1952448449 1326 WFLDRVEiVDEKDDTTYFFPCERWLavdEDDGQIA 1360
Cdd:cd01753     79 WFCNYIT-VTGPGGDEYHFPCYRWI---EGYGTLE 109
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
578-689 8.12e-12

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 64.25  E-value: 8.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  578 VYNVSVITGNIRGAGTNSKVHIILHGSKGVKNSGKIFLEGGHFERGITDIFNVELAALLSPLSRVTIGHDNGGVSSGWFC 657
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDAWFC 81
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1952448449  658 EKVIVYCPfTGIEQTFPCRKWLdedEGDGLIE 689
Cdd:cd01753     82 NYITVTGP-GGDEYHFPCYRWI---EGYGTLE 109
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1249-1353 1.23e-11

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 63.43  E-value: 1.23e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1249 YTVHVITGNVMGAGTDANVFINIFGETTDTGERYLkMSNHLNKFERGQEDIFLIK-AIDLGVLRKLRIRHDNAGGnaAWF 1327
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL-DYLFKGIFARGSTYEFTFDvDEDFGELGAVKIKNEHRHP--EWF 79
                            90       100
                    ....*....|....*....|....*.
gi 1952448449  1328 LDRVEIVDEKDDTTYFFPCERWLAVD 1353
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
579-682 1.35e-11

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 63.04  E-value: 1.35e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   579 YNVSVITGNIRGAGTNSKVHIILHGSKGV-KNSGKIFLEGGHFERGITDIFNVELAALLSPLSRVTIGHDNGgvSSGWFC 657
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDgKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWFL 80
                            90       100
                    ....*....|....*....|....*
gi 1952448449   658 EKVIVYCPFTGIEQTFPCRKWLDED 682
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
1852-1968 1.58e-11

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 63.22  E-value: 1.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1852 YHITITTGQERDAGTNSRVYIIIMGpmkIHTSRLWLELSGGKNAFLPGSMEKFQV-MGLDVGEIKKIELGHDGATPESCW 1930
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYG---KVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449 1931 LVEELEISVP-TTGTMYVFKCKCWLAKDRGDGLTaRVFN 1968
Cdd:pfam01477   78 FLKSITVEVPgETGGKYTFPCNSWVYGSKKYKET-RVFF 115
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
965-1080 2.01e-11

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 62.94  E-value: 2.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  965 IRYHIIVKTGS-VPGASSDSKVFIKLYGEKGDTSKhsLAISDNDLgnyfeqgrvdVFIIDTMDIGKLNRLLIGHDNVGLR 1043
Cdd:cd01757      1 MPYHVVIVPSKkLGGSMFTANPWICVSGELGETPP--LQIPKNSL----------EMTFDCQNLGKLTTVQIGHDNSGLL 68
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1952448449 1044 AGWFLDSVQVKVPVHGKEYMFPAHRWLCKDEADGKTE 1080
Cdd:cd01757     69 AKWLVEYVMVRNEITGHTYKFPCGRWLGEGVDDGNGE 105
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
325-434 2.68e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 62.71  E-value: 2.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  325 VYEVVTVTGDVRGAGTDANIFVTLFGECGITPKvHLTSKSRTAFEKNKTDVFRIK-TNNVGPIKKIRIEHDNTGMSASWF 403
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEK-QLLDRPGYDFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAWF 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449  404 LDRLVITDMNRPHL*fyFPCNQWLskeEGDG 434
Cdd:cd01753     81 CNYITVTGPGGDEYH--FPCYRWI---EGYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
1395-1499 4.58e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 61.94  E-value: 4.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1395 TYTVRVKTGEKKNAGTDANVFIILFGEKddtGTVNLKASKSNKNKFEKGNIDEFTIEA-VDIGSLKKIRIgHDNRGGC-A 1472
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTA---GESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRL-RKRKYLLfD 77
                           90       100
                   ....*....|....*....|....*..
gi 1952448449 1473 GWFLDWVEIDAPSlGQVLRFPCGRWLD 1499
Cdd:cd01753     78 AWFCNYITVTGPG-GDEYHFPCYRWIE 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
326-430 1.11e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 60.73  E-value: 1.11e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   326 YEVVTVTGDVRGAGTDANIFVTLFGECGITPKVHLTSKSRTAFEKNKTDVFRIKTN-NVGPIKKIRIEHDNTgmSASWFL 404
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHR--HPEWFL 80
                            90       100
                    ....*....|....*....|....*.
gi 1952448449   405 DRLVITDmNRPHL*FYFPCNQWLSKE 430
Cdd:smart00308   81 KSITVKD-LPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
2110-2217 1.37e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 61.02  E-value: 1.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2110 TYIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHS------NNSNKFERKSTDIFK-FADMLSlGDLAKVRVWHDN 2182
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAwgglmgAGHDYFERGNLDRFSgRGPCLP-SPPCWMNLTSDG 80
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1952448449 2183 KGPGAGWHLDYIEVK---DEAMEETFRFPCDRWLAKSE 2217
Cdd:cd01754     81 TGNHPGWYVNYVEVTqagQHAPCMQHLFAVEQWLATDE 118
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
1395-1518 1.62e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 61.02  E-value: 1.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1395 TYTVRVKTGEKKNAGTDANVFIILFGEKDDTGTV-NLKA----SKSNKNKFEKGNIDEFTIEAVDI-GSLKKIRIGHDNR 1468
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIaNLEAwgglMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1469 GGCAGWFLDWVEIDAPSLGQvlrfPCGRWLDKAEDdgYIVRDLFPADLQT 1518
Cdd:cd01754     82 GNHPGWYVNYVEVTQAGQHA----PCMQHLFAVEQ--WLATDESPYMLTA 125
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
2383-2485 2.04e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 60.63  E-value: 2.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2383 YEIIVITGDVKGAGTDANVSITIYGTNGDSG-------IHRLKHKFRNLFERGNTDRFILEMLDL-GELNKVKIEHDNSN 2454
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianleaWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1952448449 2455 SNAGWMLERVEITNTATGV---TTIFPCGKWLDR 2485
Cdd:cd01754     83 NHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLAT 116
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
454-553 3.42e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 59.63  E-value: 3.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  454 KYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLDNDKDNFERGNEDKFTIESP-NLGRLKKITIGHNSKGSSAGWFL 532
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPeDLGELLLVRLRKRKYLLFDAWFC 81
                           90       100
                   ....*....|....*....|.
gi 1952448449  533 DKVIIDDIGNKIVHqFPVNRW 553
Cdd:cd01753     82 NYITVTGPGGDEYH-FPCYRW 101
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
455-558 5.37e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.48  E-value: 5.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  455 YIVSVFTGDVKGSGTDADVFINIFGENGDTG--------ERRLDNDKDNFERGNEDKFTIESPNL-GRLKKITIGHNSKG 525
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianleawGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1952448449  526 SSAGWFLDKVIIDDIGNKI---VHQFPVNRWFALDE 558
Cdd:cd01754     83 NHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDE 118
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
1249-1357 6.96e-10

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 58.70  E-value: 6.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1249 YTVHVITGN-VMGAGTDANVFINIFGETTDTGERYLKMSNHLNKFErgqediflikAIDLGVLRKLRIRHDNAGGNAAWF 1327
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFD----------CQNLGKLTTVQIGHDNSGLLAKWL 72
                           90       100       110
                   ....*....|....*....|....*....|
gi 1952448449 1328 LDRVEIVDEKDDTTYFFPCERWLAVDEDDG 1357
Cdd:cd01757     73 VEYVMVRNEITGHTYKFPCGRWLGEGVDDG 102
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
1851-1963 7.07e-10

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 58.50  E-value: 7.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1851 PYHITITTGQERDAGTNSRVYIIIMGPmkiHTSRLWLELSGGKNAFLPGSMEKFQV-MGLDVGEIKKIELGHDGATPESC 1929
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGE---NGNSSDIPILDGPGSFERGSTDTFQIdLKLDIGDITKVYLRRDGSGLSDG 78
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1952448449 1930 WLVEELEISVPTTGTMYVFKCKCWLAKDRGDGLT 1963
Cdd:cd00113     79 WYCESITVQALGTKKVYTFPVNRWVLGGKWYTSV 112
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
720-808 7.44e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 58.47  E-value: 7.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  720 AGSDANVFLQLYGDKRKSDEMCLDNNSDNFETGQTDKLMIELPE-LGTIYKLRIwhEKRHP--FAGWHLNKVTLmKSLTK 796
Cdd:cd01753     15 AGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEdLGELLLVRL--RKRKYllFDAWFCNYITV-TGPGG 91
                           90
                   ....*....|..
gi 1952448449  797 EKYSFKCGRWLD 808
Cdd:cd01753     92 DEYHFPCYRWIE 103
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
1680-1788 7.96e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 58.47  E-value: 7.96e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1680 TYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSeshSNKFERNQVDTFTMEA-VDLGEVFKIKIRHDNTMASPD 1758
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRP---GYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDA 78
                           90       100       110
                   ....*....|....*....|....*....|
gi 1952448449 1759 WYLEKVEVVDVDLEEnYLFVCERWLSKTKE 1788
Cdd:cd01753     79 WFCNYITVTGPGGDE-YHFPCYRWIEGYGT 107
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
578-683 1.68e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 57.94  E-value: 1.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  578 VYNVSVITGNIRGAGTNSKVHIILHGSKG----VKN--SGKIFLEGGH--FERGITDIFNVELAALLSPLSRVTIGHDNG 649
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGpglrIANleAWGGLMGAGHdyFERGNLDRFSGRGPCLPSPPCWMNLTSDGT 81
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1952448449  650 GVSSGWFCEKVIVycPFTGI-----EQTFPCRKWLDEDE 683
Cdd:cd01754     82 GNHPGWYVNYVEV--TQAGQhapcmQHLFAVEQWLATDE 118
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
1680-1784 1.70e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 57.94  E-value: 1.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1680 TYKISVYTGDVYRAGTDANVFLTVYGDLGDTG-----ERKLSKSESHSNKFERNQVDTFTMEAVDL-GEVFKIKIRHDNT 1753
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81
                           90       100       110
                   ....*....|....*....|....*....|....
gi 1952448449 1754 MASPDWYLEKVEVVDVDLEE---NYLFVCERWLS 1784
Cdd:cd01754     82 GNHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLA 115
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
714-808 2.17e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 56.88  E-value: 2.17e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   714 TSDIKNAGSDANVFLQLYGDKRKSDEMCLDNNSDN-FETGQTDKLMIELPE-LGTIYKLRIWHEKRHPfaGWHLNKVTLM 791
Cdd:smart00308    9 TGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDEdFGELGAVKIKNEHRHP--EWFLKSITVK 86
                            90
                    ....*....|....*..
gi 1952448449   792 KSLTKEKYSFKCGRWLD 808
Cdd:smart00308   87 DLPTGGKYHFPCNSWVY 103
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
2242-2347 2.54e-09

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 57.06  E-value: 2.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2242 YEIVTETSDRDDAETKENVWVLFEGKKGKSKEfvLENSSKKKRFLRGAKDKFEFSSK-NVGDIATIcvghcprdgkKFTS 2320
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQ--LEITLDNPDFERGAEDSFEIDTDwDVGAILKI----------NLHW 68
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449 2321 KNAV---EWHVKEIIVT-EKELGNKYIFKCN 2347
Cdd:pfam01477   69 DNNGlsdEWFLKSITVEvPGETGGKYTFPCN 99
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
326-434 2.74e-09

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 56.78  E-value: 2.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  326 YEVVTVTGD-VRGAGTDANIFVTLFGECGITPKVHLTSKSrtaFEknktdvFRIKTNNVGPIKKIRIEHDNTGMSASWFL 404
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPKNS---LE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLV 73
                           90       100       110
                   ....*....|....*....|....*....|
gi 1952448449  405 DRLVITDMNRPHL*FYFPCNQWLSKEEGDG 434
Cdd:cd01757     74 EYVMVRNEITGHT-YKFPCGRWLGEGVDDG 102
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
1249-1354 2.84e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 57.55  E-value: 2.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1249 YTVHVITGNVMGAGTDANVFINIFGETTDTG-----ERYLK-MSNHLNKFERGQEDIFLIKAIDL-GVLRKLRIRHDNAG 1321
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGlMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1952448449 1322 GNAAWFLDRVEIV---DEKDDTTYFFPCERWLAVDE 1354
Cdd:cd01754     83 NHPGWYVNYVEVTqagQHAPCMQHLFAVEQWLATDE 118
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
967-1075 6.45e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 56.40  E-value: 6.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  967 YHIIVKTGSVPGASSDSKVFIKLYGEKGDT-------SKHSLAISDNDlgnYFEQGRVDVFI--IDTMDiGKLNRLLIGH 1037
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGlrianleAWGGLMGAGHD---YFERGNLDRFSgrGPCLP-SPPCWMNLTS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 1038 DNVGLRAGWFLDSVQV-KVPVHGK--EYMFPAHRWLCKDEA 1075
Cdd:cd01754     79 DGTGNHPGWYVNYVEVtQAGQHAPcmQHLFAVEQWLATDES 119
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
1527-1648 7.96e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 55.39  E-value: 7.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1527 YEITVSTSDIYGAGTDADVFIVLYGRNGiCTHQKPLCVNKRErkmfFRRGAVNKFVIEL-EDVGEcIEKIRIGHDGRGFN 1605
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAG-ESEKQLLDRPGYD----FERGAVDEYKVKVpEDLGE-LLLVRLRKRKYLLF 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1952448449 1606 SGWHLDSVEIrrllqKGKGSETTIFPCERWLaksEDDGEI-IRE 1648
Cdd:cd01753     77 DAWFCNYITV-----TGPGGDEYHFPCYRWI---EGYGTLeLRE 112
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1983-2085 1.08e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.95  E-value: 1.08e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1983 YEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKCGD-RFERGQEDTFNM-VIADIAPLRKIRIRtdIKGYRPDWFL 2060
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKgIFARGSTYEFTFdVDEDFGELGAVKIK--NEHRHPEWFL 80
                            90       100
                    ....*....|....*....|....*
gi 1952448449  2061 DKVIMLNQSTMEVTTFTYNDWLSKT 2085
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
325-431 1.21e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 55.62  E-value: 1.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  325 VYEVVTVTGDVRGAGTDANIFVTLFGECGITPKVH-------LTSKSRTAFEKNKTDVFRIKTNNV-GPIKKIRIEHDNT 396
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIAnleawggLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1952448449  397 GMSASWFLDRLVITD--MNRPHL*FYFPCNQWLSKEE 431
Cdd:cd01754     82 GNHPGWYVNYVEVTQagQHAPCMQHLFAVEQWLATDE 118
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
834-952 1.73e-08

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 54.62  E-value: 1.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  834 VKYRAIIYTGSVSGSGTDANVFICLIGLKGDTgERVLYDSKNNvnKFEKGNADEFIIEA-VSLKKVTRVRIgHDGRGGS- 911
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGES-EKQLLDRPGY--DFERGAVDEYKVKVpEDLGELLLVRL-RKRKYLLf 76
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449  912 CGWYLDKVIVKeegAPESQSVEFPCYRWLdkgEDDG-QIVRE 952
Cdd:cd01753     77 DAWFCNYITVT---GPGGDEYHFPCYRWI---EGYGtLELRE 112
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
190-300 4.05e-08

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 53.62  E-value: 4.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  190 LYEVTVKTGQKREAGTNAKVSLQMKGSKGKINKKRLCKklvsrisdmpvafQFAKGSSHTFKVYGPEIGELQNIVLEHDG 269
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQ-------------GFYPGSLKRIRFRAADVGDINAIILSNTA 68
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449  270 LEkgQAWYVEEVSIvNTARNKTWNIPCKSWL 300
Cdd:cd02899     69 LN--DPWYCDYVRI-KSEDGKVFAFNVKRWI 96
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
455-568 5.19e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 53.31  E-value: 5.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  455 YIVSVFTGD-VKGSGTDADVFINIFGENGDTGerRLDNDKDNFErgnedkFTIESPNLGRLKKITIGHNSKGSSAGWFLD 533
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETP--PLQIPKNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1952448449  534 KVIIDDIGNKIVHQFPVNRWFALDEDDGKIQRDIL 568
Cdd:cd01757     75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNGEDGSL 109
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
2110-2225 8.84e-08

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 52.70  E-value: 8.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2110 TYIITVKTSDMSGAGTDANVSLIIFGEHGDTGSLALKHSnnSNKFERKSTDIFKFADMLSLGDLAKVRVwHDNKGP-GAG 2188
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRP--GYDFERGAVDEYKVKVPEDLGELLLVRL-RKRKYLlFDA 78
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1952448449 2189 WHLDYIEVKdEAMEETFRFPCDRWLaksEDDG-QIIRE 2225
Cdd:cd01753     79 WFCNYITVT-GPGGDEYHFPCYRWI---EGYGtLELRE 112
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
636-689 9.95e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 52.54  E-value: 9.95e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1952448449  636 LSPLSRVTIGHDNGGVSSGWFCEKVIVYCPFTGIEQTFPCRKWLDEDEGDGLIE 689
Cdd:cd01757     52 LGKLTTVQIGHDNSGLLAKWLVEYVMVRNEITGHTYKFPCGRWLGEGVDDGNGE 105
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
1097-1239 1.25e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 52.31  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1097 YEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIRLRSRSDNFVRGATEMFKIEA-LDVGKLIKLRIGHDGSGLGPGWFLG 1175
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAWFCN 82
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1952448449 1176 SVIInrlnfrtveddrkkkkkkkkaEGPvDGlqeemmETYTFNCQRWLakdEGDRQLVvelLPE 1239
Cdd:cd01753     83 YITV---------------------TGP-GG------DEYHFPCYRWI---EGYGTLE---LRE 112
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
191-301 2.06e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 51.54  E-value: 2.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  191 YEVTVKTGQKREAGTNAKVSLQMKGSKGKINKKRLCKKLvsrisdmpvaFQFAKGSSHTFKVYGPE-IGELQNIVLEHDG 269
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPG----------YDFERGAVDEYKVKVPEdLGELLLVRLRKRK 72
                           90       100       110
                   ....*....|....*....|....*....|..
gi 1952448449  270 LEKGQAWYVEEVSiVNTARNKTWNIPCKSWLS 301
Cdd:cd01753     73 YLLFDAWFCNYIT-VTGPGGDEYHFPCYRWIE 103
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
1850-1963 2.34e-07

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 51.39  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1850 IPYHITITTGQERD-AGTNSRVYIIIMGPMKiHTSRLWLElsggknaflPGSME-KFQVMGLdvGEIKKIELGHDGATPE 1927
Cdd:cd01757      1 MPYHVVIVPSKKLGgSMFTANPWICVSGELG-ETPPLQIP---------KNSLEmTFDCQNL--GKLTTVQIGHDNSGLL 68
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1952448449 1928 SCWLVEELEISVPTTGTMYVFKCKCWLAKDRGDGLT 1963
Cdd:cd01757     69 AKWLVEYVMVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
1527-1640 4.20e-07

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 51.00  E-value: 4.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1527 YEITVSTSDIYGAGTDADVFIVLYGRNGICTHQKPLcvnKRERKM------FFRRGAVNKFvielEDVGECIE----KIR 1596
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANL---EAWGGLmgaghdYFERGNLDRF----SGRGPCLPsppcWMN 75
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1952448449 1597 IGHDGRGFNSGWHLDSVEIRRLLQkGKGSETTIFPCERWLAKSE 1640
Cdd:cd01754     76 LTSDGTGNHPGWYVNYVEVTQAGQ-HAPCMQHLFAVEQWLATDE 118
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
835-942 4.76e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 50.33  E-value: 4.76e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   835 KYRAIIYTGSVSGSGTDANVFICLIGLKGDTGERVLYdsKNNVNKFEKGNADEFIIE-AVSLKKVTRVRIGHDgrGGSCG 913
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLD--YLFKGIFARGSTYEFTFDvDEDFGELGAVKIKNE--HRHPE 77
                            90       100
                    ....*....|....*....|....*....
gi 1952448449   914 WYLDKVIVKeeGAPESQSVEFPCYRWLDK 942
Cdd:smart00308   78 WFLKSITVK--DLPTGGKYHFPCNSWVYP 104
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
1097-1235 4.90e-07

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 51.00  E-value: 4.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1097 YEIAVHTGDVTGAGTDAKVFIQIYGELGKTEQIR--------LRSRSDNFVRGATEMFKIEALDV-GKLIKLRIGHDGSG 1167
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIAnleawgglMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1952448449 1168 LGPGWFLGSVIINRLnfrtveddrkkkkkkkkaegpvdGLQEEMMeTYTFNCQRWLAKDEGDRQLVVE 1235
Cdd:cd01754     83 NHPGWYVNYVEVTQA-----------------------GQHAPCM-QHLFAVEQWLATDESPYMLTAV 126
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
1852-1956 4.92e-07

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 50.15  E-value: 4.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1852 YHITITTGQERDAGTNSRVYIIIMGPMKIHTSRLWlelsggKNAFLPGSMEKFQVMGLDVGEIKKIELGHDGATPEscWL 1931
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL------SQGFYPGSLKRIRFRAADVGDINAIILSNTALNDP--WY 74
                           90       100
                   ....*....|....*....|....*
gi 1952448449 1932 VEELEISvPTTGTMYVFKCKCWLAK 1956
Cdd:cd02899     75 CDYVRIK-SEDGKVFAFNVKRWIGY 98
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
1983-2063 5.87e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 50.38  E-value: 5.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1983 YEVTVVTGDTPNGGTDANIYMSVFGANGTTEEMLLDKCGDRFERGQEDTFNM-VIADIAPLRKIRIRTDIKGYRPDWFLD 2061
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVkVPEDLGELLLVRLRKRKYLLFDAWFCN 82

                   ..
gi 1952448449 2062 KV 2063
Cdd:cd01753     83 YI 84
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
1097-1226 6.86e-07

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 50.23  E-value: 6.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1097 YEIAVHTGD-VTGAGTDAKVFIQIYGELGKTEQIRLRsrsdnfvRGATEMfKIEALDVGKLIKLRIGHDGSGLGPGWFLG 1175
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIP-------KNSLEM-TFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1952448449 1176 SVIInrlnfRTveddrkkkkkkkkaegPVDGlqeemmETYTFNCQRWLAKD 1226
Cdd:cd01757     75 YVMV-----RN----------------EITG------HTYKFPCGRWLGEG 98
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
2241-2347 1.55e-06

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 49.26  E-value: 1.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2241 RYEIVTETSDRDDAETKENVWVLFEGKKGKSKEFvlENSSKKKRFLRGAKDKFEFSSK-NVGDIATIcvghcprdgkKFT 2319
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDI--PILDGPGSFERGSTDTFQIDLKlDIGDITKV----------YLR 69
                           90       100       110
                   ....*....|....*....|....*....|.
gi 1952448449 2320 SKNAV---EWHVKEIIVTEKELGNKYIFKCN 2347
Cdd:cd00113     70 RDGSGlsdGWYCESITVQALGTKKVYTFPVN 100
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
966-1070 3.17e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 48.02  E-value: 3.17e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   966 RYHIIVKTGSVPGASSDSKVFIKLYGEKGDtSKHSLAISDNDLGnyFEQGRVDVFIIDT-MDIGKLNRLLIGHDNVglRA 1044
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGD-GKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEHR--HP 76
                            90       100
                    ....*....|....*....|....*.
gi 1952448449  1045 GWFLDSVQVKVPVHGKEYMFPAHRWL 1070
Cdd:smart00308   77 EWFLKSITVKDLPTGGKYHFPCNSWV 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1097-1226 4.86e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 47.25  E-value: 4.86e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1097 YEIAVHTGDVTGAGTDAKVFIQIYG---ELGKTEQIRLRSRSdnFVRGATEMFKIE-ALDVGKLIKLRIGHDGSglGPGW 1172
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGaegDGKESKLDYLFKGI--FARGSTYEFTFDvDEDFGELGAVKIKNEHR--HPEW 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1952448449  1173 FLGSVIinrlnfrtveddrkkkkkkkkaegpVDGLQEEmmETYTFNCQRWLAKD 1226
Cdd:smart00308   79 FLKSIT-------------------------VKDLPTG--GKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
191-301 9.24e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.48  E-value: 9.24e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449   191 YEVTVKTGQKREAGTNAKVSLQMKGSKGkinkkrlCKKLVSRISdmpvAFQ--FAKGSSHTFKVYGPE-IGELQNIVLEH 267
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEG-------DGKESKLDY----LFKgiFARGSTYEFTFDVDEdFGELGAVKIKN 71
                            90       100       110
                    ....*....|....*....|....*....|....
gi 1952448449   268 DGleKGQAWYVEEVSIVNTARNKTWNIPCKSWLS 301
Cdd:smart00308   72 EH--RHPEWFLKSITVKDLPTGGKYHFPCNSWVY 103
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
1681-1796 1.20e-05

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 46.38  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1681 YKISVYTGDVYR-AGTDANVFLTVYGDLGDTGERKLSKseshsNKFErnqvdtFTMEAVDLGEVFKIKIRHDNTMASPDW 1759
Cdd:cd01757      3 YHVVIVPSKKLGgSMFTANPWICVSGELGETPPLQIPK-----NSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKW 71
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1952448449 1760 YLEKVEVVDVDLEENYLFVCERWLSK-----TKEDKRIERTL 1796
Cdd:cd01757     72 LVEYVMVRNEITGHTYKFPCGRWLGEgvddgNGEDGSLERVL 113
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
1249-1350 1.20e-05

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 46.30  E-value: 1.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1249 YTVHVITGNVMGAGTDANVFINIFGETTDTGERYLKmsnhlNKFERGQEDIFLIKAIDLGVLRKLRIRhdNAGGNAAWFL 1328
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLS-----QGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPWYC 75
                           90       100
                   ....*....|....*....|..
gi 1952448449 1329 DRVEIVDEkDDTTYFFPCERWL 1350
Cdd:cd02899     76 DYVRIKSE-DGKVFAFNVKRWI 96
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1527-1636 1.46e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 1.46e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1527 YEITVSTSDIYGAGTDADVFIVLYGRNGIC--THQKPLcvnkreRKMFFRRGAVNKFVIEL-EDVGEcIEKIRIGHDgrG 1603
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGkeSKLDYL------FKGIFARGSTYEFTFDVdEDFGE-LGAVKIKNE--H 73
                            90       100       110
                    ....*....|....*....|....*....|...
gi 1952448449  1604 FNSGWHLDSVEirrlLQKGKGSETTIFPCERWL 1636
Cdd:smart00308   74 RHPEWFLKSIT----VKDLPTGGKYHFPCNSWV 102
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
836-944 2.66e-05

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 45.99  E-value: 2.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  836 YRAIIYTGSVSGSGTDANVFICLIGLKGDTG-----ERVLYDSKNNVNKFEKGNADEFIIEAVSLK-KVTRVRIGHDGRG 909
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLPsPPCWMNLTSDGTG 82
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1952448449  910 GSCGWYLDKVIVKE--EGAPESQSvEFPCYRWLDKGE 944
Cdd:cd01754     83 NHPGWYVNYVEVTQagQHAPCMQH-LFAVEQWLATDE 118
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
454-553 2.97e-05

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 45.15  E-value: 2.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  454 KYIVSVFTGDVKGSGTDADVFINIFGENGDTGERRLDNDkdnFERGNEDKFTIESPNLGRLKKITIGHNSKGSSagWFLD 533
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG---FYPGSLKRIRFRAADVGDINAIILSNTALNDP--WYCD 76
                           90       100
                   ....*....|....*....|
gi 1952448449  534 KVIIDDIGNKiVHQFPVNRW 553
Cdd:cd02899     77 YVRIKSEDGK-VFAFNVKRW 95
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
1395-1500 3.06e-05

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 45.15  E-value: 3.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1395 TYTVRVKTGEKKNAGTDANVFIILFGEKDDTGTVNLkasksnKNKFEKGNIDEFTIEAVDIGSLKKIRIGhdNRGGCAGW 1474
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL------SQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73
                           90       100
                   ....*....|....*....|....*.
gi 1952448449 1475 FLDWVEIDAPSlGQVLRFPCGRWLDK 1500
Cdd:cd02899     74 YCDYVRIKSED-GKVFAFNVKRWIGY 98
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
190-286 1.86e-04

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 43.68  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  190 LYEVTVKTGQKREAGTNAKVSLQMKGSKGKINKkrlCKKLVSRISDMPVAFQ-FAKGSSHTFKVYGPEI-GELQNIVLEH 267
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLR---IANLEAWGGLMGAGHDyFERGNLDRFSGRGPCLpSPPCWMNLTS 78
                           90
                   ....*....|....*....
gi 1952448449  268 DGLEKGQAWYVEEVSIVNT 286
Cdd:cd01754     79 DGTGNHPGWYVNYVEVTQA 97
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1852-1957 2.52e-04

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 42.63  E-value: 2.52e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  1852 YHITITTGQERDAGTNSRVYIIIMGpmKIHTSRLWLELSGGKNAFLPGSMEKFQV-MGLDVGEIKKIELGHDGATPEscW 1930
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVG--AEGDGKESKLDYLFKGIFARGSTYEFTFdVDEDFGELGAVKIKNEHRHPE--W 78
                            90       100
                    ....*....|....*....|....*..
gi 1952448449  1931 LVEELEISVPTTGTMYVFKCKCWLAKD 1957
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
2382-2485 6.03e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 41.68  E-value: 6.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 2382 KYEIIVITGDVKGAGTDANVSITIYGTNGDSGIHRLKhkfrNLFERGNTDRFILEMLDLGELNKVKIEhdNSNSNAGWML 2461
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLS----QGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPWYC 75
                           90       100
                   ....*....|....*....|....
gi 1952448449 2462 ERVEItNTATGVTTIFPCGKWLDR 2485
Cdd:cd02899     76 DYVRI-KSEDGKVFAFNVKRWIGY 98
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
1852-1954 6.21e-04

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 41.53  E-value: 6.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1852 YHITITTGQERDAGTNSRVYIIIMGPmkiHTSRLWLELSGGKNAFLPGSMEKFQV-MGLDVGEIKKIELGHDGATPESCW 1930
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGT---AGESEKQLLDRPGYDFERGAVDEYKVkVPEDLGELLLVRLRKRKYLLFDAW 79
                           90       100
                   ....*....|....*....|....
gi 1952448449 1931 LVEELEISVPtTGTMYVFKCKCWL 1954
Cdd:cd01753     80 FCNYITVTGP-GGDEYHFPCYRWI 102
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
1983-2083 7.74e-04

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 41.76  E-value: 7.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1983 YEVTVVTGDTPNGGTDANIYMSVFGANGTTEEM--------LLDKCGDRFERGQEDTFNMVIADI-APLRKIRIRTDIKG 2053
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIanleawggLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1952448449 2054 YRPDWFLDKVimlnqstmEVTT-----------FTYNDWLS 2083
Cdd:cd01754     83 NHPGWYVNYV--------EVTQagqhapcmqhlFAVEQWLA 115
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
1680-1785 1.77e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 40.14  E-value: 1.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1680 TYKISVYTGDVYRAGTDANVFLTVYGDLGDTGERKLSKSeshsnkFERNQVDTFTMEAVDLGEVFKIKIRhdNTMASPDW 1759
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG------FYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73
                           90       100
                   ....*....|....*....|....*.
gi 1952448449 1760 YLEKVEVVDVDlEENYLFVCERWLSK 1785
Cdd:cd02899     74 YCDYVRIKSED-GKVFAFNVKRWIGY 98
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
1852-1964 3.11e-03

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 39.83  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449 1852 YHITITTGQERDAGTNSRVYIIIMGP----MKIHTSRLWLELSG-GKNAFLPGSMEKFQVMGLDV-GEIKKIELGHDGAT 1925
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDAdgpgLRIANLEAWGGLMGaGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1952448449 1926 PESCWLVEELEISvpTTG-----TMYVFKCKCWLAKDRG-DGLTA 1964
Cdd:cd01754     83 NHPGWYVNYVEVT--QAGqhapcMQHLFAVEQWLATDESpYMLTA 125
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
706-831 5.06e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 39.06  E-value: 5.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1952448449  706 NPWSLWIWTSDiknagsDANVfLQLygdKRKSDEMCLDNNSdnfetgqtdklmielpeLGTIYKLRIWHEKRHPFAGWHL 785
Cdd:cd01757     21 NPWICVSGELG------ETPP-LQI---PKNSLEMTFDCQN-----------------LGKLTTVQIGHDNSGLLAKWLV 73
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1952448449  786 NKVTLMKSLTKEKYSFKCGRWLdvneddNEIIRELPAEGDCVDEVL 831
Cdd:cd01757     74 EYVMVRNEITGHTYKFPCGRWL------GEGVDDGNGEDGSLERVL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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