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Conserved domains on  [gi|1944811768|ref|XP_038033615|]
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LOW QUALITY PROTEIN: kelch-like protein 29 [Anas platyrhynchos]

Protein Classification

kelch-like protein; BTB/POZ domain-containing protein 16( domain architecture ID 13033189)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases| BTB/POZ domain-containing protein 16 (BTBD16) is a BTB-domain-containing Kelch-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-485 1.46e-86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 272.23  E-value: 1.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 360 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsRSGEKLELAMSNLTADVLELLLEFV 439
Cdd:cd18258     1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDS-GGGEKLELTMSNINADVLELLLEFV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 440 YTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18258    80 YTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 479-580 7.44e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


:

Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 209.96  E-value: 7.44e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 479 TASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAI 558
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 1944811768 559 RAQYAAELLAVVRLPFIHPSYL 580
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102
PHA03098 super family cl33709
kelch-like protein; Provisional
 367-904 2.16e-51

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 189.59  E-value: 2.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 367 LNQQRrakeFTDLKIIVE--GKEFEVHQNVLASCSLYFKDLIKRSPRDssrsgeklELAMSNLTADVLELLLEFVYTGSL 444
Cdd:PHA03098    4 FELQK----FCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNNFKE--------NEINLNIDYDSFNEVIKYIYTGKI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 445 IIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISK 524
Cdd:PHA03098   72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 525 DDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQYAAELLAVVRlpfihPSYLlnvvdNEELIKSSEACRdLVNEAK 604
Cdd:PHA03098  152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFL-----SEEGIKKLKRWK-LRIKKK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 605 RYhmlPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMIGM-NQRALTAVTCLNPQNNKWYPLASLPFydREFFSVVSAGD 683
Cdd:PHA03098  221 KI---VFNKRCIKIIYSKKYNLNKILPRSSTFGSIIYIHItMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNN 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 684 NIYLSGGM-ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTITNQWETIAP 762
Cdd:PHA03098  296 VIYFIGGMnKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 763 LPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYIPQTNSWSFIESPMIDNKYAPAVTLNGFIFILGG-----AYARA 837
Cdd:PHA03098  376 LIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVY 455

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 838 TTI--YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYDPKTNTWTLLPNMP 904
Cdd:PHA03098  456 NIVesYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGD--KYEYYINEIEVYDDKTNTWTLFCKFP 522
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 87-287 4.59e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  87 STNRPGLLPLPIVPSRLPtPATAACTTGNSDVITSLVANSSPASTTKAPCISKTENQPQGLATSVRWGQTPINQSTPwDT 166
Cdd:pfam03154 259 SQVSPQPLPQPSLHGQMP-PMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQL-QS 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 167 DEPPskqmRENENPGAA--------PWVTTVAAGSQPALITHSYGMTQPPTFSPAANVQAP-VIGVTPSLPPHVTPQ--- 234
Cdd:pfam03154 337 QQPP----REQPLPPAPlsmphikpPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPpALKPLSSLSTHHPPSahp 412

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1944811768 235 --LPLMPAHYQLQPQPSQPlsnmvvnlqsqPLYTNSQPLSMPSMSGVGPVA-HPGP 287
Cdd:pfam03154 413 ppLQLMPQSQQLPPPPAQP-----------PVLTQSQSLPPPAASHPPTSGlHQVP 457
 
Name Accession Description Interval E-value
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-485 1.46e-86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 272.23  E-value: 1.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 360 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsRSGEKLELAMSNLTADVLELLLEFV 439
Cdd:cd18258     1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDS-GGGEKLELTMSNINADVLELLLEFV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 440 YTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18258    80 YTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 479-580 7.44e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 209.96  E-value: 7.44e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 479 TASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAI 558
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 1944811768 559 RAQYAAELLAVVRLPFIHPSYL 580
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102
PHA03098 PHA03098
kelch-like protein; Provisional
 367-904 2.16e-51

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 189.59  E-value: 2.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 367 LNQQRrakeFTDLKIIVE--GKEFEVHQNVLASCSLYFKDLIKRSPRDssrsgeklELAMSNLTADVLELLLEFVYTGSL 444
Cdd:PHA03098    4 FELQK----FCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNNFKE--------NEINLNIDYDSFNEVIKYIYTGKI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 445 IIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISK 524
Cdd:PHA03098   72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 525 DDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQYAAELLAVVRlpfihPSYLlnvvdNEELIKSSEACRdLVNEAK 604
Cdd:PHA03098  152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFL-----SEEGIKKLKRWK-LRIKKK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 605 RYhmlPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMIGM-NQRALTAVTCLNPQNNKWYPLASLPFydREFFSVVSAGD 683
Cdd:PHA03098  221 KI---VFNKRCIKIIYSKKYNLNKILPRSSTFGSIIYIHItMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNN 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 684 NIYLSGGM-ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTITNQWETIAP 762
Cdd:PHA03098  296 VIYFIGGMnKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 763 LPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYIPQTNSWSFIESPMIDNKYAPAVTLNGFIFILGG-----AYARA 837
Cdd:PHA03098  376 LIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVY 455

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 838 TTI--YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYDPKTNTWTLLPNMP 904
Cdd:PHA03098  456 NIVesYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGD--KYEYYINEIEVYDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
609-919 1.85e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 173.42  E-value: 1.85e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 609 LPHARQEMQTprtrprlsAGVAEVIVLVGGRQmigmNQRALTAVTCLNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLS 688
Cdd:COG3055     9 LPTPRSEAAA--------ALLDGKVYVAGGLS----GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 689 GGM----ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTITNQWETIAPLP 764
Cdd:COG3055    77 GGFtganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 765 KAV-HSAAATVCGGKIYVFGGVNEAGraagvlqsyipQTNSWSfiespmidnkyapavtlngfifilggayarattiydp 843
Cdd:COG3055   157 TPRdHLAAAVLPDGKILVIGGRNGSG-----------FSNTWT------------------------------------- 188

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1944811768 844 ekgnikAGPNMNHSRQFCSAVVLDGKIYATGGivssEGPALGNMEAYDPKTNTWTLLPNMPCPVFRHGCVVIKKYI 919
Cdd:COG3055   189 ------TLAPLPTARAGHAAAVLGGKILVFGG----ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKV 254
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 483-584 1.17e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 138.83  E-value: 1.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 483 CLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQY 562
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 1944811768 563 AAELLAVVRLPFIHPSYLLNVV 584
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 483-583 7.39e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 119.37  E-value: 7.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  483 CLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQY 562
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1944811768  563 AAELLAVVRLPFIHPSYLLNV 583
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 367-478 2.41e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.48  E-value: 2.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 367 LNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSlII 446
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS----EITLDDVSPEDFEALLEFMYTGK-LI 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 447 DSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 378-478 5.99e-22

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 91.21  E-value: 5.99e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  378 DLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLElamsNLTADVLELLLEFVYTGSLIIDSANAKTLLEA 457
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD----DVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 1944811768  458 ASKFQFHTFCKVCVSFLEKQL 478
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
869-917 1.52e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.18  E-value: 1.52e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1944811768  869 KIYATGGIVSSEgpALGNMEAYDPKTNTWTLLPNMPCPVFRHGCVVIKK 917
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 719-764 2.60e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.47  E-value: 2.60e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 719 PRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTITNQWETIAPLP 764
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 87-287 4.59e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  87 STNRPGLLPLPIVPSRLPtPATAACTTGNSDVITSLVANSSPASTTKAPCISKTENQPQGLATSVRWGQTPINQSTPwDT 166
Cdd:pfam03154 259 SQVSPQPLPQPSLHGQMP-PMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQL-QS 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 167 DEPPskqmRENENPGAA--------PWVTTVAAGSQPALITHSYGMTQPPTFSPAANVQAP-VIGVTPSLPPHVTPQ--- 234
Cdd:pfam03154 337 QQPP----REQPLPPAPlsmphikpPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPpALKPLSSLSTHHPPSahp 412

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1944811768 235 --LPLMPAHYQLQPQPSQPlsnmvvnlqsqPLYTNSQPLSMPSMSGVGPVA-HPGP 287
Cdd:pfam03154 413 ppLQLMPQSQQLPPPPAQP-----------PVLTQSQSLPPPAASHPPTSGlHQVP 457
PHA03247 PHA03247
large tegument protein UL36; Provisional
 82-298 1.06e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768   82 AASTTSTNRPGLlPLPIVPSRLPTPATAACTTgnsdvitsLVANSSPASTTKAPciskTENQPQGLATSvrwgQTPINQS 161
Cdd:PHA03247  2787 AVASLSESRESL-PSPWDPADPPAAVLAPAAA--------LPPAASPAGPLPPP----TSAQPTAPPPP----PGPPPPS 2849

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  162 TPWDTDEPPSKQMRENENPGAAPwvTTVAAGSQPALITHSYGMTQPPTFSPAANVQAPVIGVTPSLPPHVTPQlPLMPAH 241
Cdd:PHA03247  2850 LPLGGSVAPGGDVRRRPPSRSPA--AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ-PQPPPP 2926

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1944811768  242 YQLQPQPSQPlsnmvvNLQSQPLYTNSQPLSMPSMSGVGPvaHPGPGAVGNGHLACP 298
Cdd:PHA03247  2927 PQPQPPPPPP------PRPQPPLAPTTDPAGAGEPSGAVP--QPWLGALVPGRVAVP 2975
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 69-252 2.43e-03

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 41.44  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  69 SNGNHVGSTNCSSAASTTSTNRPgllplpivPSRLPTPATAACTTGNSDVITSLVANSSPASTtkAPCISKTENQPqgla 148
Cdd:cd22536   271 SNGNQLVSTPITTASVSTMPESP--------SSSTTCTTTASTSLTSSDTLVSSAETGQYAST--AASSERTEEEP---- 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 149 tsvrwgqtpinQSTPWDTDEPPSKQMREN---ENPGAAPWVTTVAAGSQPALITHsygMTQPPTFSPAANVQAPVIGVTP 225
Cdd:cd22536   337 -----------QTSAAESEAQSSSQLQSNglqNVQDQSNSLQQVQIVGQPILQQI---QIQQPQQQIIQAIQPQSFQLQS 402

                         170       180
                  ....*....|....*....|....*..
gi 1944811768 226 SLPPHVTPQLPLMPAHYQLQPQPSQPL 252
Cdd:cd22536   403 GQTIQTIQQQPLQNVQLQAVQSPTQVL 429
 
Name Accession Description Interval E-value
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-485 1.46e-86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 272.23  E-value: 1.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 360 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsRSGEKLELAMSNLTADVLELLLEFV 439
Cdd:cd18258     1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDS-GGGEKLELTMSNINADVLELLLEFV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 440 YTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18258    80 YTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 479-580 7.44e-64

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 209.96  E-value: 7.44e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 479 TASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAI 558
Cdd:cd18468     1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                          90       100
                  ....*....|....*....|..
gi 1944811768 559 RAQYAAELLAVVRLPFIHPSYL 580
Cdd:cd18468    81 RKQHIAELLAVVRLPFIHPSYL 102
PHA03098 PHA03098
kelch-like protein; Provisional
 367-904 2.16e-51

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 189.59  E-value: 2.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 367 LNQQRrakeFTDLKIIVE--GKEFEVHQNVLASCSLYFKDLIKRSPRDssrsgeklELAMSNLTADVLELLLEFVYTGSL 444
Cdd:PHA03098    4 FELQK----FCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNNFKE--------NEINLNIDYDSFNEVIKYIYTGKI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 445 IIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISK 524
Cdd:PHA03098   72 NITSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 525 DDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQYAAELLAVVRlpfihPSYLlnvvdNEELIKSSEACRdLVNEAK 604
Cdd:PHA03098  152 NELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLR-----ITFL-----SEEGIKKLKRWK-LRIKKK 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 605 RYhmlPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMIGM-NQRALTAVTCLNPQNNKWYPLASLPFydREFFSVVSAGD 683
Cdd:PHA03098  221 KI---VFNKRCIKIIYSKKYNLNKILPRSSTFGSIIYIHItMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNN 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 684 NIYLSGGM-ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTITNQWETIAP 762
Cdd:PHA03098  296 VIYFIGGMnKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP 375

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 763 LPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYIPQTNSWSFIESPMIDNKYAPAVTLNGFIFILGG-----AYARA 837
Cdd:PHA03098  376 LIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyidNIKVY 455

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 838 TTI--YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYDPKTNTWTLLPNMP 904
Cdd:PHA03098  456 NIVesYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGD--KYEYYINEIEVYDDKTNTWTLFCKFP 522
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
609-919 1.85e-48

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 173.42  E-value: 1.85e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 609 LPHARQEMQTprtrprlsAGVAEVIVLVGGRQmigmNQRALTAVTCLNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLS 688
Cdd:COG3055     9 LPTPRSEAAA--------ALLDGKVYVAGGLS----GGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 689 GGM----ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTITNQWETIAPLP 764
Cdd:COG3055    77 GGFtganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 765 KAV-HSAAATVCGGKIYVFGGVNEAGraagvlqsyipQTNSWSfiespmidnkyapavtlngfifilggayarattiydp 843
Cdd:COG3055   157 TPRdHLAAAVLPDGKILVIGGRNGSG-----------FSNTWT------------------------------------- 188

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1944811768 844 ekgnikAGPNMNHSRQFCSAVVLDGKIYATGGivssEGPALGNMEAYDPKTNTWTLLPNMPCPVFRHGCVVIKKYI 919
Cdd:COG3055   189 ------TLAPLPTARAGHAAAVLGGKILVFGG----ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKV 254
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 478-613 1.06e-38

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 140.61  E-value: 1.06e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1944811768 558 IRAQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHAR 613
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 483-584 1.17e-38

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 138.83  E-value: 1.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 483 CLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQY 562
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 1944811768 563 AAELLAVVRLPFIHPSYLLNVV 584
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 478-607 1.11e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 125.95  E-value: 1.11e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1944811768 558 IRAQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYH 607
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 478-607 1.77e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 125.14  E-value: 1.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1944811768 558 IRAQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYH 607
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 481-591 3.04e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 121.19  E-value: 3.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 481 SNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRA 560
Cdd:cd18445     4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1944811768 561 QYAAELLAVVRLPFIHPSYLLNVVDNEELIK 591
Cdd:cd18445    84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 483-583 7.39e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 119.37  E-value: 7.39e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  483 CLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQY 562
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 1944811768  563 AAELLAVVRLPFIHPSYLLNV 583
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 356-483 5.31e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 109.47  E-value: 5.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 356 DPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSrsGEKLELamSNLTADVLELL 435
Cdd:cd18250     1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESR--ADRVVL--HGVSAEILGLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18250    77 LDFSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 482-584 1.02e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 107.78  E-value: 1.02e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 482 NCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRAQ 561
Cdd:cd18457     5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84

                          90       100
                  ....*....|....*....|...
gi 1944811768 562 YAAELLAVVRLPFIHPSYLLNVV 584
Cdd:cd18457    85 YLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-485 2.24e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 102.18  E-value: 2.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18237     4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSS----EVELKDAEPDIIELLVEF 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18237    80 AYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-485 2.36e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 102.01  E-value: 2.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLElamSNLTADVLELLL 436
Cdd:cd18254     3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFH---DSLHPEVLELLL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18254    80 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 477-580 5.55e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 100.10  E-value: 5.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18444     1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                          90       100
                  ....*....|....*....|....
gi 1944811768 557 AIRAQYAAELLAVVRLPFIHPSYL 580
Cdd:cd18444    81 PERKKHLAKLLALIRLPLLTPQFL 104
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-485 6.75e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 100.62  E-value: 6.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLElamsNLTADVLELLL 436
Cdd:cd18265     4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQ----KVSAAAMEVLL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18265    80 DYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 367-478 2.41e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.48  E-value: 2.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 367 LNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSlII 446
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS----EITLDDVSPEDFEALLEFMYTGK-LI 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 447 DSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:pfam00651  76 SEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 343-485 2.54e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 99.52  E-value: 2.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 343 MLRTIGvgKYEFTDPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSrsGEKLEL 422
Cdd:cd18259     1 MVRNID--DLDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESI--SARVEI 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1944811768 423 amSNLTADVLELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18259    77 --KDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-483 2.96e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 98.67  E-value: 2.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEF 438
Cdd:cd18242     4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEK----GKSEVELQGLTASTMEILLDF 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18242    80 VYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-485 3.19e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 98.63  E-value: 3.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKD----VVQIHGVEPDIFHILLDF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18256    79 IYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 367-483 4.42e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 98.17  E-value: 4.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 367 LNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrsprDSSRSGEKLELAMSNLTADVLELLLEFVYTGSLII 446
Cdd:cd18240     8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFT----NGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPI 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 447 DSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18240    84 TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-483 4.90e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 97.98  E-value: 4.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEF 438
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRES----REMLVEINGILAEAMDCFLQY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18253    77 VYTGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 362-486 4.93e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 98.32  E-value: 4.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 362 EMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYT 441
Cdd:cd18268     9 ELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQA----KVDLKGIDSDVLDQIVDYVYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 442 GSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18268    85 GEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 339-486 1.33e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 94.67  E-value: 1.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 339 NRVQMLRTIGVGKYEFTDPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGE 418
Cdd:cd18267     3 NRKSRASSGSMNIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEV 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1944811768 419 KLElamSNLTADVLELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18267    83 NFH---DSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-486 1.45e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 93.86  E-value: 1.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLElamsNLTADVLELLLEF 438
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLD----GLDPDAVEVLVNY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18306    77 AYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-461 2.08e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 91.85  E-value: 2.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLL 455
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSS----EIELDDVSPEAFEALLDYIYTGELELSEENVEELL 76


                  ....*.
gi 1944811768 456 EAASKF 461
Cdd:cd18186    77 AAADKL 82
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-485 4.88e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 92.51  E-value: 4.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT----EVTIRDIDERAMELLIDF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18249    82 AYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 478-577 4.98e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 91.34  E-value: 4.98e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLnTKAEELVYETVIKWIKKDAA 557
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90       100
                  ....*....|....*....|
gi 1944811768 558 IRAQYAAELLAVVRLPFIHP 577
Cdd:cd18476    80 ARKGYIHDLFKKVRLQYVHP 99
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 378-478 5.99e-22

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 91.21  E-value: 5.99e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  378 DLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLElamsNLTADVLELLLEFVYTGSLIIDSANAKTLLEA 457
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD----DVSPEDFRALLNFLYTGKLDLPEENVEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 1944811768  458 ASKFQFHTFCKVCVSFLEKQL 478
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 479-555 6.44e-22

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 90.16  E-value: 6.44e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1944811768 479 TASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKD 555
Cdd:cd18508     1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 477-567 6.80e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 90.82  E-value: 6.80e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18458     1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                          90
                  ....*....|.
gi 1944811768 557 AIRAQYAAELL 567
Cdd:cd18458    81 ENRRQYLEALL 91
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 477-573 1.94e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 89.67  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18448     1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                          90
                  ....*....|....*..
gi 1944811768 557 AIRAQYAAELLAVVRLP 573
Cdd:cd18448    81 QHRKRHLDDLLSQVRLP 97
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 478-580 7.86e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 88.15  E-value: 7.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90       100
                  ....*....|....*....|...
gi 1944811768 558 IRAQYAAELLAVVRLPFIHPSYL 580
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLPPQLL 104
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 481-575 6.27e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 85.41  E-value: 6.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 481 SNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRA 560
Cdd:cd18515     3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                          90
                  ....*....|....*
gi 1944811768 561 QYAAELLAVVRLPFI 575
Cdd:cd18515    83 CYLSELLQTVRLALL 97
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 477-554 1.01e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 83.98  E-value: 1.01e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKK 554
Cdd:cd18463     1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 361-486 1.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 85.92  E-value: 1.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 361 KEMLKElnqqrraKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrSPRDSSRsgeKLELAMSNLTADVLELLLEFVY 440
Cdd:cd18269    19 KDLLDE-------NKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFL-SDLEESK---KKEVVLEDVDPDVMGMILKYLY 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 441 TGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18269    88 TSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-474 1.37e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 85.26  E-value: 1.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDssrSGEKLELAMSNLTADVLELLLEF 438
Cdd:cd18329     4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKE---TGQPTVATFDVFSPDTFTIILDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18329    81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-483 3.21e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 84.37  E-value: 3.21e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQD----EIELKGVSAKGLKHILDF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18255    77 AYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-480 3.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 84.13  E-value: 3.24e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrSPRDSSRSGEKLELAMSNLTAdvLELLLEF 438
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMF--TGNLSEKENSEVEFQCIDETA--LQAIVEY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTA 480
Cdd:cd18257    77 AYTGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-486 3.96e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 84.50  E-value: 3.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLL 455
Cdd:cd18340    27 FVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEES----KKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIF 102

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1944811768 456 EAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18340   103 AAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 478-555 4.59e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 82.27  E-value: 4.59e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQ-EEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKD 555
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 477-580 5.48e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 83.19  E-value: 5.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18511     1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                          90       100
                  ....*....|....*....|....
gi 1944811768 557 AIRAQYAAELLAVVRLPFIHPSYL 580
Cdd:cd18511    81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 353-487 7.60e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 83.72  E-value: 7.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 353 EFTDPWHPKEMLKELNQQRRAKEFTDLKIIVEGKE--------FEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAM 424
Cdd:cd18273     3 ELEDAAHARALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQE----TVTI 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1944811768 425 SNLTADVLELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGIL 487
Cdd:cd18273    79 HDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 356-485 7.86e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 83.34  E-value: 7.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 356 DPWHPKEMLKELNQQRRAKEFTDLKII-VEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLelamSNLTADVLEL 434
Cdd:cd18252     1 DSSHPADFLDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKL----SGIDHDILEA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1944811768 435 LLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18252    77 LVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-474 2.06e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 81.70  E-value: 2.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSR-SGEKLELamsnLTADVLELLLE 437
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRpSTASFDV----FSSDAFSIILD 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 438 FVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18199    77 FVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 478-575 2.52e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 80.76  E-value: 2.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*...
gi 1944811768 558 IRAQYAAELLAVVRLPFI 575
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLL 98
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 477-580 2.54e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 81.12  E-value: 2.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18510     1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                          90       100
                  ....*....|....*....|....
gi 1944811768 557 AIRAQYAAELLAVVRLPFIHPSYL 580
Cdd:cd18510    81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-484 4.24e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 81.01  E-value: 4.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPrdssrSGEKLELamSNLTADVLELLLEF 438
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDP-----SLQRVEL--NDISPLGLATVITY 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 484
Cdd:cd18260    74 AYTGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-478 5.60e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 80.89  E-value: 5.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGK----EFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLEL 434
Cdd:cd18248     4 HTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGME----VVPIEGVHPCVMSR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1944811768 435 LLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18248    80 LIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 478-577 5.80e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 79.77  E-value: 5.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18485     1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                          90       100
                  ....*....|....*....|
gi 1944811768 558 IRAQYAAELLAVVRLPFIHP 577
Cdd:cd18485    81 SRVQHLVELLKQVRLELVSP 100
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-478 6.94e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 80.68  E-value: 6.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLI--KRSPRDSSRS-GEKLELAMSNLTADVLELL 435
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgQASPRLVLVSpAGKCVLDLHHVTVTGFAPL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18228    82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 477-574 8.32e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 79.32  E-value: 8.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18447     1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                          90
                  ....*....|....*...
gi 1944811768 557 AIRAQYAAELLAVVRLPF 574
Cdd:cd18447    81 PNRQPYMVDILAKVRFPL 98
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 362-485 8.66e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 80.03  E-value: 8.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 362 EMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsprdssrSGEKLELAMSNLT-----ADVLELLL 436
Cdd:cd18238     1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMF---------TSEMAESKQDSITikdidEEAVELLV 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18238    72 DFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-475 1.50e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 78.92  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELamSNLTADVLELLLEFVYTG 442
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIEL--EGISVEVMEEILDYIYTG 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1944811768 443 SLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18245    79 QIKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 478-575 2.12e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 78.50  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90
                  ....*....|....*...
gi 1944811768 558 IRAQYAAELLAVVRLPFI 575
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLL 98
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 481-572 2.32e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 78.31  E-value: 2.32e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 481 SNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRA 560
Cdd:cd18464     3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                          90
                  ....*....|..
gi 1944811768 561 QYAAELLAVVRL 572
Cdd:cd18464    83 EVLPELLRSVRL 94
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 478-585 3.53e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 77.89  E-value: 3.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90       100
                  ....*....|....*....|....*...
gi 1944811768 558 IRAQYAAELLAVVRLPFIHPSYLLNVVD 585
Cdd:cd18446    81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-475 3.81e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 78.37  E-value: 3.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELamsnLTADVLELLL 436
Cdd:cd18198     6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDF----VSPEALTALL 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18198    82 EFAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 478-575 3.97e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 77.58  E-value: 3.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*...
gi 1944811768 558 IRAQYAAELLAVVRLPFI 575
Cdd:cd18514    81 KRKDYLPELLRNVRLALL 98
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-475 4.83e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 78.35  E-value: 4.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELAMSNL---TADVLE 433
Cdd:cd18327     6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGQDVCELdfvGPEALG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1944811768 434 LLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18327    86 ALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-475 1.13e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 76.90  E-value: 1.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELamsnLTADVLELLL 436
Cdd:cd18326     6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDF----VSAEALTALL 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18326    82 DFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 476-579 1.14e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 76.33  E-value: 1.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 476 KQLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKD 555
Cdd:cd18469     1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                          90       100
                  ....*....|....*....|....
gi 1944811768 556 AAIRAQYAAELLAVVRLPFIHPSY 579
Cdd:cd18469    81 PQARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 477-575 1.53e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 75.93  E-value: 1.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 477 QLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18459     1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                          90
                  ....*....|....*....
gi 1944811768 557 AIRAQYAAELLAVVRLPFI 575
Cdd:cd18459    81 QERRPHLPQVLQHVRLPLL 99
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 356-486 2.22e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 76.56  E-value: 2.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 356 DPWHPKEMLKELNQQRRAKEFTDLKIIVE-GKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLEL 434
Cdd:cd18274     2 DPLHACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQK----EVRIVGVEAESMHL 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1944811768 435 LLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18274    78 VLDYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 362-487 2.26e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 76.58  E-value: 2.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 362 EMLKELNQQrraKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYT 441
Cdd:cd18270    15 EQLKFFYEQ---QLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQT----HVHLRNVDAATLQIIITYAYT 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 442 GSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGIL 487
Cdd:cd18270    88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-478 2.61e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 75.93  E-value: 2.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrSPRDSSRSGEKLELamSNLTADVLELLL 436
Cdd:cd18235     2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMF--TGDLSESRANRVTL--QDVDGKALLLLI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18235    78 DYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 478-571 3.19e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 74.81  E-value: 3.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....
gi 1944811768 558 IRAQYAAELLAVVR 571
Cdd:cd18517    81 NRVKSLGEIFDCIR 94
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-476 3.32e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 75.77  E-value: 3.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsprdssrsgekLELAMSNLTAD-----V 431
Cdd:cd18334     2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLV-------------LHDNLINLDTDmvnptV 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 432 LELLLEFVYTGSLIIDSA----NAKTLLEAASKFQFHTFCKVCVSFLEK 476
Cdd:cd18334    69 FRQILDFIYTGKLLTSDQpgeqNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-475 4.23e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 75.30  E-value: 4.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELamsnLTADVLELLL 436
Cdd:cd18328     6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDF----VTPEALSAIL 81

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18328    82 EFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 362-468 6.18e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 74.58  E-value: 6.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 362 EMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSR-SGEKLELamsnLTADVLELLLEFVY 440
Cdd:cd18330     4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDI----VTSEAFSIILDFLY 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1944811768 441 TGSLIIDSANAKTLLEAASKFQFH---TFCK 468
Cdd:cd18330    80 SGKLDLCSENVIEVMSAASYLQMTdvvNFCK 110
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-473 6.54e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 74.41  E-value: 6.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLikrsprdsSRSGEKLELAMSNLTADVLELLLEF 438
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSL--------YGDGTSGSVVLPESFAEVFGLLLDF 72

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSF 473
Cdd:cd18232    73 FYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 478-575 9.20e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 73.68  E-value: 9.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*...
gi 1944811768 558 IRAQYAAELLAVVRLPFI 575
Cdd:cd18460    81 HRQHFWPELLQHVRLPFV 98
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 361-486 1.14e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 74.50  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 361 KEMLKElnqqrraKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrsprdSSRSGEK-LELAMSNLTADVLELLLEFV 439
Cdd:cd18341    19 KELLDE-------NKFVDCTLKAGDKSLPCHRLILAACSPYFREYFL-----SEESEEKkKEVVLDNVDPNIMDMILKYL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 440 YTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18341    87 YSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 478-571 1.62e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 72.95  E-value: 1.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....
gi 1944811768 558 IRAQYAAELLAVVR 571
Cdd:cd18477    81 NRQKALPTVFESIR 94
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-481 1.70e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 73.94  E-value: 1.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSG-EKLELamsnLTADVLELL 435
Cdd:cd18230     2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATvTHLDI----VTAQGFKAI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 481
Cdd:cd18230    78 IDFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 478-580 1.92e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 72.84  E-value: 1.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                          90       100
                  ....*....|....*....|...
gi 1944811768 558 IRAQYAAELLAVVRLPfIHPSYL 580
Cdd:cd18462    81 KRIECAYDLLSSIKLD-LDEIYL 102
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 478-572 2.94e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 72.01  E-value: 2.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18479     1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                          90
                  ....*....|....*
gi 1944811768 558 IRAQYAAELLAVVRL 572
Cdd:cd18479    81 SRSQYLSSVLSQIRI 95
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 377-484 3.57e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 72.01  E-value: 3.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 377 TDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLLE 456
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEE----EIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLA 77

                          90       100
                  ....*....|....*....|....*...
gi 1944811768 457 AASKFQFHTFCKVCVSFLEKQLTASNCL 484
Cdd:cd18234    78 TACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 356-478 4.53e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 72.41  E-value: 4.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 356 DPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrspRDSSRSGEKlELAMSNLTADVLELL 435
Cdd:cd18338     1 NPRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFT---GEMSESRAK-RVRIKEVDGWTLKML 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18338    77 IDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-473 8.11e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 71.50  E-value: 8.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPrdssrsgEKLELAMSNltADVLELLL 436
Cdd:cd18206     3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQK-------DVVHLDISN--AAGLGQVL 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSF 473
Cdd:cd18206    74 EFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-486 1.03e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 71.37  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18276     4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQR----EVVLHDITAESVSIILNY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18276    80 MYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 367-485 1.24e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 71.42  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 367 LNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRdssrsgEKLE--LAMSNLTADVLELLLEFVYTGSL 444
Cdd:cd18236    15 LENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLK------EKYEekIIIKGVDAETMQILLDYTYTSKV 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1944811768 445 IIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 485
Cdd:cd18236    89 LITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
PHA02790 PHA02790
Kelch-like protein; Provisional
 379-834 1.33e-14

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 77.39  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 379 LKIIVE--GKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEK--LELAMSNLTADVLellleFVYTGSLIIDSANAKTL 454
Cdd:PHA02790   22 FKTIIEaiGGNIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRvcLDLDIHSLTSIVI-----YSYTGKVYIDSHNVVNL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 455 LEAASKFQFHTFCKVCVSFLEKQLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVanQEEIlnISKDDFISY---M 531
Cdd:PHA02790   97 LRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEL--EDDI--IDNFDYLSMkliL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 532 SNDSLNTKAEELVYETVIKWIKKDAAIRAQYAAELLAVVRLPFIHPSYLLNV---VDNEELIKsseaCRDLVNEAKRYHM 608
Cdd:PHA02790  173 ESDELNVPDEDYVVDFVIKWYMKRRNRLGNLLLLIKNVIRSNYLSPRGINNVkwiLDCTKIFH----CDKQPRKSYKYPF 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 609 LPHARQEMQTPRT-RPRLSAGVAEVIVLVGGrqmiGMNQRALTAVTCLNPQNNKWYPLASLPfYDREFFSVVSAGDNIYL 687
Cdd:PHA02790  249 IEYPMNMDQIIDIfHMCTSTHVGEVVYLIGG----WMNNEIHNNAIAVNYISNNWIPIPPMN-SPRLYASGVPANNKLYV 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 688 SGGMESGVTLaDVWCYMSllDNWNLVSRMTVPRCRHNSLVYDGKIYTIGGvgvagnvdHVERyDTIT-------NQWETI 760
Cdd:PHA02790  324 VGGLPNPTSV-ERWFHGD--AAWVNMPSLLKPRCNPAVASINNVIYVIGG--------HSET-DTTTeyllpnhDQWQFG 391

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1944811768 761 APLPKAVHSAAATVCGGKIYVfggvneAGRAAgvlQSYIPQTNSWSFIESPMIDNKYAPAVTLNGFIFILGGAY 834
Cdd:PHA02790  392 PSTYYPHYKSCALVFGRRLFL------VGRNA---EFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFY 456
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-476 1.42e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 70.59  E-value: 1.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrSPRDSSRSGEKLELamSNLTADVLELLLEF 438
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF--SSQEIWISSHVLEL--PDLKAEVFAEILNF 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKfqfhtfcKVCVSFLEK 476
Cdd:cd18223    77 IYSSKVVVKRQETVTDLVAAGK-------KLGITFLEN 107
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 353-478 2.32e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 70.45  E-value: 2.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 353 EFTDpwHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrspRDSSRSGEKLELAMSNLTADVL 432
Cdd:cd18325     2 EFPD--HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFY----RDQLDKRDIVHLNSDIVTAPAF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 433 ELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL-EKQL 478
Cdd:cd18325    76 SLLLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLkDKEL 122
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-470 2.65e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 69.78  E-value: 2.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSprdssrSGEKLELAMSNLTADVLELLLEF 438
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDT------EDNIVFLDQSQVSADGFQKLLEF 74

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18217    75 IYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 362-478 3.21e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 69.98  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 362 EMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELAMSNLTAdvLELLLEFVYT 441
Cdd:cd18201     7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHLDVVAVQG--FSVILDFMYS 84

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 442 GSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18201    85 GNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 356-478 3.23e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 70.14  E-value: 3.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 356 DPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrspRDSSRSGEKlELAMSNLTADVLELL 435
Cdd:cd18339     1 NPAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFT---GDMSESKAK-KIEIKDVDGQTLSKL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18339    77 IDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-486 3.56e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 70.25  E-value: 3.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLelamSNLTADVLELLLEF 438
Cdd:cd18271     7 HGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTI----SNLSPKAVKAFLDY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18271    83 AYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-486 4.85e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 69.69  E-value: 4.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18336     2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQE----EIKMEGVDPDALKALVHY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18336    78 AYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-483 6.65e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 69.50  E-value: 6.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIV---EGKEFEVHQNVLASCSLYFKDLIKrSPRDSSRSGeKLEL----AMSNLTADV 431
Cdd:cd18241     6 HCSELSWRQNEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLS-GQFSESRSG-RVEMrkwsSEPGPDPDT 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1944811768 432 LELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18241    84 VEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-472 8.78e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 68.72  E-value: 8.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGeklELAMSNLTADVLELLLEF 438
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEA---VVDLSGFCKSSFLPLLEF 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVS 472
Cdd:cd18202    79 AYTSELTFDFCSMAEVAMLARHLFMNEVLEICES 112
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 478-573 1.51e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 67.19  E-value: 1.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|....*..
gi 1944811768 558 IRAQYAAELLA-VVRLP 573
Cdd:cd18483    81 KREMHLPEIFAkCIRMP 97
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-476 1.90e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 67.56  E-value: 1.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSprdssrsgEKLELAMSNLTADVLELLL 436
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD--------NLIHLDQDMVSPTVFQQIL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1944811768 437 EFVYTGSLiIDSA----NAKTLLEAASKFQFHTFCKVCVSFLEK 476
Cdd:cd18216    73 DFIYTGKL-LDSLfeepNLSEVLAAANYLQLPDLAALCRSKLKR 115
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 353-480 1.98e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 68.53  E-value: 1.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 353 EFTDpwHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrsprDSSRSGEKLELAMSNLTADVL 432
Cdd:cd18324     2 EFPD--HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYK----DQLDKRDIVHLNSDIVTAPAF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 433 ELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTA 480
Cdd:cd18324    76 ALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATT 123
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-477 2.88e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 66.92  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 360 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFV 439
Cdd:cd18247     3 PSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQD----EITMQGIEPSALEALINFA 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1944811768 440 YTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 477
Cdd:cd18247    79 YSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-470 3.65e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 66.60  E-value: 3.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEklelaMSNLTADVLELLLEF 438
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIE-----IDFLRSDIFEEVLNY 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18204    76 MYTAKISVKKEDVNLMMSSGQILGIRFLDKLC 107
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-458 4.93e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 66.36  E-value: 4.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQR-RAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSrsgekleLAMSNLTADVLELLLE 437
Cdd:cd18226     4 YNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDA-------VTLDHVSYSVFQHLLE 76

                          90       100
                  ....*....|....*....|.
gi 1944811768 438 FVYTGSLIIDSANAKTLLEAA 458
Cdd:cd18226    77 FLYTSEFFVYENEIPLVLEAA 97
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-460 5.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 66.45  E-value: 5.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELAMSnLTADVLEL---- 434
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQ-SPERVLELpgvk 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 435 ------LLEFVYTGSLIIDSANAKTLLEAASK 460
Cdd:cd18195    80 agvfsdVLNFIYSSRVALPGSAAAKELGAAGK 111
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-486 5.29e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 66.62  E-value: 5.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18337     6 HAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQE----EIKMEGVEPNALWALVQY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18337    82 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 478-572 5.36e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 65.55  E-value: 5.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18516     1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQE 80

                          90
                  ....*....|....*
gi 1944811768 558 IRAQYAAELLAVVRL 572
Cdd:cd18516    81 ERTKALPVLLESIRF 95
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 481-580 5.58e-13

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 65.96  E-value: 5.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 481 SNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAIRA 560
Cdd:cd18466     4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                          90       100
                  ....*....|....*....|
gi 1944811768 561 QYAAELLAVVRLPFIHPSYL 580
Cdd:cd18466    84 KHVVEVLEPVRFPLLPPQRL 103
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-484 7.05e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 66.53  E-value: 7.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEF 438
Cdd:cd18261    11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVES----EADEVNLHGVTSLGLKQALDF 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 484
Cdd:cd18261    87 AYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 353-481 7.35e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 66.38  E-value: 7.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 353 EFtdPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrspRDSSRSGEKLELAMSNLTADVL 432
Cdd:cd18194     2 EF--PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFY----RDRLDKRDLVRLNSDIVTAPAF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 433 ELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 481
Cdd:cd18194    76 GLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAE 124
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 479-571 7.45e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 65.42  E-value: 7.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 479 TASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAAI 558
Cdd:cd18455     1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                          90
                  ....*....|...
gi 1944811768 559 RAQYAAELLAVVR 571
Cdd:cd18455    81 RKVHLKDLMSSCW 93
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 352-474 9.58e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 65.74  E-value: 9.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 352 YEFTDPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYF-KDLIKRSPRDssrsgekLELAM-SNLTA 429
Cdd:cd18278     7 YVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFlQALVGQTEND-------LVVSLpEEVTA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 430 DVLELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18278    80 RGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-472 1.79e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 64.85  E-value: 1.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgekleLAMSNLTADVLELLLEF 438
Cdd:cd18224     9 HPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVART-----YVVDFITPANFEKVLSF 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVS 472
Cdd:cd18224    84 IYTSELFTDLINVGVIYEVAEKLGMEDLLKACHS 117
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 352-490 2.24e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 65.30  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 352 YEFTDpwHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeKLELAMSNLTAdv 431
Cdd:cd18266     3 YRWAD--HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQK--EVELVGASYIG-- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 432 LELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGILAMA 490
Cdd:cd18266    77 LKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 376-462 3.51e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 62.95  E-value: 3.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPrdssrSGEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLL 455
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETP-----PDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLL 75


                  ....*..
gi 1944811768 456 EAASKFQ 462
Cdd:cd18315    76 KLAELLQ 82
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-474 3.87e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 64.30  E-value: 3.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrSPRDSSRSGEKLELAMSNLTADVLELLL 436
Cdd:cd18196     2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALF--TVAEGDQTMNMIQLDSEVVTAEAFAALI 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18196    80 DMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 374-482 4.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 63.45  E-value: 4.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 374 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTG---SLIIDSAN 450
Cdd:cd18297    10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTP----VIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDD 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 451 AKTLLEAASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18297    86 ALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 353-492 5.99e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 63.69  E-value: 5.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 353 EFtdPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrsprdssRSGEKLELAMSN---LTA 429
Cdd:cd18323     2 EF--PDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYK-------EQLDKRDLVCINneiVTA 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1944811768 430 DVLELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCvsflEKQLTASnclgilAMAEA 492
Cdd:cd18323    73 PAFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC----KKRLQAR------ALAEA 125
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 352-470 8.26e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 63.45  E-value: 8.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 352 YEFTDPWHPKEMLKELNQQRR-AKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDssrSGEKLELAMSNLTAD 430
Cdd:cd18207     2 YTYQVSQHSADMLHNLNQQRKsGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGD---GGTPRELEMHTISSK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1944811768 431 VLELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18207    79 VFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-462 1.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 62.50  E-value: 1.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPrdsSRSGEKLELAMSNLTADVLELLLEFVYTG 442
Cdd:cd18293     2 AFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEP---PPAGQKVVLELQGLKAHTLLKLVDFLYTS 78

                          90       100
                  ....*....|....*....|
gi 1944811768 443 SLIIDSANAKTLLEAASKFQ 462
Cdd:cd18293    79 ELEVSSEEAQDVLAAARRLQ 98
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-475 1.19e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 62.22  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSprdSSRSGEKLELAMSNLTAdvLELLLEF 438
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNS---SSQKNDVFHLDIKNVGG--IGQILDF 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18233    76 MYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-462 1.41e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 62.33  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEklelAMSNLTadvLELLLEF 438
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEIE----GVSNMA---FRHLIEF 73

                          90       100
                  ....*....|....*....|....*
gi 1944811768 439 VYTGSLII-DSANAKTLLEAASKFQ 462
Cdd:cd18221    74 TYTAKLMVqGEEEANDVWKAAEYLQ 98
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 356-445 1.41e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 61.77  E-value: 1.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 356 DPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsprdsSRSGEKLELamSNLTADVLELL 435
Cdd:cd18219     1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLF-------SVAGQVVEL--NFIRADIFAEI 71

                          90
                  ....*....|
gi 1944811768 436 LEFVYTGSLI 445
Cdd:cd18219    72 LNYIYSSKIV 81
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 374-470 1.70e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 61.21  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 374 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSrsgeKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKT 453
Cdd:cd18314     4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESN----LKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                          90
                  ....*....|....*..
gi 1944811768 454 LLEAASKFQFHTFCKVC 470
Cdd:cd18314    80 LLMLASKYQVPDLEKLC 96
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-474 1.72e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 62.01  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDlikrspRDSSRSGEKLELAM-SNLTADVLELLLE 437
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHS------RIVGQADAELNITLpEEVTVKGFEPLIQ 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 438 FVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18277    84 FAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-478 2.03e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 62.36  E-value: 2.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18246    22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQT----HVTLHDIDPQALEQLVQY 97

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18246    98 AYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-486 4.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 61.21  E-value: 4.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEF 438
Cdd:cd18335     2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQE----EIKMEGIDPNALWDLVQF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18335    78 AYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 479-533 6.89e-11

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 58.06  E-value: 6.89e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1944811768 479 TASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSN 533
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 378-474 7.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 59.40  E-value: 7.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 378 DLKIIVEGKEFEVHQNVLASCSLYFkdlikrSPRDSSRSGEKLELAM-SNLTADVLELLLEFVYTGSLIIDSANAKTLLE 456
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYF------LSRVVGQTDGDLVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCR 76

                          90
                  ....*....|....*...
gi 1944811768 457 AASKFQFHTFCKVCVSFL 474
Cdd:cd18955    77 CAEFLGVHNIEKACFDFL 94
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-462 8.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 60.43  E-value: 8.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsprdSSRSGEKLELAmSNLTADVLELLLEFVYTG 442
Cdd:cd18289    16 VLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF------SGNSKSAFELP-ATVPPACFQQILSFCYTG 88

                          90       100
                  ....*....|....*....|
gi 1944811768 443 SLIIDSANAKTLLEAASKFQ 462
Cdd:cd18289    89 KLTMAASEQLVVMYTAGFLQ 108
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 356-482 8.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 60.44  E-value: 8.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 356 DPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSprdssrsgeklELAMSNLTADVLELL 435
Cdd:cd18243    12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-----------NLVLQGCSSIGLRLV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18243    81 LEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 352-487 8.18e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 60.68  E-value: 8.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 352 YEFTDPWHPKEMLKELNQQRRAKE-FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDssrsGEKLELAMSNLTAD 430
Cdd:cd18272     7 YTFTDRSHSSRVAQSIMDLCLEDGlFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKE----ARNRVIELKDVSES 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1944811768 431 VLELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGIL 487
Cdd:cd18272    83 VFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-483 1.24e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 60.20  E-value: 1.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELamsnLTADVLELLLEF 438
Cdd:cd18264    11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPV----VSAAGLQRVLDF 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18264    87 IYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
Kelch smart00612
Kelch domain;
869-917 1.52e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.18  E-value: 1.52e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1944811768  869 KIYATGGIVSSEgpALGNMEAYDPKTNTWTLLPNMPCPVFRHGCVVIKK 917
Cdd:smart00612   1 KIYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 354-483 1.99e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 59.43  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 354 FTDPWHPKEMLKELNQQRRAKEFTDLKIIVEGKE--FEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADV 431
Cdd:cd18239     1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKEQ----ELMCIKLHGVSKIG 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1944811768 432 LELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18239    77 LKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 353-470 2.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 59.06  E-value: 2.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 353 EFtdPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKdLIKRSPRDSSRSGEKLELAMsnLTADVL 432
Cdd:cd18956     2 EF--PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGDI--VTAPAF 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1944811768 433 ELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18956    77 GRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 719-764 2.60e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.47  E-value: 2.60e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1944811768 719 PRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTITNQWETIAPLP 764
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 858-904 2.76e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.08  E-value: 2.76e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 858 RQFCSAVVLDGKIYATGGIVSSEgpALGNMEAYDPKTNTWTLLPNMP 904
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 481-555 2.93e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 57.33  E-value: 2.93e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1944811768 481 SNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKD 555
Cdd:cd18480     4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHD 78
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 380-461 3.16e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 57.29  E-value: 3.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 380 KIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLLEAAS 459
Cdd:cd01165     2 VLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQA----EINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAAN 77


                  ..
gi 1944811768 460 KF 461
Cdd:cd01165    78 FL 79
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-475 3.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 58.41  E-value: 3.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKD--LIKRSPRdssrsgeklELAMSNLTADVLELLLEFVY 440
Cdd:cd18227    12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDqvLLKNSRR---------IVLPDVMNPRVFENILLSCY 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1944811768 441 TGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18227    83 TGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-473 7.99e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 56.74  E-value: 7.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrSPRDSSRSGE-KLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTL 454
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLI--SSNDMKATDElSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDL 78

                          90
                  ....*....|....*....
gi 1944811768 455 LEAASKFQFHTFCKVCVSF 473
Cdd:cd18307    79 LKGAKYFNIPRLKDHCVDF 97
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-476 8.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 57.22  E-value: 8.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSprdssrsgEKLELAMSNLTADVLELLL 436
Cdd:cd18333     2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHD--------NLINLDHEMVSPGIFRLIL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1944811768 437 EFVYTGSLI-IDSANAKTL---LEAASKFQFHTFCKVCVSFLEK 476
Cdd:cd18333    74 DYIYTGRLSeGDPGSEQNLgavLAAASYLQIPDLVALCKKKLKR 117
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 353-475 9.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 57.34  E-value: 9.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 353 EFTDPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFkdlikrspRDSSRSGEKLELAMSNL-TADV 431
Cdd:cd18220     2 QFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYF--------RDHSALSTMSGLSISVIkNPNV 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1944811768 432 LELLLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18220    74 FEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 361-474 1.04e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 56.87  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 361 KEMLKELNQqrraKEFTDLKIIV--EGKEFEVHQNVLASCSLYFKDLIKRSPrdsSRSGEKLELAMSNLTADVLELLLEF 438
Cdd:cd18294     3 ADMKSLINN----PEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGP---QKESTQSPLVLSDIEPEVFRAVLEF 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18294    76 IYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-464 1.06e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 56.75  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRsgekLELAMSNLTADVLELLL 436
Cdd:cd18192     2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQ----LNLSNMKISAECFDLIL 77

                          90       100
                  ....*....|....*....|....*...
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFH 464
Cdd:cd18192    78 QFMYLGKIMTAPSDFEQLKVAMNYLQLY 105
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-475 1.47e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 56.59  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFkdlikrspRDSSRSGEKLELAMSNL-TADVLELL 435
Cdd:cd18222     6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYF--------RDHMSLNEMSTVSISVIkNPTVFEQL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18222    78 LSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-458 1.84e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 56.34  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKrsprDSSRSGEKLELaMSNLTADVLELLLEF 438
Cdd:cd18212     6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA----DEGEVGQSIYM-LEGMVAETFGALLEF 80

                          90       100
                  ....*....|....*....|
gi 1944811768 439 VYTGSLIIDSANAKTLLEAA 458
Cdd:cd18212    81 IYTGCLQVGEKSLEQILATA 100
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-475 2.17e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 56.02  E-value: 2.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRsprdssRSGEKLELAM--SNLTADVLELLL 436
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSG------RVGEGVSVLTlpSGLEARGFQLLL 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLE 475
Cdd:cd18332    76 DFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-456 2.21e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 56.03  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSpRDSSRSGEKLELAmsnlTADVLELLLEF 438
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEK-ENESQSVFQLDFC----EPDAFENVLNY 75

                          90
                  ....*....|....*...
gi 1944811768 439 VYTGSLIIDSANAKTLLE 456
Cdd:cd18209    76 IYSSSLFVEKSSLAAVQE 93
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
846-904 2.46e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 59.40  E-value: 2.46e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 846 GNIKAGPNMNHSRQFCSAVVLDGKIYATGGIvsSEGPALGNMEAYDPKTNTWTLLPNMP 904
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL--SGGSASNSFEVYDPATNTWSELAPLP 57
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 374-484 3.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 55.75  E-value: 3.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 374 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPrdssrSGEKLELAMSNLTADVLELLLEFVYTG---SLIIDSAN 450
Cdd:cd18351    22 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKP-----SAENTCIEISYVKYHIFQLVMQYLYCGgteSLLIKNNE 96

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1944811768 451 AKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 484
Cdd:cd18351    97 IMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
PRK14131 PRK14131
N-acetylneuraminate epimerase;
717-832 4.28e-09

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 59.64  E-value: 4.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 717 TVPRCRHNSLVYDGKIYTIGGVGVAGN------VDHVERYDTITNQWE---TIAPLPKAVHSAAaTVCGGKIYVFGGVNE 787
Cdd:PRK14131   72 GGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVYKYDPKTNSWQkldTRSPVGLAGHVAV-SLHNGKAYITGGVNK 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 788 A---------GRAAG-------------------------VLqSYIPQTNSWSFI-ESPMIDNKYAPAVTLNGFIFILGG 832
Cdd:PRK14131  151 NifdgyfedlAAAGKdktpkdkindayfdkkpedyffnkeVL-SYDPSTNQWKNAgESPFLGTAGSAVVIKGNKLWLING 229
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 378-487 7.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 54.96  E-value: 7.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 378 DLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDssRSGEKLELamSNLTADVLELLLEFVYTGSLIIDSANAKTLLEA 457
Cdd:cd18244    32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRE--RDQDKIHL--KGLTATGFSHVLQFMYYGTIELSMLTVHEILQA 107

                          90       100       110
                  ....*....|....*....|....*....|
gi 1944811768 458 ASKFQFHTFCKVCVSFLEKQLTASNCLGIL 487
Cdd:cd18244   108 AMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 375-473 7.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 54.21  E-value: 7.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 375 EFTDLKIIVEGKEFEVHQNVLASCSLYFKDLI-KRSPRDSSRSgeKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKT 453
Cdd:cd18292    16 ELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsNDWWSESKQS--EIELVEDPECAAVFEKFLRYLYTGQISVNLETALP 93

                          90       100
                  ....*....|....*....|
gi 1944811768 454 LLEAASKFQFHTFCKVCVSF 473
Cdd:cd18292    94 LLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-476 8.35e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 54.09  E-value: 8.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDliKRSPRDSSRsgekleLAMSN-LTADVLELLLE 437
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHD--KLLLNDTNC------LVLPSvIEAAAFENLLQ 72

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1944811768 438 FVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 476
Cdd:cd18200    73 LIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 364-477 1.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 54.16  E-value: 1.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 364 LKELNQQRRAK-EFTDLKIIV--EGKEFEVHQNVLASCSLYFKDLIKRSprdssRSGEKLELAMSNLTADVLELLLEFVY 440
Cdd:cd18231     1 MDRLNEQRLFQpDLCDVDIVLvrQRSTFPAHKGVLAAYSQFFHSLFTQN-----KQLQRVELSLEALTSQGLQQILNFIY 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 441 TGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 477
Cdd:cd18231    76 TSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 375-486 1.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 54.62  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 375 EFTDLKIIVE-GKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELA----MSNLTADVLELLLEFVYTGSLiidSA 449
Cdd:cd18310    17 FYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRelipGGIVGYDAFMLVLSYLYSGRL---RL 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 450 NAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGI 486
Cdd:cd18310    94 VPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQI 130
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 361-470 1.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 53.71  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 361 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDlikrsprdssrsgeKLELAMSNLT------ADVLEL 434
Cdd:cd18229     3 KSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHD--------------KLLLGHSEIEvppvvpAQTVRQ 68

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1944811768 435 LLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18229    69 LVEFMYSGSLVVAQSEALQILTAASILQIKTVIDEC 104
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 364-484 1.39e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 53.66  E-value: 1.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 364 LKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGS 443
Cdd:cd18263     1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQS----VVQLPTIPAKDLRLLISFAYSGI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1944811768 444 LIIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 484
Cdd:cd18263    77 LHLSWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 363-482 1.73e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 53.36  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKI-IVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSrsgeklELAMSN-LTADVLELLLEFVY 440
Cdd:cd18311     1 FLQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDD------TLIMPNeLQADAVVPVINFMY 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1944811768 441 TGSLIIDSANAKTLLEAASKFQfhtfckvcVSFLEKQLTASN 482
Cdd:cd18311    75 TGQLEFEEKSYGKLLRTAKELN--------MTVLLKLLEAHR 108
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 374-463 2.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 53.01  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 374 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeKLELAMSNLTAdvLELLLEFVYTGSLI---IDSAN 450
Cdd:cd18287    20 EEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQS--EIELKDTNAEA--FKALLKYIYTGRLTltdLKEDV 95

                          90
                  ....*....|...
gi 1944811768 451 AKTLLEAASKFQF 463
Cdd:cd18287    96 LLDVLGLAHQYGF 108
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-473 2.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 52.95  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgekleLAMSNLT----ADVLEL 434
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNN--------VSVINLDpeiePEGFRI 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1944811768 435 LLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSF 473
Cdd:cd18215    74 LLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 354-470 2.44e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 53.34  E-value: 2.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 354 FTDPWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPrdssrsGEKLELAMSNLTADVLE 433
Cdd:cd18203     3 FQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNP------SSELQVSLMHSSRVVAD 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1944811768 434 LLLEfVYTGSLIIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18203    77 LLLS-CYTGALEFSVRDIVNYLTAASYLQMEHVVEKC 112
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-482 3.00e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 52.92  E-value: 3.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLL 455
Cdd:cd18279    18 FTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEES----KKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLL 93

                          90       100
                  ....*....|....*....|....*..
gi 1944811768 456 EAASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18279    94 AAADKYALERLKVMCEDALCSNLSVEN 120
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 478-556 3.65e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 51.35  E-value: 3.65e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18474     1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 374-484 4.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 52.93  E-value: 4.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 374 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELamSNLTADVLELLLEFVYTG---SLIIDSAN 450
Cdd:cd18350    22 KEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSKTIEI--SDIKYHIFQMLMQYLYYGgteSMEIPIAD 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1944811768 451 AKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCL 484
Cdd:cd18350   100 VLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-482 4.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 52.70  E-value: 4.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLL 455
Cdd:cd18343    21 FTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEES----KKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLL 96

                          90       100
                  ....*....|....*....|....*..
gi 1944811768 456 EAASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18343    97 AAADKYALERLKVMCEEALCNNLSVEN 123
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 378-443 4.52e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 51.52  E-value: 4.52e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1944811768 378 DLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLELAMSNLTADVLELLLEFVYTGS 443
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDVVHIEKVPPEIFEQLLQFIYTDT 85
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 478-551 6.05e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 50.46  E-value: 6.05e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKW 551
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 359-458 1.01e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 50.67  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDlikrspRDSSRSGEKLELAMsNLTADVLELLLEF 438
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRE------RLLGSNGPLPPLSL-EVTPVGWEAVLTF 73

                          90       100
                  ....*....|....*....|
gi 1944811768 439 VYTGSLIIDSANAKTLLEAA 458
Cdd:cd18262    74 AYTGVLGRNPATVGDILVAA 93
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-462 1.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 51.19  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsprdSSRSGEKLELAMSnLTADVLELLLEFVYTG 442
Cdd:cd18290    14 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF------NSSRSAVVELPAA-VQPQSFQQILSFCYTG 86

                          90       100
                  ....*....|....*....|
gi 1944811768 443 SLIIDSANAKTLLEAASKFQ 462
Cdd:cd18290    87 RLSMNVGDQFLLMYTAGFLQ 106
Kelch_6 pfam13964
Kelch motif;
858-906 1.88e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 48.49  E-value: 1.88e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 858 RQFCSAVVLDGKIYATGGIVSSeGPALGNMEAYDPKTNTWTLLPNMPCP 906
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNA-SPALNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 360-478 3.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 50.24  E-value: 3.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 360 PKEMLKELNQQRRAKEFTDLKIIVE----GKEFEVHQNVLASCSLYFKDLIKrspRDSSRSGEKLELAMSNLTADVLELL 435
Cdd:cd18211     9 PSNLLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFL---NEKISDGKNTNVMLNEIYTADFASF 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1944811768 436 LEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCvSFLEKQL 478
Cdd:cd18211    86 LEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC-FQLKKQM 127
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-474 3.60e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 49.26  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRdssrsgeklELAMSNLTADVLELLLEF 438
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQ---------HYTLDFLSPKTFQQILEY 71

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18205    72 AYTATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
PRK14131 PRK14131
N-acetylneuraminate epimerase;
729-832 3.61e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 53.48  E-value: 3.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 729 DGKIYTigGVGVAGNVDHVERYDTITNQWETIAPLPKAVHS-AAATVCGGKIYVFGGVNEAGrAAGVLQ------SYIPQ 801
Cdd:PRK14131   38 NNTVYV--GLGSAGTSWYKLDLNAPSKGWTKIAAFPGGPREqAVAAFIDGKLYVFGGIGKTN-SEGSPQvfddvyKYDPK 114

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1944811768 802 TNSWSFI--ESPMIDNKYAPAVTLNGFIFILGG 832
Cdd:PRK14131  115 TNSWQKLdtRSPVGLAGHVAVSLHNGKAYITGG 147
Kelch_4 pfam13418
Galactose oxidase, central domain;
858-905 4.32e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.22  E-value: 4.32e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 858 RQFCSAVVL-DGKIYATGGIvSSEGPALGNMEAYDPKTNTWTLLPNMPC 905
Cdd:pfam13418   2 RAYHTSTSIpDDTIYLFGGE-GEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 357-474 4.76e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 49.44  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 357 PWHPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSprdssrsgEKLELAMSNLTADVLELLL 436
Cdd:cd18225     4 PNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDST--------DTISIDASVVSPEEFALLL 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1944811768 437 EFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18225    76 EMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-474 5.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 49.08  E-value: 5.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSprdssrsgEKLELAMSNLTADV----LEL 434
Cdd:cd18331     7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQ--------LKCNLSVINLDPEInpegFNI 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1944811768 435 LLEFVYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18331    79 LLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 377-482 6.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 49.01  E-value: 6.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 377 TDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLLE 456
Cdd:cd18352    14 SDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREK----EARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLR 89

                          90       100
                  ....*....|....*....|....*.
gi 1944811768 457 AASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18352    90 AADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-476 7.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 48.91  E-value: 7.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDssrsgekLELAmSNLTADVLELLLEFVYTG 442
Cdd:cd18208    12 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSD-------IEIP-SVVSVQSVQKLIDFMYSG 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1944811768 443 SLIIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 476
Cdd:cd18208    84 VLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
PHA02713 PHA02713
hypothetical protein; Provisional
 382-760 7.94e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 52.70  E-value: 7.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 382 IVEGKEFEVHQNVLASCSLYFKDLIKrSPRDSSRSGEKLELAMsnLTADVLELLLEFVYTGSliIDSANAKTLLEAASKF 461
Cdd:PHA02713   32 IGDGEEIKAHKTILAAGSKYFRTLFT-TPMIIRDLVTRVNLQM--FDKDAVKNIVQYLYNRH--ISSMNVIDVLKCADYL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 462 QFHTFCKVCVSFLEKQLTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKD---DFISymSNDSLNT 538
Cdd:PHA02713  107 LIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTDAFKKTVFEilfDIIS--TNDNVYL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 539 KAEELVYETVIKWIKKDAAIRAQYAAeLLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPhaRQ---- 614
Cdd:PHA02713  185 YREGYKVTILLKWLEYNYITEEQLLC-ILSCIDIQNLDKKSRLLLYSNKTINMYPSCIQFLLDNKQNRNIIP--RQlclv 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 615 ---------------------EMQTPRTRPR-----LSAGVAEVIVLVGGRQMigmNQRALTAVTCLNPQNNKWYPLASL 668
Cdd:PHA02713  262 chdtkynvcnpcilvynintmEYSVISTIPNhiinyASAIVDNEIIIAGGYNF---NNPSLNKVYKINIENKIHVELPPM 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 669 pFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTIGG---------VG 739
Cdd:PHA02713  339 -IKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidytsVH 417

                         410       420       430
                  ....*....|....*....|....*....|
gi 1944811768 740 VAGNVD---------HVERYDTITNQWETI 760
Cdd:PHA02713  418 HMNSIDmeedthssnKVIRYDTVNNIWETL 447
PLN02153 PLN02153
epithiospecifier protein
 719-919 8.69e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.91  E-value: 8.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 719 PRCRHNSLVYDGKIYTIGGVGVAGnvDHVER----YDTITNQWeTIAP----LPK-AVHSAAATVCGGKIYVFGGVNEAg 789
Cdd:PLN02153   22 PRCSHGIAVVGDKLYSFGGELKPN--EHIDKdlyvFDFNTHTW-SIAPangdVPRiSCLGVRMVAVGTKLYIFGGRDEK- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 790 RAAGVLQSYIPQTNSWSFIESpmIDNKYAP-AVTLNG------FIFILGGAyARATTIYDPEK------GNIKAG----- 851
Cdd:PLN02153   98 REFSDFYSYDTVKNEWTFLTK--LDEEGGPeARTFHSmasdenHVYVFGGV-SKGGLMKTPERfrtieaYNIADGkwvql 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 852 --PNMN-HSRQFCSAVVLDGKIYATGGIVSSEGPALGN------MEAYDPKTNTWTLLPNMPC-----PVFRHGcvVIKK 917
Cdd:PLN02153  175 pdPGENfEKRGGAGFAVVQGKIWVVYGFATSILPGGKSdyesnaVQFFDPASGKWTEVETTGAkpsarSVFAHA--VVGK 252


                  ..
gi 1944811768 918 YI 919
Cdd:PLN02153  253 YI 254
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-474 9.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 48.66  E-value: 9.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgEKLELAMSNLTADVLELLLEF 438
Cdd:cd18251     6 HSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREM----QQTEVLIHGVSYNAMCKILDF 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18251    82 IYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 375-474 1.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 48.05  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 375 EFTDLKIIVEGKEFEVHQNVLASCSlYFKDLIKRSPRDSSRSGEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTL 454
Cdd:cd18305    14 ENSDITICALGREWKLHKIYLCQSG-YFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSLYRDEIEIKPSRVVSI 92

                          90       100
                  ....*....|....*....|
gi 1944811768 455 LEAASKFQFHTFCKVCVSFL 474
Cdd:cd18305    93 LAAATLLQLDGLIQQCSEVM 112
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-474 1.67e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 47.53  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKD--LIKRSPRDSsrsgekLELAMSNLTadvLELLLEFVY 440
Cdd:cd18210     8 LLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDqvLLKNMSSIS------LPGVMDPGA---FESVLASAY 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1944811768 441 TGSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18210    79 TGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 376-478 2.63e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 47.29  E-value: 2.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKL-ELAMSNLTADVLELLLEFVYTGSLIIDSANAKTL 454
Cdd:cd18296    17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNGSIpVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                          90       100
                  ....*....|....*....|....
gi 1944811768 455 LEAASKFQFHTFCKVCVSFLEKQL 478
Cdd:cd18296    97 LYVADMYLLPGLKRLCGTVLAQSL 120
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 478-571 3.34e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 46.34  E-value: 3.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPE-VANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDA 556
Cdd:cd18482     1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                          90
                  ....*....|....*
gi 1944811768 557 AIRAQYAAELLAVVR 571
Cdd:cd18482    81 KERAASAAEVLKCVR 95
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 482-573 4.13e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 45.88  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 482 NCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDaAIRAQ 561
Cdd:cd18449     5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                          90
                  ....*....|..
gi 1944811768 562 YAAELLAVVRLP 573
Cdd:cd18449    84 FAAKLMENIRFP 95
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 478-575 4.43e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 46.06  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18465     1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80

                          90
                  ....*....|....*...
gi 1944811768 558 IRAQyAAELLAVVRLPFI 575
Cdd:cd18465    81 RRAS-ASHVLCHIRFPLM 97
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 87-287 4.59e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  87 STNRPGLLPLPIVPSRLPtPATAACTTGNSDVITSLVANSSPASTTKAPCISKTENQPQGLATSVRWGQTPINQSTPwDT 166
Cdd:pfam03154 259 SQVSPQPLPQPSLHGQMP-PMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQL-QS 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 167 DEPPskqmRENENPGAA--------PWVTTVAAGSQPALITHSYGMTQPPTFSPAANVQAP-VIGVTPSLPPHVTPQ--- 234
Cdd:pfam03154 337 QQPP----REQPLPPAPlsmphikpPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPpALKPLSSLSTHHPPSahp 412

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1944811768 235 --LPLMPAHYQLQPQPSQPlsnmvvnlqsqPLYTNSQPLSMPSMSGVGPVA-HPGP 287
Cdd:pfam03154 413 ppLQLMPQSQQLPPPPAQP-----------PVLTQSQSLPPPAASHPPTSGlHQVP 457
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 478-572 4.69e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 46.02  E-value: 4.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18470     1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQK 80

                          90
                  ....*....|....*
gi 1944811768 558 iRAQYAAELLAVVRL 572
Cdd:cd18470    81 -RVKYAADLLSNIRF 94
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-470 5.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 46.09  E-value: 5.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSlyfkdliKRSPRDSSRSGEKLELAMSNLTADVLELLLEF 438
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGAS-------QQLGRQLTNPNPGQWCLGEGISPSTFKQLLDF 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18218    74 VYGESVEVQPGELRPLLEAARALEVESLEEAC 105
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 361-463 8.00e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 45.28  E-value: 8.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 361 KEMLKELNQQRrakeFTDLKIIVEGKE-FEVHQNVLASCSLYFKDLIkrsprdssrsGEKLELAMSNL-TADVLELLLEF 438
Cdd:cd18299     1 EDLRNLLHSPS----CADVVFILQGGVrIFAHRIVLAAASSVFADLF----------LMMTVVTLDSDiTPEAFRRVLEF 66

                          90       100
                  ....*....|....*....|....*
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQF 463
Cdd:cd18299    67 LYTGVLDENEDDLKELKDAAELLEL 91
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-482 8.18e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 46.25  E-value: 8.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLL 455
Cdd:cd18342    22 FTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKN----RVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLL 97

                          90       100
                  ....*....|....*....|....*..
gi 1944811768 456 EAASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18342    98 AAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 375-461 8.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 45.78  E-value: 8.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 375 EFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrspRDSSRSGEKLELAMSNLTADVLELLLEFVYTGSLI--------- 445
Cdd:cd18280    13 EGADVTFNVDGEKFRAHKLVLAARSPVFRSML----FGPMREENEGEIVIEDVEPPVFKALLHFIYKDELPddvepagsd 88

                          90
                  ....*....|....*....
gi 1944811768 446 ---IDSANAKTLLEAASKF 461
Cdd:cd18280    89 sssLDTTMAQHLLAAADRY 107
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 57-287 9.06e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.77  E-value: 9.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  57 DYRAGWDRRDWSSNGNhvgstNCSSAASTTSTNRPG---LLPLPIVPSRLPTPATAAC---TTGNSDVITSLVANSSPAS 130
Cdd:pfam03154  29 DGRASPTNEDLRSSGR-----NSPSAASTSSNDSKAesmKKSSKKIKEEAPSPLKSAKrqrEKGASDTEEPERATAKKSK 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 131 TTKapcISKTENQPQGLATSVrwGQTPINQ---STPWDTDE------PPSKQMRENENPGAAPWVTTVAAGSQPALITHS 201
Cdd:pfam03154 104 TQE---ISRPNSPSEGEGESS--DGRSVNDegsSDPKDIDQdnrstsPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQS 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 202 yGMTQPPTFSPAANVQAPVIGVTP---SLPPHVTP---QLPLMPA---------------HYQLQPQPSQPLSNMV---- 256
Cdd:pfam03154 179 -GAASPPSPPPPGTTQAATAGPTPsapSVPPQGSPatsQPPNQTQstaaphtliqqtptlHPQRLPSPHPPLQPMTqppp 257

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1944811768 257 ---VNLQSQP---LYTNSQPLSMPSMSGVGPVAHPGP 287
Cdd:pfam03154 258 psqVSPQPLPqpsLHGQMPPMPHSLQTGPSHMQHPVP 294
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 65-335 9.97e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.19  E-value: 9.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  65 RDWSSNGNHVGSTNCSSAASTTSTNRPgllPLPIVPSRLPTPATAACTTGNSDVITSLVANSSPASTTKAPCISKTenQP 144
Cdd:pfam17823 176 RTAASSTTAASSTTAASSAPTTAASSA---PATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTV--TP 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 145 QGLATSVRWGQT------PINQSTPWDTDEPPSKQMRENEnpgaapwvttvaagsqpalithsygMTQPPTFSPAANVQA 218
Cdd:pfam17823 251 AALATLAAAAGTvasaagTINMGDPHARRLSPAKHMPSDT-------------------------MARNPAAPMGAQAQG 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 219 PVIGVTPSLPPHVTPQLPlMPAHYQLQPQPSQPLSNMVVNL------QSQPLYTNSQPLSMPSMS------GVGPVAHPG 286
Cdd:pfam17823 306 PIIQVSTDQPVHNTAGEP-TPSPSNTTLEPNTPKSVASTNLavvtttKAQAKEPSASPVPVLHTSmipeveATSPTTQPS 384

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1944811768 287 P-----GAVGNGHLACPmlpppppalpsaaLPSSAPTTNGQAAAPLPPNTAGGP 335
Cdd:pfam17823 385 PllptqGAAGPGILLAP-------------EQVATEATAGTASAGPTPRSSGDP 425
PHA03247 PHA03247
large tegument protein UL36; Provisional
 82-298 1.06e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768   82 AASTTSTNRPGLlPLPIVPSRLPTPATAACTTgnsdvitsLVANSSPASTTKAPciskTENQPQGLATSvrwgQTPINQS 161
Cdd:PHA03247  2787 AVASLSESRESL-PSPWDPADPPAAVLAPAAA--------LPPAASPAGPLPPP----TSAQPTAPPPP----PGPPPPS 2849

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  162 TPWDTDEPPSKQMRENENPGAAPwvTTVAAGSQPALITHSYGMTQPPTFSPAANVQAPVIGVTPSLPPHVTPQlPLMPAH 241
Cdd:PHA03247  2850 LPLGGSVAPGGDVRRRPPSRSPA--AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ-PQPPPP 2926

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1944811768  242 YQLQPQPSQPlsnmvvNLQSQPLYTNSQPLSMPSMSGVGPvaHPGPGAVGNGHLACP 298
Cdd:PHA03247  2927 PQPQPPPPPP------PRPQPPLAPTTDPAGAGEPSGAVP--QPWLGALVPGRVAVP 2975
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 373-487 1.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 44.79  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 373 AKEFTDLKIIVEGKEFEVHQNVLASCSLYFKdliKRSPRDSsrsgekleLAMSNLTADVLELLLEFVYTGSLIIDSANAK 452
Cdd:cd18275     1 PLGEPDLVIEVSGQRIRAHKSVLAAKSDYFR---ARLSRDI--------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVV 69

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1944811768 453 TLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGIL 487
Cdd:cd18275    70 EVVAGARFLQMPCAAQCAVDAVRAQLCLGNCYEVL 104
Kelch smart00612
Kelch domain;
685-730 1.58e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 1.58e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1944811768  685 IYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDG 730
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
719-766 1.91e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 1.91e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 719 PRCRHNSLVYDGKIYTIGGVGVAGN-VDHVERYDTITNQWETIAPLPKA 766
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-483 2.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 44.62  E-value: 2.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFkdlikrSPRDSSRSGEkleLAMSNLTADVLELLLEFVYTGsLIIDSANAKTLL 455
Cdd:cd18303    18 YSDITIKLADKSIPAHKFVLAARSEKW------SNENLASTNE---LDLSDISYEVVLALLRWLYTD-ELDLTLDDEFLL 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1944811768 456 E---AASKFQFHTFCKVCVSFLEKQLTASNC 483
Cdd:cd18303    88 ElmkAAKRFQLTDLVERCERALMSSVNVDNC 118
Kelch smart00612
Kelch domain;
731-777 2.28e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.55  E-value: 2.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1944811768  731 KIYTIGGVGvaGNVDH--VERYDTITNQWETIAPLPKAVHSAAATVCGG 777
Cdd:smart00612   1 KIYVVGGFD--GGQRLksVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA03247 PHA03247
large tegument protein UL36; Provisional
 83-287 2.57e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 2.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768   83 ASTTSTNRPGllPLPIVPSRLPTPATAActtgnsdVITSLVANSSPASTTKAPCISKTENQPQGLATSVrwgqTPINQST 162
Cdd:PHA03247  2693 GSLTSLADPP--PPPPTPEPAPHALVSA-------TPLPPGPAAARQASPALPAAPAPPAVPAGPATPG----GPARPAR 2759

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  163 PWDTDEPPSKQmrenenPGAAPWVTTVAAGSQPALITHSYGMTQPPTFSPAANVQAPVIGVTPSLPPHVTPQLPLMPAHY 242
Cdd:PHA03247  2760 PPTTAGPPAPA------PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1944811768  243 QLQPQPSQPlsnmvvnlqSQPLytnsqPLSMPSMSGV---GPVAHPGP 287
Cdd:PHA03247  2834 AQPTAPPPP---------PGPP-----PPSLPLGGSVapgGDVRRRPP 2867
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 478-554 2.99e-05

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 43.76  E-value: 2.99e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNIS--KDDFISyMSNDSLNTKAEELVYETVIKWIKK 554
Cdd:cd18502     1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPrlQIEVIL-ESNQELESINERKLCQLVLEWVQR 78
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 719-763 5.65e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 41.17  E-value: 5.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 719 PRCRHNSLVYDGKIYTIGGVGVAGN--VDHVERYDTITNQWETIAPL 763
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDlsSSDVLVYDPETNVWTEVPRL 47
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 478-565 8.70e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 42.25  E-value: 8.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 478 LTASNCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIKKDAA 557
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                  ....*...
gi 1944811768 558 IRAQYAAE 565
Cdd:cd18451    81 ERERYFEE 88
PLN02193 PLN02193
nitrile-specifier protein
 678-835 8.76e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.10  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 678 VVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNL---VSRMTVPRCRHNSLVYDGKIYTIGGVGVAGNVDHVERYDTIT 754
Cdd:PLN02193  224 MVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLltpVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 755 NQW---ETIAPLPKAVHSAAATVCGGKIYVFGGVNeaGRAAGVLQSYIPQTNSWSFIES----PMIDNKYAPAVtLNGFI 827
Cdd:PLN02193  304 KKWfhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFN--GCEVDDVHYYDPVQDKWTQVETfgvrPSERSVFASAA-VGKHI 380


                  ....*...
gi 1944811768 828 FILGGAYA 835
Cdd:PLN02193  381 VIFGGEIA 388
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 482-553 8.98e-05

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 41.56  E-value: 8.98e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1944811768 482 NCLGILAMAEAMQCTELYNMAKAYALQIFPEVANQEEILNISKDDFISYMSNDSLNTKAEELVYETVIKWIK 553
Cdd:cd18503     5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTE 76
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-482 9.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 42.91  E-value: 9.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLL 455
Cdd:cd18345    18 FSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQN----RVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLL 93

                          90       100
                  ....*....|....*....|....*..
gi 1944811768 456 EAASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18345    94 AAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-482 9.54e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 43.02  E-value: 9.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 376 FTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSGEKLElamsNLTADVLELLLEFVYTGSL--IIDSANAKT 453
Cdd:cd18344    23 FTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIH----DLDPQVFKEMMGFIYTGKAphLHSHSMACD 98

                          90       100
                  ....*....|....*....|....*....
gi 1944811768 454 LLEAASKFQFHTFCKVCVSFLEKQLTASN 482
Cdd:cd18344    99 VLAAADKYGLEGLKVLCEDALCRNLSVEN 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 768-812 1.01e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.67  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 768 HSAAATVCGGKIYVFGGVNEAGRAAGVlQSYIPQTNSWSFIESPM 812
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSV-EVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
768-814 1.25e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 1.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1944811768 768 HSAAAtvCGGKIYVFGGVNEAGRAAGVLQSYIPQTNSWSFIESPMID 814
Cdd:pfam13964   5 HSVVS--VGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
719-764 1.35e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 40.29  E-value: 1.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 719 PRCRHnSLVY--DGKIYTIGGVGVAGNV-DHVERYDTITNQWETIAPLP 764
Cdd:pfam13418   1 PRAYH-TSTSipDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTRLGSLP 48
PLN02153 PLN02153
epithiospecifier protein
 678-832 1.64e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.98  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 678 VVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTV---PRCR--HNSLVYDGKIYTIGGVGVAGNVDHVERYDT 752
Cdd:PLN02153   81 MVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEeggPEARtfHSMASDENHVYVFGGVSKGGLMKTPERFRT 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 753 IT------NQWETIaPLP----KAVHSAAATVCGGKIYVFGGVNEAGRAAG-------VLQSYIPQTNSWSFIES----P 811
Cdd:PLN02153  161 IEayniadGKWVQL-PDPgenfEKRGGAGFAVVQGKIWVVYGFATSILPGGksdyesnAVQFFDPASGKWTEVETtgakP 239

                         170       180
                  ....*....|....*....|.
gi 1944811768 812 MIDNKYAPAVtLNGFIFILGG 832
Cdd:PLN02153  240 SARSVFAHAV-VGKYIIIFGG 259
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 377-444 1.89e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 41.16  E-value: 1.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1944811768 377 TDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPrdssrsGEKLELAMSNLTADV----LELLLEFVYTGSL 444
Cdd:cd18283     3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSP------GYGAEIPVDLPTAGIdvpmFSALLRYLYTGEF 68
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-461 2.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 41.90  E-value: 2.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRsgekleLAMSNLTADVLELLLEFVYTG 442
Cdd:cd18193     8 LLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVR------LKPTDIQPDIFSYLLHLMYTG 81

                          90       100
                  ....*....|....*....|..
gi 1944811768 443 SL---IIDSANaktlLEAASKF 461
Cdd:cd18193    82 KMapqLIDPVR----LEQGIKF 99
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 378-476 2.28e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 41.47  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 378 DLKIIVEGKEFEVHQNVLASCSLYFkdliKRSPRDSSRSGEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTLLEA 457
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYF----RSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDL 89

                          90
                  ....*....|....*....
gi 1944811768 458 ASKFQFHTFCKVCVSFLEK 476
Cdd:cd18298    90 ANSYCEERLKKLCEDIIKQ 108
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 363-474 2.53e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 41.39  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 363 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFkdlikrspRDSSRSGEKLELAMSNL-TADVLELLLEFVYT 441
Cdd:cd18197    12 VLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFM--------RDQFLLNQSKQVRITILqSAEVGRKLLLSCYT 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1944811768 442 GSLIIDSANAKTLLEAASKFQFHTFCKVCVSFL 474
Cdd:cd18197    84 GALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
Kelch_3 pfam13415
Galactose oxidase, central domain;
867-915 2.87e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 2.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 867 DGKIYATGGIVSSEGPALGNMEAYDPKTNTWTLLPNMPCPVFRHGCVVI 915
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 370-470 3.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 41.46  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 370 QRRAKEF-----TDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSsrsgekleLAMSNLTADVLELLLEFVYTGSL 444
Cdd:cd18354     9 ESLKREFdnpdtADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEI--------IEMSQFSYPVYRAFLEYLYTDSI 80

                          90       100
                  ....*....|....*....|....*.
gi 1944811768 445 IIDSANAKTLLEAASKFQFHTFCKVC 470
Cdd:cd18354    81 SLSPEDAIGLLDLATFYRENRLKKLC 106
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 375-458 3.46e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 41.09  E-value: 3.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 375 EFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSL-IIDSANAKT 453
Cdd:cd18286    16 EDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS----EITLTGVSHAAVSFVLLFIYGGVLdLPDDVNLGE 91


                  ....*
gi 1944811768 454 LLEAA 458
Cdd:cd18286    92 LLSLA 96
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
729-914 4.53e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.08  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 729 DGKIYtiggvgVAGNVDH-VERYDTITNQWETIA-PLPKAVHSAAATVCGGKIYVfggvneAGRAAGVLQSYIPQTNSWS 806
Cdd:COG4257    69 DGNLW------FTDNGNNrIGRIDPKTGEITTFAlPGGGSNPHGIAFDPDGNLWF------TDQGGNRIGRLDPATGEVT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 807 FIESPMIDNK-YAPAVTLNGFIFIL---GGAYARattiYDPEKGNIK--AGPN-MNHSRQFcsAVVLDGKIYatggIVSS 879
Cdd:COG4257   137 EFPLPTGGAGpYGIAVDPDGNLWVTdfgANAIGR----IDPDTGTLTeyALPTpGAGPRGL--AVDPDGNLW----VADT 206

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1944811768 880 EGPALGnmeAYDPKTNTWTLLPNMPCPVFRHGCVV 914
Cdd:COG4257   207 GSGRIG---RFDPKTGTVTEYPLPGGGARPYGVAV 238
PLN02193 PLN02193
nitrile-specifier protein
 719-898 6.08e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.41  E-value: 6.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 719 PRCRHNSLVYDGKIYTIGGVGVAGN-VD-HVERYDTITNQWeTIAPLPKAV-HSAAATVC----GGKIYVFGGvNEAGRA 791
Cdd:PLN02193  165 LRCSHGIAQVGNKIYSFGGEFTPNQpIDkHLYVFDLETRTW-SISPATGDVpHLSCLGVRmvsiGSTLYVFGG-RDASRQ 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 792 AGVLQSYIPQTNSWSFI----ESPMIDNKYAPAVTLNGfIFILGGAYARAT-------TIYDPEKGNIKAGPNMNHSRQF 860
Cdd:PLN02193  243 YNGFYSFDTTTNEWKLLtpveEGPTPRSFHSMAADEEN-VYVFGGVSATARlktldsyNIVDKKWFHCSTPGDSFSIRGG 321

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1944811768 861 CSAVVLDGKIYATGGIvssEGPALGNMEAYDPKTNTWT 898
Cdd:PLN02193  322 AGLEVVQGKVWVVYGF---NGCEVDDVHYYDPVQDKWT 356
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 375-441 8.63e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 40.04  E-value: 8.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1944811768 375 EFTDLKII-VEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgEKLELAMSnltADVLELLLEFVYT 441
Cdd:cd18302     4 DLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSC-SALTMPIP---SDILEIILDYLYT 67
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 374-462 1.07e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 39.53  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 374 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRSgeklELAMSNLTADVLELLLEFVYTGSL-IIDSANAK 452
Cdd:cd18300     7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAK----EVELPGVSKETFLALLEYLYTDQApILEDGDCV 82

                          90
                  ....*....|
gi 1944811768 453 TLLEAASKFQ 462
Cdd:cd18300    83 GLIVLANRLC 92
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 861-903 1.33e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.32  E-value: 1.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1944811768 861 CSAVVLDGKIYATGGIVSSEGPALGNMEAYDPKTNTWTLLPNM 903
Cdd:pfam07646   5 HASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEVPRL 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
729-774 2.31e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.88  E-value: 2.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1944811768 729 DGKIYTIGGVGVAGN--VDHVERYDTITNQWETIAPLPKAVHSAAATV 774
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
SP4_N cd22536
N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins ...
 69-252 2.43e-03

N-terminal domain of transcription factor Specificity Protein (SP) 4; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Human SP4 is a risk gene of multiple psychiatric disorders including schizophrenia, bipolar disorder, and major depression. SP4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP4.


Pssm-ID: 411773 [Multi-domain]  Cd Length: 623  Bit Score: 41.44  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768  69 SNGNHVGSTNCSSAASTTSTNRPgllplpivPSRLPTPATAACTTGNSDVITSLVANSSPASTtkAPCISKTENQPqgla 148
Cdd:cd22536   271 SNGNQLVSTPITTASVSTMPESP--------SSSTTCTTTASTSLTSSDTLVSSAETGQYAST--AASSERTEEEP---- 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 149 tsvrwgqtpinQSTPWDTDEPPSKQMREN---ENPGAAPWVTTVAAGSQPALITHsygMTQPPTFSPAANVQAPVIGVTP 225
Cdd:cd22536   337 -----------QTSAAESEAQSSSQLQSNglqNVQDQSNSLQQVQIVGQPILQQI---QIQQPQQQIIQAIQPQSFQLQS 402

                         170       180
                  ....*....|....*....|....*..
gi 1944811768 226 SLPPHVTPQLPLMPAHYQLQPQPSQPL 252
Cdd:cd22536   403 GQTIQTIQQQPLQNVQLQAVQSPTQVL 429
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 359-499 2.67e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 38.72  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 359 HPKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRsprdssRSGEKLELAMSNLTADVLELLLEF 438
Cdd:cd18213     4 HSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIH------QSSECIKIQPTDIQPDIFSYLLHI 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1944811768 439 VYTGSLIIDSANAKTLLEAASKFQFHTFCKVcvsflekqltaSNCLGILAMAEAMQCTELY 499
Cdd:cd18213    78 MYTGKGPKQSVDHSRLEEGIRFLHANYLSRI-----------ATEMNQDFSPETMQSSNLY 127
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 365-476 3.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 38.01  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 365 KELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSRsgEKLELamSNLTADVLELLLEFVYTGSL 444
Cdd:cd18353     9 ESLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMK--EVIEI--DQFSYPVYRAFLEYLYTDSV 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1944811768 445 IIDSANAKTLLEAASKFQFHTFCKVCVSFLEK 476
Cdd:cd18353    85 DLPPEDAIGLLDLATSYCENRLKKLCQHIIKR 116
Kelch smart00612
Kelch domain;
827-868 4.07e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 4.07e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1944811768  827 IFILGGaYARATT-----IYDPEKGNIKAGPNMNHSRQFCSAVVLDG 868
Cdd:smart00612   2 IYVVGG-FDGGQRlksveVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA02713 PHA02713
hypothetical protein; Provisional
 817-919 4.47e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 40.76  E-value: 4.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 817 YAPAVTLNGFIfILGGAYARATTIYDPEKGNIKAG-----PNMNHSRQFCSAVVLDGKIYATGGivsSEGPALG-NMEAY 890
Cdd:PHA02713  297 YASAIVDNEII-IAGGYNFNNPSLNKVYKINIENKihvelPPMIKNRCRFSLAVIDDTIYAIGG---QNGTNVErTIECY 372

                          90       100
                  ....*....|....*....|....*....
gi 1944811768 891 DPKTNTWTLLPNMPCPVFRHGCVVIKKYI 919
Cdd:PHA02713  373 TMGDDKWKMLPDMPIALSSYGMCVLDQYI 401
PRK14131 PRK14131
N-acetylneuraminate epimerase;
863-907 5.22e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.38  E-value: 5.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1944811768 863 AVVLDGKIYATGGI--VSSEGP--ALGNMEAYDPKTNTWTLLPNMPcPV 907
Cdd:PRK14131   80 AAFIDGKLYVFGGIgkTNSEGSpqVFDDVYKYDPKTNSWQKLDTRS-PV 127
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 375-458 6.50e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 37.31  E-value: 6.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1944811768 375 EFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSPRDSSrsgEKLELAMSNLTADVLELLLEFVYTGSLIIDSANAKTL 454
Cdd:cd18312     8 EPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDP---SEIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGL 84


                  ....
gi 1944811768 455 LEAA 458
Cdd:cd18312    85 RCAA 88
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 673-717 7.48e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 7.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1944811768 673 REFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 717
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
673-720 8.70e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 8.70e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1944811768 673 REFFSVVSAGDNIYLSGG-MESGVTLADVWCYmSLLDN-WNLVSRMTVPR 720
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVY-NPLTKsWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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