BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  18 FPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSEVVTAEAFAALID 97
Cdd:cd18196     1 FPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSEVVTAEAFAALID 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1943013793  98 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPLSP 143
Cdd:cd18196    81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSP 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  18 FPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSEVVTAEAFAALID 97
Cdd:cd18196     1 FPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSEVVTAEAFAALID 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1943013793  98 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPLSP 143
Cdd:cd18196    81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSP 126

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793   40 DCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSevVTAEAFAALIDMMYTSTLMLGESNVMDVLLAAS 119
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*
gi 1943013793  120 HLHLNSVVKACKHYL 134
Cdd:smart00225  79 YLQIPGLVELCEEFL 93

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 1943013793 641 KKHIRVHTGEKPYACLKCGKRFSQ 664
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  18 FPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSEVVTAEAFAALID 97
Cdd:cd18196     1 FPGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSEVVTAEAFAALID 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1943013793  98 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPLSP 143
Cdd:cd18196    81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPMSP 126

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  29 LNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDseVVTAEAFAALIDMMYTSTLMlGE 108
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD--DVSPEDFEALLEFMYTGKLI-SE 77

                          90       100
                  ....*....|....*....|....*...
gi 1943013793 109 SNVMDVLLAASHLHLNSVVKACKHYLTT 136
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  16 MDFPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRaLFTVAEGDQSmNMIQLDSEVVTAEAFAAL 95
Cdd:cd18324     1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFH-LFYKDQLDKR-DIVHLNSDIVTAPAFALL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1943013793  96 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPLSPPSERAQEQSA 153
Cdd:cd18324    79 LEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASS 136

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  16 MDFPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRaLFTVAEGDQSMNMIQLDSEVVTAEAFAAL 95
Cdd:cd18956     1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGDIVTAPAFGRL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1943013793  96 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPLSPP 144
Cdd:cd18956    80 LDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLREKDPALPRG 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  18 FPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDseVVTAEAFAALID 97
Cdd:cd18326     5 FPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEID--FVSAEALTALLD 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1943013793  98 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 134
Cdd:cd18326    83 FAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  17 DFPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTvaegDQSmNMIQLDseVVTAEAFAALI 96
Cdd:cd18206     1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV----DQK-DVVHLD--ISNAAGLGQVL 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1943013793  97 DMMYTSTLMLGESNVMDVLLAASHLHLNSVVKAC 130
Cdd:cd18206    74 EFMYTAKLSLSPENVDDVLAVATFLQMQDIVTAC 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  18 FPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDseVVTAEAFAALID 97
Cdd:cd18198     5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEID--FVSPEALTALLE 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1943013793  98 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKAC 130
Cdd:cd18198    83 FAYTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  20 GHFEQVFQQLNYQRLHGQLCDCVIVVGSRH----FKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLdsEVVTAEAFAAL 95
Cdd:cd18248     3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQDpkeeFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPI--EGVHPCVMSRL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1943013793  96 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 134
Cdd:cd18248    81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  18 FPGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDseVVTAEAFAALID 97
Cdd:cd18328     5 FPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEID--FVTPEALSAILE 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1943013793  98 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKAC 130
Cdd:cd18328    83 FAYTSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  19 PGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSevVTAEAFAALIDM 98
Cdd:cd18235     2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQD--VDGKALLLLIDY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1943013793  99 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 140
Cdd:cd18235    80 VYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  24 QVFQQLnyqRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSevVTAEAFAALIDMMYTST 103
Cdd:cd18240     6 NVFNEL---RLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPG--VSPEMMELIIEYAYTRT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1943013793 104 LMLGESNVMDVLLAASHLHLNSVVKACKHYLTTR 137
Cdd:cd18240    81 VPITAENVEELLPAADQFNIMGIVKACCDFLEDQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  27 QQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSEVVTAEAFAALIDMMYTSTLML 106
Cdd:cd18245     3 RALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKL 82

                          90       100
                  ....*....|....*....|....*...
gi 1943013793 107 GESNVMDVLLAASHLHLNSVVKACKHYL 134
Cdd:cd18245    83 SEDNIQDIVQAADLLLMTDLKDLCCEFL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFT-VAEGDQSMNMIQLDseVVTAEAFAALIDMM 99
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLShYIQDTGRPSTASFD--VFSSDAFSIILDFV 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1943013793 100 YTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 134
Cdd:cd18199    79 YSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFT--VAEGDQSmnmiQLDSEVVTAEAFAALIDM 98
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTgnLSEKENS----EVEFQCIDETALQAIVEY 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1943013793  99 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 134
Cdd:cd18257    77 AYTGTVFISQATVESLLPAANLLQIKLVLKECCDFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSevVTAEAFAALIDMMY 100
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDG--LDPDAVEVLVNYAY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1943013793 101 TSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPLS 142
Cdd:cd18306    79 TSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSevVTAEAFAALIDMMY 100
Cdd:cd18261    11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHG--VTSLGLKQALDFAY 88

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1943013793 101 TSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLT 135
Cdd:cd18261    89 TGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLI 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALF-------TVAEGDQSMNMIQLDSevVTAEAFA 93
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprLVLVSPAGKCVLDLHH--VTVTGFA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1943013793  94 ALIDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTL 139
Cdd:cd18228    80 PLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSIL 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFtvaeGDQSMNMIQLDSEVvtAEAFAALIDMMY 100
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY----GDGTSGSVVLPESF--AEVFGLLLDFFY 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1943013793 101 TSTLMLGESNVMDVLLAASHLHLNSVVKACKHY 133
Cdd:cd18232    75 TGELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTVAEGDQSMNMIQLDSevVTAEAFAALIDMMY 100
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHG--VEPDIFHILLDFIY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1943013793 101 TSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLPL 141
Cdd:cd18256    81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPS 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  19 PGHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTvaegdqSMNMIQLDSEVVTAEAFAALIDM 98
Cdd:cd18333     2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVV------HDNLINLDHEMVSPGIFRLILDY 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1943013793  99 MYTSTLMLG----ESNVMDVLLAASHLHLNSVVKACKHYL 134
Cdd:cd18333    76 IYTGRLSEGdpgsEQNLGAVLAAASYLQIPDLVALCKKKL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFT--VAEGDQSMNMIQLDSEvvtaEAFAALIDM 98
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVTIRDIDE----RAMELLIDF 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1943013793  99 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 134
Cdd:cd18249    82 AYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  21 HFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFTvAEGDQSMNMIQLDSEvVTAEAFAALIDMMY 100
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFT-DQLKNNVSVINLDPE-IEPEGFRILLDFMY 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1943013793 101 TSTLMLGESNVMDVLLAASHLHLNSVVKAC 130
Cdd:cd18215    80 TSRLNLREGNIMAVMATAMYLQMEHVVDTC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943013793  20 GHFEQVFQQLNYQRLHGQLCDCVIVVGSRHFKAHRSVLAACSTHFRALFtVAEGDQSMNMIQLDSEVVTAEAFAALIDMM 99
Cdd:cd18202     1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELF-IEKGAVSSHEAVVDLSGFCKSSFLPLLEFA 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1943013793 100 YTSTLMLGESNVMDVLLAASHLHLNSVVKACKH 132
Cdd:cd18202    80 YTSELTFDFCSMAEVAMLARHLFMNEVLEICES 112