|
Name |
Accession |
Description |
Interval |
E-value |
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1489-1815 |
1.24e-38 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 147.89 E-value: 1.24e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1489 ELDLRGNDPGDTGVkklTDLQKDLKCKLTLRFLNTPDAEKACDSLIKVLEINPLLLrELDLSGKIQGDSE--LQLLCSLL 1566
Cdd:cd00116 2 QLSLKGELLKTERA---TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLK-ELCLSLNETGRIPrgLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1567 EdSHCKIQELSLSKCNITVESCAALASVLRleSSSVRKMDLSNNNLQDSGMLDLAGGLTNPKCNLKIIILKTCALTEGSC 1646
Cdd:cd00116 78 T-KGCGLQELDLSDNALGPDGCGVLESLLR--SSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1647 SALANVLNSKDAhLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGN 1726
Cdd:cd00116 155 EALAKALRANRD-LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1727 KVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGDKGVKLLIDLQKDPKYKL 1806
Cdd:cd00116 232 NLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
....*....
gi 1917046687 1807 QTLRLLKCS 1815
Cdd:cd00116 310 ESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
534-700 |
3.09e-35 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 132.81 E-value: 3.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 534 RTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECqSLMKTINLFFPETQG-------LRLTDQ 606
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNAR-SLADLLFSQWPEPAApvsevwaVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 607 NKVLFILDGLDECQlplefqknEILNNVTKAAPLDAVMTNLIKGNLLPSALIWITTRPAAASMIPAE-CIDRVTEVRGFN 685
Cdd:pfam05729 80 ERLLLILDGLDELV--------SDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGlEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1917046687 686 DEQKEEYFRKRISDQ 700
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
839-967 |
5.37e-35 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 130.10 E-value: 5.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 839 HLSIQEFLAAVFAYISLKNGTKNVLdhqSESQESKKTEvidLLKTAVDKALKSDHGHLDLFLRFLLGLSLESNEKLIRGL 918
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPL---KEFFGLRKRE---SLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1917046687 919 LtQTGSRSDCQKDIVEYIKLKFKENPSPERSVNLFYCLNELNDDSLVKE 967
Cdd:pfam17776 75 L-GCKLSSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1052-1350 |
1.40e-34 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 135.95 E-value: 1.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1052 LENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPG--DTGVKELTDLLEDPhCKLKTLRL----LSPAAEEVC 1125
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLLQGLTKG-CGLQELDLsdnaLGPDGCGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1126 DSLTKtlgiNPLLQrELDLSGKIQDDSEMKKISDLLEDLHCRTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSEN 1205
Cdd:cd00116 102 ESLLR----SSSLQ-ELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD-LKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1206 KLGNSGVNQICSLLKnSNCTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNNQHCKLQ 1285
Cdd:cd00116 176 GIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDNNLTDAGAAALASALLSPNISLL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046687 1286 KLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDPNCKLKARFLKT 1350
Cdd:cd00116 254 TLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316
|
|
| FISNA |
pfam14484 |
Fish-specific NACHT associated domain; This domain is frequently found associated with the ... |
451-525 |
5.12e-24 |
|
Fish-specific NACHT associated domain; This domain is frequently found associated with the NACHT domain (pfam05729) in fish and other vertebrates.
:
Pssm-ID: 464185 [Multi-domain] Cd Length: 72 Bit Score: 96.91 E-value: 5.12e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046687 451 LKEDLIKKFDRVCEGIPKQGESTSLNTIYTDLYITEGGAGQVNKEHEVRLIEKTSVTRHTnqmeQEVQIKCKDMF 525
Cdd:pfam14484 1 LKSNLKKKFQCIFEGNAKGGESTLLNEIYTELYITEGESGEVNEEHEVRQIEAASKKPES----EETPIRCEDIF 71
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1710-1926 |
1.05e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 69.43 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1710 ALKLNPSHLMELDLSGNKVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGD 1789
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVT--TLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1790 KGVKLLID-LQKDPkyKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHcRT 1864
Cdd:COG5238 223 EGAEILAEaLKGNK--SLTTLDLsnnqIGDEGVIALAEAL-----KNNTTVETLYLSGNQIGAEGAIALAKALQGNT-TL 294
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1917046687 1865 QKLKMNKSSITEEGCAALSSALCSNpSHLIELDLSDSKLGGSGLEKICGVLR-NKQFKLLKLQ 1926
Cdd:COG5238 295 TSLDLSVNRIGDEGAIALAEGLQGN-KTLHTLNLAYNGIGAQGAIALAKALQeNTTLHSLDLS 356
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
783-837 |
1.10e-09 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
:
Pssm-ID: 465501 Cd Length: 57 Bit Score: 55.65 E-value: 1.10e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1917046687 783 IRSLGKLAFQHLEKNSLIFYSSDLEACEISLSniSVYSGLCTQ--ETVRFHDTVFSF 837
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES--DLSSGLLTEilQKDLGCEKVYSF 57
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1489-1815 |
1.24e-38 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 147.89 E-value: 1.24e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1489 ELDLRGNDPGDTGVkklTDLQKDLKCKLTLRFLNTPDAEKACDSLIKVLEINPLLLrELDLSGKIQGDSE--LQLLCSLL 1566
Cdd:cd00116 2 QLSLKGELLKTERA---TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLK-ELCLSLNETGRIPrgLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1567 EdSHCKIQELSLSKCNITVESCAALASVLRleSSSVRKMDLSNNNLQDSGMLDLAGGLTNPKCNLKIIILKTCALTEGSC 1646
Cdd:cd00116 78 T-KGCGLQELDLSDNALGPDGCGVLESLLR--SSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1647 SALANVLNSKDAhLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGN 1726
Cdd:cd00116 155 EALAKALRANRD-LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1727 KVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGDKGVKLLIDLQKDPKYKL 1806
Cdd:cd00116 232 NLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
....*....
gi 1917046687 1807 QTLRLLKCS 1815
Cdd:cd00116 310 ESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
534-700 |
3.09e-35 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 132.81 E-value: 3.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 534 RTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECqSLMKTINLFFPETQG-------LRLTDQ 606
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNAR-SLADLLFSQWPEPAApvsevwaVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 607 NKVLFILDGLDECQlplefqknEILNNVTKAAPLDAVMTNLIKGNLLPSALIWITTRPAAASMIPAE-CIDRVTEVRGFN 685
Cdd:pfam05729 80 ERLLLILDGLDELV--------SDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGlEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1917046687 686 DEQKEEYFRKRISDQ 700
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
839-967 |
5.37e-35 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 130.10 E-value: 5.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 839 HLSIQEFLAAVFAYISLKNGTKNVLdhqSESQESKKTEvidLLKTAVDKALKSDHGHLDLFLRFLLGLSLESNEKLIRGL 918
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPL---KEFFGLRKRE---SLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1917046687 919 LtQTGSRSDCQKDIVEYIKLKFKENPSPERSVNLFYCLNELNDDSLVKE 967
Cdd:pfam17776 75 L-GCKLSSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1052-1350 |
1.40e-34 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 135.95 E-value: 1.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1052 LENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPG--DTGVKELTDLLEDPhCKLKTLRL----LSPAAEEVC 1125
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLLQGLTKG-CGLQELDLsdnaLGPDGCGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1126 DSLTKtlgiNPLLQrELDLSGKIQDDSEMKKISDLLEDLHCRTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSEN 1205
Cdd:cd00116 102 ESLLR----SSSLQ-ELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD-LKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1206 KLGNSGVNQICSLLKnSNCTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNNQHCKLQ 1285
Cdd:cd00116 176 GIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDNNLTDAGAAALASALLSPNISLL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046687 1286 KLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDPNCKLKARFLKT 1350
Cdd:cd00116 254 TLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1016-1337 |
1.28e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 124.13 E-value: 1.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1016 LNRLLLVVKEATSALNPIQDRGVELLSEGLKNENCKLENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPGDT 1095
Cdd:COG5238 146 VLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTT--VTTLWLKRNPIGDE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1096 GVKELTDLLedphCKLKTLrllspaaeevcdsltktlginpllqRELDLSGKIQDDSEMKKISDLLEDLHcRTQKLKLNN 1175
Cdd:COG5238 224 GAEILAEAL----KGNKSL-------------------------TTLDLSNNQIGDEGVIALAEALKNNT-TVETLYLSG 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1176 NSITEKGCAALSSALCSNPsHLIELDLSENKLGNSGVNQICSLLKNSNcTLAKLNLSFCSITEEGCPFLSSAFCSNPShL 1255
Cdd:COG5238 274 NQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTT-L 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1256 LELDLSKNKLESSGVRQICSLLNNqHCKLQKLGLSDCSITEKGYADLASALKSNPssyLIELDLRGNYPGDTGVELIIDL 1335
Cdd:COG5238 351 HSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTNR---LHTLILDGNLIGAEAQQRLEQL 426
|
..
gi 1917046687 1336 LK 1337
Cdd:COG5238 427 LE 428
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1573-1858 |
1.09e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 121.44 E-value: 1.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1573 IQELSLSKCNITVESCAALASVLRLESSSVRKMDLSNNNLQDSGMLDLAGGLTNPKcNLKIIILKTCALTEGSCSALANV 1652
Cdd:COG5238 153 GNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEA 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1653 LnSKDAHLSELDLSNNNLEDSGVMQLCAGLKNPQSaLEIMRLSKCNIGEEGCCALASALKLNPsHLMELDLSGNKVGNSG 1732
Cdd:COG5238 232 L-KGNKSLTTLDLSNNQIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGDEG 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1733 VKQLSDLLKNSNCLVqKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGDKGVKLLIDLQKDPKyKLQTLRLL 1812
Cdd:COG5238 309 AIALAEGLQGNKTLH-TLNLAYNGIGAQGAIALAKALQENTTLH--SLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLG 384
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1917046687 1813 KCSAAEDICNSLTKTLGKNPllLRELDLSGKIQGDSHMKQISHLLE 1858
Cdd:COG5238 385 KNNIGKQGAEALIDALQTNR--LHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| FISNA |
pfam14484 |
Fish-specific NACHT associated domain; This domain is frequently found associated with the ... |
451-525 |
5.12e-24 |
|
Fish-specific NACHT associated domain; This domain is frequently found associated with the NACHT domain (pfam05729) in fish and other vertebrates.
Pssm-ID: 464185 [Multi-domain] Cd Length: 72 Bit Score: 96.91 E-value: 5.12e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046687 451 LKEDLIKKFDRVCEGIPKQGESTSLNTIYTDLYITEGGAGQVNKEHEVRLIEKTSVTRHTnqmeQEVQIKCKDMF 525
Cdd:pfam14484 1 LKSNLKKKFQCIFEGNAKGGESTLLNEIYTELYITEGESGEVNEEHEVRQIEAASKKPES----EETPIRCEDIF 71
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1710-1926 |
1.05e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 69.43 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1710 ALKLNPSHLMELDLSGNKVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGD 1789
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVT--TLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1790 KGVKLLID-LQKDPkyKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHcRT 1864
Cdd:COG5238 223 EGAEILAEaLKGNK--SLTTLDLsnnqIGDEGVIALAEAL-----KNNTTVETLYLSGNQIGAEGAIALAKALQGNT-TL 294
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1917046687 1865 QKLKMNKSSITEEGCAALSSALCSNpSHLIELDLSDSKLGGSGLEKICGVLR-NKQFKLLKLQ 1926
Cdd:COG5238 295 TSLDLSVNRIGDEGAIALAEGLQGN-KTLHTLNLAYNGIGAQGAIALAKALQeNTTLHSLDLS 356
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
783-837 |
1.10e-09 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 55.65 E-value: 1.10e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1917046687 783 IRSLGKLAFQHLEKNSLIFYSSDLEACEISLSniSVYSGLCTQ--ETVRFHDTVFSF 837
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES--DLSSGLLTEilQKDLGCEKVYSF 57
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1719-1926 |
3.15e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.04 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1719 MELDLSGNKVGNSGVKQLSDLLKNsnclVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPG--DKGVKLLI 1796
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1797 DlqkdpkyklqtlrllkcsaaedicnSLTKTLGknpllLRELDLSgkiqgdshmkqishlledshcrtqklkmnKSSITE 1876
Cdd:cd00116 75 Q-------------------------GLTKGCG-----LQELDLS-----------------------------DNALGP 95
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1877 EGCAALSSALCSnpSHLIELDLSDSKLGGSGLEKICGVLRNKQFKLLKLQ 1926
Cdd:cd00116 96 DGCGVLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLV 143
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1659-1683 |
4.42e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.31 E-value: 4.42e-04
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1489-1815 |
1.24e-38 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 147.89 E-value: 1.24e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1489 ELDLRGNDPGDTGVkklTDLQKDLKCKLTLRFLNTPDAEKACDSLIKVLEINPLLLrELDLSGKIQGDSE--LQLLCSLL 1566
Cdd:cd00116 2 QLSLKGELLKTERA---TELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLK-ELCLSLNETGRIPrgLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1567 EdSHCKIQELSLSKCNITVESCAALASVLRleSSSVRKMDLSNNNLQDSGMLDLAGGLTNPKCNLKIIILKTCALTEGSC 1646
Cdd:cd00116 78 T-KGCGLQELDLSDNALGPDGCGVLESLLR--SSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1647 SALANVLNSKDAhLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGN 1726
Cdd:cd00116 155 EALAKALRANRD-LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1727 KVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGDKGVKLLIDLQKDPKYKL 1806
Cdd:cd00116 232 NLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
....*....
gi 1917046687 1807 QTLRLLKCS 1815
Cdd:cd00116 310 ESLWVKDDS 318
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
534-700 |
3.09e-35 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 132.81 E-value: 3.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 534 RTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECqSLMKTINLFFPETQG-------LRLTDQ 606
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNAR-SLADLLFSQWPEPAApvsevwaVILELP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 607 NKVLFILDGLDECQlplefqknEILNNVTKAAPLDAVMTNLIKGNLLPSALIWITTRPAAASMIPAE-CIDRVTEVRGFN 685
Cdd:pfam05729 80 ERLLLILDGLDELV--------SDLGQLDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDALRDLRRGlEEPRYLEVRGFS 151
|
170
....*....|....*
gi 1917046687 686 DEQKEEYFRKRISDQ 700
Cdd:pfam05729 152 ESDRKQYVRKYFSDE 166
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
839-967 |
5.37e-35 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 130.10 E-value: 5.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 839 HLSIQEFLAAVFAYISLKNGTKNVLdhqSESQESKKTEvidLLKTAVDKALKSDHGHLDLFLRFLLGLSLESNEKLIRGL 918
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPL---KEFFGLRKRE---SLKSLLDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL 74
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1917046687 919 LtQTGSRSDCQKDIVEYIKLKFKENPSPERSVNLFYCLNELNDDSLVKE 967
Cdd:pfam17776 75 L-GCKLSSEIKQELLQWIKSLIQKELSSERFLNLFHCLYELQDESFVKE 122
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1052-1350 |
1.40e-34 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 135.95 E-value: 1.40e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1052 LENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPG--DTGVKELTDLLEDPhCKLKTLRL----LSPAAEEVC 1125
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLLQGLTKG-CGLQELDLsdnaLGPDGCGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1126 DSLTKtlgiNPLLQrELDLSGKIQDDSEMKKISDLLEDLHCRTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSEN 1205
Cdd:cd00116 102 ESLLR----SSSLQ-ELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD-LKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1206 KLGNSGVNQICSLLKnSNCTLAKLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNNQHCKLQ 1285
Cdd:cd00116 176 GIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS-LEVLNLGDNNLTDAGAAALASALLSPNISLL 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046687 1286 KLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDPNCKLKARFLKT 1350
Cdd:cd00116 254 TLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKD 316
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1552-1867 |
5.46e-32 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 128.63 E-value: 5.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1552 KIQGDSELQLLCSLLEDSHCKIQELSLSKCNITVESCAALASVLRLESSSVRkMDLSNNNLQ--DSGMLDLAGGLTNpKC 1629
Cdd:cd00116 4 SLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKE-LCLSLNETGriPRGLQSLLQGLTK-GC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1630 NLKIIILKTCALTEGSCSALANVLNSkdAHLSELDLSNNNLEDSGVMQLCAGLKNPQSALEIMRLSKCNIGEEGCCALAS 1709
Cdd:cd00116 82 GLQELDLSDNALGPDGCGVLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1710 ALKLNPShLMELDLSGNKVGNSGVKQLSDLLKnSNCLVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPGD 1789
Cdd:cd00116 160 ALRANRD-LKELNLANNGIGDAGIRALAEGLK-ANCNLEVLDLNNNGLTDEGASALAETLASLKS--LEVLNLGDNNLTD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1790 KGVKLLIDLQKDPKYKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHCRTQ 1865
Cdd:cd00116 236 AGAAALASALLSPNISLLTLSLscndITDDGAKDLAEVL-----AEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELE 310
|
..
gi 1917046687 1866 KL 1867
Cdd:cd00116 311 SL 312
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1016-1337 |
1.28e-29 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 124.13 E-value: 1.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1016 LNRLLLVVKEATSALNPIQDRGVELLSEGLKNENCKLENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPGDT 1095
Cdd:COG5238 146 VLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTT--VTTLWLKRNPIGDE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1096 GVKELTDLLedphCKLKTLrllspaaeevcdsltktlginpllqRELDLSGKIQDDSEMKKISDLLEDLHcRTQKLKLNN 1175
Cdd:COG5238 224 GAEILAEAL----KGNKSL-------------------------TTLDLSNNQIGDEGVIALAEALKNNT-TVETLYLSG 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1176 NSITEKGCAALSSALCSNPsHLIELDLSENKLGNSGVNQICSLLKNSNcTLAKLNLSFCSITEEGCPFLSSAFCSNPShL 1255
Cdd:COG5238 274 NQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTT-L 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1256 LELDLSKNKLESSGVRQICSLLNNqHCKLQKLGLSDCSITEKGYADLASALKSNPssyLIELDLRGNYPGDTGVELIIDL 1335
Cdd:COG5238 351 HSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTNR---LHTLILDGNLIGAEAQQRLEQL 426
|
..
gi 1917046687 1336 LK 1337
Cdd:COG5238 427 LE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1035-1294 |
1.49e-29 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 121.31 E-value: 1.49e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1035 DRGVELLSEGLKNeNCKLENLGLSCCSITEEGYAALALALKSnpsSLLIELDLRGNDPGDTGVKELTDLLEDPHCKLKTL 1114
Cdd:cd00116 67 PRGLQSLLQGLTK-GCGLQELDLSDNALGPDGCGVLESLLRS---SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1115 ----RLLSPAAeevCDSLTKTLGINPLLQrELDLS-GKIQDDSemkkISDLLEDL--HCRTQKLKLNNNSITEKGCAALS 1187
Cdd:cd00116 143 vlgrNRLEGAS---CEALAKALRANRDLK-ELNLAnNGIGDAG----IRALAEGLkaNCNLEVLDLNNNGLTDEGASALA 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1188 SALCSNPShLIELDLSENKLGNSGVNQICSLLKNSNCTLAKLNLSFCSITEEGCPFLSSaFCSNPSHLLELDLSKNKLES 1267
Cdd:cd00116 215 ETLASLKS-LEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAE-VLAEKESLLELDLRGNKFGE 292
|
250 260
....*....|....*....|....*..
gi 1917046687 1268 SGVRQICSLLNNQHCKLQKLGLSDCSI 1294
Cdd:cd00116 293 EGAQLLAESLLEPGNELESLWVKDDSF 319
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1573-1858 |
1.09e-28 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 121.44 E-value: 1.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1573 IQELSLSKCNITVESCAALASVLRLESSSVRKMDLSNNNLQDSGMLDLAGGLTNPKcNLKIIILKTCALTEGSCSALANV 1652
Cdd:COG5238 153 GNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEA 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1653 LnSKDAHLSELDLSNNNLEDSGVMQLCAGLKNPQSaLEIMRLSKCNIGEEGCCALASALKLNPsHLMELDLSGNKVGNSG 1732
Cdd:COG5238 232 L-KGNKSLTTLDLSNNQIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGDEG 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1733 VKQLSDLLKNSNCLVqKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGDKGVKLLIDLQKDPKyKLQTLRLL 1812
Cdd:COG5238 309 AIALAEGLQGNKTLH-TLNLAYNGIGAQGAIALAKALQENTTLH--SLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLG 384
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1917046687 1813 KCSAAEDICNSLTKTLGKNPllLRELDLSGKIQGDSHMKQISHLLE 1858
Cdd:COG5238 385 KNNIGKQGAEALIDALQTNR--LHTLILDGNLIGAEAQQRLEQLLE 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1141-1467 |
2.48e-28 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 117.84 E-value: 2.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1141 ELDLSGKIQDDSEMKkisDLLEDLHCrTQKLKLNNNSITEKGCAALSSALCSNPShLIELDLSENKLGNSGVN-QICSLL 1219
Cdd:cd00116 2 QLSLKGELLKTERAT---ELLPKLLC-LQVLRLEGNTLGEEAAKALASALRPQPS-LKELCLSLNETGRIPRGlQSLLQG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1220 KNSNCTLAKLNLSFCSITEEGCPFLSSafCSNPSHLLELDLSKNKLESSGVRQICSLLNNQHCKLQKLGLSDCSITEKGY 1299
Cdd:cd00116 77 LTKGCGLQELDLSDNALGPDGCGVLES--LLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASC 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1300 ADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDpNCKLKARFLK--TAAEKACDSLTEALgKNPLLLKELHLSG 1377
Cdd:cd00116 155 EALAKALRANRD--LKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNnnGLTDEGASALAETL-ASLKSLEVLNLGD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1378 KIQGDSEMKKISDLLKDSHCTTQKLKLNKCSITEEGCAALSSALCSNPSyLTELDLSENKLGNSGVKQICTLLNNQCCKL 1457
Cdd:cd00116 231 NNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES-LLELDLRGNKFGEEGAQLLAESLLEPGNEL 309
|
330
....*....|
gi 1917046687 1458 QKLKLTLCSI 1467
Cdd:cd00116 310 ESLWVKDDSF 319
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
526-1106 |
1.00e-25 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 116.06 E-value: 1.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 526 VSEEDKPIRTVLTQGVAGIGKSISVQKFILDWAEGKEYQDIQFIFPLPFRELNLKKKECQSLMKTINLFFPETQGL--RL 603
Cdd:COG5635 173 LELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIPILIELRDLAEEASLEDLLAEALEKRGGEPEDAleRL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 604 TDQNKVLFILDGLDEcqLPLEFQKNEILNNVTkaapldavmtNLIKGnlLPSALIWITTRPAAAsmiPAECIDRVTEVR- 682
Cdd:COG5635 253 LRNGRLLLLLDGLDE--VPDEADRDEVLNQLR----------RFLER--YPKARVIITSRPEGY---DSSELEGFEVLEl 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 683 -GFNDEQKEEYFRKRI-SDQDLANKIIDHIRESRSLHIMCHIPVFCWISASVLQRileetaSEDTPKTLTQMYTCFL--I 758
Cdd:COG5635 316 aPLSDEQIEEFLKKWFeATERKAERLLEALEENPELRELARNPLLLTLLALLLRE------RGELPDTRAELYEQFVelL 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 759 FQTVQGNAKYIGKNALDIpwdEEGIRSLGKLAFQHLEKNSLIFYSSDLEA--CEISLSNISVYSGLctQETVRFH----- 831
Cdd:COG5635 390 LERWDEQRGLTIYRELSR---EELRELLSELALAMQENGRTEFAREELEEilREYLGRRKDAEALL--DELLLRTgllve 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 832 --DTVFSFVHLSIQEFLAAVFAYISLKNGTKNVLDHQSEsqESKKTEVIDLLktavdKALKSDHGHLDLFLRFLLGLSLE 909
Cdd:COG5635 465 rgEGRYSFAHRSFQEYLAARALVEELDEELLELLAEHLE--DPRWREVLLLL-----AGLLDDVKQIKELIDALLARDDA 537
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 910 SNEKLIRGLLTQTGSRSDcqkdiveYIKLKFKENPSPERSVNLFYCLNELNDDSLVKEIQSYMSSGRLSEAELSPAQWSA 989
Cdd:COG5635 538 AALALAAALLLALLLALA-------LLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLL 610
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 990 LVFVLLTSKEKLEVFELKKFIRSDECLNRLLLVVKEATSALNPIQDRGVELLSEGLKNENCKLENLGL-SCCSITEEGYA 1068
Cdd:COG5635 611 LLLLLLALALLLALLLLLLLLLLAELLLLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLaELLLALLALAS 690
|
570 580 590
....*....|....*....|....*....|....*...
gi 1917046687 1069 ALALALKSNPSSLLIELDLRGNDPGDTGVKELTDLLED 1106
Cdd:COG5635 691 LLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLAL 728
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1547-1798 |
1.23e-25 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 112.19 E-value: 1.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1547 LDLSGKIQGDSELQLLCSLLEdSHCKIQELSLSKCNITVESCAALASVLRlESSSVRKMDLSNNNLQDSGMLDLAGGLTN 1626
Cdd:COG5238 185 VYLGCNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIGDEGAEILAEALK-GNKSLTTLDLSNNQIGDEGVIALAEALKN 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1627 PKcNLKIIILKTCALTEGSCSALANVLnSKDAHLSELDLSNNNLEDSGVMQLCAGLKNpQSALEIMRLSKCNIGEEGCCA 1706
Cdd:COG5238 263 NT-TVETLYLSGNQIGAEGAIALAKAL-QGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1707 LASALKLNPShLMELDLSGNKVGNSGVKQLSDLLKNsNCLVQKLKVSDNNVKGEGYAALASALKSNpssHLIELDLRGND 1786
Cdd:COG5238 340 LAKALQENTT-LHSLDLSDNQIGDEGAIALAKYLEG-NTTLRELNLGKNNIGKQGAEALIDALQTN---RLHTLILDGNL 414
|
250
....*....|..
gi 1917046687 1787 PGDKGVKLLIDL 1798
Cdd:COG5238 415 IGAEAQQRLEQL 426
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1636-1904 |
2.24e-25 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 111.42 E-value: 2.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1636 LKTCALTEGSCSALANVLNSKDAHLSELDLSNNNLEDSGVMQLCAGLKNPQSaLEIMRLSKCNIGEEGCCALASALKLNP 1715
Cdd:COG5238 158 LLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNK 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1716 ShLMELDLSGNKVGNSGVKQLSDLLKNsNCLVQKLKVSDNNVKGEGYAALASALKSNPssHLIELDLRGNDPGDKGVKLL 1795
Cdd:COG5238 237 S-LTTLDLSNNQIGDEGVIALAEALKN-NTTVETLYLSGNQIGAEGAIALAKALQGNT--TLTSLDLSVNRIGDEGAIAL 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1796 ID-LQKDPkyKLQTLRLLKCSAAEDICNSLTKTLGKNPLLLReLDLSGKIQGDSHMKQISHLLEDshcRTQKLKMN--KS 1872
Cdd:COG5238 313 AEgLQGNK--TLHTLNLAYNGIGAQGAIALAKALQENTTLHS-LDLSDNQIGDEGAIALAKYLEG---NTTLRELNlgKN 386
|
250 260 270
....*....|....*....|....*....|..
gi 1917046687 1873 SITEEGCAALSSALCSNpsHLIELDLSDSKLG 1904
Cdd:COG5238 387 NIGKQGAEALIDALQTN--RLHTLILDGNLIG 416
|
|
| FISNA |
pfam14484 |
Fish-specific NACHT associated domain; This domain is frequently found associated with the ... |
451-525 |
5.12e-24 |
|
Fish-specific NACHT associated domain; This domain is frequently found associated with the NACHT domain (pfam05729) in fish and other vertebrates.
Pssm-ID: 464185 [Multi-domain] Cd Length: 72 Bit Score: 96.91 E-value: 5.12e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917046687 451 LKEDLIKKFDRVCEGIPKQGESTSLNTIYTDLYITEGGAGQVNKEHEVRLIEKTSVTRHTnqmeQEVQIKCKDMF 525
Cdd:pfam14484 1 LKSNLKKKFQCIFEGNAKGGESTLLNEIYTELYITEGESGEVNEEHEVRQIEAASKKPES----EETPIRCEDIF 71
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1256-1668 |
1.36e-23 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 103.97 E-value: 1.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1256 LELDLSKNKLESSGVRQICSLLnnqHCkLQKLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTgveliidl 1335
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKL---LC-LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGRI-------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1336 lkdpncklkarflktaaEKACDSLTEALGKNPLLlkelhlsgkiqgdsemkkisdllkdshcttQKLKLNKCSITEEGCA 1415
Cdd:cd00116 67 -----------------PRGLQSLLQGLTKGCGL------------------------------QELDLSDNALGPDGCG 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1416 ALSSALCSnpSYLTELDLSENKLGNSGVKQICTLLNNQCCKLQKLKLTLCSITEEGYADLASALKSNSSshLIELDLRGN 1495
Cdd:cd00116 100 VLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRD--LKELNLANN 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1496 DPGDTGVKKLTDLQKDLKckltlrflntpdaekacdslikvleinplLLRELDLSGKIQGDSELQLLCSLLEDShCKIQE 1575
Cdd:cd00116 176 GIGDAGIRALAEGLKANC-----------------------------NLEVLDLNNNGLTDEGASALAETLASL-KSLEV 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1576 LSLSKCNITVESCAALASVLRLESSSVRKMDLSNNNLQDSGMLDLAGGLTNpKCNLKIIILKTCALTEGSCSALANVLNS 1655
Cdd:cd00116 226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAE-KESLLELDLRGNKFGEEGAQLLAESLLE 304
|
410
....*....|...
gi 1917046687 1656 KDAHLSELDLSNN 1668
Cdd:cd00116 305 PGNELESLWVKDD 317
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1200-1513 |
2.67e-23 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 105.26 E-value: 2.67e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1200 LDLSENKLGNSGVNQICSLLKNSNCTLakLNLSFCSITEEGCPFLSSAFCSNPShLLELDLSKNKLESSGVRQICSLLNN 1279
Cdd:COG5238 158 LLGLAARLGLLAAISMAKALQNNSVET--VYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKG 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1280 QHcKLQKLGLSDCSITEKGYADLASALKSNPSsyLIELDLRGNYPGDTGVELIIDLLKDpncklkarflktaaekacdsl 1359
Cdd:COG5238 235 NK-SLTTLDLSNNQIGDEGVIALAEALKNNTT--VETLYLSGNQIGAEGAIALAKALQG--------------------- 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1360 tealGKNpllLKELHLSGKIQGDSEMKKISDLLKDSHcTTQKLKLNKCSITEEGCAALSSALCSNPSyLTELDLSENKLG 1439
Cdd:COG5238 291 ----NTT---LTSLDLSVNRIGDEGAIALAEGLQGNK-TLHTLNLAYNGIGAQGAIALAKALQENTT-LHSLDLSDNQIG 361
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1917046687 1440 NSGVKQICTLLNNQcCKLQKLKLTLCSITEEGYADLASALKSNSsshLIELDLRGNDPGDTGVKKLTDLQKDLK 1513
Cdd:COG5238 362 DEGAIALAKYLEGN-TTLRELNLGKNNIGKQGAEALIDALQTNR---LHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1663-1925 |
1.13e-21 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 100.25 E-value: 1.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1663 LDLSNNNLEDSGVMQLCAGLKNPQsaLEIMRLSKCNIGEEGCCALASALKLNPShLMELDLSGNKVGNSGVKQLSDLLKn 1742
Cdd:COG5238 158 LLGLAARLGLLAAISMAKALQNNS--VETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALK- 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1743 SNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGDKGVKLLIDLQKDPKyKLQTLRL----LKCSAAE 1818
Cdd:COG5238 234 GNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVE--TLYLSGNQIGAEGAIALAKALQGNT-TLTSLDLsvnrIGDEGAI 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1819 DICNSLTKTlgknpLLLRELDLSGKIQGDSHMKQI-SHLLEDSHCRTQKLKMNKssITEEGCAALSSALCSNPShLIELD 1897
Cdd:COG5238 311 ALAEGLQGN-----KTLHTLNLAYNGIGAQGAIALaKALQENTTLHSLDLSDNQ--IGDEGAIALAKYLEGNTT-LRELN 382
|
250 260
....*....|....*....|....*...
gi 1917046687 1898 LSDSKLGGSGLEKICGVLRNKQFKLLKL 1925
Cdd:COG5238 383 LGKNNIGKQGAEALIDALQTNRLHTLIL 410
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1710-1926 |
1.05e-11 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 69.43 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1710 ALKLNPSHLMELDLSGNKVGNSGVKQLSDLLKNSNCLVQKLKVSDNNVKGEGYAALASALKSNPSSHliELDLRGNDPGD 1789
Cdd:COG5238 145 QVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVT--TLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1790 KGVKLLID-LQKDPkyKLQTLRL----LKCSAAEDICNSLtktlgKNPLLLRELDLSGKIQGDSHMKQISHLLEDSHcRT 1864
Cdd:COG5238 223 EGAEILAEaLKGNK--SLTTLDLsnnqIGDEGVIALAEAL-----KNNTTVETLYLSGNQIGAEGAIALAKALQGNT-TL 294
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1917046687 1865 QKLKMNKSSITEEGCAALSSALCSNpSHLIELDLSDSKLGGSGLEKICGVLR-NKQFKLLKLQ 1926
Cdd:COG5238 295 TSLDLSVNRIGDEGAIALAEGLQGN-KTLHTLNLAYNGIGAQGAIALAKALQeNTTLHSLDLS 356
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1031-1119 |
4.21e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 63.14 E-value: 4.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1031 NPIQDRGVELLSEGLKNENCKLENLGLSCCSITEEGYAALALALKSNPSslLIELDLRGNDPGDTGVKELTDLLEDPHCK 1110
Cdd:cd00116 231 NNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAESLLEPGNE 308
|
....*....
gi 1917046687 1111 LKTLRLLSP 1119
Cdd:cd00116 309 LESLWVKDD 317
|
|
| NOD2_WH |
pfam17779 |
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular ... |
783-837 |
1.10e-09 |
|
NOD2 winged helix domain; This winged helix domain is found in the NOD2 protein. Its molecular function is not known.
Pssm-ID: 465501 Cd Length: 57 Bit Score: 55.65 E-value: 1.10e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1917046687 783 IRSLGKLAFQHLEKNSLIFYSSDLEACEISLSniSVYSGLCTQ--ETVRFHDTVFSF 837
Cdd:pfam17779 3 LLKLGKLAFEGLWKKKLVFSEEDLKEYGLDES--DLSSGLLTEilQKDLGCEKVYSF 57
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1719-1926 |
3.15e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.04 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1719 MELDLSGNKVGNSGVKQLSDLLKNsnclVQKLKVSDNNVKGEGYAALASALKSNPSshLIELDLRGNDPG--DKGVKLLI 1796
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLLC----LQVLRLEGNTLGEEAAKALASALRPQPS--LKELCLSLNETGriPRGLQSLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1797 DlqkdpkyklqtlrllkcsaaedicnSLTKTLGknpllLRELDLSgkiqgdshmkqishlledshcrtqklkmnKSSITE 1876
Cdd:cd00116 75 Q-------------------------GLTKGCG-----LQELDLS-----------------------------DNALGP 95
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1877 EGCAALSSALCSnpSHLIELDLSDSKLGGSGLEKICGVLRNKQFKLLKLQ 1926
Cdd:cd00116 96 DGCGVLESLLRS--SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLV 143
|
|
| LRR_RI |
smart00368 |
Leucine rich repeat, ribonuclease inhibitor type; |
1659-1683 |
4.42e-04 |
|
Leucine rich repeat, ribonuclease inhibitor type;
Pssm-ID: 197686 [Multi-domain] Cd Length: 28 Bit Score: 39.31 E-value: 4.42e-04
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
977-1338 |
9.20e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.77 E-value: 9.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 977 LSEAELSPAQWSALVFVLLTSKEKLEVFELKKFIRSDECLNRLLLVVKEATSALNPIQDRGVELLSEGLKNENCKLENLG 1056
Cdd:COG4886 6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1057 LSCCSITEEGYAALALALKSNPS----SLLIELDLRGNdpgdtGVKELTDLLEDPHcKLKTLRL----LSpaaeevcdSL 1128
Cdd:COG4886 86 LLGLTDLGDLTNLTELDLSGNEElsnlTNLESLDLSGN-----QLTDLPEELANLT-NLKELDLsnnqLT--------DL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1129 TKTLGINPLLQrELDLSgkiqdDSEMKKISDLLEDLHcRTQKLKLNNNSITEkgcaaLSSALcSNPSHLIELDLSENKLG 1208
Cdd:COG4886 152 PEPLGNLTNLK-SLDLS-----NNQLTDLPEELGNLT-NLKELDLSNNQITD-----LPEPL-GNLTNLEELDLSGNQLT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1209 NSGvnqiCSLLKNSNctLAKLNLSFCSITEegCPFLssafcSNPSHLLELDLSKNKLESsgvrqICSLLNNQhcKLQKLG 1288
Cdd:COG4886 219 DLP----EPLANLTN--LETLDLSNNQLTD--LPEL-----GNLTNLEELDLSNNQLTD-----LPPLANLT--NLKTLD 278
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1917046687 1289 LSDCSITEKGYADLASALKSNPSSYLIELDLRGNYPGDTGVELIIDLLKD 1338
Cdd:COG4886 279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
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|
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