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Conserved domains on  [gi|1910419158|ref|XP_036079818|]
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large neutral amino acids transporter small subunit 4 isoform X2 [Rousettus aegyptiacus]

Protein Classification

MFS transporter( domain architecture ID 10150691)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-239 2.03e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


:

Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYgasnPNSLSVLIFISLSLNGFGGMCMTFTSL 166
Cdd:cd06174    32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF----APSFWLLLLGRFLLGLGSGLIDPAVLA 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1910419158 167 TLPNMFGDLRSTF---IALMIGSYASSAVTFPGIKLIYDFGASFIIILVVWAGCSGLVFLNCFFNWPLEPFPGPED 239
Cdd:cd06174   108 LIADLFPERERGRalgLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
 
Name Accession Description Interval E-value
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-239 2.03e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYgasnPNSLSVLIFISLSLNGFGGMCMTFTSL 166
Cdd:cd06174    32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF----APSFWLLLLGRFLLGLGSGLIDPAVLA 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1910419158 167 TLPNMFGDLRSTF---IALMIGSYASSAVTFPGIKLIYDFGASFIIILVVWAGCSGLVFLNCFFNWPLEPFPGPED 239
Cdd:cd06174   108 LIADLFPERERGRalgLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
90-215 3.66e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 3.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGasnpNSLSVLIFISLsLNGFGGMCMTFTSLTLP 169
Cdd:COG2223    44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA----VSYWLLLLLGL-LLGIGGGGSFAVGIALV 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1910419158 170 NMF--GDLRSTF--IALMIGSYASSAVTFPGIKLIYDFG--ASFIIILVVWA 215
Cdd:COG2223   119 SKWfpPDRRGLAlgLAAGGGNLGAAVAAFLAPLLIAAFGwrNAFLILGILLL 170
MFS_1 pfam07690
Major Facilitator Superfamily;
87-227 3.04e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.18  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNPNSLSVLIFISLSLNGFGGMCMTFTSL 166
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1910419158 167 TLPnmfGDLRSTFIALMIGSYASSAVTFPGIKLIYDFGASFIIILVVWAGCSGLVFLNCFF 227
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
 
Name Accession Description Interval E-value
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-239 2.03e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYgasnPNSLSVLIFISLSLNGFGGMCMTFTSL 166
Cdd:cd06174    32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF----APSFWLLLLGRFLLGLGSGLIDPAVLA 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1910419158 167 TLPNMFGDLRSTF---IALMIGSYASSAVTFPGIKLIYDFGASFIIILVVWAGCSGLVFLNCFFNWPLEPFPGPED 239
Cdd:cd06174   108 LIADLFPERERGRalgLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
90-215 3.66e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 3.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGasnpNSLSVLIFISLsLNGFGGMCMTFTSLTLP 169
Cdd:COG2223    44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA----VSYWLLLLLGL-LLGIGGGGSFAVGIALV 118

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1910419158 170 NMF--GDLRSTF--IALMIGSYASSAVTFPGIKLIYDFG--ASFIIILVVWA 215
Cdd:COG2223   119 SKWfpPDRRGLAlgLAAGGGNLGAAVAAFLAPLLIAAFGwrNAFLILGILLL 170
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
91-231 4.54e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.02  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  91 AFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYgASNPNSLSVLIFislsLNGFG-GMCMTFTSLTLP 169
Cdd:COG2271    53 AFFLGYALGQ---IPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-ATSFWQLLLLRF----LLGLGeAGFFPAALKLIA 124

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1910419158 170 NMF-GDLRSTFIAL-MIGSYASSAVTFPGIKLI---YDFGASFII---ILVVWAGCS--GLVFLNCFFNWPL 231
Cdd:COG2271   125 EWFpPKERGRALGIfNAGGPLGGALAPPLLGWLlaaFGWRAAFLIlglPGLLLALLRfwLLALAYFLVYFAL 196
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 90-204 5.48e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 45.72  E-value: 5.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  90 LAFTVGsFLLSAITLPL-GIVMDKYGPRKLRLLGSACFAVSCLLIAYgASNPNSLSVLIFIsLSLNGFGGMCMTFTSLTL 168
Cdd:cd17355    42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLAL-ATSLWQLYLLWGL-LGGGGAGTLAAVAFATVA 118

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1910419158 169 PNMFGDLRSTFIALMIGSYASSAVTFP--GIKLIYDFG 204
Cdd:cd17355   119 AWWFERRRGLALGILTAGGGLGSLVFLplGAALIEAFG 156
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
87-227 1.22e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.46  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLSaitLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASnpnslSVLIFISLSLNGFG-GMCMTFTS 165
Cdd:COG0738    47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1910419158 166 LTLPNMFGDLRSTFIALMIGSYASSAVTFPGI--KLIY-DFGASFIIILVVWAGCSGLVFLNCFF 227
Cdd:COG0738   119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILlGLSLSWHLPYLILAVLLLLLALLFLR 183
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 98-167 2.42e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.72  E-value: 2.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1910419158  98 LLSAITLPL-GIVMDKYGPRKLRLLGSACFAVSCLLIAYgaSNPNSLSVLIFISLSLNGFgGMCMTFTSLT 167
Cdd:cd17503   225 LASAILSPLvGRLLDKFGPRLLLLAGLLLLALGTLLLAF--LTPDTSLWLIILPLFIRGL-GMGLVFMPLN 292
MFS_1 pfam07690
Major Facilitator Superfamily;
87-227 3.04e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.18  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNPNSLSVLIFISLSLNGFGGMCMTFTSL 166
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1910419158 167 TLPnmfGDLRSTFIALMIGSYASSAVTFPGIKLIYDFGASFIIILVVWAGCSGLVFLNCFF 227
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 90-140 4.92e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.60  E-value: 4.92e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1910419158  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNP 140
Cdd:cd17353    42 LAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLP 92
MFS_1 pfam07690
Major Facilitator Superfamily;
90-195 1.26e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.25  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNPNSLSVLIFISLSLNGFGGMCMTFTSLTLP 169
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                          90       100
                  ....*....|....*....|....*.
gi 1910419158 170 NMFGDLRSTFIALMIGSYASSAVTFP 195
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
87-223 2.23e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYgASNPNSLSVLIFIS-LSLNGFGGMCMTFTS 165
Cdd:COG2814    46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-APSLWLLLAARFLQgLGAGALFPAALALIA 124

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1910419158 166 LTLPnmfGDLRSTFIALMIGSYASSAVTFP----GIKLIYDFGASFIIILVVWAGCSGLVFL 223
Cdd:COG2814   125 DLVP---PERRGRALGLLGAGLGLGPALGPllggLLADLFGWRWVFLVNAVLALLALLLLLR 183
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 88-194 2.92e-03

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 40.31  E-value: 2.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  88 LNLAFtVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNP-NSLSV-LIFISLSLNGFGGMCMTFTS 165
Cdd:cd17354    40 NNLLS-VAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVVTGLiSDLSFwLMCLCFFLIGNSTSSLYTAA 118

                          90       100       110
                  ....*....|....*....|....*....|
gi 1910419158 166 LTLPN-MFGDLRSTFIALMIGSYASSAVTF 194
Cdd:cd17354   119 LVTCAkNFPESRGLAIGIPKGCYGLSGAIG 148
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 88-223 3.15e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.91  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  88 LNLAFTVGSFLLSAI-------TLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNPNSLSVLIFIslslnGFGGMC 160
Cdd:cd17475    26 LHLSLAQVGLLLSALnlgvavsMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV-----GAGYGS 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1910419158 161 MTFTSLTL------PNMFG---DLRSTFIALmigSYASSAVTFPGIKLIYDFGASFIIILVVWAGCSGLVFL 223
Cdd:cd17475   101 VQPGGGRAimrwfpPRERGlamGIRQTGVPL---GGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWL 169
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 92-220 3.93e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  92 FTVGSFLLSAIT--LPLGIVMDKYGPRKLRLLGSACFAVSCLLiaYGASnpNSLSVLIFISLsLNGFG------------ 157
Cdd:cd17489    35 LVVGLFTLAALLarPFAGRLLDRFGRKRLLLIGLLIFALATLL--YLLA--TSVALLLVLRL-IHGIGwgafttaaatlv 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1910419158 158 -----------GMCMTFTSLTLPNMFGdlrstfiaLMIGSYASSAVTFPGIkliydFGASFIIILVVWAGCSGL 220
Cdd:cd17489   110 adiippsrrgeGIGYYGLATTLAMALG--------PALGLFLYQHLGFAVL-----FIVAAVLALLALLLVFLV 170
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 90-167 6.95e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.08  E-value: 6.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1910419158  90 LAFTVGSFLLSAITlplGIVMDKYGPRKLRLLGSACFAVSCLLIAYgaSNPNSLSVLIFISLSLNGFgGMCMTFTSLT 167
Cdd:cd17321   211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLAL--LGADSSVWLLLPGLVLLGL-GLGLFATPLT 282
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 91-168 7.20e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.69  E-value: 7.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1910419158  91 AFTVGSFLLsaiTLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNPNSLSVLIFIslslngFGGMCMTFTSLTL 168
Cdd:cd17477   231 AFVLGGLLL---QWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFL------WGGAAGPLYTLAL 299
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
90-187 7.65e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 7.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  90 LAFTVGSFLLSAITLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNPNSLSVLIFISLSLNGFGGMCMTFTSLTLP 169
Cdd:COG2814   247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                          90
                  ....*....|....*...
gi 1910419158 170 nmfGDLRSTFIALMIGSY 187
Cdd:COG2814   327 ---PEARGRASGLYNSAF 341
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-185 9.78e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 38.34  E-value: 9.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910419158  87 MLNLAFTVGSFLLsaitlplGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASNPNSLSVLIFISlslngfgGMCMTFTSL 166
Cdd:cd17365   214 LLNIGGVIGSLLL-------GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLA-------GACVNGAQV 279

                          90       100
                  ....*....|....*....|....
gi 1910419158 167 TLPNMFGDL-----RSTFIALMIG 185
Cdd:cd17365   280 GLYALAARFyptevRATGVGWALG 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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