NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907172429|ref|XP_036022003|]
View 

zinc finger protein 775 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-371 8.55e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907172429 323 RPYACPECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQ------KQHLLKH 371
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-233 1.95e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 148 KPYLCGKCGKSFSQKPNLVRHQR--HHTGE--RPFCCPE--CTRRFSQKQHLLKHQKTHSRPATHTCPECERCFRHQVGL 221
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90
                  ....*....|....
gi 1907172429 222 RI--HQRAHARNRL 233
Cdd:COG5048   368 NNepPQSLQQYKDL 381
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
490-547 8.29e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907172429 490 RPYACPDCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQ------KQHLLKHQRVHRGTQA 547
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTHHNNPSDLNS 95
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-371 8.55e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907172429 323 RPYACPECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQ------KQHLLKH 371
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-233 1.95e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 148 KPYLCGKCGKSFSQKPNLVRHQR--HHTGE--RPFCCPE--CTRRFSQKQHLLKHQKTHSRPATHTCPECERCFRHQVGL 221
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90
                  ....*....|....
gi 1907172429 222 RI--HQRAHARNRL 233
Cdd:COG5048   368 NNepPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 1.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 339 NLTRHLRNHTGERPHPCSHCGRSFRQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-189 1.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 164 NLVRHQRHHTGERPFCCPECTRRFSQ 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
490-547 8.29e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907172429 490 RPYACPDCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQ------KQHLLKHQRVHRGTQA 547
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
478-503 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 478 ALTIHQRIHTGERPYACPDCGRCFSQ 503
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
323-371 8.55e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907172429 323 RPYACPECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQ------KQHLLKH 371
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-233 1.95e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 148 KPYLCGKCGKSFSQKPNLVRHQR--HHTGE--RPFCCPE--CTRRFSQKQHLLKHQKTHSRPATHTCPECERCFRHQVGL 221
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90
                  ....*....|....
gi 1907172429 222 RI--HQRAHARNRL 233
Cdd:COG5048   368 NNepPQSLQQYKDL 381
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 1.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 339 NLTRHLRNHTGERPHPCSHCGRSFRQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-189 1.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 164 NLVRHQRHHTGERPFCCPECTRRFSQ 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-533 1.79e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 176 RPFCCPECTRRFSQKQHLLKHQKTHSRPATHTCPECER--------CFRHQVgLRIHQRAHARNRLGARVNLHEMFRYAA 247
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksfsrplELSRHL-RTHHNNPSDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 248 ARRWSCRLRPGSPRGHPewvwlglcrswWGQHGVRTTAHSRLGPSeqrQFICNDCGKSFTWWSSLNIHQRIHTgerPYAC 327
Cdd:COG5048   111 SSSSSNSNDNNLLSSHS-----------LPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLHP---PLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 328 PECGRCFSQKPNLTRHLRNHTGERPHPCSHCGRSFRQKQHLL-KHLRTHLPGAQAARCTSCGQSCPSRAALRAHQRVHTA 406
Cdd:COG5048   174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 407 AELLRSQSAVRDGVPGSeSQAEIAQSVVVKPQGPQgakevlcgqecetlavpseqRQFICNECGKSFSWWSALTIHQR-- 484
Cdd:COG5048   254 SSSASESPRSSLPTASS-QSSSPNESDSSSEKGFS--------------------LPIKSKQCNISFSRSSPLTRHLRsv 312

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907172429 485 IHTGE--RPYACP--DCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQKQ 533
Cdd:COG5048   313 NHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSP 365
zf-H2C2_2 pfam13465
Zinc-finger double domain;
136-161 2.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 136 SLKIHQRTHTGEKPYLCGKCGKSFSQ 161
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
291-544 2.68e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 291 PSEQRQFICNDCGKSFTWWSSLNIHQRIHTGERPYACPECGRCFSQKP--NLTRHLRNHTGERPHPCSHCGRSFRQK--- 365
Cdd:COG5048    28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKass 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 366 -----------------QHLLKH-----------LRTHLPGAQAARCTSCGQSCPSRAALRA------------------ 399
Cdd:COG5048   108 sslsssssnsndnnllsSHSLPPssrdpqlpdllSISNLRNNPLPGNNSSSVNTPQSNSLHPplpanslskdpssnlsll 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 400 -HQRVHTAA------ELLRSQSAVRDGVPG-----SESQAEIAQSVVVKPQGPQGAKEVlcgQECETLAVPSEQRQFICN 467
Cdd:COG5048   188 iSSNVSTSIpsssenSPLSSSYSIPSSSSDqnlenSSSSLPLTTNSQLSPKSLLSQSPS---SLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 468 ECGKSFSWWSALTIHQRIHTGER-PYACPDCGRCFSQKPNLTRHRR--NHTGE--RPYLCTA--CGRGFRQKQHLLKHQR 540
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344


                  ....
gi 1907172429 541 VHRG 544
Cdd:COG5048   345 LHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
311-336 3.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 311 SLNIHQRIHTGERPYACPECGRCFSQ 336
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
490-547 8.29e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 8.29e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907172429 490 RPYACPDCGRCFSQKPNLTRHRRNHTGERPYLCTACGRGFRQ------KQHLLKHQRVHRGTQA 547
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrplelSRHLRTHHNNPSDLNS 95
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 353-375 9.99e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 9.99e-04
                          10        20
                  ....*....|....*....|...
gi 1907172429 353 HPCSHCGRSFRQKQHLLKHLRTH 375
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
478-503 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907172429 478 ALTIHQRIHTGERPYACPDCGRCFSQ 503
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 492-514 1.32e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.32e-03
                          10        20
                  ....*....|....*....|...
gi 1907172429 492 YACPDCGRCFSQKPNLTRHRRNH 514
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 325-347 1.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|...
gi 1907172429 325 YACPECGRCFSQKPNLTRHLRNH 347
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-203 1.46e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172429 122 FVCVDCGKRFSWWSSLKIHQRT--HTGE--KPYLCGK--CGKSFSQKPNLVRHQRHHTGERPFCCP--ECTRRFSQKQHL 193
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNN 369

                          90
                  ....*....|
gi 1907172429 194 LKHQKTHSRP 203
Cdd:COG5048   370 EPPQSLQQYK 379
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
456-527 1.79e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 1.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907172429 456 AVPSEQRQFICNECGKSFSWWSALTIHQRIHTGERPYACPDCGRCFSQKP--NLTRHRRNHTGERPYLCTACGR 527
Cdd:COG5048    26 SLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLP 99
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 178-200 8.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.49e-03
                          10        20
                  ....*....|....*....|...
gi 1907172429 178 FCCPECTRRFSQKQHLLKHQKTH 200
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 150-172 9.09e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.09e-03
                          10        20
                  ....*....|....*....|...
gi 1907172429 150 YLCGKCGKSFSQKPNLVRHQRHH 172
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH