NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907069437|ref|XP_036021709|]
View 

protein unc-80 homolog isoform X4 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
UNC80_C pfam20262
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1898-2985 0e+00

Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


:

Pssm-ID: 466412  Cd Length: 1079  Bit Score: 2116.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1898 DEEHATEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISN 1977
Cdd:pfam20262    1 GEEERTEHTPTHHVLQPAQAVFPSCICAAVLPIVHLLEDGEVREDGVAVSEVAEKVIWNCLVEDPALFLRHFLEKLTNRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1978 RQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQ 2057
Cdd:pfam20262   81 RQEELIFLLRKLLLNIRDLPAQTAHILFNYLVGFIMFYVRSPCEGGMEAISAALSFLWEVVPYVEGIFFKDLKQTLKKEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2058 CEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDI 2137
Cdd:pfam20262  161 CDPKLLVTANVPSAKKIVVHGPDECSIPSQLPVHEDTQFSQILQESLDFFNIPEEQHAEYFLVDTKTNQIHNSNSYVRDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2138 YPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAE 2217
Cdd:pfam20262  241 YFFRRNVYPQLSLVHMDPEKAQEALQKQVFTLKFEEVGKVLFTISILQSIPTHQKQNHVSFLQEELLKLPSFPRKALEAE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2218 FSLFSDPQaGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHF 2297
Cdd:pfam20262  321 FSLYKGPQ-GKELFGLDTLHKYLWIKLLEEMFLGMTSTFPWSGDIMLFLNVINGALILHPEDTALLRFCLATLINTARHF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2298 NHLFSLSGYQWILPTMLQVYSDYESNPQLRRAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANTGSSKGVSAQCLF 2377
Cdd:pfam20262  400 KHIFSTSGFLYIMPTLLQVYSNNQSNPVLRQAIEFACKQFYILHRKPFVLQMFGSVAPLLDFTDSAATGDCKKVSAQCLF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2378 DLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKM 2457
Cdd:pfam20262  480 DLLLSLEGDTPDILDILELVKGEKPLKALDFCYGNEPDTFSMLEAINLCVTVVAYAPDSFRSLQMLTILEALVPCYLQHL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2458 KRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRSDQGHKGTTTANHTMSSGVNTrypeqgaklhf 2537
Cdd:pfam20262  560 KSNTTRVESPSAAREEIAAIAALAVSLRALLYSCEYLTRNMTAPQMSRCDQGHKGATTANHSMSGGVDT----------- 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2538 iRENLHL--LEEGQGLPREELDERISREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTALELLDVKSHMRLAE 2615
Cdd:pfam20262  629 -RDDSHLrhMEEGQGRPREELDERIAREEFRRPRDSLLNICAEFYKHCGPRLKELRKLLGDPRVRPPELLDHKSHNRLAE 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2616 IAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWSAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASSLIEGVC 2695
Cdd:pfam20262  708 IAHTLLKLAPYDPQTMECRGLQRYMVEILPITDWSQEAVRPALILILRRLDRMFNKIHKKPTLRRQVDWEAAANLLKGVC 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2696 LTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVI- 2774
Cdd:pfam20262  788 LTLQRQPIIAFLPHLKSLINVCLNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFCSAVVRLVALQMQALGEQFSLEQVCg 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2775 -SPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDA 2853
Cdd:pfam20262  868 gSPFTSPEKREGMLLNLLIPLCLRVGCGRKDSPKLRQPDIFFALQTVLNILLPPRIISTSRSKNFMLSSSPAHCSSPGDS 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2854 GKDLRKEGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQC 2933
Cdd:pfam20262  948 GKDLRREGLAESTSQAAYLGLKVLLVCFDRQLSSEWYRLSLQIKEMGLRGVGGLALWDFLDFVVTTRIPIFVLLRPFIQY 1027
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907069437 2934 KLLAQPAENHEELSARQHISDQLERRFIPRPLCKSSLIAEFNSELKILKEAV 2985
Cdd:pfam20262 1028 KLMKQPCETQEEYYAQQHIADKLEGRSIPRPKCKASLLAELANELKILKEEV 1079
UNC80 pfam19424
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1166-1848 0e+00

Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


:

Pssm-ID: 466075  Cd Length: 704  Bit Score: 1216.18  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1166 KSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNIT 1245
Cdd:pfam19424    1 KEKKLVNLGAIKSGMLRFQFLLNCCEPGTIPDASLLAAALDLEAPVVARAALFLECARFVHRCNRGDWPEWMKGNLPNFR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1246 KKGLSRGRSPTVGNKRNQKLQWSAAKLFYQWGDAIGIRLNELCHGESESPANLLGLIYDEETKRRLRKEdeeedflddSK 1325
Cdd:pfam19424   81 KSGLLRGRGPPSGNRRNQKLQRAAGKMFYQWGEAIGTRLEELCHSESESPANLIGDIYDEETKRELRKE---------DE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1326 ETPFTTRApacTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPR-------------------TEPLVDLESCR 1386
Cdd:pfam19424  152 EEDFLDEA---TVNPTGCECPYALKMAACQLLLEITTFLRETFQCLPRPRreagwdkmtsgrrrwssvlSSPGHSLESCR 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1387 LRLDPELDRHRYERKISFAGVLDEnEDSKDSLHSSSHTIKSDAGAEEKK--------VPSRKIRIGGSRLLQIKGTRSFQ 1458
Cdd:pfam19424  229 LRLDPELPRHRYERKISFAGVLDE-EDSSDSLHSSSHTLKSDPGCSEKKtgrapkgrKPLRKIRRGGSRLLSIKGNRSFK 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1459 VKKGGSLSSIRRVGSLKSSKLSRQDSESEAEelQLSQSRDTVTDLEGSPWSASEPSIEPEGLSNAGTEENYHRNMSWLHV 1538
Cdd:pfam19424  308 LKKGGSLSSIRRAGSLKSRKVSRQDSESNEE--LLSQSRDTVTDIEGSPWSDSEPSIEPEGDSEEGEDDNYHRNMPWLKV 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1539 MILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESNHI-SNVALRGKKQKECSDKSCLRTPSLK 1617
Cdd:pfam19424  386 VILLANQSNFICTHQDYCHPNCYERQRRSCARLVRAIKKVYGSTVDSLRTESATaDNLKDRLKRRKECSDKSCLRTPLLE 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1618 KRVSDVNL--EGKKDSGMLKYIRFQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAV 1695
Cdd:pfam19424  466 KIKTDVNTekEGKKDSGMLKYIRSQVQSLTPAPLSLLIKAAPILTEEMYGDIQPVAWELLLEVDQEMAAAAAAMFLLCSV 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1696 KVPDAVSDMLMSEFHHAETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWV 1775
Cdd:pfam19424  546 KVPDAVRDMMMKEFQHEETCQRINAVLRFGTLWRFRYQVWPRMEEGAQQIFKIPPPSIDFTLPSPTIGLPSVPVFDPPWV 625
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907069437 1776 PQCSGSVQD-PINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNS 1848
Cdd:pfam19424  626 PQFKAKVEEvTINQDQSKSFVTATVTRRKQQAEMILKALQAEEEKKRLGREAFLITTVPITQEAAYEPALHHAS 699
UNC80_N pfam15778
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
16-235 6.82e-98

UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.


:

Pssm-ID: 464864  Cd Length: 187  Bit Score: 313.52  E-value: 6.82e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437   16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSN 95
Cdd:pfam15778    1 LSVPLPIQTFLWRQTSPFIRPKLGKLHEASCMSFERVLVQNILHGLSPSLTEAIGSIPRWRLVQAALPHVMHCCAALLHN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437   96 RNKLgHQDKLGVAETKLLHTLHWMLLEAPQDCNNdqfggtdrgsswggsssafihqienqgspgqpcrsssHDEEENNRR 175
Cdd:pfam15778   81 RKKT-NLQKLGTAETKLLYTLHWILLDAAEECAD-------------------------------------ADEEKGNFQ 122
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907069437  176 K---TFQNSMATVELFVFLFAPLVHRIKESDL-TFRLASGLVIWQPMWEHRQPEVSGFTALVKP 235
Cdd:pfam15778  123 SlpfQYLFPIPTITLFVYLFAPLIHHLKESDFqNFRLENGLKIWQAMWEYRHPDIPCFTAPVKP 186
 
Name Accession Description Interval E-value
UNC80_C pfam20262
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1898-2985 0e+00

Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466412  Cd Length: 1079  Bit Score: 2116.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1898 DEEHATEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISN 1977
Cdd:pfam20262    1 GEEERTEHTPTHHVLQPAQAVFPSCICAAVLPIVHLLEDGEVREDGVAVSEVAEKVIWNCLVEDPALFLRHFLEKLTNRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1978 RQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQ 2057
Cdd:pfam20262   81 RQEELIFLLRKLLLNIRDLPAQTAHILFNYLVGFIMFYVRSPCEGGMEAISAALSFLWEVVPYVEGIFFKDLKQTLKKEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2058 CEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDI 2137
Cdd:pfam20262  161 CDPKLLVTANVPSAKKIVVHGPDECSIPSQLPVHEDTQFSQILQESLDFFNIPEEQHAEYFLVDTKTNQIHNSNSYVRDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2138 YPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAE 2217
Cdd:pfam20262  241 YFFRRNVYPQLSLVHMDPEKAQEALQKQVFTLKFEEVGKVLFTISILQSIPTHQKQNHVSFLQEELLKLPSFPRKALEAE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2218 FSLFSDPQaGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHF 2297
Cdd:pfam20262  321 FSLYKGPQ-GKELFGLDTLHKYLWIKLLEEMFLGMTSTFPWSGDIMLFLNVINGALILHPEDTALLRFCLATLINTARHF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2298 NHLFSLSGYQWILPTMLQVYSDYESNPQLRRAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANTGSSKGVSAQCLF 2377
Cdd:pfam20262  400 KHIFSTSGFLYIMPTLLQVYSNNQSNPVLRQAIEFACKQFYILHRKPFVLQMFGSVAPLLDFTDSAATGDCKKVSAQCLF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2378 DLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKM 2457
Cdd:pfam20262  480 DLLLSLEGDTPDILDILELVKGEKPLKALDFCYGNEPDTFSMLEAINLCVTVVAYAPDSFRSLQMLTILEALVPCYLQHL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2458 KRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRSDQGHKGTTTANHTMSSGVNTrypeqgaklhf 2537
Cdd:pfam20262  560 KSNTTRVESPSAAREEIAAIAALAVSLRALLYSCEYLTRNMTAPQMSRCDQGHKGATTANHSMSGGVDT----------- 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2538 iRENLHL--LEEGQGLPREELDERISREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTALELLDVKSHMRLAE 2615
Cdd:pfam20262  629 -RDDSHLrhMEEGQGRPREELDERIAREEFRRPRDSLLNICAEFYKHCGPRLKELRKLLGDPRVRPPELLDHKSHNRLAE 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2616 IAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWSAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASSLIEGVC 2695
Cdd:pfam20262  708 IAHTLLKLAPYDPQTMECRGLQRYMVEILPITDWSQEAVRPALILILRRLDRMFNKIHKKPTLRRQVDWEAAANLLKGVC 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2696 LTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVI- 2774
Cdd:pfam20262  788 LTLQRQPIIAFLPHLKSLINVCLNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFCSAVVRLVALQMQALGEQFSLEQVCg 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2775 -SPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDA 2853
Cdd:pfam20262  868 gSPFTSPEKREGMLLNLLIPLCLRVGCGRKDSPKLRQPDIFFALQTVLNILLPPRIISTSRSKNFMLSSSPAHCSSPGDS 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2854 GKDLRKEGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQC 2933
Cdd:pfam20262  948 GKDLRREGLAESTSQAAYLGLKVLLVCFDRQLSSEWYRLSLQIKEMGLRGVGGLALWDFLDFVVTTRIPIFVLLRPFIQY 1027
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907069437 2934 KLLAQPAENHEELSARQHISDQLERRFIPRPLCKSSLIAEFNSELKILKEAV 2985
Cdd:pfam20262 1028 KLMKQPCETQEEYYAQQHIADKLEGRSIPRPKCKASLLAELANELKILKEEV 1079
UNC80 pfam19424
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1166-1848 0e+00

Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466075  Cd Length: 704  Bit Score: 1216.18  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1166 KSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNIT 1245
Cdd:pfam19424    1 KEKKLVNLGAIKSGMLRFQFLLNCCEPGTIPDASLLAAALDLEAPVVARAALFLECARFVHRCNRGDWPEWMKGNLPNFR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1246 KKGLSRGRSPTVGNKRNQKLQWSAAKLFYQWGDAIGIRLNELCHGESESPANLLGLIYDEETKRRLRKEdeeedflddSK 1325
Cdd:pfam19424   81 KSGLLRGRGPPSGNRRNQKLQRAAGKMFYQWGEAIGTRLEELCHSESESPANLIGDIYDEETKRELRKE---------DE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1326 ETPFTTRApacTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPR-------------------TEPLVDLESCR 1386
Cdd:pfam19424  152 EEDFLDEA---TVNPTGCECPYALKMAACQLLLEITTFLRETFQCLPRPRreagwdkmtsgrrrwssvlSSPGHSLESCR 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1387 LRLDPELDRHRYERKISFAGVLDEnEDSKDSLHSSSHTIKSDAGAEEKK--------VPSRKIRIGGSRLLQIKGTRSFQ 1458
Cdd:pfam19424  229 LRLDPELPRHRYERKISFAGVLDE-EDSSDSLHSSSHTLKSDPGCSEKKtgrapkgrKPLRKIRRGGSRLLSIKGNRSFK 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1459 VKKGGSLSSIRRVGSLKSSKLSRQDSESEAEelQLSQSRDTVTDLEGSPWSASEPSIEPEGLSNAGTEENYHRNMSWLHV 1538
Cdd:pfam19424  308 LKKGGSLSSIRRAGSLKSRKVSRQDSESNEE--LLSQSRDTVTDIEGSPWSDSEPSIEPEGDSEEGEDDNYHRNMPWLKV 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1539 MILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESNHI-SNVALRGKKQKECSDKSCLRTPSLK 1617
Cdd:pfam19424  386 VILLANQSNFICTHQDYCHPNCYERQRRSCARLVRAIKKVYGSTVDSLRTESATaDNLKDRLKRRKECSDKSCLRTPLLE 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1618 KRVSDVNL--EGKKDSGMLKYIRFQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAV 1695
Cdd:pfam19424  466 KIKTDVNTekEGKKDSGMLKYIRSQVQSLTPAPLSLLIKAAPILTEEMYGDIQPVAWELLLEVDQEMAAAAAAMFLLCSV 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1696 KVPDAVSDMLMSEFHHAETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWV 1775
Cdd:pfam19424  546 KVPDAVRDMMMKEFQHEETCQRINAVLRFGTLWRFRYQVWPRMEEGAQQIFKIPPPSIDFTLPSPTIGLPSVPVFDPPWV 625
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907069437 1776 PQCSGSVQD-PINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNS 1848
Cdd:pfam19424  626 PQFKAKVEEvTINQDQSKSFVTATVTRRKQQAEMILKALQAEEEKKRLGREAFLITTVPITQEAAYEPALHHAS 699
UNC80_N pfam15778
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
16-235 6.82e-98

UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.


Pssm-ID: 464864  Cd Length: 187  Bit Score: 313.52  E-value: 6.82e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437   16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSN 95
Cdd:pfam15778    1 LSVPLPIQTFLWRQTSPFIRPKLGKLHEASCMSFERVLVQNILHGLSPSLTEAIGSIPRWRLVQAALPHVMHCCAALLHN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437   96 RNKLgHQDKLGVAETKLLHTLHWMLLEAPQDCNNdqfggtdrgsswggsssafihqienqgspgqpcrsssHDEEENNRR 175
Cdd:pfam15778   81 RKKT-NLQKLGTAETKLLYTLHWILLDAAEECAD-------------------------------------ADEEKGNFQ 122
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907069437  176 K---TFQNSMATVELFVFLFAPLVHRIKESDL-TFRLASGLVIWQPMWEHRQPEVSGFTALVKP 235
Cdd:pfam15778  123 SlpfQYLFPIPTITLFVYLFAPLIHHLKESDFqNFRLENGLKIWQAMWEYRHPDIPCFTAPVKP 186
 
Name Accession Description Interval E-value
UNC80_C pfam20262
Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, ...
1898-2985 0e+00

Protein UNC80 C-terminal region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466412  Cd Length: 1079  Bit Score: 2116.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1898 DEEHATEHTPNHHVPQPPQAVFPACICAAVLPIVHLMEDGEVREDGVAVSAVAQQVLWNCLIEDPSTVLRHFLEKLTISN 1977
Cdd:pfam20262    1 GEEERTEHTPTHHVLQPAQAVFPSCICAAVLPIVHLLEDGEVREDGVAVSEVAEKVIWNCLVEDPALFLRHFLEKLTNRD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1978 RQDELMYMLRKLLLNIGDFPAQTSHILFNYLVGLIMYFVRTPCEWGMDAISATLTFLWEVVGYVEGLFFKDLKQTMKKEQ 2057
Cdd:pfam20262   81 RQEELIFLLRKLLLNIRDLPAQTAHILFNYLVGFIMFYVRSPCEGGMEAISAALSFLWEVVPYVEGIFFKDLKQTLKKEQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2058 CEVKLLVTASMPGTKTLVVHGQNECDIPTQLPVHEDTQFEALLKECLEFFNIPESQSTHYFLMDKRWNLIHYNKTYVRDI 2137
Cdd:pfam20262  161 CDPKLLVTANVPSAKKIVVHGPDECSIPSQLPVHEDTQFSQILQESLDFFNIPEEQHAEYFLVDTKTNQIHNSNSYVRDF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2138 YPFRRSVSPQLNLVHMHPEKGQELIQKQVFTRKLEEVGRVLFLISLTQKIPTAHKQSHVSMLQEDLLRLPSFPRSAIDAE 2217
Cdd:pfam20262  241 YFFRRNVYPQLSLVHMDPEKAQEALQKQVFTLKFEEVGKVLFTISILQSIPTHQKQNHVSFLQEELLKLPSFPRKALEAE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2218 FSLFSDPQaGKELFGLDTLQKSLWIQLLEEMFLGMPSEFPWGDEIMLFLNVFNGALILHPEDSALLRQYAATVINTAVHF 2297
Cdd:pfam20262  321 FSLYKGPQ-GKELFGLDTLHKYLWIKLLEEMFLGMTSTFPWSGDIMLFLNVINGALILHPEDTALLRFCLATLINTARHF 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2298 NHLFSLSGYQWILPTMLQVYSDYESNPQLRRAIEFACHQFYILHRKPFVLQLFASVAPLLEFPDAANTGSSKGVSAQCLF 2377
Cdd:pfam20262  400 KHIFSTSGFLYIMPTLLQVYSNNQSNPVLRQAIEFACKQFYILHRKPFVLQMFGSVAPLLDFTDSAATGDCKKVSAQCLF 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2378 DLLQSLEGETTDILDILELVKAEKPLKSLDFCYGNEDLTFSISEAIKLCVTVVAYAPESFRSLQMLMVLEALVPCYLQKM 2457
Cdd:pfam20262  480 DLLLSLEGDTPDILDILELVKGEKPLKALDFCYGNEPDTFSMLEAINLCVTVVAYAPDSFRSLQMLTILEALVPCYLQHL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2458 KRQTSQVETVPAAREEIAATAALATSLQALLYSVEVLTRPMTAPQMSRSDQGHKGTTTANHTMSSGVNTrypeqgaklhf 2537
Cdd:pfam20262  560 KSNTTRVESPSAAREEIAAIAALAVSLRALLYSCEYLTRNMTAPQMSRCDQGHKGATTANHSMSGGVDT----------- 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2538 iRENLHL--LEEGQGLPREELDERISREEFRRPRESLLNICTEFYKHCGPRLKILQNLAGEPRVTALELLDVKSHMRLAE 2615
Cdd:pfam20262  629 -RDDSHLrhMEEGQGRPREELDERIAREEFRRPRDSLLNICAEFYKHCGPRLKELRKLLGDPRVRPPELLDHKSHNRLAE 707
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2616 IAHSLLKLAPYDTQTMESRGLRRYIMEMLPITDWSAEAVRPALILILKRLDRMFNKIHKMPTLRRQVEWEPASSLIEGVC 2695
Cdd:pfam20262  708 IAHTLLKLAPYDPQTMECRGLQRYMVEILPITDWSQEAVRPALILILRRLDRMFNKIHKKPTLRRQVDWEAAANLLKGVC 787
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2696 LTLQRQPIISFLPHLRSLINVCVNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFSTAVVRLVALQIQALKEDFPLSHVI- 2774
Cdd:pfam20262  788 LTLQRQPIIAFLPHLKSLINVCLNLVMGVVGPSSVADGLPLLHLSPYLSPPLPFCSAVVRLVALQMQALGEQFSLEQVCg 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2775 -SPFTNQERREGMLLNLLIPFVLTVGSGSKDSPWLEQPEVQLLLQTVINVLLPPRIISTSRSKNFMLESSPAHCSTPGDA 2853
Cdd:pfam20262  868 gSPFTSPEKREGMLLNLLIPLCLRVGCGRKDSPKLRQPDIFFALQTVLNILLPPRIISTSRSKNFMLSSSPAHCSSPGDS 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 2854 GKDLRKEGLAESTSQAAYLALKVILVCFERQLGSQWYWLSLQVKEMALRKVGGLALWDFLDFIVRTRIPIFVLLRPFIQC 2933
Cdd:pfam20262  948 GKDLRREGLAESTSQAAYLGLKVLLVCFDRQLSSEWYRLSLQIKEMGLRGVGGLALWDFLDFVVTTRIPIFVLLRPFIQY 1027
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907069437 2934 KLLAQPAENHEELSARQHISDQLERRFIPRPLCKSSLIAEFNSELKILKEAV 2985
Cdd:pfam20262 1028 KLMKQPCETQEEYYAQQHIADKLEGRSIPRPKCKASLLAELANELKILKEEV 1079
UNC80 pfam19424
Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a ...
1166-1848 0e+00

Protein UNC80 central region; This family represents the protein UNC80 found in eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localization of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN.


Pssm-ID: 466075  Cd Length: 704  Bit Score: 1216.18  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1166 KSKNVVNLGAIRQGMKRFQFLLNCCEPGTIPDASILAAALDLEAPVVARAALFLECARFVHRCNRGNWPEWMKGHHVNIT 1245
Cdd:pfam19424    1 KEKKLVNLGAIKSGMLRFQFLLNCCEPGTIPDASLLAAALDLEAPVVARAALFLECARFVHRCNRGDWPEWMKGNLPNFR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1246 KKGLSRGRSPTVGNKRNQKLQWSAAKLFYQWGDAIGIRLNELCHGESESPANLLGLIYDEETKRRLRKEdeeedflddSK 1325
Cdd:pfam19424   81 KSGLLRGRGPPSGNRRNQKLQRAAGKMFYQWGEAIGTRLEELCHSESESPANLIGDIYDEETKRELRKE---------DE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1326 ETPFTTRApacTVNPSKCGCPFALKMAACQLLLEITTFLRETFSCLPRPR-------------------TEPLVDLESCR 1386
Cdd:pfam19424  152 EEDFLDEA---TVNPTGCECPYALKMAACQLLLEITTFLRETFQCLPRPRreagwdkmtsgrrrwssvlSSPGHSLESCR 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1387 LRLDPELDRHRYERKISFAGVLDEnEDSKDSLHSSSHTIKSDAGAEEKK--------VPSRKIRIGGSRLLQIKGTRSFQ 1458
Cdd:pfam19424  229 LRLDPELPRHRYERKISFAGVLDE-EDSSDSLHSSSHTLKSDPGCSEKKtgrapkgrKPLRKIRRGGSRLLSIKGNRSFK 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1459 VKKGGSLSSIRRVGSLKSSKLSRQDSESEAEelQLSQSRDTVTDLEGSPWSASEPSIEPEGLSNAGTEENYHRNMSWLHV 1538
Cdd:pfam19424  308 LKKGGSLSSIRRAGSLKSRKVSRQDSESNEE--LLSQSRDTVTDIEGSPWSDSEPSIEPEGDSEEGEDDNYHRNMPWLKV 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1539 MILLCNQQSFICTHVDYCHPHCYLHHSRSCARLVRAIKLLYGDSVDSLRESNHI-SNVALRGKKQKECSDKSCLRTPSLK 1617
Cdd:pfam19424  386 VILLANQSNFICTHQDYCHPNCYERQRRSCARLVRAIKKVYGSTVDSLRTESATaDNLKDRLKRRKECSDKSCLRTPLLE 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1618 KRVSDVNL--EGKKDSGMLKYIRFQVMSLSPAPLSLLIKAAPILTEEMYGDIQPAAWELLLSMDEHMAGAAAAMFLLCAV 1695
Cdd:pfam19424  466 KIKTDVNTekEGKKDSGMLKYIRSQVQSLTPAPLSLLIKAAPILTEEMYGDIQPVAWELLLEVDQEMAAAAAAMFLLCSV 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437 1696 KVPDAVSDMLMSEFHHAETVQRLNAVLKFHTLWRFRYQVWPRMEEGAQQIFKIPPPSINFTLPSPVLGMPSVPMFDPPWV 1775
Cdd:pfam19424  546 KVPDAVRDMMMKEFQHEETCQRINAVLRFGTLWRFRYQVWPRMEEGAQQIFKIPPPSIDFTLPSPTIGLPSVPVFDPPWV 625
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907069437 1776 PQCSGSVQD-PINEDQSKSFSARAVSRSHQRAEHILKNLQQEEEKKRLGREASLITAIPITQEACYEPTCTPNS 1848
Cdd:pfam19424  626 PQFKAKVEEvTINQDQSKSFVTATVTRRKQQAEMILKALQAEEEKKRLGREAFLITTVPITQEAAYEPALHHAS 699
UNC80_N pfam15778
UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the ...
16-235 6.82e-98

UNC80 N-terminal; UNC80 is a family of proteins found in eukaryotes. This entry represents the N-terminal domain. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.


Pssm-ID: 464864  Cd Length: 187  Bit Score: 313.52  E-value: 6.82e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437   16 RGIPLPIQTFLWRQTSAFLRPKLGKQYEASCVSFERVLVENKLHGLSPALSEAIQSISRWELVQAALPHVLHCTATLLSN 95
Cdd:pfam15778    1 LSVPLPIQTFLWRQTSPFIRPKLGKLHEASCMSFERVLVQNILHGLSPSLTEAIGSIPRWRLVQAALPHVMHCCAALLHN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907069437   96 RNKLgHQDKLGVAETKLLHTLHWMLLEAPQDCNNdqfggtdrgsswggsssafihqienqgspgqpcrsssHDEEENNRR 175
Cdd:pfam15778   81 RKKT-NLQKLGTAETKLLYTLHWILLDAAEECAD-------------------------------------ADEEKGNFQ 122
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907069437  176 K---TFQNSMATVELFVFLFAPLVHRIKESDL-TFRLASGLVIWQPMWEHRQPEVSGFTALVKP 235
Cdd:pfam15778  123 SlpfQYLFPIPTITLFVYLFAPLIHHLKESDFqNFRLENGLKIWQAMWEYRHPDIPCFTAPVKP 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH