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Conserved domains on  [gi|1907067579|ref|XP_036018381|]
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protein crumbs homolog 1 isoform X11 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 211-328 1.47e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.47  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 211 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 286
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907067579 287 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 328
Cdd:pfam02210  81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1-117 2.59e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.00  E-value: 2.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579   1 MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKCTTKSSVPVENHQSICALQDS 79
Cdd:pfam02210  21 LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQTVVSSLPPGESLLLNLNGPL 94

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907067579  80 FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 117
Cdd:pfam02210  95 YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 448-573 9.92e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 74.38  E-value: 9.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 448 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 526
Cdd:pfam02210   1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067579 527 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 573
Cdd:pfam02210  75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-801 7.31e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 7.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907067579 765 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 801
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 144-175 6.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 6.58e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907067579 144 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 175
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-680 1.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907067579 645 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 680
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 609-643 1.29e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907067579 609 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 643
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 1.47e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907067579 682 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 717
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 357-391 2.11e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907067579 357 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 391
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 211-328 1.47e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.47  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 211 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 286
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907067579 287 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 328
Cdd:pfam02210  81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1-117 2.59e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.00  E-value: 2.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579   1 MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKCTTKSSVPVENHQSICALQDS 79
Cdd:pfam02210  21 LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQTVVSSLPPGESLLLNLNGPL 94

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907067579  80 FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 117
Cdd:pfam02210  95 YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 448-573 9.92e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 74.38  E-value: 9.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 448 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 526
Cdd:pfam02210   1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067579 527 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 573
Cdd:pfam02210  75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 188-326 2.70e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 2.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 188 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 263
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907067579 264 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 326
Cdd:cd00110    85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 420-570 3.82e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 3.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 420 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 497
Cdd:cd00110     2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 498 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 570
Cdd:cd00110    78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
443-572 8.83e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 8.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579  443 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 520
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067579  521 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 572
Cdd:smart00282  75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
206-328 2.85e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.89  E-value: 2.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579  206 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 278
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907067579  279 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 328
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1-117 2.52e-08

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.96  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579   1 MKLELLNGCVHLSIEVwNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqds 79
Cdd:cd00110    49 LALELEDGRLVLRYDL-GSGSLVLSSKTPLNDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------ 121

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907067579  80 FLGGLPMGTANNSVsvlniynvPSTPSFVGCLQDIRFD 117
Cdd:cd00110   122 YLGGLPEDLKSPGL--------PVSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-801 7.31e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 7.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907067579 765 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 801
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG smart00282
Laminin G domain;
1-117 1.60e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579    1 MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvggsckekcttksSVPVENHQSICALQDS 79
Cdd:smart00282  27 LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL---------------SVDGGNRVSGESPGGL 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1907067579   80 ---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 117
Cdd:smart00282  92 tilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 144-175 6.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 6.58e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907067579 144 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 175
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-680 1.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907067579 645 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 680
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 144-174 1.10e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907067579 144 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 174
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 609-643 1.29e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907067579 609 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 643
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-801 2.04e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907067579  765 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 801
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 1.47e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907067579 682 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 717
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 357-391 2.11e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907067579 357 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 391
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 359-388 2.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.12e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907067579 359 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 388
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 769-799 2.96e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.96e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907067579 769 CASDPCINGGLCRDLVNRFLCICDVAFAGER 799
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
645-680 4.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.94e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907067579  645 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 680
Cdd:smart00179   1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
609-643 6.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067579  609 NACHS-SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 643
Cdd:smart00179   3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 611-639 8.23e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 8.23e-04
                          10        20
                  ....*....|....*....|....*....
gi 1907067579 611 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 639
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
144-175 1.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.22e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907067579  144 CES-QPCQNRGRCINLWQGYQCECDRPYT-GSNC 175
Cdd:smart00179   5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 649-723 1.69e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 39.62  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 649 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 720
Cdd:PHA03099   53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                  ...
gi 1907067579 721 RLP 723
Cdd:PHA03099  130 KLP 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
359-391 6.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 6.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907067579  359 CKS-NPCHNGGVCHSLWDDFSCSCPTN-TAGRACE 391
Cdd:smart00179   5 CASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 649-678 7.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 7.99e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907067579 649 CFSSPCIH-GNCSDGVAAYHCRCEPGYTGVN 678
Cdd:pfam00008   1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 211-328 1.47e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.47  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 211 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 286
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907067579 287 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 328
Cdd:pfam02210  81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1-117 2.59e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 79.00  E-value: 2.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579   1 MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKCTTKSSVPVENHQSICALQDS 79
Cdd:pfam02210  21 LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQTVVSSLPPGESLLLNLNGPL 94

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907067579  80 FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 117
Cdd:pfam02210  95 YLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 448-573 9.92e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 74.38  E-value: 9.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 448 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 526
Cdd:pfam02210   1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907067579 527 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 573
Cdd:pfam02210  75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 188-326 2.70e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 2.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 188 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 263
Cdd:cd00110     5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907067579 264 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 326
Cdd:cd00110    85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 420-570 3.82e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 3.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 420 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 497
Cdd:cd00110     2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 498 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 570
Cdd:cd00110    78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
443-572 8.83e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 8.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579  443 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 520
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907067579  521 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 572
Cdd:smart00282  75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
206-328 2.85e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.89  E-value: 2.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579  206 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 278
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907067579  279 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 328
Cdd:smart00282  81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
448-572 1.37e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 1.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 448 FRTHDTNVMILHAEK--EPEFLNISIQDARLFFQLRSGNSfyTLHLMGSQLVNDGTWHQVTFSMIdpvaqTSRWQMEVND 525
Cdd:pfam00054   1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907067579 526 QTPFVISEVaTGSLNFLKDNTDIYVG---DQSVDNP-----KGLQGCLSTIEIGG 572
Cdd:pfam00054  74 EARPTGESP-LGATTDLDVDGPLYVGglpSLGVKKRrlaisPSFDGCIRDVIVNG 127
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1-117 2.52e-08

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.96  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579   1 MKLELLNGCVHLSIEVwNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqds 79
Cdd:cd00110    49 LALELEDGRLVLRYDL-GSGSLVLSSKTPLNDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------ 121

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1907067579  80 FLGGLPMGTANNSVsvlniynvPSTPSFVGCLQDIRFD 117
Cdd:cd00110   122 YLGGLPEDLKSPGL--------PVSPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-801 7.31e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 7.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907067579 765 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 801
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG smart00282
Laminin G domain;
1-117 1.60e-06

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 48.10  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579    1 MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvggsckekcttksSVPVENHQSICALQDS 79
Cdd:smart00282  27 LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL---------------SVDGGNRVSGESPGGL 91

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1907067579   80 ---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 117
Cdd:smart00282  92 tilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 144-175 6.58e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 6.58e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1907067579 144 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 175
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-680 1.03e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.03e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907067579 645 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 680
Cdd:cd00054     1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 144-174 1.10e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 1.10e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907067579 144 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 174
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 609-643 1.29e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 1.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907067579 609 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 643
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-801 2.04e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 2.04e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907067579  765 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 801
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 1.47e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1907067579 682 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 717
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 357-391 2.11e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1907067579 357 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 391
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 359-388 2.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 2.12e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907067579 359 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 388
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 769-799 2.96e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 2.96e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907067579 769 CASDPCINGGLCRDLVNRFLCICDVAFAGER 799
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
645-680 4.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.94e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1907067579  645 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 680
Cdd:smart00179   1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
609-643 6.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907067579  609 NACHS-SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 643
Cdd:smart00179   3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 611-639 8.23e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 8.23e-04
                          10        20
                  ....*....|....*....|....*....
gi 1907067579 611 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 639
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
144-175 1.22e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.22e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907067579  144 CES-QPCQNRGRCINLWQGYQCECDRPYT-GSNC 175
Cdd:smart00179   5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 613-643 1.42e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.42e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907067579 613 SSPCLHGGNCEDSYSSYRCACLSGWSG-THCE 643
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 649-723 1.69e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 39.62  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 649 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 720
Cdd:PHA03099   53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                  ...
gi 1907067579 721 RLP 723
Cdd:PHA03099  130 KLP 132
Laminin_G_1 pfam00054
Laminin G domain;
211-331 1.80e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579 211 VRTRQPLGLLLALENSTY-QYVSVWLEHGSL----------ALQTPGSPkfmvnffLSDGNVHLI---------SLRIKP 270
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLevsydlgsgaAVVRSGDK-------LNDGKWHSVelerngrsgTLSVDG 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907067579 271 NEIELYQS-SQNLGFISVPTwtirrgdVIFIGGLPDREKTE---VYGGFFKGCVQDVRLNSQTLE 331
Cdd:pfam00054  74 EARPTGESpLGATTDLDVDG-------PLYVGGLPSLGVKKrrlAISPSFDGCIRDVIVNGKPLD 131
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 145-174 3.21e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 3.21e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1907067579 145 ESQPCQNRGRCINLWQGYQCECDRPYTGSN 174
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
Laminin_G_1 pfam00054
Laminin G domain;
3-117 3.70e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 38.45  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907067579   3 LELLNGCVHLSIEVWNQlKVLLSISHNTSDGEWHFVEVTIAET-LTLALVGGSckekcTTKSSVPVENHQSICALQDSFL 81
Cdd:pfam00054  24 LELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVELERNGRsGTLSVDGEA-----RPTGESPLGATTDLDVDGPLYV 97

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907067579  82 GGLPmgtannSVSVLNiYNVPSTPSFVGCLQDIRFD 117
Cdd:pfam00054  98 GGLP------SLGVKK-RRLAISPSFDGCIRDVIVN 126
EGF_CA smart00179
Calcium-binding EGF-like domain;
359-391 6.39e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 6.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907067579  359 CKS-NPCHNGGVCHSLWDDFSCSCPTN-TAGRACE 391
Cdd:smart00179   5 CASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 649-678 7.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 34.67  E-value: 7.99e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1907067579 649 CFSSPCIH-GNCSDGVAAYHCRCEPGYTGVN 678
Cdd:pfam00008   1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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