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Conserved domains on  [gi|1907139889|ref|XP_036018120|]
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mitogen-activated protein kinase-binding protein 1 isoform X3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
184-622 2.80e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 2.80e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  184 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 263
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  264 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 342
Cdd:COG2319    152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  343 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 422
Cdd:COG2319    200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  423 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 502
Cdd:COG2319    258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  503 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 582
Cdd:COG2319    301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907139889  583 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 622
Cdd:COG2319    364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-315 3.92e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 3.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    4 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVT 82
Cdd:cd00200     33 IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   83 AG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACGRGEKaDSTFcITSSGllcefSDR--RLldkWvE 159
Cdd:cd00200    111 SSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSVAFSP-DGTF-VASSS-----QDGtiKL---W-D 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  160 LRNTDSFTTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNAry 232
Cdd:cd00200    164 LRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGH----------------ENGVNS-- 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  233 pdtiaLTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSVEVYPEIKDshqaclppssFITCSSDNTIR 312
Cdd:cd00200    225 -----VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSLAWSPDGKR----------LASGSADGTIR 286


                   ...
gi 1907139889  313 LWN 315
Cdd:cd00200    287 IWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
184-622 2.80e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 2.80e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  184 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 263
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  264 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 342
Cdd:COG2319    152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  343 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 422
Cdd:COG2319    200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  423 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 502
Cdd:COG2319    258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  503 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 582
Cdd:COG2319    301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907139889  583 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 622
Cdd:COG2319    364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-619 1.11e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 1.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  237 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWN 315
Cdd:cd00200     14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  316 TESSGVHgSTLHrnilsndlikiiyvdgntqalldtelpgGDKADgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHE 395
Cdd:cd00200     80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  396 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 475
Cdd:cd00200    122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  476 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 555
Cdd:cd00200    196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907139889  556 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 619
Cdd:cd00200    226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-315 3.92e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 3.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    4 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVT 82
Cdd:cd00200     33 IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   83 AG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACGRGEKaDSTFcITSSGllcefSDR--RLldkWvE 159
Cdd:cd00200    111 SSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSVAFSP-DGTF-VASSS-----QDGtiKL---W-D 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  160 LRNTDSFTTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNAry 232
Cdd:cd00200    164 LRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGH----------------ENGVNS-- 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  233 pdtiaLTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSVEVYPEIKDshqaclppssFITCSSDNTIR 312
Cdd:cd00200    225 -----VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSLAWSPDGKR----------LASGSADGTIR 286


                   ...
gi 1907139889  313 LWN 315
Cdd:cd00200    287 IWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 580-618 2.28e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.28e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907139889   580 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 618
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
581-618 6.30e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 6.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907139889  581 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 618
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 4-169 2.82e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    4 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 83
Cdd:PLN00181   557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   84 GNRHIKFWYLDDSktskvNATVPL---LGRSGLLGELRnnlFTDVACGRGEKADST-----FCITSSGL----LCEFSDR 151
Cdd:PLN00181   636 GSADHKVYYYDLR-----NPKLPLctmIGHSKTVSYVR---FVDSSTLVSSSTDNTlklwdLSMSISGInetpLHSFMGH 707

                          170
                   ....*....|....*...
gi 1907139889  152 RLLDKWVELRNTDSFTTT 169
Cdd:PLN00181   708 TNVKNFVGLSVSDGYIAT 725
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-51 6.81e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 6.81e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907139889    12 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 51
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
12-51 5.57e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 5.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907139889   12 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 51
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
184-622 2.80e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 2.80e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  184 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 263
Cdd:COG2319     96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  264 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 342
Cdd:COG2319    152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  343 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 422
Cdd:COG2319    200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  423 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 502
Cdd:COG2319    258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  503 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 582
Cdd:COG2319    301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907139889  583 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 622
Cdd:COG2319    364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
306-642 2.24e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.24e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  306 SSDNTIRLWNTES-------SGVHGSTLHRNILSNDLIKIIYVDGNTQALLDTElpgGDKADGSLMDPRVGIRSVCISPN 378
Cdd:COG2319     55 AGDLTLLLLDAAAgallatlLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHTGAVRSVAFSPD 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  379 GQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDtGlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSI 458
Cdd:COG2319    132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PD-G-KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAV 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  459 TAVKFAAsDGQvRMISCGADKSIYFRTAQkSGEGVQFTRTHHvvrkTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQ 538
Cdd:COG2319    208 RSVAFSP-DGK-LLASGSADGTVRLWDLA-TGKLLRTLTGHS----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  539 KKLFKgsqGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 618
Cdd:COG2319    281 LRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                          330       340
                   ....*....|....*....|....
gi 1907139889  619 RLSSemtismRQRLAELRQRQRGI 642
Cdd:COG2319    358 DLAT------GELLRTLTGHTGAV 375
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-619 1.11e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 1.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  237 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWN 315
Cdd:cd00200     14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  316 TESSGVHgSTLHrnilsndlikiiyvdgntqalldtelpgGDKADgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHE 395
Cdd:cd00200     80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  396 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 475
Cdd:cd00200    122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  476 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 555
Cdd:cd00200    196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907139889  556 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 619
Cdd:cd00200    226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-481 1.14e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 1.14e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    3 AVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWK-KNIVVASNKVSSRVTAVSFSEDCSYFV 81
Cdd:COG2319     59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA--DGTVRLWDLAtGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   82 TAGNRH-IKFWyldDSKTSKVNATvpLLGRSGLLgelrnnlfTDVAcgrgekadstfcitssgllceFS-DRRLLdkwve 159
Cdd:COG2319    137 SGSADGtVRLW---DLATGKLLRT--LTGHSGAV--------TSVA---------------------FSpDGKLL----- 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  160 lrntdsftttvahcisVTqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGVNArypdtiaLT 239
Cdd:COG2319    178 ----------------AS------GSDDGTVRLWDLATGKLLRTLTGH-----------------TGAVRS-------VA 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  240 FDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWNTESs 319
Cdd:COG2319    212 FSPDGKLLASGSADGTVRLWDLATGKLL-RTLTG--HSGSVRSVAFSP---DGRL-------LASGSADGTVRLWDLAT- 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  320 gvhGSTLHRnilsndlikiiyvdgntqalldtelpggdkadgsLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSL 399
Cdd:COG2319    278 ---GELLRT----------------------------------LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  400 SEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGQvRMISCGADK 479
Cdd:COG2319    321 KLLRTLTGHTGAVRSVAFS-PDG--KTLASGSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSP-DGR-TLASGSADG 394


                   ..
gi 1907139889  480 SI 481
Cdd:COG2319    395 TV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 369-623 9.06e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 9.06e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  369 GIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREYSLQ 448
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADG--TYLASGSSDKTIRLWDLETGECVR 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  449 qTLDEHSSSITAVKFAASDgqvRMI-SCGADKSIYFRTAQkSGEGVQFTRTHhvvrKTTLYDMDVEPSWKYTAIGCQDRN 527
Cdd:cd00200     88 -TLTGHTSYVSSVAFSPDG---RILsSSSRDKTIKVWDVE-TGKCLTTLRGH----TDWVNSVAFSPDGTFVASSSQDGT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  528 IRIFNISSGKQKKLFKGSQGEdgtLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLI 607
Cdd:cd00200    159 IKLWDLRTGKCVATLTGHTGE---VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                          250
                   ....*....|....*.
gi 1907139889  608 SVSGDSCIFVWRLSSE 623
Cdd:cd00200    236 SGSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
179-535 4.37e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 4.37e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  179 EYIFCGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYV 258
Cdd:COG2319    133 KTLASGSADGTVRLWDLATGKLLRTLTGH-----------------SGAVTS-------VAFSPDGKLLASGSDDGTVRL 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  259 WDVRDPKKVGKVYSalyHSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWNTEssgvhgstlhrnilsndliki 338
Cdd:COG2319    189 WDLATGKLLRTLTG---HTGAVRSVAFSP---DGKL-------LASGSADGTVRLWDLA--------------------- 234

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  339 iyvdgnTQALLDTelpggdkadgsLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYS 418
Cdd:COG2319    235 ------TGKLLRT-----------LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  419 kPDtGlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQKSGEGVQFTRT 498
Cdd:COG2319    298 -PD-G-KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSP-DGK-TLASGSDDGTVRLWDLATGELLRTLTGH 371

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1907139889  499 HHVVrkttlYDMDVEPSWKYTAIGCQDRNIRIFNISS 535
Cdd:COG2319    372 TGAV-----TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
3-441 4.47e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 4.47e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    3 AVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHdmIVNVWAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFV 81
Cdd:COG2319    101 TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLA 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   82 TAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGLLgelrnnlfTDVAcgrgekadstfcitssgllceFS-DRRLLdkwve 159
Cdd:COG2319    179 SGSdDGTVRLWDLATGKLLRT-----LTGHTGAV--------RSVA---------------------FSpDGKLL----- 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  160 lrntdsftttvahcisvtqeyiFCGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGVNarypdtiALT 239
Cdd:COG2319    220 ----------------------ASGSADGTVRLWDLATGKLLRTLTGH-----------------SGSVR-------SVA 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  240 FDPTNQWLSCVYNDHSIYVWDVRDPKkvgKVYSALYHSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWNTESs 319
Cdd:COG2319    254 FSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSP---DGKL-------LASGSDDGTVRLWDLAT- 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  320 gvhGSTLHrnilsndlikiiyvdgntqalldtelpggdkadgSLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSL 399
Cdd:COG2319    320 ---GKLLR----------------------------------TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 1907139889  400 SEMLKVEAHDSEILCLEYSkPDtGlKLLASASRDRLIHVLDA 441
Cdd:COG2319    363 ELLRTLTGHTGAVTSVAFS-PD-G-RTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-626 4.17e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 4.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  408 HDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAASDGQvrMISCGADKSIYFRTAQ 487
Cdd:cd00200      8 HTGGVTCVAFS-PDG--KLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTY--LASGSSDKTIRLWDLE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  488 KSGEGVQFTrtHHvvrKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGedgTLIKVQTDPSGIYIATS 567
Cdd:cd00200     82 TGECVRTLT--GH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVASS 153

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907139889  568 CSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTI 626
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-438 5.88e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.65  E-value: 5.88e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   15 VAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVASNKV-SSRVTAVSFSEDCSYFVTAG-NRHIKFWy 92
Cdd:cd00200      2 RRTLKGHTGGVTCVAFSPDGKLLATGSG--DGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSsDKTIRLW- 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   93 ldDSKTSKVNATVpllgrsgllgelrnnlftdvacgRGEKaDSTFCItssgllcefsdrrlldkwvelrntdsftttvah 172
Cdd:cd00200     79 --DLETGECVRTL-----------------------TGHT-SYVSSV--------------------------------- 99

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  173 CISVTQEYIFCGCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYN 252
Cdd:cd00200    100 AFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGH----------------TDWVNS-------VAFSPDGTFVASSSQ 155

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  253 DHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPEikdshqaclpPSSFITCSSDNTIRLWNTeSSGVHGSTL--HRNi 330
Cdd:cd00200    156 DGTIKLWDLRTGKCV-ATLTG--HTGEVNSVAFSPD----------GEKLLSSSSDGTIKLWDL-STGKCLGTLrgHEN- 220

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  331 lsndlikiiyvdgntqalldtelpggdkadgslmdprvGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDS 410
Cdd:cd00200    221 --------------------------------------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN 262

                          410       420
                   ....*....|....*....|....*...
gi 1907139889  411 EILCLEYSkPDTglKLLASASRDRLIHV 438
Cdd:cd00200    263 SVTSLAWS-PDG--KRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
4-398 2.62e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 2.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    4 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVT 82
Cdd:COG2319    144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLAS 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   83 AG-NRHIKFWyldDSKTSKVNATVPllGRSGLLgelrnnlfTDVAcgrgekadstfcitssgllceFS-DRRLLdkwvel 160
Cdd:COG2319    222 GSaDGTVRLW---DLATGKLLRTLT--GHSGSV--------RSVA---------------------FSpDGRLL------ 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  161 rntdsftttvahcisVTqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGVNarypdtiALTF 240
Cdd:COG2319    262 ---------------AS------GSADGTVRLWDLATGELLRTLTGH-----------------SGGVN-------SVAF 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  241 DPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWNTESSG 320
Cdd:COG2319    297 SPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LASGSDDGTVRLWDLATGE 363

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907139889  321 vhgstlhrnilsndlikiiyvdgntqalLDTELPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQS 398
Cdd:COG2319    364 ----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-315 3.92e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 3.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    4 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVT 82
Cdd:cd00200     33 IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSS 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   83 AG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACGRGEKaDSTFcITSSGllcefSDR--RLldkWvE 159
Cdd:cd00200    111 SSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSVAFSP-DGTF-VASSS-----QDGtiKL---W-D 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  160 LRNTDSFTTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNAry 232
Cdd:cd00200    164 LRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGH----------------ENGVNS-- 224

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  233 pdtiaLTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSVEVYPEIKDshqaclppssFITCSSDNTIR 312
Cdd:cd00200    225 -----VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSLAWSPDGKR----------LASGSADGTIR 286


                   ...
gi 1907139889  313 LWN 315
Cdd:cd00200    287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
426-622 2.45e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 2.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  426 LLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAvkfAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKT 505
Cdd:COG2319      8 ALAAASADLALALLAAALGALLLLLLGLAAAVASL---AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889  506 TlydmdVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFkgsQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVA 585
Cdd:COG2319     85 A-----FSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1907139889  586 TMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 622
Cdd:COG2319    157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 580-618 2.28e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.28e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907139889   580 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 618
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
581-618 6.30e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 6.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907139889  581 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 618
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 4-169 2.82e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889    4 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 83
Cdd:PLN00181   557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907139889   84 GNRHIKFWYLDDSktskvNATVPL---LGRSGLLGELRnnlFTDVACGRGEKADST-----FCITSSGL----LCEFSDR 151
Cdd:PLN00181   636 GSADHKVYYYDLR-----NPKLPLctmIGHSKTVSYVR---FVDSSTLVSSSTDNTlklwdLSMSISGInetpLHSFMGH 707

                          170
                   ....*....|....*...
gi 1907139889  152 RLLDKWVELRNTDSFTTT 169
Cdd:PLN00181   708 TNVKNFVGLSVSDGYIAT 725
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-51 6.81e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 6.81e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907139889    12 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 51
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 583-623 8.81e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 8.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1907139889  583 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSE 623
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG 41
WD40 pfam00400
WD domain, G-beta repeat;
12-51 5.57e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 5.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907139889   12 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 51
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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