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Conserved domains on  [gi|1907132573|ref|XP_036017514|]
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zinc finger protein 950 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.23e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 3.23e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907132573   4 VTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-514 3.71e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 101 KPYGCNHCGKAFAHHSNLQRHERIHTGEKPYECNQ--CGKAFVTHSDLQIHKRTHTGEKPYECN-QCGKAFAYHSNLQRH 177
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 178 ERIHTGEKPYECNQCGKAFAYHSNLQRHERIHTGEKPYECNKCGKAFAWHSHLQRHEITHTGekpyecNQCGKAFAHDSN 257
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 258 LHIHKRKHAGEKPYECNQCGKAFPCYNLLQIHKRTHTGEKPYECNQCGKTFAYHSYLQMH------ERIHTGEKPYECNH 331
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 332 CGKAFSQHSSLRVHKRTHTG-EKPYECNQCGEAFVYHSHLQIHK--TMHTGE--KPFQC--NQCDKAFVYNNHLLVHKRI 404
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 405 HTGEKPYEC--NHCGKAFSQLS-----GLHVHKRTHTGEKPYKC--NECGKAFARNSHLQRHKRIHTGEKPHECN--QCG 473
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1907132573 474 KAFARHSTLQVHKRKHAGEKPYECNQCGKAFPSHNLLHIHK 514
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.23e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 3.23e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907132573   4 VTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 8.78e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.55  E-value: 8.78e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907132573    4 VTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.77e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 1.77e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907132573   4 VTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-514 3.71e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 101 KPYGCNHCGKAFAHHSNLQRHERIHTGEKPYECNQ--CGKAFVTHSDLQIHKRTHTGEKPYECN-QCGKAFAYHSNLQRH 177
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 178 ERIHTGEKPYECNQCGKAFAYHSNLQRHERIHTGEKPYECNKCGKAFAWHSHLQRHEITHTGekpyecNQCGKAFAHDSN 257
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 258 LHIHKRKHAGEKPYECNQCGKAFPCYNLLQIHKRTHTGEKPYECNQCGKTFAYHSYLQMH------ERIHTGEKPYECNH 331
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 332 CGKAFSQHSSLRVHKRTHTG-EKPYECNQCGEAFVYHSHLQIHK--TMHTGE--KPFQC--NQCDKAFVYNNHLLVHKRI 404
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 405 HTGEKPYEC--NHCGKAFSQLS-----GLHVHKRTHTGEKPYKC--NECGKAFARNSHLQRHKRIHTGEKPHECN--QCG 473
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1907132573 474 KAFARHSTLQVHKRKHAGEKPYECNQCGKAFPSHNLLHIHK 514
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 3.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 173 NLQRHERIHTGEKPYECNQCGKAFAY 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 3.23e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 3.23e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907132573   4 VTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 8.78e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.55  E-value: 8.78e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1907132573    4 VTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.77e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.97  E-value: 1.77e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907132573   4 VTYDEVHVNFTQEEWALLDHSQKSLYRDVMLETYKNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-514 3.71e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 101 KPYGCNHCGKAFAHHSNLQRHERIHTGEKPYECNQ--CGKAFVTHSDLQIHKRTHTGEKPYECN-QCGKAFAYHSNLQRH 177
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 178 ERIHTGEKPYECNQCGKAFAYHSNLQRHERIHTGEKPYECNKCGKAFAWHSHLQRHEITHTGekpyecNQCGKAFAHDSN 257
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 258 LHIHKRKHAGEKPYECNQCGKAFPCYNLLQIHKRTHTGEKPYECNQCGKTFAYHSYLQMH------ERIHTGEKPYECNH 331
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 332 CGKAFSQHSSLRVHKRTHTG-EKPYECNQCGEAFVYHSHLQIHK--TMHTGE--KPFQC--NQCDKAFVYNNHLLVHKRI 404
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 405 HTGEKPYEC--NHCGKAFSQLS-----GLHVHKRTHTGEKPYKC--NECGKAFARNSHLQRHKRIHTGEKPHECN--QCG 473
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1907132573 474 KAFARHSTLQVHKRKHAGEKPYECNQCGKAFPSHNLLHIHK 514
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-533 1.82e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.89  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 157 KPYECNQCGKAFAYHSNLQRHERIHTGEKPYECNQCGKAFAYH--SNLQRHERIHTGEKPYECNK-CGKAFAWHSHLQRH 233
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 234 EITHTGEKPYECNQCGKAFAHDSNLHI--HKRKHAGEKPYE-CNQCGKAFPCYNLLQ-------------------IHKR 291
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 292 THTGEKPYECNQCGKTFAY---HSYLQMHERIHTGEKPYECNHCGKA---FSQHSSLRVHKRTHTGEKPYECNQCGEAFV 365
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSipsSSSDQNLENSSSSLPLTTNSQLSPKsllSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 366 YHSHLQIHKTMHTG-EKPFQCNQCDKAFVYNNHLLVHKR--IHTGE--KPYECNH--CGKAFSQLSGLHVHKRTHTGEKP 438
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 439 YKC--NECGKAFARNSH-----LQRHKRIHTGEKPHEC--NQCGKAFARHSTLQVHKRKHAGEKPYECN--QCGKAFPSH 507
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*.
gi 1907132573 508 NLLHIHKRTHTGEKPYECNQCGKTFA 533
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
241-590 8.67e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 8.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 241 KPYECNQCGKAFAHDSNLHIHKRKHAGEKPYECNQCGKAFPCYNL--LQIHKRTHTGEKPYECN-QCGKTFAYHSYLQMH 317
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 318 ERIHTGEKPYECNHCGKAFSQHSSLRVHKRTHTGEKPYECNQCGEAFV----------------------YHSHLQIHKT 375
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 376 MHTGEKPFQCNQCDKAFVYNNHLLVHKRIHTGEKPYECNHCG----------------------------------KAFS 421
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssasesprsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 422 QLSGLHVHKRTHTG-EKPYKCNECGKAFARNSHLQRHKR--IHTGE--KPHEC--NQCGKAFARHSTLQVHKRKHAGEKP 494
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 495 YEC--NQCGKAF-----PSHNLLHIHKRTHTGEKPYEC--NQCGKTFAYHSHLQVHGRIHTGEKP--YKCNQCGKAFACH 563
Cdd:COG5048   352 AKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420
                  ....*....|....*....|....*..
gi 1907132573 564 RNLRVHKRKHTGEKPYEFNHYSKAFSQ 590
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-603 1.24e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 297 KPYECNQCGKTFAYHSYLQMHERIHTGEKPYECNH--CGKAFSQHSSLRVHKRTHTGEKPYECN-QCGEAFVYHSHLQI- 372
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLs 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 373 HKTMHT--GEKPFQCNQCDKAFVYNNHLLVHKRIHTGEKPYECNHCGKAFSQLSGLHVHKRTHtgekpykcnECGKAFAR 450
Cdd:COG5048   112 SSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---------SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 451 NSHLQRHKRIHTGEKPHECNQCGKAFARHSTLQVHKRKHAGEKPYECNQCGKAFPSHNLLHIHKRT------HTGEKPYE 524
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 525 CNQCGKTFAYHSHLQVHGRIHTG-EKPYKCNQCGKAFACHRNLRVHKRK--HTGEKPYEF----NHYSKAFSQHSSLQVH 597
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFscpySLCGKLFSRNDALKRH 342


                  ....*.
gi 1907132573 598 KRTHIG 603
Cdd:COG5048   343 ILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 3.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.31e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 173 NLQRHERIHTGEKPYECNQCGKAFAY 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
117-142 3.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.87e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 117 NLQRHERIHTGEKPYECNQCGKAFVT 142
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 453 HLQRHKRIHTGEKPHECNQCGKAFAR 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-225 7.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.77e-04
                          10        20
                  ....*....|....*....|....*
gi 1907132573 201 NLQRHERIHTGEKPYECNKCGKAFA 225
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
229-254 1.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.37e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 229 HLQRHEITHTGEKPYECNQCGKAFAH 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 313 YLQMHERIHTGEKPYECNHCGKAFSQ 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 3.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.23e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 145 DLQIHKRTHTGEKPYECNQCGKAFAY 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 225-350 3.60e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907132573 225 AWHSHLQRHEITHTGEKPYECNQCGKAFAHDSNLHI----HKRKHAGEKPYECN--QCGKAFPCYNLLQIHKRT-HTGEK 297
Cdd:COG5189   300 EIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQK 379

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907132573 298 PYECNQCGKtfayhsylqmHERIHTGEKPYECNHCGKAFSQHSSLRVHkRTHT 350
Cdd:COG5189   380 LHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 5.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 341 SLRVHKRTHTGEKPYECNQCGEAFVY 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 5.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.22e-03
                          10        20
                  ....*....|....*....|....*
gi 1907132573 286 LQIHKRTHTGEKPYECNQCGKTFAY 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-422 5.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.28e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907132573 397 HLLVHKRIHTGEKPYECNHCGKAFSQ 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-450 7.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.59e-03
                          10        20
                  ....*....|....*....|..
gi 1907132573 429 HKRTHTGEKPYKCNECGKAFAR 450
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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