NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907093003|ref|XP_036013816|]
View 

doublecortin domain-containing protein 2 isoform X2 [Mus musculus]

Protein Classification

ubiquitin family protein( domain architecture ID 13217724)

ubiquitin family protein such as polyubiquitin, which when attached to a target protein, has different functions depending on the Lys residue of the ubiquitin that is linked

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 138-217 2.43e-51

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


:

Pssm-ID: 340672  Cd Length: 80  Bit Score: 168.44  E-value: 2.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKR 217
Cdd:cd17152     1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFKK 80
Ubl1_cv_Nsp3_N-like super family cl28922
first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV ...
 17-96 1.68e-49

first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.


The actual alignment was detected with superfamily member cd17149:

Pssm-ID: 475130  Cd Length: 80  Bit Score: 163.79  E-value: 1.68e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKK 96
Cdd:cd17149     1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 246-466 1.82e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 47.30  E-value: 1.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  246 GSRKSKGSGNYRQSKSTIGSSDNSSPQPLKRKGKKDSNSEKPTKVKQSVKSKTSHQAIPDNGEGIFKAGAE---RSETRG 322
Cdd:TIGR00927  657 GENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEdegEIETGE 736

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  323 AAEVQEDEDT-------QVEVPVDQRPAEIVDEEEDGEKTSKDAN--QKEDFSAMNGETEDRGGSKAAGTSEqEEGIPDH 393
Cdd:TIGR00927  737 EGEEVEDEGEgeaegkhEVETEGDRKETEHEGETEAEGKEDEDEGeiQAGEDGEMKGDEGAEGKVEHEGETE-AGEKDEH 815

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907093003  394 GEKKASPSRVNGGTDEENGEEL-----DQVAEELQSTEDEKGKAEGDNsgQDEAGLDAQRPPRPEVTVTSPQENEENE 466
Cdd:TIGR00927  816 EGQSETQADDTEVKDETGEQELnaenqGEAKQDEKGVDGGGGSDGGDS--EEEEEEEEEEEEEEEEEEEEEEEEEENE 891
PRK08163 super family cl32270
3-hydroxybenzoate 6-monooxygenase;
69-138 6.84e-03

3-hydroxybenzoate 6-monooxygenase;


The actual alignment was detected with superfamily member PRK08163:

Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 38.86  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  69 RTGHRIRKLDQIESGGNYVAG---GPEAFKKLNYLDIGEIKKRP---------MEAVNTEVkpVIhsRINVSARFRKSLH 136
Cdd:PRK08163   25 RQGIKVKLLEQAAEIGEIGAGiqlGPNAFSALDALGVGEAARQRavftdhltmMDAVDAEE--VV--RIPTGQAFRARFG 100


                  ..
gi 1907093003 137 EP 138
Cdd:PRK08163  101 NP 102
 
Name Accession Description Interval E-value
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 138-217 2.43e-51

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 168.44  E-value: 2.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKR 217
Cdd:cd17152     1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFKK 80
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 17-96 1.68e-49

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 163.79  E-value: 1.68e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKK 96
Cdd:cd17149     1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 12-100 2.33e-30

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 113.12  E-value: 2.33e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003   12 SQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTG--GVQAPFGaVRNIYTPRtGHRIRKLDQIESGGNYVAG 89
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEvvKLDLPHG-VRKLYTLD-GKKVTSLDELEDGGSYVAS 78

                           90
                   ....*....|.
gi 1907093003   90 GPEAFKKLNYL 100
Cdd:smart00537  79 GTEAFKKVDYG 89
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 134-221 2.00e-28

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 107.73  E-value: 2.00e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  134 SLHEPCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSG-AVHRLYTLEGKLVESGAELENGQFYVAVGR 212
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGT 80


                   ....*....
gi 1907093003  213 DKFKRLPYS 221
Cdd:smart00537  81 EAFKKVDYG 89
DCX pfam03607
Doublecortin;
157-215 2.38e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 81.34  E-value: 2.38e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 157 LIPKKALNQWDHVLQMVTEKI-TLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKF 215
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVvKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX pfam03607
Doublecortin;
35-94 2.75e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 81.34  E-value: 2.75e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907093003  35 VIHEKKVSSFDVFLKEVTGGVQ-APFGAVRNIYTPRtGHRIRKLDQIESGGNYVAGGPEAF 94
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVVkLPFGAVRKLYTLD-GKRVTSLDELEDGGVYVAAGREKF 60
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 246-466 1.82e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 47.30  E-value: 1.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  246 GSRKSKGSGNYRQSKSTIGSSDNSSPQPLKRKGKKDSNSEKPTKVKQSVKSKTSHQAIPDNGEGIFKAGAE---RSETRG 322
Cdd:TIGR00927  657 GENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEdegEIETGE 736

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  323 AAEVQEDEDT-------QVEVPVDQRPAEIVDEEEDGEKTSKDAN--QKEDFSAMNGETEDRGGSKAAGTSEqEEGIPDH 393
Cdd:TIGR00927  737 EGEEVEDEGEgeaegkhEVETEGDRKETEHEGETEAEGKEDEDEGeiQAGEDGEMKGDEGAEGKVEHEGETE-AGEKDEH 815

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907093003  394 GEKKASPSRVNGGTDEENGEEL-----DQVAEELQSTEDEKGKAEGDNsgQDEAGLDAQRPPRPEVTVTSPQENEENE 466
Cdd:TIGR00927  816 EGQSETQADDTEVKDETGEQELnaenqGEAKQDEKGVDGGGGSDGGDS--EEEEEEEEEEEEEEEEEEEEEEEEEENE 891
PTZ00121 PTZ00121
MAEBL; Provisional
 275-473 3.85e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 3.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  275 KRKGKKDSNSEKPTKVKQSVKSKTSHQaipdngegifKAGAERSETRgAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEK 354
Cdd:PTZ00121  1350 AEAEAAADEAEAAEEKAEAAEKKKEEA----------KKKADAAKKK-AEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  355 TSKDANQKedfsAMNGETEDRGGSKAAGTSEQEEGIPDHGEKKASPSRVNGGTDEENGEELDQVAEELQSTEDEKGKAEG 434
Cdd:PTZ00121  1419 KADEAKKK----AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEE 1494

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1907093003  435 DNSGQDEAGLDAQRPPRPEVTVTSPQENEENEANKASSA 473
Cdd:PTZ00121  1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEA 1533
PRK08163 PRK08163
3-hydroxybenzoate 6-monooxygenase;
69-138 6.84e-03

3-hydroxybenzoate 6-monooxygenase;


Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 38.86  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  69 RTGHRIRKLDQIESGGNYVAG---GPEAFKKLNYLDIGEIKKRP---------MEAVNTEVkpVIhsRINVSARFRKSLH 136
Cdd:PRK08163   25 RQGIKVKLLEQAAEIGEIGAGiqlGPNAFSALDALGVGEAARQRavftdhltmMDAVDAEE--VV--RIPTGQAFRARFG 100


                  ..
gi 1907093003 137 EP 138
Cdd:PRK08163  101 NP 102
 
Name Accession Description Interval E-value
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 138-217 2.43e-51

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 168.44  E-value: 2.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFKR 217
Cdd:cd17152     1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFKK 80
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 17-96 1.68e-49

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 163.79  E-value: 1.68e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKK 96
Cdd:cd17149     1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 17-96 3.33e-41

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 141.59  E-value: 3.33e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKK 96
Cdd:cd17071     1 KIIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFGAVRSIYTPTGGHRVKDLDSLQNGGVYVAAGSERFKK 80
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 138-211 1.11e-33

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 121.53  E-value: 1.11e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVG 211
Cdd:cd16113     1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTGAVRKLYTLDGKRISDPDELVNGGQYVAVG 74
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 138-216 3.36e-31

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 114.85  E-value: 3.36e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFK 216
Cdd:cd17153     1 PCIIHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTGAVRKLCTLDGVPLSSGKELVSGQYYVAVGSEKFK 79
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 12-100 2.33e-30

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 113.12  E-value: 2.33e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003   12 SQPVVKSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTG--GVQAPFGaVRNIYTPRtGHRIRKLDQIESGGNYVAG 89
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEvvKLDLPHG-VRKLYTLD-GKKVTSLDELEDGGSYVAS 78

                           90
                   ....*....|.
gi 1907093003   90 GPEAFKKLNYL 100
Cdd:smart00537  79 GTEAFKKVDYG 89
DCX1_DCDC2B cd17150
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 17-96 4.03e-30

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340670  Cd Length: 79  Bit Score: 112.20  E-value: 4.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFgAVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKK 96
Cdd:cd17150     1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPV-AVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 17-96 9.01e-29

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 108.34  E-value: 9.01e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYVAGGPEAFKK 96
Cdd:cd17151     1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFG-VRCLYTPRNGHRVKGLDDLQGGGKYVAAGRERFKK 79
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 134-221 2.00e-28

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 107.73  E-value: 2.00e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  134 SLHEPCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSG-AVHRLYTLEGKLVESGAELENGQFYVAVGR 212
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGT 80


                   ....*....
gi 1907093003  213 DKFKRLPYS 221
Cdd:smart00537  81 EAFKKVDYG 89
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 138-216 3.20e-24

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 96.03  E-value: 3.20e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKFK 216
Cdd:cd17154     1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTGGVFRLCTLNGHPVSDSTELEDNHYYVAVGSEKFK 79
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 139-211 6.44e-21

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 86.51  E-value: 6.44e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093003 139 CTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAELENGQFYVAVG 211
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 17-90 2.26e-19

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 81.89  E-value: 2.26e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTPRtGHRIRKLDQIESGGNYVAGG 90
Cdd:cd01617     1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTGGVRKLYTPS-GKLVKSLSDLEDGESYVVCG 73
DCX pfam03607
Doublecortin;
157-215 2.38e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 81.34  E-value: 2.38e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 157 LIPKKALNQWDHVLQMVTEKI-TLRSGAVHRLYTLEGKLVESGAELENGQFYVAVGRDKF 215
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVvKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX pfam03607
Doublecortin;
35-94 2.75e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 81.34  E-value: 2.75e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907093003  35 VIHEKKVSSFDVFLKEVTGGVQ-APFGAVRNIYTPRtGHRIRKLDQIESGGNYVAGGPEAF 94
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVVkLPFGAVRKLYTLD-GKRVTSLDELEDGGVYVAAGREKF 60
DCX1_RP_like cd16110
Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 17-88 3.77e-19

Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) family. It has double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340527  Cd Length: 75  Bit Score: 81.58  E-value: 3.77e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYVA 88
Cdd:cd16110     1 KNVTFYKDGDVHFSGVRVAINPRRYRTFDALLDELSRKVPLPFG-VRSITTPRGRHSITSLEQLEDGGKYVC 71
DCX1_RP1L1 cd17146
Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 17-87 3.89e-14

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340666  Cd Length: 79  Bit Score: 67.55  E-value: 3.89e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYV 87
Cdd:cd17146     1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFG-VRTITTPRGTHSISRLEQLEDGGCYL 70
DCX1_RP1 cd17145
Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also ...
 17-87 1.21e-13

Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors and is required for correct stacking of outer segment discs. It interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340665  Cd Length: 79  Bit Score: 65.99  E-value: 1.21e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYV 87
Cdd:cd17145     1 KRVCFYKSGDPQFGGLRMVVNSRSFKTFDALLDNLSKKVPLPFG-VRNITTPRGVHHITSLEDLEDGKSYI 70
DCX1 cd16109
Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are ...
 17-96 5.33e-13

Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or single repeats. The family represents the first repeat of the DCX domain which has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340526  Cd Length: 85  Bit Score: 64.24  E-value: 5.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVT----GGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYVAGGPE 92
Cdd:cd16109     3 KKVRFYRNGDRFFKGIVYAVSSERFRSFEALLADLTrslsDNVNLPQG-VRTIFTIDGSRKITSLDELEDGESYVCASTD 81


                  ....
gi 1907093003  93 AFKK 96
Cdd:cd16109    82 AFKK 85
DCX1_DCLK1 cd17140
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 17-99 1.63e-11

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340660  Cd Length: 89  Bit Score: 60.40  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVT----GGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYVAGGPE 92
Cdd:cd17140     3 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQG-VRTIYTIDGLKKISSLDQLVEGESYVCGSIE 81


                  ....*..
gi 1907093003  93 AFKKLNY 99
Cdd:cd17140    82 PFKKLEY 88
DCX1_DCX cd16112
Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 17-99 1.45e-09

Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340529  Cd Length: 89  Bit Score: 54.92  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVT----GGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYVAGGPE 92
Cdd:cd16112     3 KKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTrslsDNINLPQG-VRYIYTIDGSRKIGSMDELEEGESYVCSSDN 81


                  ....*..
gi 1907093003  93 AFKKLNY 99
Cdd:cd16112    82 FFKKVEY 88
DCX2 cd17069
Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are ...
 138-215 2.14e-09

Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or as a single repeat. The first repeat of DCX domain has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340589  Cd Length: 84  Bit Score: 53.93  E-value: 2.14e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAEL-ENGQFYVAVGRDKF 215
Cdd:cd17069     4 PKLVTVIRNGTKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGAVRKLFTLDGRQVTCLQDFfGDDDVFIAYGPEKF 82
DCX1_DCLK2 cd17141
Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 17-96 2.66e-09

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340661  Cd Length: 85  Bit Score: 53.76  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVT----GGVQAPFGaVRNIYTPRTGHRIRKLDQIESGGNYVAGGPE 92
Cdd:cd17141     3 KKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELTrslsDNVNLPQG-VRTIYTIDGSKKITSLDELLEGESYVCASNE 81


                  ....
gi 1907093003  93 AFKK 96
Cdd:cd17141    82 PFRK 85
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 18-96 1.85e-08

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 51.34  E-value: 1.85e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093003  18 SVLVYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTpRTGHRIRKLDQIESGGNYVAGGPEAFKK 96
Cdd:cd17152     3 TIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYT-LDGKLINDGSELENGQFYVAVGREKFKK 80
DCX2_RP1 cd17147
Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed ...
 17-95 4.42e-08

Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of doublecortin (DCX) superfamily that contains double tandem repeats of the DCX domains. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors that is required for correct stacking of outer segment discs. RP1 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340667  Cd Length: 76  Bit Score: 50.14  E-value: 4.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  17 KSVLVYRNGDPFFAgRRVVIHEKKVSSFDVFLKEVTGGVQAPfgaVRNIYTPrTGHRIRKLDQ-IESGGNYVAGGPEAFK 95
Cdd:cd17147     1 RKLIVFKNGDPGFK-HTLILNKKTTQSFEALLDHVSELMQFP---VVKLYTT-DGRRVDSLQAlILSSGAVVAAGREPFK 75
DCX2_DCLK1 cd17143
Dublecortin-like domain 2 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 137-216 1.16e-06

Dublecortin-like domain 2 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340663  Cd Length: 84  Bit Score: 46.49  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 137 EPCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAE-LENGQFYVAVGRDKF 215
Cdd:cd17143     3 RPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDfFGDDDIFIACGPEKF 82


                  .
gi 1907093003 216 K 216
Cdd:cd17143    83 R 83
DCX2_DCX cd17142
Dublecortin-like domain 2 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 138-216 3.17e-06

Dublecortin-like domain 2 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of its structure, but also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340662  Cd Length: 84  Bit Score: 45.04  E-value: 3.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 138 PCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAE-LENGQFYVAVGRDKFK 216
Cdd:cd17142     4 PKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDfFGDDDVFIACGPEKFR 83
DCX2_DCLK2 cd17144
Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 137-216 8.78e-06

Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in double tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK2 members regulate cyclic AMP signaling. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340664  Cd Length: 84  Bit Score: 43.86  E-value: 8.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 137 EPCTIFLIANGDLISPASRLLIPKKALNQWDHVLQMVTEKITLRSGAVHRLYTLEGKLVESGAE-LENGQFYVAVGRDKF 215
Cdd:cd17144     3 KPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDfFGDDDVFIACGPEKY 82


                  .
gi 1907093003 216 K 216
Cdd:cd17144    83 R 83
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 246-466 1.82e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 47.30  E-value: 1.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  246 GSRKSKGSGNYRQSKSTIGSSDNSSPQPLKRKGKKDSNSEKPTKVKQSVKSKTSHQAIPDNGEGIFKAGAE---RSETRG 322
Cdd:TIGR00927  657 GENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEdegEIETGE 736

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  323 AAEVQEDEDT-------QVEVPVDQRPAEIVDEEEDGEKTSKDAN--QKEDFSAMNGETEDRGGSKAAGTSEqEEGIPDH 393
Cdd:TIGR00927  737 EGEEVEDEGEgeaegkhEVETEGDRKETEHEGETEAEGKEDEDEGeiQAGEDGEMKGDEGAEGKVEHEGETE-AGEKDEH 815

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907093003  394 GEKKASPSRVNGGTDEENGEEL-----DQVAEELQSTEDEKGKAEGDNsgQDEAGLDAQRPPRPEVTVTSPQENEENE 466
Cdd:TIGR00927  816 EGQSETQADDTEVKDETGEQELnaenqGEAKQDEKGVDGGGGSDGGDS--EEEEEEEEEEEEEEEEEEEEEEEEEENE 891
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 17-80 4.17e-05

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 41.46  E-value: 4.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907093003  17 KSVLVYRNGDPfFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPfgaVRNIYTpRTGHRIRKLDQI 80
Cdd:cd17070     1 KVITVISNGDP-HSRHTILLNRRTTQSFEQVLQDLSELLKGP---VRKLYT-TDGKKVESLSAL 59
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 21-95 2.07e-04

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 39.79  E-value: 2.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907093003  21 VYRNGDPFFAGRRVVIHEKKVSSFDVFLKEVTGGVQAPFGAVRNIYTpRTGHRIRKLDQIESGGNYVAGGPEAFK 95
Cdd:cd17154     6 VFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTGGVFRLCT-LNGHPVSDSTELEDNHYYVAVGSEKFK 79
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 340-466 3.69e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 43.06  E-value: 3.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  340 QRPAEIVDEEEDGEKTSKDAN--QKEDFSAMNGETEDRGGSKAAGTSEQEEGIPDHGEKKASPSRVNGGTDEENGEELDQ 417
Cdd:TIGR00927  639 EHTGERTGEEGERPTEAEGENgeESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHE 718

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907093003  418 VAEELQSTEDE---KGKAEGDNSGQDEAGlDAQRPPRPEVTVTSPQENEENE 466
Cdd:TIGR00927  719 GETEAEGTEDEgeiETGEEGEEVEDEGEG-EAEGKHEVETEGDRKETEHEGE 769
PTZ00121 PTZ00121
MAEBL; Provisional
 275-473 3.85e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 3.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  275 KRKGKKDSNSEKPTKVKQSVKSKTSHQaipdngegifKAGAERSETRgAAEVQEDEDTQVEVPVDQRPAEIVDEEEDGEK 354
Cdd:PTZ00121  1350 AEAEAAADEAEAAEEKAEAAEKKKEEA----------KKKADAAKKK-AEEKKKADEAKKKAEEDKKKADELKKAAAAKK 1418

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  355 TSKDANQKedfsAMNGETEDRGGSKAAGTSEQEEGIPDHGEKKASPSRVNGGTDEENGEELDQVAEELQSTEDEKGKAEG 434
Cdd:PTZ00121  1419 KADEAKKK----AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEE 1494

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1907093003  435 DNSGQDEAGLDAQRPPRPEVTVTSPQENEENEANKASSA 473
Cdd:PTZ00121  1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEA 1533
PTZ00121 PTZ00121
MAEBL; Provisional
 276-441 6.84e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 6.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  276 RKGKKDSNSEKPTKVKQSVKSKTSHQAIPDNGEGIFKAGAER--SETRGAAEVQEDEDTQvEVPVDQRPAEIVDEEEDGE 353
Cdd:PTZ00121  1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKkaEEKKKADEAKKAEEKK-KADEAKKKAEEAKKADEAK 1321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  354 KTSKDANQKEDFSAMNGETEDRGGSKAAGTSEQEEGIPDHGEKKASPSRVNGGTDEENGEELDQVAEELQSTEDEKGKAE 433
Cdd:PTZ00121  1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAE 1401


                   ....*...
gi 1907093003  434 GDNSGQDE 441
Cdd:PTZ00121  1402 EDKKKADE 1409
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 141-209 3.44e-03

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 36.07  E-value: 3.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093003 141 IFLIANGDlisPASR--LLIPKKALNQWDHVLQMVTEkiTLRsGAVHRLYTLEGKLVESGAELENGQ--FYVA 209
Cdd:cd17070     3 ITVISNGD---PHSRhtILLNRRTTQSFEQVLQDLSE--LLK-GPVRKLYTTDGKKVESLSALFHGPdeYVAA 69
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 313-453 6.03e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 39.12  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003 313 AGAERSETRGAAevqEDEDTQVEVPVDQRPAEIVDEEEDGEKTSKDANQKEDfsamNGETEDRGGSKAAGTSEQEEGIPD 392
Cdd:PRK12678  105 APAARAAAAAAA---EAASAPEAAQARERRERGEAARRGAARKAGEGGEQPA----TEARADAAERTEEEERDERRRRGD 177

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907093003 393 HGEKKASPSRVNGGTDEENGEELDQVAEELQSTEDEKGKAEGDNSGQDEAGLDAQRPPRPE 453
Cdd:PRK12678  178 REDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRRDA 238
PRK08163 PRK08163
3-hydroxybenzoate 6-monooxygenase;
69-138 6.84e-03

3-hydroxybenzoate 6-monooxygenase;


Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 38.86  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093003  69 RTGHRIRKLDQIESGGNYVAG---GPEAFKKLNYLDIGEIKKRP---------MEAVNTEVkpVIhsRINVSARFRKSLH 136
Cdd:PRK08163   25 RQGIKVKLLEQAAEIGEIGAGiqlGPNAFSALDALGVGEAARQRavftdhltmMDAVDAEE--VV--RIPTGQAFRARFG 100


                  ..
gi 1907093003 137 EP 138
Cdd:PRK08163  101 NP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH