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Conserved domains on  [gi|1907086248|ref|XP_036013117|]
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nuclear receptor coactivator 1 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 253-332 1.83e-25

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


:

Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 100.93  E-value: 1.83e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248  253 TSH-KLVQLLTTTAEQQ-----LRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEG-SPSD 325
Cdd:pfam08832    1 KGHkKLLQLLTTPTEQLgpsplRSHADADTDCKDSLAGVTSPSSGVSSSSGSSCPSHHSSLQEKHKILHRLLQNGnSPDD 80


                   ....*..
gi 1907086248  326 ITTLSVE 332
Cdd:pfam08832   81 VAKLTAE 87
NCOA_u2 super family cl25027
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 89-211 8.17e-17

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


The actual alignment was detected with superfamily member pfam16665:

Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 77.47  E-value: 8.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248   89 SLNLNNSPMEGTGIALSQ---FMSPRRQansglaTRARMSNNSFPPNIpTLSSPVGITSGAC--NNNNRSYSNIPVTSLQ 163
Cdd:pfam16665    2 GLNMNSPPQGSPGMTPPQqnlMMSPRHR------GSPKMPANQFSPGM-GLHSPMGSVSSGGsgGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907086248  164 GMNEGPNNSVGFSAGSPVLRQMSSQNSPsrlSMQPAKAESKDSKEIAS 211
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSPNIN---STQQKKEGSSDSKSPSS 119
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 550-595 2.88e-16

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


:

Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 73.59  E-value: 2.88e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907086248  550 EGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVL 595
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVgQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 775-831 4.33e-12

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


:

Pssm-ID: 462174  Cd Length: 58  Bit Score: 62.09  E-value: 4.33e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907086248  775 GLPVQMGTPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAA-NPEASLATRSSMV 831
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPmMSPRMGPSQSPMM 58
DUF4927 super family cl24752
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 367-444 2.16e-08

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


The actual alignment was detected with superfamily member pfam16279:

Pssm-ID: 465083  Cd Length: 87  Bit Score: 52.49  E-value: 2.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248  367 KESKDHQLLRYLLDKDE-KDLRSTpnlcldDVKVKVEKKE-QMDPCNTNPTPMTKPAPEEVKLESQSQFTADLDQFDQLL 444
Cdd:pfam16279    8 KKKKNNALLRYLLDKDDsKDPLSK------DIKPKLEGLDgKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAIL 81
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 838-894 3.95e-07

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


:

Pssm-ID: 462174  Cd Length: 58  Bit Score: 47.84  E-value: 3.95e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907086248  838 NMGGQFGAGISPQMQQNVFQYPGP-GLVPQGEATFAPSLSPGSSMVPMPVPPPQSSLL 894
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNyGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
 
Name Accession Description Interval E-value
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 253-332 1.83e-25

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 100.93  E-value: 1.83e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248  253 TSH-KLVQLLTTTAEQQ-----LRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEG-SPSD 325
Cdd:pfam08832    1 KGHkKLLQLLTTPTEQLgpsplRSHADADTDCKDSLAGVTSPSSGVSSSSGSSCPSHHSSLQEKHKILHRLLQNGnSPDD 80


                   ....*..
gi 1907086248  326 ITTLSVE 332
Cdd:pfam08832   81 VAKLTAE 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 89-211 8.17e-17

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 77.47  E-value: 8.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248   89 SLNLNNSPMEGTGIALSQ---FMSPRRQansglaTRARMSNNSFPPNIpTLSSPVGITSGAC--NNNNRSYSNIPVTSLQ 163
Cdd:pfam16665    2 GLNMNSPPQGSPGMTPPQqnlMMSPRHR------GSPKMPANQFSPGM-GLHSPMGSVSSGGsgGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907086248  164 GMNEGPNNSVGFSAGSPVLRQMSSQNSPsrlSMQPAKAESKDSKEIAS 211
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSPNIN---STQQKKEGSSDSKSPSS 119
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 550-595 2.88e-16

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 73.59  E-value: 2.88e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907086248  550 EGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVL 595
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVgQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 775-831 4.33e-12

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 62.09  E-value: 4.33e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907086248  775 GLPVQMGTPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAA-NPEASLATRSSMV 831
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPmMSPRMGPSQSPMM 58
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 367-444 2.16e-08

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 52.49  E-value: 2.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248  367 KESKDHQLLRYLLDKDE-KDLRSTpnlcldDVKVKVEKKE-QMDPCNTNPTPMTKPAPEEVKLESQSQFTADLDQFDQLL 444
Cdd:pfam16279    8 KKKKNNALLRYLLDKDDsKDPLSK------DIKPKLEGLDgKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAIL 81
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 838-894 3.95e-07

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 47.84  E-value: 3.95e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907086248  838 NMGGQFGAGISPQMQQNVFQYPGP-GLVPQGEATFAPSLSPGSSMVPMPVPPPQSSLL 894
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNyGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
 
Name Accession Description Interval E-value
SRC-1 pfam08832
Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators ...
 253-332 1.83e-25

Steroid receptor coactivator; This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.


Pssm-ID: 462615 [Multi-domain]  Cd Length: 87  Bit Score: 100.93  E-value: 1.83e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248  253 TSH-KLVQLLTTTAEQQ-----LRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEG-SPSD 325
Cdd:pfam08832    1 KGHkKLLQLLTTPTEQLgpsplRSHADADTDCKDSLAGVTSPSSGVSSSSGSSCPSHHSSLQEKHKILHRLLQNGnSPDD 80


                   ....*..
gi 1907086248  326 ITTLSVE 332
Cdd:pfam08832   81 VAKLTAE 87
NCOA_u2 pfam16665
Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively ...
 89-211 8.17e-17

Unstructured region on nuclear receptor coactivator protein; NCOA_u2 is a region of natively unstructured but highly conserved sequence found on higher eukaryote nuclear receptor coactivator proteins. It lies between a PAS domain, pfam14598 and a steroid receptor coactivator domain, pfam08832. The function is not known.


Pssm-ID: 465223 [Multi-domain]  Cd Length: 119  Bit Score: 77.47  E-value: 8.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248   89 SLNLNNSPMEGTGIALSQ---FMSPRRQansglaTRARMSNNSFPPNIpTLSSPVGITSGAC--NNNNRSYSNIPVTSLQ 163
Cdd:pfam16665    2 GLNMNSPPQGSPGMTPPQqnlMMSPRHR------GSPKMPANQFSPGM-GLHSPMGSVSSGGsgGGGSRTYSSSSLNALQ 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1907086248  164 GMNEGPNNSVGFSAGSPVLRQMSSQNSPsrlSMQPAKAESKDSKEIAS 211
Cdd:pfam16665   75 AISEGVGNSLGSSLTSPVPKQDSSPNIN---STQQKKEGSSDSKSPSS 119
Nuc_rec_co-act pfam08815
Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators ...
 550-595 2.88e-16

Nuclear receptor coactivator; This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.


Pssm-ID: 462608 [Multi-domain]  Cd Length: 47  Bit Score: 73.59  E-value: 2.88e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907086248  550 EGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVL 595
Cdd:pfam08815    1 EGPSDEGALLDQLVSFLSNTDETGLEEIDRALGIPELVgQGQGLDPD 47
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 775-831 4.33e-12

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 62.09  E-value: 4.33e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907086248  775 GLPVQMGTPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAA-NPEASLATRSSMV 831
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNYGMSQQPDPAFTSALSPQSPmMSPRMGPSQSPMM 58
DUF4927 pfam16279
Domain of unknown function (DUF4927); This family, around 80 residues, consists of ...
 367-444 2.16e-08

Domain of unknown function (DUF4927); This family, around 80 residues, consists of uncharacterized and nuclear receptor coactivator 2 proteins and is mainly found in mammalia species. The specific function of this family is still unknown.


Pssm-ID: 465083  Cd Length: 87  Bit Score: 52.49  E-value: 2.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907086248  367 KESKDHQLLRYLLDKDE-KDLRSTpnlcldDVKVKVEKKE-QMDPCNTNPTPMTKPAPEEVKLESQSQFTADLDQFDQLL 444
Cdd:pfam16279    8 KKKKNNALLRYLLDKDDsKDPLSK------DIKPKLEGLDgKTGPCSSSKIPTSKSEKEESKIKTEPPDELSLDNLDAIL 81
DUF1518 pfam07469
Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually ...
 838-894 3.95e-07

Nuclear receptor coactivator, DUF1518; This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors.


Pssm-ID: 462174  Cd Length: 58  Bit Score: 47.84  E-value: 3.95e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907086248  838 NMGGQFGAGISPQMQQNVFQYPGP-GLVPQGEATFAPSLSPGSSMVPMPVPPPQSSLL 894
Cdd:pfam07469    1 GMGGQFGGPRNPQAQPQQFPYPPNyGMSQQPDPAFTSALSPQSPMMSPRMGPSQSPMM 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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