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Conserved domains on  [gi|1907177725|ref|XP_036008605|]
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potassium voltage-gated channel subfamily C member 3 isoform X15 [Mus musculus]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
47-308 9.69e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 158.20  E-value: 9.69e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725  47 NQYVAFASLFFILISITTFCLETHEGFIHISNKtvtqaspipgappenitnvevetepFLTYVEGVCVVWFTFEFLMRVT 126
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-------------------------VLEILDYVFTGIFTLEMLLKII 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725 127 FCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSkaakdvLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 206
Cdd:pfam00520  56 AAGFKKRYFRSPWNILDFVVVLPSLISLVLSSVGS------LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSL 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725 207 LLLIIFLALGVLIFATMIY----YAERIGADPDDilgsNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM------- 275
Cdd:pfam00520 130 GNLLLLLLLFLFIFAIIGYqlfgGKLKTWENPDN----GRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayi 205
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1907177725 276 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 308
Cdd:pfam00520 206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
47-308 9.69e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 158.20  E-value: 9.69e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725  47 NQYVAFASLFFILISITTFCLETHEGFIHISNKtvtqaspipgappenitnvevetepFLTYVEGVCVVWFTFEFLMRVT 126
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-------------------------VLEILDYVFTGIFTLEMLLKII 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725 127 FCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSkaakdvLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 206
Cdd:pfam00520  56 AAGFKKRYFRSPWNILDFVVVLPSLISLVLSSVGS------LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSL 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725 207 LLLIIFLALGVLIFATMIY----YAERIGADPDDilgsNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM------- 275
Cdd:pfam00520 130 GNLLLLLLLFLFIFAIIGYqlfgGKLKTWENPDN----GRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayi 205
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1907177725 276 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 308
Cdd:pfam00520 206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PRK10537 PRK10537
voltage-gated potassium channel protein;
247-300 1.26e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.16  E-value: 1.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907177725 247 NIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPV-----PVIVNNF 300
Cdd:PRK10537  168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSIsaifgPVIRGNL 226
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
47-308 9.69e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 158.20  E-value: 9.69e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725  47 NQYVAFASLFFILISITTFCLETHEGFIHISNKtvtqaspipgappenitnvevetepFLTYVEGVCVVWFTFEFLMRVT 126
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-------------------------VLEILDYVFTGIFTLEMLLKII 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725 127 FCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSkaakdvLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 206
Cdd:pfam00520  56 AAGFKKRYFRSPWNILDFVVVLPSLISLVLSSVGS------LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSL 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725 207 LLLIIFLALGVLIFATMIY----YAERIGADPDDilgsNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM------- 275
Cdd:pfam00520 130 GNLLLLLLLFLFIFAIIGYqlfgGKLKTWENPDN----GRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayi 205
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1907177725 276 LVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 308
Cdd:pfam00520 206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
217-298 3.26e-09

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 53.43  E-value: 3.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177725 217 VLIFATMIYYAErigadpddilgsnHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVI 296
Cdd:pfam07885   6 VLIFGTVYYLLE-------------EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVL 72

                  ..
gi 1907177725 297 VN 298
Cdd:pfam07885  73 GR 74
PRK10537 PRK10537
voltage-gated potassium channel protein;
247-300 1.26e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.16  E-value: 1.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907177725 247 NIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPV-----PVIVNNF 300
Cdd:PRK10537  168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSIsaifgPVIRGNL 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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