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Conserved domains on  [gi|1825698276|ref|XP_033022871|]
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cyclin-F isoform X3 [Lacerta agilis]

Protein Classification

cyclin F( domain architecture ID 17778166)

cyclin F functions as the substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle

CATH:  1.20.1280.50|1.10.472.10
Gene Symbol:  CCNF
Gene Ontology:  GO:0006511|GO:0019005|GO:0000079|GO:0019901
PubMed:  20596027|11178263|31898225|30185601|1842340
SCOP:  4001927|4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 285-379 5.13e-64

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410225  Cd Length: 95  Bit Score: 207.94  E-value: 5.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 285 ETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLTDNTYK 364
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                          90
                  ....*....|....*
gi 1825698276 365 YEDLVRMMGEIISAL 379
Cdd:cd20521    81 YEDVVRMMGEIVAAL 95
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 407-518 1.97e-45

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410226  Cd Length: 112  Bit Score: 157.79  E-value: 1.97e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 407 HLYSFICELSLLNTGLCIYSPARLSAAALLLAKVLHKQAHPWTSQLCEATGFSLEELIPCALNIHKKCFHEDVPKDYRQV 486
Cdd:cd20522     1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSCVLHLHKKCFHEDSPKDYRNV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1825698276 487 SLTAVKQRFEDERYEEIGKEEVMNYSQLCSLL 518
Cdd:cd20522    81 SLTAVKQRYEDERFLSISKIKVMSYEELCALL 112
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 9-60 9.98e-26

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438854  Cd Length: 52  Bit Score: 100.01  E-value: 9.98e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1825698276   9 TLLCLPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVDNHASVWACASFQDVW 60
Cdd:cd22082     1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANASFQGSW 52
 
Name Accession Description Interval E-value
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 285-379 5.13e-64

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 207.94  E-value: 5.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 285 ETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLTDNTYK 364
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                          90
                  ....*....|....*
gi 1825698276 365 YEDLVRMMGEIISAL 379
Cdd:cd20521    81 YEDVVRMMGEIVAAL 95
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 407-518 1.97e-45

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 157.79  E-value: 1.97e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 407 HLYSFICELSLLNTGLCIYSPARLSAAALLLAKVLHKQAHPWTSQLCEATGFSLEELIPCALNIHKKCFHEDVPKDYRQV 486
Cdd:cd20522     1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSCVLHLHKKCFHEDSPKDYRNV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1825698276 487 SLTAVKQRFEDERYEEIGKEEVMNYSQLCSLL 518
Cdd:cd20522    81 SLTAVKQRYEDERFLSISKIKVMSYEELCALL 112
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 271-383 1.55e-29

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 113.77  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 271 LSKQSIFTVQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEIL 350
Cdd:pfam00134  14 LPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPP 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1825698276 351 TIREAVWLTDNTYKYEDLVRMMGEIISALEGKI 383
Cdd:pfam00134  94 TVEDLVYITDNAYTREEILRMERLILETLNFDL 126
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 9-60 9.98e-26

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 100.01  E-value: 9.98e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1825698276   9 TLLCLPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVDNHASVWACASFQDVW 60
Cdd:cd22082     1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANASFQGSW 52
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
259-419 2.41e-11

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 66.72  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 259 EMVSQLFQASLP----LSKQSIFTVQkgmnetMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLG 334
Cdd:COG5024   186 EYLLKLELIDLPnpnyLIKQSLYEWS------MRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVG 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 335 IACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIISALEGKIKIPTILDYkevLLNII-----PLERRTVHLY 409
Cdd:COG5024   260 ISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF---LRRISkasdyDIFSRTPAKF 336

                         170
                  ....*....|
gi 1825698276 410 SfiCELSLLN 419
Cdd:COG5024   337 S--SEISPVD 344
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 293-377 1.87e-08

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 51.82  E-value: 1.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276  293 DWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLTDntYKYEDLVRMM 372
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 1825698276  373 GEIIS 377
Cdd:smart00385  79 RLLLE 83
FBOX smart00256
A Receptor for Ubiquitination Targets;
13-51 8.44e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.19  E-value: 8.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1825698276   13 LPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVDNHASVW 51
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 10-47 7.88e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.60  E-value: 7.88e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1825698276  10 LLCLPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVDNH 47
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSL 38
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 444-503 8.11e-05

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 42.61  E-value: 8.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 444 QAHPWTSQLCEATGFSLEELIPCALNIHKKCfhedvpKDYRQVSLTAVKQRFEDERYEEI 503
Cdd:pfam02984  60 NSPEWTETLEHYTGYSEEDLKPCVKLLLELL------LNAPSSKLQAVRRKYSSSKFMKV 113
 
Name Accession Description Interval E-value
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 285-379 5.13e-64

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 207.94  E-value: 5.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 285 ETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLTDNTYK 364
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                          90
                  ....*....|....*
gi 1825698276 365 YEDLVRMMGEIISAL 379
Cdd:cd20521    81 YEDVVRMMGEIVAAL 95
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 407-518 1.97e-45

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 157.79  E-value: 1.97e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 407 HLYSFICELSLLNTGLCIYSPARLSAAALLLAKVLHKQAHPWTSQLCEATGFSLEELIPCALNIHKKCFHEDVPKDYRQV 486
Cdd:cd20522     1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSCVLHLHKKCFHEDSPKDYRNV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1825698276 487 SLTAVKQRFEDERYEEIGKEEVMNYSQLCSLL 518
Cdd:cd20522    81 SLTAVKQRYEDERFLSISKIKVMSYEELCALL 112
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 271-383 1.55e-29

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 113.77  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 271 LSKQSIFTVQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEIL 350
Cdd:pfam00134  14 LPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPP 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1825698276 351 TIREAVWLTDNTYKYEDLVRMMGEIISALEGKI 383
Cdd:pfam00134  94 TVEDLVYITDNAYTREEILRMERLILETLNFDL 126
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 9-60 9.98e-26

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 100.01  E-value: 9.98e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1825698276   9 TLLCLPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVDNHASVWACASFQDVW 60
Cdd:cd22082     1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANASFQGSW 52
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 258-380 5.53e-24

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 98.25  E-value: 5.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 258 NEMVSQLFQASLPlskQSIFTVQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIAC 337
Cdd:cd20562    15 NLRVAELKRRPLP---DYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSC 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1825698276 338 MVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIISALE 380
Cdd:cd20562    92 MLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQ 134
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 280-380 3.71e-23

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 95.29  E-value: 3.71e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 280 QKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFisKEILT--IREAVW 357
Cdd:cd20507    29 QPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKY--EEIYPpeIKDFVY 106

                          90       100
                  ....*....|....*....|...
gi 1825698276 358 LTDNTYKYEDLVRMMGEIISALE 380
Cdd:cd20507   107 ITDNAYTREEILQMERDILKTLD 129
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 279-380 1.94e-21

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 90.38  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 279 VQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFisKEI--LTIREAV 356
Cdd:cd20504    26 KQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGTACMFIAAKY--EEIypPEVEEFV 103

                          90       100
                  ....*....|....*....|....
gi 1825698276 357 WLTDNTYKYEDLVRMMGEIISALE 380
Cdd:cd20504   104 YITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 280-380 3.86e-17

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 78.92  E-value: 3.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 280 QKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFisKEILT--IREAVW 357
Cdd:cd20567    46 QPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKY--EEIWApeVNDFVY 123

                          90       100
                  ....*....|....*....|...
gi 1825698276 358 LTDNTYKYEDLVRMMGEIISALE 380
Cdd:cd20567   124 ISDNAYTRKQILVMEKTMLNTLE 146
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 273-376 6.10e-16

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 74.90  E-value: 6.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 273 KQSI---FTVQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEI 349
Cdd:cd20566    22 QQSIrphYLDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKYEEMYS 101

                          90       100
                  ....*....|....*....|....*..
gi 1825698276 350 LTIREAVWLTDNTYKYEDlVRMMGEII 376
Cdd:cd20566   102 PEIGDFVYITDNAYTKAQ-IREMEMLI 127
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 288-380 2.17e-15

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 71.97  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 288 RYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYED 367
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                          90
                  ....*....|...
gi 1825698276 368 LVRMMGEIISALE 380
Cdd:cd20542    81 VLRMERRVLRRLR 93
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 280-379 1.19e-14

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 71.24  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 280 QKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFisKEIL--TIREAVW 357
Cdd:cd20561    29 QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKF--EEIYppEVAEFVY 106

                          90       100
                  ....*....|....*....|..
gi 1825698276 358 LTDNTYKYEDLVRMMGEIISAL 379
Cdd:cd20561   107 ITDDTYTKKQVLRMEHLVLKVL 128
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 287-379 3.69e-14

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 68.51  E-value: 3.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 287 MRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFIskEIL--TIREAVWLTDNTYK 364
Cdd:cd20536     1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQE--EIYppEVKDLLALCCGAYT 78

                          90
                  ....*....|....*
gi 1825698276 365 YEDLVRMMGEIISAL 379
Cdd:cd20536    79 REQICNLECIILTKL 93
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 287-380 8.02e-13

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 66.05  E-value: 8.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 287 MRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYE 366
Cdd:cd20565    35 MRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKH 114

                          90
                  ....*....|....
gi 1825698276 367 DLVRMMGEIISALE 380
Cdd:cd20565   115 QIRQMEMKILRALD 128
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 280-380 8.74e-13

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 66.12  E-value: 8.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 280 QKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLT 359
Cdd:cd20508    40 QTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYIC 119

                          90       100
                  ....*....|....*....|.
gi 1825698276 360 DNTYKYEDLVRMMGEIISALE 380
Cdd:cd20508   120 DDAYTREELLKMEREILKTLD 140
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 280-380 1.19e-12

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 65.39  E-value: 1.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 280 QKGMNETMRYILIDWLVEVATmkDFSSL--CLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFisKEIL--TIREA 355
Cdd:cd20568    33 QKELRWKMRGILVDWLVEVHE--KFRLLpeTLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASKY--EEVNspSIKNF 108

                          90       100
                  ....*....|....*....|....*
gi 1825698276 356 VWLTDNTYKYEDLVRMMGEIISALE 380
Cdd:cd20568   109 AYMTDGAYTVEDILRAERYMLNTLE 133
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 280-371 3.61e-12

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 65.25  E-value: 3.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 280 QKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFisKEIL--TIREAVW 357
Cdd:cd20560    61 QPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKY--EEIYppEVDEFVY 138

                          90
                  ....*....|....
gi 1825698276 358 LTDNTYKYEDLVRM 371
Cdd:cd20560   139 ITDDTYTKKQLLRM 152
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
259-419 2.41e-11

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 66.72  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 259 EMVSQLFQASLP----LSKQSIFTVQkgmnetMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLG 334
Cdd:COG5024   186 EYLLKLELIDLPnpnyLIKQSLYEWS------MRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVG 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 335 IACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIISALEGKIKIPTILDYkevLLNII-----PLERRTVHLY 409
Cdd:COG5024   260 ISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF---LRRISkasdyDIFSRTPAKF 336

                         170
                  ....*....|
gi 1825698276 410 SfiCELSLLN 419
Cdd:COG5024   337 S--SEISPVD 344
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 272-371 2.43e-09

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 56.54  E-value: 2.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 272 SKQSIFTVQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILT 351
Cdd:cd20515    40 SASYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPLT 119

                          90       100
                  ....*....|....*....|
gi 1825698276 352 IREAVWLTDNTYKYEDLVRM 371
Cdd:cd20515   120 AEKLCIYTDNSITLQELLDW 139
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 279-368 4.06e-09

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 55.77  E-value: 4.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 279 VQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWL 358
Cdd:cd20575    47 VQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIY 126

                          90
                  ....*....|
gi 1825698276 359 TDNTYKYEDL 368
Cdd:cd20575   127 TDNSISPRQL 136
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 279-371 7.54e-09

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 54.99  E-value: 7.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 279 VQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWL 358
Cdd:cd20573    46 VQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIY 125

                          90
                  ....*....|...
gi 1825698276 359 TDNTYKYEDLVRM 371
Cdd:cd20573   126 TDNSIRPEELLQM 138
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 282-380 1.51e-08

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 53.86  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 282 GMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKI-RPVSRACLQLLGIACMvictrFISKEILTIR-----EA 355
Cdd:cd20519    31 SLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTqTNVPKTQLQLIGITCL-----FIAAKLEEIYppklsEF 105

                          90       100
                  ....*....|....*....|....*
gi 1825698276 356 VWLTDNTYKYEDLVRMMGEIISALE 380
Cdd:cd20519   106 AYVTDGACTEDEILTMELIILKALN 130
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 293-377 1.87e-08

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 51.82  E-value: 1.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276  293 DWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWLTDntYKYEDLVRMM 372
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 1825698276  373 GEIIS 377
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 279-369 1.27e-07

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 51.53  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 279 VQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKEILTIREAVWL 358
Cdd:cd20574    47 VQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIY 126

                          90
                  ....*....|.
gi 1825698276 359 TDNTYKYEDLV 369
Cdd:cd20574   127 TDNSIKPQELL 137
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 291-380 6.54e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 48.15  E-value: 6.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 291 LIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRFISKE--ILTIREAVWLTDNTYKYEDL 368
Cdd:cd20559     2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKarVPLLSELSKMCCNSYGEELF 81

                          90
                  ....*....|..
gi 1825698276 369 VRMMGEIISALE 380
Cdd:cd20559    82 IQMEMHILNTLN 93
FBOX smart00256
A Receptor for Ubiquitination Targets;
13-51 8.44e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 43.19  E-value: 8.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1825698276   13 LPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVDNHASVW 51
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 10-47 7.88e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.60  E-value: 7.88e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1825698276  10 LLCLPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVDNH 47
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSL 38
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 444-503 8.11e-05

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 42.61  E-value: 8.11e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 444 QAHPWTSQLCEATGFSLEELIPCALNIHKKCfhedvpKDYRQVSLTAVKQRFEDERYEEI 503
Cdd:pfam02984  60 NSPEWTETLEHYTGYSEEDLKPCVKLLLELL------LNAPSSKLQAVRRKYSSSKFMKV 113
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 274-379 1.26e-04

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 42.53  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 274 QSIFTVQKGMNETMRYILIDWLVEVATMKDFSSLCLHMTVGCVDRY-LKIRPVSRACLQLLGIACMVICTRFisKEIL-- 350
Cdd:cd20580    29 KHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKL--EEIYpp 106

                          90       100
                  ....*....|....*....|....*....
gi 1825698276 351 TIREAVWLTDNTYKYEDLVRMMGEIISAL 379
Cdd:cd20580   107 KLHEFAYVTDGACSEDDILDMELIILKAL 135
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 288-338 1.55e-04

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 41.53  E-value: 1.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1825698276 288 RYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIR--PVSRA-CLQLLGIACM 338
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYdlPKDKPwMLQLLAVACL 55
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 386-472 1.85e-04

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 40.75  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 386 PTILDYKEVLLNIIPLERRTVHLYSFICELSLLNTGLCIYSPARLSAAALLLAKVLHKQAHPWTSQLCEATGFSLEELIP 465
Cdd:cd20537     1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLQLVTGYSENDLQE 80


                  ....*..
gi 1825698276 466 CALNIHK 472
Cdd:cd20537    81 CAKELLE 87
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 291-372 3.56e-04

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 39.70  E-value: 3.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 291 LIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRPVSRACLQLLGIACMVICTRfISKEILTIREAVWLTDNTYKyeDLVR 370
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACK-LEELPRTLKEIAKVSGVSEK--ELRK 78


                  ..
gi 1825698276 371 MM 372
Cdd:cd00043    79 AE 80
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 287-380 5.60e-04

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 40.63  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 287 MRYILIDWLVEVATMKDFSSLCLHMTVGCVDRYLKIRP-VSRACLQLLGIACMVICTRFisKEIL--TIREAVWLTDNTY 363
Cdd:cd20579    42 MRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVKTRLQLIGISSLFIAAKL--EEIYppKLHQFAYVTDGAC 119

                          90
                  ....*....|....*..
gi 1825698276 364 KYEDLVRMMGEIISALE 380
Cdd:cd20579   120 TEDEILSMELIIMKALK 136
F-box_FBXL15 cd22126
F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins; FBXL15, also ...
 10-47 3.01e-03

F-box domain found in F-box/LRR-repeat protein 15 (FBXL15) and similar proteins; FBXL15, also called F-box only protein 37 (FBXO37), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Smad ubiquitination regulatory factor 1 (SMURF1), thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance. It also mediates ubiquitination of SMURF2 and WWP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438898  Cd Length: 44  Bit Score: 35.94  E-value: 3.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1825698276  10 LLCLP-EDVLF-HVLKGLPAEDILSLRAVHSHLKYLVDNH 47
Cdd:cd22126     1 LLDLPwEDVLFpHILPHLSLKDLFNLRRVSKAFKSLVDEY 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 11-45 4.67e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 35.11  E-value: 4.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1825698276  11 LCLPEDVLFHVLKGLPAEDILSLRAVHSHLKYLVD 45
Cdd:cd09917     1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 7-45 6.60e-03

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 36.11  E-value: 6.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1825698276   7 VLTLLCLPEDVLFHVLKGLPAED-ILSLRAVHSHLKYLVD 45
Cdd:cd22168     1 MLTISDLPEDVLLEILSLVPARDlILSCRLVCSRWRDLVD 40
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 404-500 6.79e-03

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 37.48  E-value: 6.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 404 RTVHLYSFICELSLLNTGLCI-YSPARLSAAALLLAKVLHKQaHPWTSQLCEATGFSLEELIPCALNIHKKCFheDVPKD 482
Cdd:cd20563    19 KTENLAMYVAELSLLEVDPFLkYLPSLTAAAAYCLANYTVNK-VFWPETLAAFTGYSLSEIVPCLSDLHKACL--GAPHR 95

                          90
                  ....*....|....*...
gi 1825698276 483 YRQvsltAVKQRFEDERY 500
Cdd:cd20563    96 PQQ----AIREKYKGSKY 109
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 407-500 9.34e-03

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 36.46  E-value: 9.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1825698276 407 HLYSFICELSLLNTGLCIYSPARLSAAALLLAKVLHKQaHPWTSQLCEATGFSLEELIPCALNIHkkcfheDVPKDYRQV 486
Cdd:cd20506    25 FLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNP-HPWNPTLEHYTGYKAADLKPCVQALH------DLQLNASGS 97

                          90
                  ....*....|....
gi 1825698276 487 SLTAVKQRFEDERY 500
Cdd:cd20506    98 SLQAVREKYKQHKF 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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