BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  18 EISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELC 97
Cdd:cd18427     1 EISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELC 80

                          90       100
                  ....*....|....*....|....*..
gi 1804017191  98 VFSFSQEIEYWGINEFFIDSCCSYSYH 124
Cdd:cd18427    81 VFSFSQEIEYWGINEFFIDSCCSYSYH 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  18 EISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELC 97
Cdd:cd18427     1 EISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELC 80

                          90       100
                  ....*....|....*....|....*..
gi 1804017191  98 VFSFSQEIEYWGINEFFIDSCCSYSYH 124
Cdd:cd18427    81 VFSFSQEIEYWGINEFFIDSCCSYSYH 107

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNskesilelCDDYDDTKNEFYFDRNPELFPYVLHFYNT-GKLHVMGELC 97
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE--------CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVC 72

                          90       100
                  ....*....|....*....|.
gi 1804017191  98 VFSFSQEIEYWGINEFFIDSC 118
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93

voltage-gated potassium channel protein;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191 240 FELVARFAVAPDFLQFFKHALNLIDLMSIL--PFYITLIVNLVVesSPALANLGRVAQVLRLMRIFRILKLARHSTGlrS 317
Cdd:PRK10537   31 LKPVYGMAALNLFDIWHIKALSALDLSLLAnaPQFMLGVFLVLM--AIGLLFRARLAWAISILLLLAALAITLHFYP--W 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191 318 LGATLKYSYREVGLLLLY--------LSVG-----ISIFSVVAYTI------EKEENRALETIPACWWWATVSMTTVGYG 378
Cdd:PRK10537  107 LKFLIGYCIVLLVALLIYrrdfdrssLAAGtlfavISITSLLFYSTfgalylGDGFSPPIESLSTAFYFSIVTMSTVGYG 186

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1804017191 379 DVVPLTIAGRLTASACILAGILVVVLPITLIF 410
Cdd:PRK10537  187 DIVPVSESARLFTISVIILGITVFATSISAIF 218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  18 EISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELC 97
Cdd:cd18427     1 EISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELC 80

                          90       100
                  ....*....|....*....|....*..
gi 1804017191  98 VFSFSQEIEYWGINEFFIDSCCSYSYH 124
Cdd:cd18427    81 VFSFSQEIEYWGINEFFIDSCCSYSYH 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18384     1 IRINVGGFRRRLSASALLRFPGTRLGRLLACHSEEAILELCDDYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                          90       100
                  ....*....|....*....|....*.
gi 1804017191  99 FSFSQEIEYWGINEFFIDSCCSYSYH 124
Cdd:cd18384    81 FSFSQEIEYWGINEFFLDSCCSYRYH 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18378     4 VLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNTHESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMCV 83

                          90       100
                  ....*....|....*....|....*.
gi 1804017191  99 FSFSQEIEYWGINEFFIDSCCSYSYH 124
Cdd:cd18378    84 LSFSQELEYWGIDEIYLESCCQHRYH 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  21 LNVGGFKKKMRYNTLLRFPETRLGKLlSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCVFS 100
Cdd:cd18424     3 INVGGSRFVLSQQVLSSHPETRLGKL-AVSVRDSVLELCDDANFVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAIS 81

                          90       100
                  ....*....|....*....|....*..
gi 1804017191 101 FSQEIEYWGINEFFIDSCCSYSYHGRK 127
Cdd:cd18424    82 FLQEIEYWGIDELSIDSCCRERYYRRK 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18411    12 VKLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHESLMEICDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 91

                          90       100
                  ....*....|....*....|....*.
gi 1804017191  99 FSFSQEIEYWGINEFFIDSCCSYSYH 124
Cdd:cd18411    92 LSFSQELDYWGIDEIYLESCCQARYH 117

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNskesilelCDDYDDTKNEFYFDRNPELFPYVLHFYNT-GKLHVMGELC 97
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE--------CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVC 72

                          90       100
                  ....*....|....*....|.
gi 1804017191  98 VFSFSQEIEYWGINEFFIDSC 118
Cdd:pfam02214  73 LDEFLEEAEFYGLDELALELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  21 LNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCVFS 100
Cdd:cd18421     8 INVGGIKYRIPWTTLEEFPLTRLGQLKSCNNFDEIMDICDDYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREMCALS 87

                          90       100
                  ....*....|....*....|...
gi 1804017191 101 FSQEIEYWGINEFFIDSCCSYSY 123
Cdd:cd18421    88 FQEELLYWGIEEENLEWCCRRRL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  18 EISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSK--ESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGE 95
Cdd:cd18381     2 EIVVNVGGVRQVLYGDVLNRYPETRLAELLNCLSGgyDAIFSLCDDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKKG 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1804017191  96 LCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKME 129
Cdd:cd18381    82 ICPICFKNEMDFWRVDLDFLDECCKCHLSEKREE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESilelcdDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18379     1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAF------DYDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCG 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1804017191  99 FSFSQEIEYWGINEFFIDSCCSYSYhgRKMEPDQEKW 135
Cdd:cd18379    75 PLFEEELAFWGIDETQIEPCCWMTY--RQHRDAQETL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKllscNSKESIlelcddYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18380     2 IVINVSGRRFETWKNTLEKYPDTLLGS----TEKEFF------YDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECI 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1804017191  99 FSFSQEIEYWGINEFFIDSCCSYSYHGRKME 129
Cdd:cd18380    72 SAYDDELAFFGILPEIIGDCCYEDYRDRKRE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  15 EDNEISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESIlelcdDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMG 94
Cdd:cd18414     1 ESDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPA 75

                          90       100
                  ....*....|....*....|....*....
gi 1804017191  95 ELCVFSFSQEIEYWGINEFFIDSCCSYSY 123
Cdd:cd18414    76 DVCGPLYEEELAFWGIDETDVEPCCWMTY 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILELC------DDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHV 92
Cdd:cd18415     4 IILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCsqvggsDGSPGGGNEFFFDRHPGVFAYVLNYYRTGKLHC 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1804017191  93 MGELCVFSFSQEIEYWGINEFFIDSCCSYSYH 124
Cdd:cd18415    84 PADVCGPLFEEELAFWGIDETDVEPCCWMTYR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  16 DNEISLNVGGFKKKMRYNTLLRFPETRLGKllscNSKESIlelcddYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGE 95
Cdd:cd18417    34 DEILVVNVSGRRFQTWKNTLDRYPDTLLGS----SEKEFF------YNEDTQEYFFDRDPEMFRHILNFYRTGRLHYPRH 103

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1804017191  96 LCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKME 129
Cdd:cd18417   104 ECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKE 137

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGkllscNSKESILelcddYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18418     2 IVLNVSGTRFQTWRNTLERYPDTLLG-----SSERDFF-----YHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECI 71

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1804017191  99 FSFSQEIEYWGINEFFIDSCCSYSYHGRKME 129
Cdd:cd18418    72 SAYDEELAFFGIIPEIIGDCCYEEYKDRRRE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESilelcddYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFT-------FPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISI 73

                          90
                  ....*....|
gi 1804017191  99 FSFSQEIEYW 108
Cdd:cd18187    74 PDLREECDFY 83

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191   19 ISLNVGGfkkkmryntlLRFPETRLgkLLSCNSK--ESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGEl 96
Cdd:smart00225   2 VTLVVGG----------KKFHAHKA--VLAAHSPyfKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE- 68

                           90       100
                   ....*....|....*....|....*...
gi 1804017191   97 CVFSFSQEIEYWGInEFFIDSCCSYSYH 124
Cdd:smart00225  69 NVEELLELADYLQI-PGLVELCEEFLLK 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESILElcddydDTKNEFYFDRNPELFPYVLHFYNTGKLH 91
Cdd:cd18367     5 VELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQELAR------DSKGRYFLDRDGVLFRYILDYLRNQKLV 71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shaker and similar proteins; Shaker, also termed protein minisleep, represents a family of putative potassium channel proteins in the nervous system of Drosophila. It is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Shaker plays a role in the regulation of sleep need or efficiency. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaker is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKesilelcddYDDTKNEFYFDRNPELFPYVLHFYNT-GKLHVMGELC 97
Cdd:cd18410     3 VVINVSGLRFETQLKTLNQFPDTLLGDPQRRNRY---------YDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVP 73

                          90
                  ....*....|....*
gi 1804017191  98 VFSFSQEIEYWGINE 112
Cdd:cd18410    74 LDVFSEEIKFYELGE 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 1 (KCNA1); KCNA1 is also called voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, or voltage-gated potassium channel subunit Kv1.1. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. It is involved in the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGkllscNSKESILElcddYDDTKNEFYFDRNPELFPYVLHFYNT-GKLHVMGELC 97
Cdd:cd18402    11 VVINIAGLRFETQLKTLAQFPNTLLG-----NPKKRMRY----FDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVP 81

                          90
                  ....*....|....*
gi 1804017191  98 VFSFSQEIEYWGINE 112
Cdd:cd18402    82 LDMFSEEIKFYELGE 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLscnskesilelcdDYDDTK-----NEFYFDRNPELFPYVLHFYNTGKLHVM 93
Cdd:cd18375     3 VTLNVGGKKFTTRPSTLRRFPDSRLARML-------------DGKDQDfkvvnGQFFVDRDGSLFSYILDYLRTGQLTLP 69

                          90
                  ....*....|....*...
gi 1804017191  94 GELCVFS-FSQEIEYWGI 110
Cdd:cd18375    70 TEFSDYNrLAREAEFYGL 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCnSKESILELCddyDDTKNEFYFDRNPELFPYVLHF 84
Cdd:cd18398     5 VELNVGGQVYFTRHATLVSIPHSLLWKMFSP-KRDTANDLA---KDSKGRFFIDRDGFLFRYILDY 66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  21 LNVGGFKKKMRYNTLLRFPETRLGKLLscNSKESILelcddYDDTKNEFYFDRNPELFPYVLHFYNTGKL 90
Cdd:cd18361     3 IDVGGHIYTSSLETLTKYPESRLGKLF--NGSIPIV-----LDSLKQHYFIDRDGKMFRHILNFLRTSKL 65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKesilelcddYDDTKNEFYFDRNPELFPYVLHFYNTG 88
Cdd:cd18377     3 VVINVSGLRFETQLKTLAQFPNTLLGDPNKRMRF---------FDPLRNEYFFDRNRPSFDAILYYYQSG 63

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESilelcddyDDTKNEFYFDRNPELFPYVLHFYNTGKL 90
Cdd:cd18394     5 VTLNVGGHLYTTSLSTLTRYPDSMLGAMFRGDFPTA--------RDSQGNYFIDRDGPLFRYILNFLRTSEL 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLSCNSKESIlelcddydDTKNEFYFDRNPELFPYVLHFYNTGKL 90
Cdd:cd18365     3 VNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMPTTR--------DDQGNYFIDRDGTLFRYILNFLRSSQL 66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLlsCNSKEsilELCDDYDDTkNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 98
Cdd:cd18389     3 VRLNVGGTYFVSTKQTLCRDPKSFLYRL--CQEDP---DLDSDKDET-GAYLIDRDPTYFGPILNYLRHGKLIINKELAE 76

                          90
                  ....*....|..
gi 1804017191  99 FSFSQEIEYWGI 110
Cdd:cd18389    77 EGVLEEAEFYNI 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1804017191  19 ISLNVGGFKKKMRYNTLLRFPETRLGKLLScnSKESILElcddydDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGeLCV 98
Cdd:cd18393     4 IHLNVGGKRFSTSRQTLTWIPDSFFSSLLS--GRISTLK------DETGAIFIDRDPTVFAPILNFLRTKELDPRG-IHV 74