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Conserved domains on  [gi|1758353115|ref|XP_030991246|]
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uncharacterized protein E0L32_009278 [Thyridium curvatum]

Protein Classification

WDR46/Utp7 family protein( domain architecture ID 13237426)

WDR46/Utp7 family protein is a WD40 repeat domain-containing protein, similar to Saccharomyces cerevisiae U3 small nucleolar RNA-associated protein 7 that is involved in nucleolar processing of pre-18S ribosomal RNA

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042274|GO:0030490|GO:0003723
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 375-454 4.78e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


:

Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.94  E-value: 4.78e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115  375 PYMAWGGEAKRVERVRWCPFEDVLGVGHDSGFSSLLVPGAGESNFDALEVNPFETTKQRQEAEVKGLLNKLQPEMIALDP 454
Cdd:smart01033   1 PYMTHGLPGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-358 6.25e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 6.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 132 YALDYTRNGREILLAGRKGHVATMDWREGRLGCEL-NLKETIRDAKWLHNNQFFALAQK-NACYIYD-HNGVEVHRLKKH 208
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASADGTYLASGSSdKTIRLWDlETGECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 209 T-DVTHLDFLPYHFLLTTLSSTGQLKYQDTSTGQLVSEISTKMGTPTSLRQNPYNAVLHIGHQNGAVTLWSPNSSEPLVK 287
Cdd:cd00200    93 TsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1758353115 288 LLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDIRMFREVNNYFT-RAPGTSVAISDTGLTAVGWSTNTTIW 358
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIR 244
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 375-454 4.78e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.94  E-value: 4.78e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115  375 PYMAWGGEAKRVERVRWCPFEDVLGVGHDSGFSSLLVPGAGESNFDALEVNPFETTKQRQEAEVKGLLNKLQPEMIALDP 454
Cdd:smart01033   1 PYMTHGLPGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 375-453 5.34e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 163.78  E-value: 5.34e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1758353115 375 PYMAWGGEAKRVERVRWCPFEDVLGVGHDSGFSSLLVPGAGESNFDALEVNPFETTKQRQEAEVKGLLNKLQPEMIALD 453
Cdd:pfam08149   1 PYLTHLLPGSTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-358 6.25e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 6.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 132 YALDYTRNGREILLAGRKGHVATMDWREGRLGCEL-NLKETIRDAKWLHNNQFFALAQK-NACYIYD-HNGVEVHRLKKH 208
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASADGTYLASGSSdKTIRLWDlETGECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 209 T-DVTHLDFLPYHFLLTTLSSTGQLKYQDTSTGQLVSEISTKMGTPTSLRQNPYNAVLHIGHQNGAVTLWSPNSSEPLVK 287
Cdd:cd00200    93 TsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1758353115 288 LLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDIRMFREVNNYFT-RAPGTSVAISDTGLTAVGWSTNTTIW 358
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
115-358 3.28e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 3.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 115 IETAQKGFELKLDQLGPYALDYTRNGREILLAGRKGHVATMDWREGRLGCELNL-KETIRDAKWLHNNQFFALA-QKNAC 192
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGsDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 193 YIYD-HNGVEVHRLKKHTD-VTHLDFLPYHFLLTTLSSTGQLKYQDTSTGQLVSEISTKMGTPTSLRQNPYNAVLHIGHQ 270
Cdd:COG2319   187 RLWDlATGKLLRTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 271 NGAVTLWSPNSSEPLVKLLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDIRMFREVNNY-FTRAPGTSVAISDTGLT-A 348
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTlA 346

                         250
                  ....*....|.
gi 1758353115 349 VGWSTNT-TIW 358
Cdd:COG2319   347 SGSDDGTvRLW 357
WD40 pfam00400
WD domain, G-beta repeat;
282-320 3.49e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1758353115 282 SEPLVKLLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWD 320
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 281-320 4.62e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1758353115  281 SSEPLVKLLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWD 320
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BING4CT smart01033
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 375-454 4.78e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 198101  Cd Length: 80  Bit Score: 163.94  E-value: 4.78e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115  375 PYMAWGGEAKRVERVRWCPFEDVLGVGHDSGFSSLLVPGAGESNFDALEVNPFETTKQRQEAEVKGLLNKLQPEMIALDP 454
Cdd:smart01033   1 PYMTHGLPGSRVESVRFCPFEDVLGIGHAGGFSSIIVPGAGEPNFDSLEANPFETRKQRREREVRSLLEKLPPELISLDP 80
BING4CT pfam08149
BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 ...
 375-453 5.34e-49

BING4CT (NUC141) domain; This C terminal domain is found in the BING4 family of nucleolar WD40 repeat proteins.


Pssm-ID: 462375  Cd Length: 79  Bit Score: 163.78  E-value: 5.34e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1758353115 375 PYMAWGGEAKRVERVRWCPFEDVLGVGHDSGFSSLLVPGAGESNFDALEVNPFETTKQRQEAEVKGLLNKLQPEMIALD 453
Cdd:pfam08149   1 PYLTHLLPGSTITSLRFCPFEDVLGVGHSKGFSSIIVPGSGEPNFDALEANPYETKKQRREREVRSLLEKIPPEMITLD 79
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-358 6.25e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 6.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 132 YALDYTRNGREILLAGRKGHVATMDWREGRLGCEL-NLKETIRDAKWLHNNQFFALAQK-NACYIYD-HNGVEVHRLKKH 208
Cdd:cd00200    13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTGPVRDVAASADGTYLASGSSdKTIRLWDlETGECVRTLTGH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 209 T-DVTHLDFLPYHFLLTTLSSTGQLKYQDTSTGQLVSEISTKMGTPTSLRQNPYNAVLHIGHQNGAVTLWSPNSSEPLVK 287
Cdd:cd00200    93 TsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1758353115 288 LLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDIRMFREVNNYFT-RAPGTSVAISDTGLTAVGWSTNTTIW 358
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIR 244
WD40 COG2319
WD40 repeat [General function prediction only];
115-358 3.28e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 3.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 115 IETAQKGFELKLDQLGPYALDYTRNGREILLAGRKGHVATMDWREGRLGCELNL-KETIRDAKWLHNNQFFALA-QKNAC 192
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGsDDGTV 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 193 YIYD-HNGVEVHRLKKHTD-VTHLDFLPYHFLLTTLSSTGQLKYQDTSTGQLVSEISTKMGTPTSLRQNPYNAVLHIGHQ 270
Cdd:COG2319   187 RLWDlATGKLLRTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 271 NGAVTLWSPNSSEPLVKLLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDIRMFREVNNY-FTRAPGTSVAISDTGLT-A 348
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTlA 346

                         250
                  ....*....|.
gi 1758353115 349 VGWSTNT-TIW 358
Cdd:COG2319   347 SGSDDGTvRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
115-322 3.73e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 3.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 115 IETAQKGFELKLDQLGPYALDYTRNGREILLAGRKGHVATMDWREGRLGCELNLKE-TIRDAKWLHNNQFFALA-QKNAC 192
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGRLLASGsADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 193 YIYD-HNGVEVHRLKKHTD-VTHLDFLPYHFLLTTLSSTGQLKYQDTSTGQLVSEISTKMGTPTSLRQNPYNAVLHIGHQ 270
Cdd:COG2319   271 RLWDlATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1758353115 271 NGAVTLWSPNSSEPLVKLLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDIR 322
Cdd:COG2319   351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
208-393 2.72e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 2.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 208 HTDVTHLDFLPYHFLLTTLSSTGQLKYQDTSTGQLVSEISTKMGTPTSLRQNPYNAVLHIGHQNGAVTLWSPNSSEPLVK 287
Cdd:COG2319    36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1758353115 288 LLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDIRMFREVNNYFTRAPG-TSVAISDTGLTAVGWSTNTTI--Wkglfsk 364
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAvTSVAFSPDGKLLASGSDDGTVrlW------ 189

                         170       180
                  ....*....|....*....|....*....
gi 1758353115 365 HAAEQEKVQSpymaWGGEAKRVERVRWCP 393
Cdd:COG2319   190 DLATGKLLRT----LTGHTGAVRSVAFSP 214
WD40 pfam00400
WD domain, G-beta repeat;
282-320 3.49e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.49e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1758353115 282 SEPLVKLLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWD 320
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 281-320 4.62e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1758353115  281 SSEPLVKLLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWD 320
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 288-321 6.37e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 6.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1758353115 288 LLAHKGPVRSLAVDREGRYMVSTGQDCKMAVWDI 321
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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