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Conserved domains on  [gi|1720390838|ref|XP_030105821|]
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uncharacterized protein LOC631624 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-612 5.92e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 5.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 171 KPYKCNECEKCFSYKSSLRTHQRIHTGENPYKCS--ECDKCFSHKGSLSIHQMYHTGKKPYKCSeceKCFIQVGDLRRHE 248
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 249 RIHtgEKPYKCNECEKCFSSKTNLRTHQRIHtgekpykcsecdkGFTLKCSLIIHQVYHTGKKPYKCSECEKCFIQvgdl 328
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQL-------------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 329 rKHQRIHTGEKPYKCSecdksftqkgSLSIHQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKTYKCSECDkCFSH 408
Cdd:COG5048   170 -PLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 409 KGSLKV-HLRIHTGENLYKCSECDKCFTKKWRLTSHQTIHTGE-------KPYKCSECDKSFTLKGNLRDHQR--IHTGE 478
Cdd:COG5048   238 KSLLSQsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 479 --KPYKCSE--CDKYYTRKSHLIVHQKIHAGEKPYKC--SECDKYYTRKS----HLIVHQRIHIGEKPYKC---SECNKC 545
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720390838 546 FTNKYHLRTH--QRIHSANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLNVHQ 612
Cdd:COG5048   398 FKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
607-631 9.30e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390838 607 SLNVHQRVHTGEKPYKCSECDKCFS 631
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-612 5.92e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 5.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 171 KPYKCNECEKCFSYKSSLRTHQRIHTGENPYKCS--ECDKCFSHKGSLSIHQMYHTGKKPYKCSeceKCFIQVGDLRRHE 248
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 249 RIHtgEKPYKCNECEKCFSSKTNLRTHQRIHtgekpykcsecdkGFTLKCSLIIHQVYHTGKKPYKCSECEKCFIQvgdl 328
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQL-------------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 329 rKHQRIHTGEKPYKCSecdksftqkgSLSIHQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKTYKCSECDkCFSH 408
Cdd:COG5048   170 -PLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 409 KGSLKV-HLRIHTGENLYKCSECDKCFTKKWRLTSHQTIHTGE-------KPYKCSECDKSFTLKGNLRDHQR--IHTGE 478
Cdd:COG5048   238 KSLLSQsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 479 --KPYKCSE--CDKYYTRKSHLIVHQKIHAGEKPYKC--SECDKYYTRKS----HLIVHQRIHIGEKPYKC---SECNKC 545
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720390838 546 FTNKYHLRTH--QRIHSANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLNVHQ 612
Cdd:COG5048   398 FKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390838 327 DLRKHQRIHTGEKPYKCSECDKSFTQ 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 563-615 5.17e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 5.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720390838 563 KPYkCSECDKCF-TEKYrLIIHQRIHTgekpYKCSECDKYFTRKSSLNVH-QRVH 615
Cdd:cd20908     1 KPW-CYYCDREFdDEKI-LIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
607-631 9.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390838 607 SLNVHQRVHTGEKPYKCSECDKCFS 631
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-612 5.92e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 5.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 171 KPYKCNECEKCFSYKSSLRTHQRIHTGENPYKCS--ECDKCFSHKGSLSIHQMYHTGKKPYKCSeceKCFIQVGDLRRHE 248
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 249 RIHtgEKPYKCNECEKCFSSKTNLRTHQRIHtgekpykcsecdkGFTLKCSLIIHQVYHTGKKPYKCSECEKCFIQvgdl 328
Cdd:COG5048   109 SLS--SSSSNSNDNNLLSSHSLPPSSRDPQL-------------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 329 rKHQRIHTGEKPYKCSecdksftqkgSLSIHQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKTYKCSECDkCFSH 408
Cdd:COG5048   170 -PLPANSLSKDPSSNL----------SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 409 KGSLKV-HLRIHTGENLYKCSECDKCFTKKWRLTSHQTIHTGE-------KPYKCSECDKSFTLKGNLRDHQR--IHTGE 478
Cdd:COG5048   238 KSLLSQsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 479 --KPYKCSE--CDKYYTRKSHLIVHQKIHAGEKPYKC--SECDKYYTRKS----HLIVHQRIHIGEKPYKC---SECNKC 545
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720390838 546 FTNKYHLRTH--QRIHSANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLNVHQ 612
Cdd:COG5048   398 FKRDSNLSLHiiTHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-650 4.03e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 4.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 255 KPYKCNECEKCFSSKTNLRTHQRIHTGEKPYKCS--ECDKGFTLKCSLIIHQVYHTGKKPYKCSecEKCFIQVGDLRKHQ 332
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 333 RIHTGE---KPYKCSECDKSFTQKGSLSI--HQRIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTgektykcSECDKCFS 407
Cdd:COG5048   110 LSSSSSnsnDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-------SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 408 HKGSLKVHLRIHTGENLYKCSECDKcFTKKWRLTSHQTIHTGEKPYKCSECdkSFTLKGNLRDHQRIHTGEKPYKCSECD 487
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 488 KYYTRKSHLIVHQKIH---------AGEKPYKCSECDKYYTRKSHLIVHQR--IHIGE--KPYKCSE--CNKCFTNKYHL 552
Cdd:COG5048   260 SPRSSLPTASSQSSSPnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 553 RTHQRIHSANKPYKCSEC------DKCFTEKYRLIIHQRIHTGEKPYKC---SECDKYFTRKSSLNVHQRVHTGEKP--Y 621
Cdd:COG5048   340 KRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynC 419

                         410       420
                  ....*....|....*....|....*....
gi 1720390838 622 KCSECDKCFSLKGDLRKHQRIHTGERTLQ 650
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
124-568 1.74e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 124 DKVFDSKETLILKQTKSVKKPYKCSECEKCFIQVGDLRKHQRIHKGEKPYKCN--ECEKCFSYKSSLRTHQRIHTGENPY 201
Cdd:COG5048    13 NSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 202 KCS-ECDKCFSHKGSLSIHQMYHTGKKPYKCSECEKCFIQVGDLRRHERIHTGekpYKCNECEKCFSSKTNLRTHQRIHt 280
Cdd:COG5048    93 LNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISN---LRNNPLPGNNSSSVNTPQSNSLH- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 281 GEKPYKCSeCDKGFTLKCSLIIHQVYHTGKKPYKCSECEKcFIQVGDLRKHQRIHTGEKPYKCSECDKSFTQKGSLSIHQ 360
Cdd:COG5048   169 PPLPANSL-SKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 361 RIHAGEKPYRCSECDKGFTLKCSLIIHQIIHTGEKT-------YKCSECDKCFSHKGSLKVHLR--IHTGENLYKCSE-- 429
Cdd:COG5048   247 SLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpy 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 430 --CDKCFTKKWRLTSHQTIHTGEKPYKC--SECDKSFTLKGNLRDHQRIHtgekpykcsecdkyytrKSHLIVHQKIHAG 505
Cdd:COG5048   327 slCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------QYKDLKNDKKSET 389

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720390838 506 EKPYKCSECDKYYTRKSHLIVH--QRIHigekPYKCSECNKCFTNKYHLRTHQRIHSANKPYKCS 568
Cdd:COG5048   390 LSNSCIRNFKRDSNLSLHIITHlsFRPY----NCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 532-616 1.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 532 IGEKPYKCS--ECNKCFTNKYHLRTHqRIHSankpykcsECDKCFTEKYRLIIHQRIHTGEKPYKCSECDKYFTRKSSLN 609
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1720390838 610 VHqRVHT 616
Cdd:COG5189   416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-352 3.20e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.20e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390838 327 DLRKHQRIHTGEKPYKCSECDKSFTQ 352
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 477-555 3.94e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 477 GEKPYKCS--ECDKYYTRKSHLIVHqKIHAgekpykcsECDKYYTRKSHLIVHQRIHIGEKPYKCSECNKCFTN----KY 550
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNlnglKY 416


                  ....*
gi 1720390838 551 HlRTH 555
Cdd:COG5189   417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 5.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390838 243 DLRRHERIHTGEKPYKCNECEKCFSS 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 337-415 8.61e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 337 GEKPYKCS--ECDKSFTQKGSLSIHqRIHAgekpyrcsECDKGFTLKCSLIIHQIIHTGEKTYKCSECDKCFSHKGSLKV 414
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720390838 415 H 415
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-295 1.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.17e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390838 271 NLRTHQRIHTGEKPYKCSECDKGFT 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 449-527 1.46e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390838 449 GEKPYKCS--ECDKSFTLKGNLRDHqRIHtgekpykcSECDKYYTRKSHLIVHQKIHAGEKPYKCSECDKYYTRKSHLIV 526
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  .
gi 1720390838 527 H 527
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 2.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390838 467 NLRDHQRIHTGEKPYKCSECDKYYTR 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
560-624 3.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720390838 560 SANKPYKCSECDKCFTEKYRLIIHQRIHTGEKPYKCS--ECDKYFTRKSSLNVHQRVHTGEKPYKCS 624
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-212 3.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390838 187 SLRTHQRIHTGENPYKCSECDKCFSH 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 4.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.28e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390838 159 DLRKHQRIHKGEKPYKCNECEKCFSY 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 563-615 5.17e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 5.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720390838 563 KPYkCSECDKCF-TEKYrLIIHQRIHTgekpYKCSECDKYFTRKSSLNVH-QRVH 615
Cdd:cd20908     1 KPW-CYYCDREFdDEKI-LIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
607-631 9.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390838 607 SLNVHQRVHTGEKPYKCSECDKCFS 631
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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