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Conserved domains on  [gi|1720387366|ref|XP_030105047|]
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structure-specific endonuclease subunit SLX4 isoform X9 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP_SLX4 cd22999
SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also ...
 746-795 1.09e-20

SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations in the SLX4 gene are found in Fanconi anemia. This model corresponds to a conserved region called the SAP domain, which is responsible for the binding of MUS81, which plays a distinct role in interstrand crosslink repair.


:

Pssm-ID: 439380 [Multi-domain]  Cd Length: 51  Bit Score: 86.08  E-value: 1.09e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720387366  746 PKVPITPMPRYSIMETPVLKKELDRFGVRALPKRQMVLKLKEIFQYTHQT 795
Cdd:cd22999      1 KPSPVTPMPDYESMTTPELKKELKKYGFKPLPRKKMIALLEEIWEQTHPY 50
Slx4 pfam09494
Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found ...
 943-1000 2.31e-14

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.


:

Pssm-ID: 430644  Cd Length: 60  Bit Score: 68.30  E-value: 2.31e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387366  943 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 1000
Cdd:pfam09494    1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60
 
Name Accession Description Interval E-value
SAP_SLX4 cd22999
SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also ...
 746-795 1.09e-20

SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations in the SLX4 gene are found in Fanconi anemia. This model corresponds to a conserved region called the SAP domain, which is responsible for the binding of MUS81, which plays a distinct role in interstrand crosslink repair.


Pssm-ID: 439380 [Multi-domain]  Cd Length: 51  Bit Score: 86.08  E-value: 1.09e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720387366  746 PKVPITPMPRYSIMETPVLKKELDRFGVRALPKRQMVLKLKEIFQYTHQT 795
Cdd:cd22999      1 KPSPVTPMPDYESMTTPELKKELKKYGFKPLPRKKMIALLEEIWEQTHPY 50
Slx4 pfam09494
Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found ...
 943-1000 2.31e-14

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.


Pssm-ID: 430644  Cd Length: 60  Bit Score: 68.30  E-value: 2.31e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387366  943 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 1000
Cdd:pfam09494    1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60
 
Name Accession Description Interval E-value
SAP_SLX4 cd22999
SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also ...
 746-795 1.09e-20

SAP domain of structure-specific endonuclease subunit SLX4 and similar proteins; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations in the SLX4 gene are found in Fanconi anemia. This model corresponds to a conserved region called the SAP domain, which is responsible for the binding of MUS81, which plays a distinct role in interstrand crosslink repair.


Pssm-ID: 439380 [Multi-domain]  Cd Length: 51  Bit Score: 86.08  E-value: 1.09e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720387366  746 PKVPITPMPRYSIMETPVLKKELDRFGVRALPKRQMVLKLKEIFQYTHQT 795
Cdd:cd22999      1 KPSPVTPMPDYESMTTPELKKELKKYGFKPLPRKKMIALLEEIWEQTHPY 50
Slx4 pfam09494
Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found ...
 943-1000 2.31e-14

Slx4 endonuclease; The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates.


Pssm-ID: 430644  Cd Length: 60  Bit Score: 68.30  E-value: 2.31e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720387366  943 EEAVRRYIRSKPALHRQVLRYQPVELAELQAELKQNG--IPVAMGKLSDILDAQCITFTT 1000
Cdd:pfam09494    1 FEAITELIKSDPSLYEKILTYEPIVLEDLTAWLNEGGflIEVDPGTLKEWCDSQGICFTN 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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