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Conserved domains on  [gi|1720374708|ref|XP_030103017|]
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phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Mus musculus]

Protein Classification

Int_alpha and FG-GAP domain-containing protein( domain architecture ID 10640729)

Int_alpha and FG-GAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 321-377 1.67e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.92  E-value: 1.67e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720374708  321 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSGQLTynGSVYVYYGSQQG-RLSSSPNV 377
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 252-309 2.36e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.53  E-value: 2.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720374708  252 PYARLGWVMTSA-DLNQDGHGDLVVGAPGYSHPGRfqIGRVYIIYGNDLGLPPIDLDLD 309
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 389-422 2.09e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.33  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720374708 389 GWTLLATDADGDGRHDLVISSPFAPGGGKQRGIV 422
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGAGAVYV 35
 
Name Accession Description Interval E-value
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 321-377 1.67e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.92  E-value: 1.67e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720374708  321 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSGQLTynGSVYVYYGSQQG-RLSSSPNV 377
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 252-309 2.36e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.53  E-value: 2.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720374708  252 PYARLGWVMTSA-DLNQDGHGDLVVGAPGYSHPGRfqIGRVYIIYGNDLGLPPIDLDLD 309
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 325-363 6.28e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 6.28e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720374708 325 FGSALAVLDFNQDGLPDLAVGAPSVGSgqlTYNGSVYVY 363
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGG---AGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 257-294 6.59e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 43.27  E-value: 6.59e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720374708 257 GWVMTSADLNQDGHGDLVVGAPGYSHPGRfqiGRVYII 294
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGA---GAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 389-422 2.09e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.33  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720374708 389 GWTLLATDADGDGRHDLVISSPFAPGGGKQRGIV 422
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGAGAVYV 35
 
Name Accession Description Interval E-value
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 321-377 1.67e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.92  E-value: 1.67e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720374708  321 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSGQLTynGSVYVYYGSQQG-RLSSSPNV 377
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 252-309 2.36e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.53  E-value: 2.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720374708  252 PYARLGWVMTSA-DLNQDGHGDLVVGAPGYSHPGRfqIGRVYIIYGNDLGLPPIDLDLD 309
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 325-363 6.28e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 6.28e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720374708 325 FGSALAVLDFNQDGLPDLAVGAPSVGSgqlTYNGSVYVY 363
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEGG---AGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 333-407 1.01e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.45  E-value: 1.01e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720374708 333 DFNQDGLPDLAVgapsvgsgqlTYNGSVYVYYGSQQGRLSSSPNVTISCKDTycnlGWTLLATDADGDGRHDLVI 407
Cdd:pfam13517   1 DLDGDGKLDLVV----------ANDGGLRLYLNNGDGTFTFITSVSLGGGGG----GLSVAVGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 257-294 6.59e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 43.27  E-value: 6.59e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1720374708 257 GWVMTSADLNQDGHGDLVVGAPGYSHPGRfqiGRVYII 294
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGA---GAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 264-344 2.39e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.52  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720374708 264 DLNQDGHGDLVVGAPGYShpgrfqigRVYIIYGNDLGLPPIDLDLdkeahgilegfqPSGRFGSALAVLDFNQDGLPDLA 343
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL--------RLYLNNGDGTFTFITSVSL------------GGGGGGLSVAVGDLDGDGRLDLL 60


                  .
gi 1720374708 344 V 344
Cdd:pfam13517  61 V 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 389-422 2.09e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.33  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720374708 389 GWTLLATDADGDGRHDLVISSPFAPGGGKQRGIV 422
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAGAGAVYV 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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