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Conserved domains on  [gi|1720366619|ref|XP_030101964|]
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leucine-rich repeat-containing protein 37A isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 3506-3652 7.62e-69

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


:

Pssm-ID: 464370  Cd Length: 147  Bit Score: 228.84  E-value: 7.62e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 3506 TPGEQFESHLNQQLRVLIPNNDVRRLISHVIRTLKMDCSDSQVQLSCAKLISRTGLLMKLLSEQQDFKLSRADWDTDQWK 3585
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720366619 3586 TENYINENTETQSKLKSLGRSQFGKEVSEFSYNNKVTLAISVTVVVIVLIIIFCLIEICSHRTKKGD 3652
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1115-1187 7.84e-19

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 83.18  E-value: 7.84e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619 1115 EGELLQTLQNSTGQITESPTAVAIPVPVYLDMTVPTLSQDQAEYLTSPTVSFQPLDLESTITPEPTREAEHFT 1187
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1348-1412 7.30e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.49  E-value: 7.30e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 1348 QETTTQISETPKQVVTPVPEYQEVAVSAPIQDQAKYPLLPTVSFHPLDLELTISSEPPREAYPTT 1412
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1786-1854 9.38e-17

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 77.40  E-value: 9.38e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1786 SKPVQETPTQITKSPKEVAAHTLEYKEGVVLAPVEGQAESVALPNMSLQALDQEFTISPQPPAWTHHPP 1854
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2325-2389 1.50e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 76.63  E-value: 1.50e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2325 QETPSLITKSPKEVAAHTLEYKKRLPPVPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPP 2389
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 992-1065 4.21e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 75.48  E-value: 4.21e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720366619  992 EGELPQTLQDSTSQIIrEPLIEVVALVPIYQEVTVQTPSQDQAEYLTSSTVSFQPLDLELSITPESTREPHLPT 1065
Cdd:pfam15779    1 EVEPSPTQQETPTQPP-ESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2218-2282 6.72e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 74.71  E-value: 6.72e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2218 QENPTQITKSPKEVVGQTLDYKEGVLSGPIEGQDESPAPPSMSLQPLDQELTMSSQPPGYTHHSP 2282
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2103-2174 3.07e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 72.78  E-value: 3.07e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720366619 2103 ETTNSKPVQETLTQISESPKEVAAQTLKYKKVVLPAPVQEQDESATSPKMSLQPLDQELTVSSQPPAWNHNP 2174
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1236-1301 1.83e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.86  E-value: 1.83e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619 1236 EGELSQTVQESTTQITEPHKEIIVPVPVFQEVTVPTPSQDQAEYQ-----TFQHLNLELT--SEPTKEAYRST 1301
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPtlpnvTVQPLDLELTitPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 887-942 8.23e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 68.93  E-value: 8.23e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720366619  887 PLKEVTVQAPEHHEGTIPIPTQDQANYPRSPTVSFQSLDLEPTITPEANGEPYHPT 942
Cdd:pfam15779   18 SPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
2859-2916 9.78e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 9.78e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720366619 2859 EKLILSENHLTELHKESFEGLLSLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLL 2916
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1897-1961 7.68e-13

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 66.23  E-value: 7.68e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 1897 QKNPTQMTKSPKEILAQTPEYKEWVLPVPVEGQAESPTPPNMSLQLLDQEVIIPSLLSPPARDTP 1961
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1679-1747 1.41e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 65.46  E-value: 1.41e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1679 SKPTQKTPTQIKKLRKKVATHTLKYKKGMLTAPVEGQAESVPPPNMSLQPLDQELTISSQLPAWTHNSP 1747
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1461-1532 1.76e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 65.08  E-value: 1.76e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720366619 1461 EEEHSQSIRKNTTQITEPVKEVEALAPEGEDVTIPMPILEQTEFPTPNSVSLQSVDQELAILSDLPGWTYHP 1532
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2000-2068 4.72e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.92  E-value: 4.72e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2000 SKSVQETPTQIINSPKDVTAPTREYKKGVLPASVEGQAESSLLPHISLQHLDQELIIPSLPPPQAHNPS 2068
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2428-2496 5.41e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.54  E-value: 5.41e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2428 SEPVQETPSQITKLPKEIIAQTLEYKEGLLPVPFGGEDDSTTPPNVSLQPLDQEIIISFPSLGQAQQPP 2496
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2836-2987 4.31e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2836 ILNFKGNDISFIDKNVwkvYRWT--EKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERGtFEPLPFLKYMNLGC 2913
Cdd:COG4886    117 SLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2914 NLLTELSfgtfQAWHGMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESilIKTL-ELEHLIL 2987
Cdd:COG4886    192 NQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPE--LGNLtNLEELDL 257
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2534-2601 5.92e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 60.84  E-value: 5.92e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2534 SKPVQEAPTQITKSPKEGVVQTLEYKELVVSSIIEGNVKYVT-PNVSYRPLDLGLSESSGSTTEVYRST 2601
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTlPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 752-819 9.22e-10

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 57.37  E-value: 9.22e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619  752 NFSLIHNKIPHHSPKPLKNMVTDIPGH-KMTVPRPDQDQGEYIISSNGSFQSLDLEVTVTSGITPETMH 819
Cdd:pfam15779    3 EPSPTQQETPTQPPESPKEVVAQPPVHhEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEH 71
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1572-1640 1.83e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 56.60  E-value: 1.83e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1572 SKPVQETSIYITKSSKEIVARSPEHKEAVLPDPVEGQEKSLNPPNMSLKLLDQERIIPFLPRGLAQEPP 1640
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 646-710 3.81e-06

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 46.97  E-value: 3.81e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619  646 EGEPFPDQQETPEHSLELPTEEIAQPPGHHEVTGLPLGHGQVYSPASQNI--------LTQYPTAPEEDQYSP 710
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVtvqpldleLTITPEPTKEAEHST 73
LRRC37 super family cl24370
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 419-481 3.07e-05

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


The actual alignment was detected with superfamily member pfam15779:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 44.66  E-value: 3.07e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720366619  419 FPVVEQEAPFGAPESPIETVVETSPIPEIQ---PTQNENYQYHLPNVTVIPVDVTLTITLGPIKEV 481
Cdd:pfam15779    4 PSPTQQETPTQPPESPKEVVAQPPVHHEVTvptPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEA 69
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 3506-3652 7.62e-69

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 228.84  E-value: 7.62e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 3506 TPGEQFESHLNQQLRVLIPNNDVRRLISHVIRTLKMDCSDSQVQLSCAKLISRTGLLMKLLSEQQDFKLSRADWDTDQWK 3585
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720366619 3586 TENYINENTETQSKLKSLGRSQFGKEVSEFSYNNKVTLAISVTVVVIVLIIIFCLIEICSHRTKKGD 3652
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1115-1187 7.84e-19

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 83.18  E-value: 7.84e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619 1115 EGELLQTLQNSTGQITESPTAVAIPVPVYLDMTVPTLSQDQAEYLTSPTVSFQPLDLESTITPEPTREAEHFT 1187
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1348-1412 7.30e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.49  E-value: 7.30e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 1348 QETTTQISETPKQVVTPVPEYQEVAVSAPIQDQAKYPLLPTVSFHPLDLELTISSEPPREAYPTT 1412
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1786-1854 9.38e-17

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 77.40  E-value: 9.38e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1786 SKPVQETPTQITKSPKEVAAHTLEYKEGVVLAPVEGQAESVALPNMSLQALDQEFTISPQPPAWTHHPP 1854
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2325-2389 1.50e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 76.63  E-value: 1.50e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2325 QETPSLITKSPKEVAAHTLEYKKRLPPVPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPP 2389
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 992-1065 4.21e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 75.48  E-value: 4.21e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720366619  992 EGELPQTLQDSTSQIIrEPLIEVVALVPIYQEVTVQTPSQDQAEYLTSSTVSFQPLDLELSITPESTREPHLPT 1065
Cdd:pfam15779    1 EVEPSPTQQETPTQPP-ESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2218-2282 6.72e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 74.71  E-value: 6.72e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2218 QENPTQITKSPKEVVGQTLDYKEGVLSGPIEGQDESPAPPSMSLQPLDQELTMSSQPPGYTHHSP 2282
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2103-2174 3.07e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 72.78  E-value: 3.07e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720366619 2103 ETTNSKPVQETLTQISESPKEVAAQTLKYKKVVLPAPVQEQDESATSPKMSLQPLDQELTVSSQPPAWNHNP 2174
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1236-1301 1.83e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.86  E-value: 1.83e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619 1236 EGELSQTVQESTTQITEPHKEIIVPVPVFQEVTVPTPSQDQAEYQ-----TFQHLNLELT--SEPTKEAYRST 1301
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPtlpnvTVQPLDLELTitPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 887-942 8.23e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 68.93  E-value: 8.23e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720366619  887 PLKEVTVQAPEHHEGTIPIPTQDQANYPRSPTVSFQSLDLEPTITPEANGEPYHPT 942
Cdd:pfam15779   18 SPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
2859-2916 9.78e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 9.78e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720366619 2859 EKLILSENHLTELHKESFEGLLSLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLL 2916
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1897-1961 7.68e-13

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 66.23  E-value: 7.68e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 1897 QKNPTQMTKSPKEILAQTPEYKEWVLPVPVEGQAESPTPPNMSLQLLDQEVIIPSLLSPPARDTP 1961
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1679-1747 1.41e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 65.46  E-value: 1.41e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1679 SKPTQKTPTQIKKLRKKVATHTLKYKKGMLTAPVEGQAESVPPPNMSLQPLDQELTISSQLPAWTHNSP 1747
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1461-1532 1.76e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 65.08  E-value: 1.76e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720366619 1461 EEEHSQSIRKNTTQITEPVKEVEALAPEGEDVTIPMPILEQTEFPTPNSVSLQSVDQELAILSDLPGWTYHP 1532
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2000-2068 4.72e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.92  E-value: 4.72e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2000 SKSVQETPTQIINSPKDVTAPTREYKKGVLPASVEGQAESSLLPHISLQHLDQELIIPSLPPPQAHNPS 2068
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2428-2496 5.41e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.54  E-value: 5.41e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2428 SEPVQETPSQITKLPKEIIAQTLEYKEGLLPVPFGGEDDSTTPPNVSLQPLDQEIIISFPSLGQAQQPP 2496
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2836-2987 4.31e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2836 ILNFKGNDISFIDKNVwkvYRWT--EKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERGtFEPLPFLKYMNLGC 2913
Cdd:COG4886    117 SLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2914 NLLTELSfgtfQAWHGMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESilIKTL-ELEHLIL 2987
Cdd:COG4886    192 NQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPE--LGNLtNLEELDL 257
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2534-2601 5.92e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 60.84  E-value: 5.92e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2534 SKPVQEAPTQITKSPKEGVVQTLEYKELVVSSIIEGNVKYVT-PNVSYRPLDLGLSESSGSTTEVYRST 2601
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTlPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 752-819 9.22e-10

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 57.37  E-value: 9.22e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619  752 NFSLIHNKIPHHSPKPLKNMVTDIPGH-KMTVPRPDQDQGEYIISSNGSFQSLDLEVTVTSGITPETMH 819
Cdd:pfam15779    3 EPSPTQQETPTQPPESPKEVVAQPPVHhEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEH 71
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1572-1640 1.83e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 56.60  E-value: 1.83e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1572 SKPVQETSIYITKSSKEIVARSPEHKEAVLPDPVEGQEKSLNPPNMSLKLLDQERIIPFLPRGLAQEPP 1640
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 646-710 3.81e-06

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 46.97  E-value: 3.81e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619  646 EGEPFPDQQETPEHSLELPTEEIAQPPGHHEVTGLPLGHGQVYSPASQNI--------LTQYPTAPEEDQYSP 710
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVtvqpldleLTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 419-481 3.07e-05

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 44.66  E-value: 3.07e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720366619  419 FPVVEQEAPFGAPESPIETVVETSPIPEIQ---PTQNENYQYHLPNVTVIPVDVTLTITLGPIKEV 481
Cdd:pfam15779    4 PSPTQQETPTQPPESPKEVVAQPPVHHEVTvptPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEA 69
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2861-2962 4.88e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 4.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2861 LILSENHLTELhkESFEGLLSLQVLDLSCNKIR--------------YIER-----G---TFEP------LPFLKYMNL- 2911
Cdd:cd21340     51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISvveglenltnleelHIENqrlppGeklTFDPrslaalSNSLRVLNIs 128

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2912 GCNL--LTELSfgtfqawhGMQFLQQLILSRNPLAVVED--PYFFKLPALKYLDL 2962
Cdd:cd21340    129 GNNIdsLEPLA--------PLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 902-1440 5.57e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.23  E-value: 5.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619  902 TIPIPTQDQAnyPRSPTVSFQSL----DLEPTITPEANGEPYHPTVSQqiiivhppkhPLVIYSEqvHTQHPNPTEATAQ 977
Cdd:PRK10263   343 TPPVASVDVP--PAQPTVAWQPVpgpqTGEPVIAPAPEGYPQQSQYAQ----------PAVQYNE--PLQQPVQPQQPYY 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619  978 PLNLELILTSQPTAEGELPQTLQDSTSQIIREPLIEvvalvPIYQEVTVQTPSQDQAEYLTSSTVSfQPLDLELSITPES 1057
Cdd:PRK10263   409 APAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAG-----NAWQAEEQQSTFAPQSTYQTEQTYQ-QPAAQEPLYQQPQ 482

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1058 TREPHLPTVPQQTIIVHPPKNPLVIHSEQVHTQHPNPTE---ATVQPLdlqptitPQPTAEGELLQTLQNSTGQITESP- 1133
Cdd:PRK10263   483 PVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREqlaAWYQPI-------PEPVKEPEPIKSSLKAPSVAAVPPv 555

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1134 TAVAIPVPVYLDMTVPTLSQDQAEYLTSPTVSfqpldLESTITPEP-TREAEHFTTPKnttafppkythmtlPQEVSVqh 1212
Cdd:PRK10263   556 EAAAAVSPLASGVKKATLATGAAATVAAPVFS-----LANSGGPRPqVKEGIGPQLPR--------------PKRIRV-- 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1213 lkPTEGIVPPLNLEL---TITPQPATEGELSQ---TVQESTTQITEPHKEiivpvpvfqEVTVPTPSQDQAEY-QTFQHl 1285
Cdd:PRK10263   615 --PTRRELASYGIKLpsqRAAEEKAREAQRNQydsGDQYNDDEIDAMQQD---------ELARQFAQTQQQRYgEQYQH- 682

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1286 nleltSEPTKEAYRSTVSKTTITVNFPKRTQH----PNPAEATDKPL-DLELTIGSSYQSTAEGERFQETTTQISETPKQ 1360
Cdd:PRK10263   683 -----DVPVNAEDADAAAEAELARQFAQTQQQrysgEQPAGANPFSLdDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQQ 757

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1361 VVTPVPEYQEVAVSAPIQDQAKYPLLPTvsfhPLDLELTISSEPPREAYPTTTPDQTMVPPQKYPLGIYPGDAHIQHLNP 1440
Cdd:PRK10263   758 PVAPQQQYQQPQQPVAPQPQYQQPQQPV----APQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP 833
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
 3506-3652 7.62e-69

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 464370  Cd Length: 147  Bit Score: 228.84  E-value: 7.62e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 3506 TPGEQFESHLNQQLRVLIPNNDVRRLISHVIRTLKMDCSDSQVQLSCAKLISRTGLLMKLLSEQQDFKLSRADWDTDQWK 3585
Cdd:pfam14914    1 SPGDQFEIQLNQQLLSLIPNVDVRRLISHVIRTLKMDCSEPQMQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720366619 3586 TENYINENTETQSKLKSLGRSQFGKEVSEFSYNNKVTLAISVTVVVIVLIIIFCLIEICSHRTKKGD 3652
Cdd:pfam14914   81 NENYINESTEAQSKQKKQSSRELTKEVPGYGYNNKLILAISVTVVIMILIIILCLIEICSHRSASGE 147
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1115-1187 7.84e-19

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 83.18  E-value: 7.84e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619 1115 EGELLQTLQNSTGQITESPTAVAIPVPVYLDMTVPTLSQDQAEYLTSPTVSFQPLDLESTITPEPTREAEHFT 1187
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1348-1412 7.30e-18

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 80.49  E-value: 7.30e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 1348 QETTTQISETPKQVVTPVPEYQEVAVSAPIQDQAKYPLLPTVSFHPLDLELTISSEPPREAYPTT 1412
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1786-1854 9.38e-17

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 77.40  E-value: 9.38e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1786 SKPVQETPTQITKSPKEVAAHTLEYKEGVVLAPVEGQAESVALPNMSLQALDQEFTISPQPPAWTHHPP 1854
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2325-2389 1.50e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 76.63  E-value: 1.50e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2325 QETPSLITKSPKEVAAHTLEYKKRLPPVPVEGQAESPPPPNISLQPLDQELTISSQPPGWTHHPP 2389
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 992-1065 4.21e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 75.48  E-value: 4.21e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720366619  992 EGELPQTLQDSTSQIIrEPLIEVVALVPIYQEVTVQTPSQDQAEYLTSSTVSFQPLDLELSITPESTREPHLPT 1065
Cdd:pfam15779    1 EVEPSPTQQETPTQPP-ESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2218-2282 6.72e-16

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 74.71  E-value: 6.72e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2218 QENPTQITKSPKEVVGQTLDYKEGVLSGPIEGQDESPAPPSMSLQPLDQELTMSSQPPGYTHHSP 2282
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2103-2174 3.07e-15

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 72.78  E-value: 3.07e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720366619 2103 ETTNSKPVQETLTQISESPKEVAAQTLKYKKVVLPAPVQEQDESATSPKMSLQPLDQELTVSSQPPAWNHNP 2174
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1236-1301 1.83e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.86  E-value: 1.83e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619 1236 EGELSQTVQESTTQITEPHKEIIVPVPVFQEVTVPTPSQDQAEYQ-----TFQHLNLELT--SEPTKEAYRST 1301
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPtlpnvTVQPLDLELTitPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 887-942 8.23e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 68.93  E-value: 8.23e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720366619  887 PLKEVTVQAPEHHEGTIPIPTQDQANYPRSPTVSFQSLDLEPTITPEANGEPYHPT 942
Cdd:pfam15779   18 SPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
2859-2916 9.78e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 9.78e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720366619 2859 EKLILSENHLTELHKESFEGLLSLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLL 2916
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1897-1961 7.68e-13

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 66.23  E-value: 7.68e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 1897 QKNPTQMTKSPKEILAQTPEYKEWVLPVPVEGQAESPTPPNMSLQLLDQEVIIPSLLSPPARDTP 1961
Cdd:pfam15779    9 QETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1679-1747 1.41e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 65.46  E-value: 1.41e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1679 SKPTQKTPTQIKKLRKKVATHTLKYKKGMLTAPVEGQAESVPPPNMSLQPLDQELTISSQLPAWTHNSP 1747
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1461-1532 1.76e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 65.08  E-value: 1.76e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720366619 1461 EEEHSQSIRKNTTQITEPVKEVEALAPEGEDVTIPMPILEQTEFPTPNSVSLQSVDQELAILSDLPGWTYHP 1532
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2000-2068 4.72e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.92  E-value: 4.72e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2000 SKSVQETPTQIINSPKDVTAPTREYKKGVLPASVEGQAESSLLPHISLQHLDQELIIPSLPPPQAHNPS 2068
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2428-2496 5.41e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.54  E-value: 5.41e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2428 SEPVQETPSQITKLPKEIIAQTLEYKEGLLPVPFGGEDDSTTPPNVSLQPLDQEIIISFPSLGQAQQPP 2496
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2836-2987 4.31e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 4.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2836 ILNFKGNDISFIDKNVwkvYRWT--EKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERGtFEPLPFLKYMNLGC 2913
Cdd:COG4886    117 SLDLSGNQLTDLPEEL---ANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN 191

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2914 NLLTELSfgtfQAWHGMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESilIKTL-ELEHLIL 2987
Cdd:COG4886    192 NQITDLP----EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--QLTDLPE--LGNLtNLEELDL 257
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 2534-2601 5.92e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 60.84  E-value: 5.92e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 2534 SKPVQEAPTQITKSPKEGVVQTLEYKELVVSSIIEGNVKYVT-PNVSYRPLDLGLSESSGSTTEVYRST 2601
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTlPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
2881-2943 6.16e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 6.16e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619 2881 SLQVLDLSCNKIRYIERGTFEPLPFLKYMNLGCNLLTELSFGTFqawHGMQFLQQLILSRNPL 2943
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2837-2987 1.92e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 1.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2837 LNFKGNDISFIDKNVWKVYRwTEKLILSENHLTELHkESFEGLLSLQVLDLSCNKIRYIERgTFEPLPFLKYMNLGCNLL 2916
Cdd:COG4886    164 LDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720366619 2917 TELSfgtfqAWHGMQFLQQLILSRNPLAVVedPYFFKLPALKYLDLGTTQVQLTTVESILIKTLELEHLIL 2987
Cdd:COG4886    241 TDLP-----ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 752-819 9.22e-10

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 57.37  E-value: 9.22e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619  752 NFSLIHNKIPHHSPKPLKNMVTDIPGH-KMTVPRPDQDQGEYIISSNGSFQSLDLEVTVTSGITPETMH 819
Cdd:pfam15779    3 EPSPTQQETPTQPPESPKEVVAQPPVHhEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEH 71
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 1572-1640 1.83e-09

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 56.60  E-value: 1.83e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720366619 1572 SKPVQETSIYITKSSKEIVARSPEHKEAVLPDPVEGQEKSLNPPNMSLKLLDQERIIPFLPRGLAQEPP 1640
Cdd:pfam15779    5 SPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2819-2987 2.32e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 2.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2819 LQQVPVPRPNTYNDTFVILNFKGNDISFIDKNVWKVYRWTEKLILSENHLTELHKESFEGLLSLQVLDLSCNKiryierg 2898
Cdd:COG4886     35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2899 TFEPLPFLKYMNLGCNLLTELSFGTFQawhgMQFLQQLILSRNPLAVVEDPyFFKLPALKYLDLGTTqvQLTTVESILIK 2978
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELAN----LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN--QLTDLPEELGN 180


                   ....*....
gi 1720366619 2979 TLELEHLIL 2987
Cdd:COG4886    181 LTNLKELDL 189
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2803-2987 2.38e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 2.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2803 CENETLLCVHLSPKWRLQQVPVPRPNTYNDTFVILNFKGNDISFIDKNVWKVYRWTEKLILSENhltelhkESFEGLLSL 2882
Cdd:COG4886     43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNL 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2883 QVLDLSCNKIRYIERgTFEPLPFLKYMNLGCNLLTEL--SFGTFQAwhgmqfLQQLILSRNPLAVVEDPyFFKLPALKYL 2960
Cdd:COG4886    116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLpePLGNLTN------LKSLDLSNNQLTDLPEE-LGNLTNLKEL 187

                          170       180
                   ....*....|....*....|....*..
gi 1720366619 2961 DLGTTqvQLTTVESILIKTLELEHLIL 2987
Cdd:COG4886    188 DLSNN--QITDLPEPLGNLTNLEELDL 212
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 646-710 3.81e-06

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 46.97  E-value: 3.81e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720366619  646 EGEPFPDQQETPEHSLELPTEEIAQPPGHHEVTGLPLGHGQVYSPASQNI--------LTQYPTAPEEDQYSP 710
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVtvqpldleLTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
 419-481 3.07e-05

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 44.66  E-value: 3.07e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720366619  419 FPVVEQEAPFGAPESPIETVVETSPIPEIQ---PTQNENYQYHLPNVTVIPVDVTLTITLGPIKEV 481
Cdd:pfam15779    4 PSPTQQETPTQPPESPKEVVAQPPVHHEVTvptPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEA 69
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 2861-2962 4.88e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 4.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2861 LILSENHLTELhkESFEGLLSLQVLDLSCNKIR--------------YIER-----G---TFEP------LPFLKYMNL- 2911
Cdd:cd21340     51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISvveglenltnleelHIENqrlppGeklTFDPrslaalSNSLRVLNIs 128

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2912 GCNL--LTELSfgtfqawhGMQFLQQLILSRNPLAVVED--PYFFKLPALKYLDL 2962
Cdd:cd21340    129 GNNIdsLEPLA--------PLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2859-2993 7.54e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 7.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2859 EKLILSENHLTELhkESFEGLLSLQVLDLSCNKIRYIerGTFEPLPFLKYMNLGCNLLTELSFGTFQAWHGMQFLQQLIL 2938
Cdd:COG4886    231 ETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1720366619 2939 SRNPLAVVEDPYFFKLPALKYLDLGTTQVQLTTVESILIKTLELEHLILPSHMAC 2993
Cdd:COG4886    307 LLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 902-1440 5.57e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.23  E-value: 5.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619  902 TIPIPTQDQAnyPRSPTVSFQSL----DLEPTITPEANGEPYHPTVSQqiiivhppkhPLVIYSEqvHTQHPNPTEATAQ 977
Cdd:PRK10263   343 TPPVASVDVP--PAQPTVAWQPVpgpqTGEPVIAPAPEGYPQQSQYAQ----------PAVQYNE--PLQQPVQPQQPYY 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619  978 PLNLELILTSQPTAEGELPQTLQDSTSQIIREPLIEvvalvPIYQEVTVQTPSQDQAEYLTSSTVSfQPLDLELSITPES 1057
Cdd:PRK10263   409 APAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAG-----NAWQAEEQQSTFAPQSTYQTEQTYQ-QPAAQEPLYQQPQ 482

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1058 TREPHLPTVPQQTIIVHPPKNPLVIHSEQVHTQHPNPTE---ATVQPLdlqptitPQPTAEGELLQTLQNSTGQITESP- 1133
Cdd:PRK10263   483 PVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREqlaAWYQPI-------PEPVKEPEPIKSSLKAPSVAAVPPv 555

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1134 TAVAIPVPVYLDMTVPTLSQDQAEYLTSPTVSfqpldLESTITPEP-TREAEHFTTPKnttafppkythmtlPQEVSVqh 1212
Cdd:PRK10263   556 EAAAAVSPLASGVKKATLATGAAATVAAPVFS-----LANSGGPRPqVKEGIGPQLPR--------------PKRIRV-- 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1213 lkPTEGIVPPLNLEL---TITPQPATEGELSQ---TVQESTTQITEPHKEiivpvpvfqEVTVPTPSQDQAEY-QTFQHl 1285
Cdd:PRK10263   615 --PTRRELASYGIKLpsqRAAEEKAREAQRNQydsGDQYNDDEIDAMQQD---------ELARQFAQTQQQRYgEQYQH- 682

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1286 nleltSEPTKEAYRSTVSKTTITVNFPKRTQH----PNPAEATDKPL-DLELTIGSSYQSTAEGERFQETTTQISETPKQ 1360
Cdd:PRK10263   683 -----DVPVNAEDADAAAEAELARQFAQTQQQrysgEQPAGANPFSLdDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQQ 757

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1361 VVTPVPEYQEVAVSAPIQDQAKYPLLPTvsfhPLDLELTISSEPPREAYPTTTPDQTMVPPQKYPLGIYPGDAHIQHLNP 1440
Cdd:PRK10263   758 PVAPQQQYQQPQQPVAPQPQYQQPQQPV----APQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP 833
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1172-1495 1.01e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.29  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1172 ESTITpEPTREAEHFTTPKNTTAFPPKY---THMTLPQEV-----SVQHLKPTEGIVPPLNLELTITPQPATEGELSQT- 1242
Cdd:pfam05109  426 ESTTT-SPTLNTTGFAAPNTTTGLPSSThvpTNLTAPASTgptvsTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAp 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1243 -VQESTTQITEPHKEIIVPVPVfqeVTVPTPSQDQAEYQTFQHLNLELTSEPTKEAYRSTVSKTTITVNFPKRTQ-HPNP 1320
Cdd:pfam05109  505 dMTSPTSAVTTPTPNATSPTPA---VTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKtSPTS 581

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1321 AEATDKPLDLELTIGssyQSTAEGERFQETTTQISETPkqVVTPVPEYQEVAVSAPiQDQAKYPLLPTVSFHPLDLELTI 1400
Cdd:pfam05109  582 AVTTPTPNATSPTVG---ETSPQANTTNHTLGGTSSTP--VVTSPPKNATSAVTTG-QHNITSSSTSSMSLRPSSISETL 655

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1401 SseppreayPTTTPDQTMVPP---QKYPLG------IYPGDAHIQHLNPTDITIQPLdlELTVHSQPTTEEEHSQSIRKN 1471
Cdd:pfam05109  656 S--------PSTSDNSTSHMPlltSAHPTGgenitqVTPASTSTHHVSTSSPAPRPG--TTSQASGPGNSSTSTKPGEVN 725

                          330       340
                   ....*....|....*....|....
gi 1720366619 1472 TTQITEPVKEVEALAPEGEDVTIP 1495
Cdd:pfam05109  726 VTKGTPPKNATSPQAPSGQKTAVP 749
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1838-2348 7.45e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 7.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1838 QEFTISPQPPAWTHHPPNPKETKNHTPGKIFLHYAEPPMGMVVEPPdlfllKTTKYNSVQKNPTQMTKSPKEILAQTPEY 1917
Cdd:pfam03154  163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPP-----QGSPATSQPPNQTQSTAAPHTLIQQTPTL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1918 KEWVLPVP---VEGQAESPTPPNMSLQLLDQEVIIPSLLSPPARDTPNPKETKTHTPGKIFPhyAEPPIRMSVEPPDLFF 1994
Cdd:pfam03154  238 HPQRLPSPhppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFP--LTPQSSQSQVPPGPSP 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 1995 LRSTKSKSVQETPTQIINSPKDvtAPTREYKKGVLPASvegqaesslLPHISLQhldqeliiPSLPPPQAHNPSNPKETK 2074
Cdd:pfam03154  316 AAPGQSQQRIHTPPSQSQLQSQ--QPPREQPLPPAPLS---------MPHIKPP--------PTTPIPQLPNPQSHKHPP 376

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2075 KYTPGKVFLYYADPPmgmvvEPPDLfflettnsKPVQETLTQISESPKEVAAQTLKYKKVVLPAPVQ----EQDESATSP 2150
Cdd:pfam03154  377 HLSGPSPFQMNSNLP-----PPPAL--------KPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQppvlTQSQSLPPP 443

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2151 KMSLQPLDQELTVSSQPPawnhnplnpkeiknYAPgkislHYAEPPMGTVVEPPDLFLLNTSKSNPGQENPTQITKSpke 2230
Cdd:pfam03154  444 AASHPPTSGLHQVPSQSP--------------FPQ-----HPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVS--- 501

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720366619 2231 vvgqtldykegvLSGPIEGQDESPAPP-SMSLQPLDQELTMSSQPPGYTHHS--PNAAKTENHTPENNFFpYAEPPMGM- 2306
Cdd:pfam03154  502 ------------SSGPVPAAVSCPLPPvQIKEEALDEAEEPESPPPPPRSPSpePTVVNTPSHASQSARF-YKHLDRGYn 568

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1720366619 2307 VVQPPDLFFLKSTKSNLVQETPSLITKSPKEVAAHTLEYKKR 2348
Cdd:pfam03154  569 SCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKER 610
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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