forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 405 WPPSMRVIVIRSPVLQTGSLYMITATEhSTIGRKKGLEHTIVIPEAAVSKFHAEVFFSHDLQSYVIVDQGSQTGTVINGN 484
Cdd:cd22686     1 YPPCIRVIVVESPSLQVGSLFIVTATG-ATIGREKDHGHTIRIPELGVSKFHAEIYYDDDEQSYTIVDLGSQNGTYLNGV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1694540190 485 LILQPDIISEPYILEHGDEVKFGETVLSFHVHPGRGTCDGCDPG 528
Cdd:cd22686    80 RISQPKEKSDPYPLTHGDELKIGETTLLFHIHPGSDTCDGCEPG 123

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1694540190 765 SNKGRKMLERMGWKKGEGLGKDGGGMRDPIQLQLRKKQAGLGA 807
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGA 44

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 405 WPPSMRVIVIRSPVLQTGSLYMITATEhSTIGRKKGLEHTIVIPEAAVSKFHAEVFFSHDLQSYVIVDQGSQTGTVINGN 484
Cdd:cd22686     1 YPPCIRVIVVESPSLQVGSLFIVTATG-ATIGREKDHGHTIRIPELGVSKFHAEIYYDDDEQSYTIVDLGSQNGTYLNGV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1694540190 485 LILQPDIISEPYILEHGDEVKFGETVLSFHVHPGRGTCDGCDPG 528
Cdd:cd22686    80 RISQPKEKSDPYPLTHGDELKIGETTLLFHIHPGSDTCDGCEPG 123

OCRE domain; The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known to regulate alternative splicing of Fas and Bcl-x pre-mRNA transcripts. The structure of the domain consists of an anti-parallel arrangement of six beta strands.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1694540190 196 SQTGFTYDESSGLYYDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 246
Cdd:pfam17780   1 DSSGYVYDEASGYYYDPTTGYYYDPNTGLYYDPATGKYYTYDEETKSYVPH 51

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 579 TIGRDGnlEHTVLIPEAAVSKFHAEVFFDHEleSYVIVDQGSQIGTVINGNLIlqpgviSEPCVLEHGDEVRFGETVLSF 658
Cdd:COG1716    24 TIGRAP--DNDIVLDDPTVSRRHARIRRDGG--GWVLEDLGSTNGTFVNGQRV------TEPAPLRDGDVIRLGKTELRF 93

                  ..
gi 1694540190 659 HV 660
Cdd:COG1716    94 RL 95

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1694540190 579 TIGRDGnlEHTVLIPEAAVSKFHAEVFFDhELESYVIVDQGSQIGTVINGNLILQpgvisEPCVLEHGDEVRF 651
Cdd:pfam00498   2 TIGRSP--DCDIVLDDPSVSRRHAEIRYD-GGGRFYLEDLGSTNGTFVNGQRLGP-----EPVRLKDGDVIRL 66

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1694540190  762 INDSNKGRKMLERMGWKKGEGLGKDGGGMRDPIQLQLRKKQAGLGAS 808
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1694540190  434 TIGRKKGLEHtIVIPEAAVSKFHAEVFFsHDLQSYVIVDQGSQTGTVINGNLI 486
Cdd:smart00240   2 TIGRSSEDCD-IQLDGPSISRRHAVIVY-DGGGRFYLIDLGSTNGTFVNGKRI 52

forkhead associated (FHA) domain found in angiogenic factor with G patch and FHA domains 1 (AGGF1) and similar proteins; AGGF1, also called angiogenic factor VG5Q, or G patch domain-containing protein 7 (GPATC7), or vasculogenesis gene on 5q protein, is an angiogenic factor involved in vascular development, angiogenesis, specification of hemangioblasts, and differentiation of veins. It promotes angiogenesis and the proliferation of endothelial cells. It inhibits inflammatory effect and preserve vascular integrity in non-nervous system diseases. Mutated AGGF1 causes susceptibility to Klippel-Trenaunay syndrome, a vascular disorder. Increased AGGF1 expression is associated with tumor angiogenesis. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 405 WPPSMRVIVIRSPVLQTGSLYMITATEhSTIGRKKGLEHTIVIPEAAVSKFHAEVFFSHDLQSYVIVDQGSQTGTVINGN 484
Cdd:cd22686     1 YPPCIRVIVVESPSLQVGSLFIVTATG-ATIGREKDHGHTIRIPELGVSKFHAEIYYDDDEQSYTIVDLGSQNGTYLNGV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1694540190 485 LILQPDIISEPYILEHGDEVKFGETVLSFHVHPGRGTCDGCDPG 528
Cdd:cd22686    80 RISQPKEKSDPYPLTHGDELKIGETTLLFHIHPGSDTCDGCEPG 123

OCRE domain; The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known to regulate alternative splicing of Fas and Bcl-x pre-mRNA transcripts. The structure of the domain consists of an anti-parallel arrangement of six beta strands.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1694540190 196 SQTGFTYDESSGLYYDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 246
Cdd:pfam17780   1 DSSGYVYDEASGYYYDPTTGYYYDPNTGLYYDPATGKYYTYDEETKSYVPH 51

OCRE domain found in Suppressor of ABI3-5 (SUA) and similar proteins; SUA is an RNA-binding protein located in the nucleus and expressed in all plant tissues. It functions as a splicing factor that influences seed maturation by controlling alternative splicing of ABI3. The suppression of the cryptic ABI3 intron indicates a role of SUA in mRNA processing. SUA also interacts with the prespliceosomal component U2AF65, the larger subunit of the conserved pre-mRNA splicing factor U2AF. SUA contains two RNA recognition motifs surrounding a zinc finger domain, an OCtamer REpeat (OCRE) domain, and a Gly-rich domain close to the C-terminus.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1694540190 193 AAVSQTGFTYDESSGLYYDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQ 244
Cdd:cd16166     1 KAAPPSGFVYDPASGYYYDASSGYYYDANTGLYYDAASGRWYSYDEETGQYV 52

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 579 TIGRDGnlEHTVLIPEAAVSKFHAEVFFDHEleSYVIVDQGSQIGTVINGNLIlqpgviSEPCVLEHGDEVRFGETVLSF 658
Cdd:COG1716    24 TIGRAP--DNDIVLDDPTVSRRHARIRRDGG--GWVLEDLGSTNGTFVNGQRV------TEPAPLRDGDVIRLGKTELRF 93

                  ..
gi 1694540190 659 HV 660
Cdd:COG1716    94 RL 95

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 555 RVIVIRSPvlQIGSLYIITATKHaTIGRDGnlEHTVLIPEAAVSKFHAEVFFDHEleSYVIVDQGSQIGTVINGNLIlqp 634
Cdd:cd00060     1 RLIVLDGD--GGGREFPLTKGVV-TIGRSP--DCDIVLDDPSVSRRHARIEVDGG--GVYLEDLGSTNGTFVNGKRI--- 70

                          90       100
                  ....*....|....*....|....*
gi 1694540190 635 gviSEPCVLEHGDEVRFGETVLSFH 659
Cdd:cd00060    71 ---TPPVPLQDGDVIRLGDTTFRFE 92

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1694540190 434 TIGRKKglEHTIVIPEAAVSKFHAEVFFsHDLQSYVIVDQGSQTGTVINGNLILQpdiisEPYILEHGDEVKF 506
Cdd:pfam00498   2 TIGRSP--DCDIVLDDPSVSRRHAEIRY-DGGGRFYLEDLGSTNGTFVNGQRLGP-----EPVRLKDGDVIRL 66

OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins; RBM10, also called G patch domain-containing protein 9, or RNA-binding protein S1-1 (S1-1), is a paralogue of putative tumor suppressor RNA-binding protein 5 (RBM5 or LUCA15 or H37). It may play an important role in mRNA generation, processing and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. RBM10 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1694540190 200 FTYDESSGLYYDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRY 243
Cdd:cd16167     9 YQYDETSGYYYDPQTGLYYDPNSQYYYNAQTQQYLYWDGERRTY 52

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1694540190 579 TIGRDGNleHTVLIPEAAVSKFHAEVFFDHelESYVIVDQGSQIGTVINGNLILQPGVISEpcvLEHGDEVRFG 652
Cdd:cd22665    24 VIGRDPS--CSVVLPDKSVSKQHACIEVDG--GTHLIEDLGSTNGTRIGNKVRLKPNVRYE---LIDGDLLLFG 90

OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins; RBM6, also called lung cancer antigen NY-LU-12, or protein G16, or RNA-binding protein DEF-3, has been predicted to be a nuclear factor based on its nuclear localization signal. It shows high sequence similarity to RNA-binding protein 5 (RBM5 or LUCA15 or NY-REN-9). Both specifically binds poly(G) RNA. RBM6 contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain. In contrast to RBM5, RBM6 has an additional unique domain, the POZ (poxvirus and zinc finger) domain, which may be involved in protein-protein interactions and inhibit binding of target sequences by zinc fingers.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1694540190 179 EGTSLAESLRATAEaavsqTGFTYDESSGLYYDHSTGFYYDSENQLYYDPSTGIYYY 235
Cdd:cd16163     1 EGSGPAPTYRSDPD-----SGYIYDPETGYYYDPVTGLYYDPATGEYVDPDTGTLPY 52

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 411 VIVIRSPVLQTGSLYMITATEhSTIGRKkgLEHTIVIPEAAVSKFHAEVFFSHDLQSyvIVDQGSQTGTVINGNLILQpd 490
Cdd:cd22682     1 ALLMIIGPPGVGKQFPITEST-IVIGRS--VESQVQIDDDSVSRYHAKLAVNPSAVS--IIDLGSTNGTIVNGKKIPK-- 73

                          90       100
                  ....*....|....*....|....*
gi 1694540190 491 iiSEPYILEHGDEVKFGETVLSFHV 515
Cdd:cd22682    74 --LASCDLQNGDQIKIGNTIFKFHE 96

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 411 VIVIRSPVLQTGSLYMITATEhSTIGRKkgLEHTIVIPEAAVSKFHAEVFFshDLQSYVIVDQGSqtgtvINGNLILQPD 490
Cdd:cd22680     2 VLEILSSPNLTGKKFPFDFSS-VSIGRD--PENVIVIPDPFVSRNHARITV--DSNEIYIEDLGS-----TNGTFVNDFK 71

                          90       100
                  ....*....|....*....|....
gi 1694540190 491 IISEPYILEHGDEVKFGE-TVLSF 513
Cdd:cd22680    72 RIKGPAKLHPNDIIKLGRtTVLKV 95

OCRE domain found in RNA-binding protein RBM5, RBM10, and similar proteins; RBM5 is a known modulator of apoptosis. It may also act as a tumor suppressor or an RNA splicing factor; it specifically binds poly(G) RNA. RBM10, a paralog of RBM5, may play an important role in mRNA generation, processing, and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. Both RBM5 and RBM10, contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1694540190 198 TGFTYDESSGLYYDHSTGFYYDSENQ--LYYDPSTGIY 233
Cdd:cd16162    14 SGYYYDPTTGLYYDPNSQYFYNSQTQqyLYWDQTKKTY 51

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 555 RVIVIRSPVlQIGSLYIITAtKHATIGRDgnLEHTVLIPEAAVSKFHAEVFFDHELESYVIVDQGSqIGTVINGNlilqp 634
Cdd:cd22673     2 KLVVIKKDG-TDGSRFPLTK-KSCTFGRD--LSCDIRIQLPGVSREHCRIEVDENGKAYLENLSTT-NPTLVNGK----- 71

                          90       100
                  ....*....|....*....|....*
gi 1694540190 635 gVISEPCVLEHGDEVRFGETVLSFH 659
Cdd:cd22673    72 -AIEKSAELKDGDVITIGGRSFRFE 95

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 411 VIVIRSPvlQTGSLYMITaTEHSTIGRKKglEHTIVIPEAAVSKFHAEvfFSHDLQSYVIVDQGSQTGTVINGNLIlqpd 490
Cdd:cd22684     4 LVVRRGP--NAGARFLLD-QDVTTAGRHP--ESDIFLDDVTVSRRHAE--FRRAEGGFVVRDVGSLNGTYVNRERI---- 72

                          90       100
                  ....*....|....*....|....*
gi 1694540190 491 iisEPYILEHGDEVKFGETVLSFHV 515
Cdd:cd22684    73 ---DSAVLRNGDEVQIGKFRLVFFA 94

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaB and similar proteins; FhaB, also called FtsZ-interacting protein A (FipA), is a putative virulence factor involved in regulating cell shape. It can interact with polyketide-associated protein PapA5, a putative membrane protein involved in the biosynthesis of virulence enhancing lipids. FhaB regulates growth and cell division. It is probably required for divisomal protein assembly under oxidative stress. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 420 QTGSLYMITaTEHSTIGRkkGLEHTIVIPEAAVSKFHAEVFFSHdlQSYVIVDQGSQTGTVINGNLilqpdiISEPYILE 499
Cdd:cd22693     8 LQGQTFPID-KSGITIGR--ADDNDLVLSDDFVSSRHARIYLQG--SSWYLEDLGSTNGTFVNGNR------VTQPVVVQ 76

                          90
                  ....*....|..
gi 1694540190 500 HGDEVKFGETVL 511
Cdd:cd22693    77 PGDTIRIGATVF 88

OCRE domain found in Zinc-finger and OCRE domain-containing Protein 1 (ZOP1) and similar proteins found in plant; ZOP1 is a novel plant-specific nucleic acid-binding protein required for both RNA-directed DNA methylation (RdDM) and pre-mRNA splicing. It promotes RNA polymerase IV (Pol IV)-dependent siRNA accumulation, DNA methylation, and transcriptional silencing. As a pre-mRNA splicing factor, ZOP1 associates with several typical splicing proteins as well as with RNA polymerase II (RNAP II and Pol II). It also shows both RdDM-dependent and -independent roles in transcriptional silencing. ZOP1 contains an N-terminal C2H2-type ZnF domain and an OCtamer REpeat (OCRE) domain that is usually related to RNA processing.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1694540190 198 TGFTYDESSGLYYDHSTGFYYDSENQLYYDPSTG 231
Cdd:cd16165     6 GDWVLDSKSGYYYNAATRYYYDPKTGMYYSDETG 39

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 572 ITATKHATIGRDGNLEhtVLIPEAAVSKFHAEvfFDHELESYVIVDQGSQIGTVINGNLILQPGVIsepcvLEHGDEVRF 651
Cdd:cd22683    17 ITNRNVTTIGRSRSCD--LVLSDPSISRFHAE--LRLEQNGINVIDNNSANGTFINGKRIKGKTYI-----LKNGDIIVF 87

                  ....*..
gi 1694540190 652 GETVLSF 658
Cdd:cd22683    88 GKCSFLI 94

forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Synechocystis sp. protein Slr1951 and protein Sll1895. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 434 TIGRKKGleHTIVIPEAAVSKFHAEVF--FSHDLQ-SYVIVD-----QGSQTGTVINGNLILQpdiisepYILEHGDEVK 505
Cdd:cd22697    21 TIGRHPG--NDIQIPSQQISRRHATLRrkINPNLDiSFWIIDgdlegAESLNGLWVNGERILQ-------HELVNGDEIA 91

                          90
                  ....*....|.
gi 1694540190 506 FGET-VLSFHV 515
Cdd:cd22697    92 LGPKiVLRYQA 102

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 556 VIVIRSPVLqiGSLYIITaTKHATIGRdgNLEHTVLIPEAAVSKFHAEvfFDHELESYVIVDQGSQIGTVINGNLIlqpg 635
Cdd:cd22684     4 LVVRRGPNA--GARFLLD-QDVTTAGR--HPESDIFLDDVTVSRRHAE--FRRAEGGFVVRDVGSLNGTYVNRERI---- 72

                          90       100
                  ....*....|....*....|....*
gi 1694540190 636 visEPCVLEHGDEVRFGETVLSFHV 660
Cdd:cd22684    73 ---DSAVLRNGDEVQIGKFRLVFFA 94

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 570 YIITaTKHATIGRDGNLEHTV--------LIPEAAVSKFHAEVFFDHELESYVIVDQGSqIGTVINGNLiLQPGviSEPC 641
Cdd:cd22701    12 YYVQ-KLEVVLGRNSKNSSSTaadsvdidLGPSKKISRRHARIFYDFTTQCFELSVLGR-NGVKVDGIL-VKPG--SPPV 86

                          90
                  ....*....|....*..
gi 1694540190 642 VLEHGDEVRFGETVLSF 658
Cdd:cd22701    87 PLRSGSLIQIGGVLFYF 103

forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1694540190 434 TIGRKKGLEHTIVIPE-AAVSKFHAeVFFSHDLQSYVIVDQGSQTGTVINGNLIlqpdIISEPYILEHGDEVKFG 507
Cdd:cd22663    24 TVGRGLGVTYQLVSTCpLMISRNHC-VLKKNDEGQWTIKDNKSLNGVWVNGERI----EPLKPYPLNEGDLIQLG 93

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1694540190 445 IVIPEAAVSKFHAEVFFSHDLQSYVIVDQGSQTGTVINGNLIlqpdIISEPYILEHGDEVKFG 507
Cdd:cd22691    41 IVLDHPSISRFHLEIRIIPSRRKITLTDLSSVHGTWVNGQRI----EPGVPVELEEGDTVRLG 99

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1694540190 765 SNKGRKMLERMGWKKGEGLGKDGGGMRDPIQLQLRKKQAGLGA 807
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGA 44

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1694540190  762 INDSNKGRKMLERMGWKKGEGLGKDGGGMRDPIQLQLRKKQAGLGAS 808
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGAV 47

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1694540190 434 TIGRKKGLeHTIVIPEAAVSKFHAEVFFSHDLQSYVIVDQGSQTGTVInGNLILQPDiisEPYILEHGDEVKFG 507
Cdd:cd22674    30 LFGRNSDV-CDFVLDHPSCSRVHAALVYHKHLNRVFLIDLGSTHGTFV-GGIRLEPH---KPQQLPIDSTLRFG 98

forkhead associated (FHA) domain found in Saccharomyces cerevisiae defective in mitotic arrest protein 1 (DMA1), 2 (DMA2) and similar proteins; DMA1 (also known as checkpoint forkhead associated with RING domains-containing protein 1, or CHF1) and DMA2 (also known as checkpoint forkhead associated with RING domains-containing protein 2, or CHF2) are E3 ubiquitin-protein ligases which function in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, two E2 ubiquitin conjugating enzymes. They are involved in nutritional control of the cell cycle and required for proper spindle positioning, likely regulating septin ring deposition at the bud neck. DMA1 targets the degradation of G1 cyclin PCL1. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1694540190 437 RKKGLEHTIVIPEAAVSKFHAEVFfsHDLQSYVIVDQGSQTGTVINGNLILQPDIISEPYILEHGDEVKFG 507
Cdd:cd22692    48 VRQAIYHPVVFKSKVVSRTHGCIK--VDEGNWYIKDVKSSSGTFLNHQRLSPASRTSKPYPLRDGDILQLG 116

forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar proteins; ZEP, also called protein ABA DEFICIENT 1, ABA1, protein IMPAIRED IN BABA-INDUCED STERILITY 3, protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6, or protein NON-PHOTOCHEMICAL QUENCHING 2, plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. It converts zeaxanthin into antheraxanthin and subsequently violaxanthin. ZEP is required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression, and disease resistance and non-photochemical quencing (NPQ). The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1694540190 434 TIGRK---KGLEHTIVIPEAAVSKFHAEVFFSHDlqSYVIVDQGSQTGTVINGNLI-LQPDIISEPYILEHGDEVKFGET 509
Cdd:cd22702    35 IIGSDphqAISGISVVIPSPQVSELHARITCKNG--AFFLTDLGSEHGTWINDNEGrRYRAPPNFPVRLHPSDVIEFGSD 112

                  ....*....
gi 1694540190 510 V-LSFHVHP 517
Cdd:cd22702   113 KkARFRVKV 121

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1694540190 427 ITATEHSTIGRKKglEHTIVIPEAAVSKFHAE---VFFSHDLQSYVIVDQGSQTGTVINGNLILQPDiisePYILEHGD 502
Cdd:cd22670    18 IYKNQVITIGRSP--SCDIVINDPFVSRTHCRiysVQFDESSAPLVYVEDLSSNGTYLNGKLIGRNN----TVLLSDGD 90