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Conserved domains on  [gi|1679820911|ref|XP_029324786|]
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vinculin isoform X3 [Mus caroli]

Protein Classification

vinculin family protein( domain architecture ID 10470736)

vinculin family protein similar to Homo sapiens vinculin and catenin alpha-1 and -2

CATH:  1.20.120.230
Gene Ontology:  GO:0007155|GO:0003779
SCOP:  4000832

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Vinculin pfam01044
Vinculin family;
3-1134 0e+00

Vinculin family;


:

Pssm-ID: 460040  Cd Length: 852  Bit Score: 1041.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911    3 VFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDqiLKRDMPPAFIKVE 82
Cdd:pfam01044    1 EFRTKTVEKILEPLAQQVTTLVITHEPSEKDGGASPDLTAPVAAVSQAVSNLIEVGYDIANSSPD--LKQDMPPALERVE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911   83 NACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTK 162
Cdd:pfam01044   79 KTGQLMEQASREFASDPYSSPKRGKLIRGARGLLSAVSRLLILADEADVRKIIRVCKKVLDYLAVAEVAETMEDLVQFYK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  163 NLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKnsknqGIEEALKNRNFTVEKMSAEIN 242
Cdd:pfam01044  159 DLGPNMTKLNKMVDRRQQELTHQVHRDILAAARDTLKKLAPILITAMKIFVRHP-----GVEEARENRDYTAKQMSDAMN 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  243 EIIRVLQLTSWdedawaskdtEAMKRALASIDSKLNQAKGWLRDPnaspgdageqairQILDEAGKVGELCAGKERREIL 322
Cdd:pfam01044  234 EIIRVLQLTSY----------TVMKKALSGIGSELAAALDWLDDP-------------IIIDPATYIEERCRPSLEERIE 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  323 GTCKMLGQMTDQVADLRARGQgaspvamqkaqqvsqgldvltakvenaarkleamtnskqsiakkidaaqnwladpnggp 402
Cdd:pfam01044  291 SIISGAASMADSLCTRRNRGQ----------------------------------------------------------- 311
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  403 egeeqirgalaeaRKIAELCddpkerddilrslgeiaaltsklgdlrrqgkgdspearalakqvatalqnlqtktnrava 482
Cdd:pfam01044  312 -------------AIVAECN------------------------------------------------------------ 318
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  483 nsrpakaavhlegkieqaqrwidnptvddrGVGQAAIRGLVAEGHRLANVMMgpyrqDLLAKCDRVDQltaqladlaARG 562
Cdd:pfam01044  319 ------------------------------GAGRQALQDLLSEYMKLAGRKD-----DLDALCDAIDR---------MRK 354
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  563 EGespqaralasqlqdslKDLKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAppdapNREEVFDERAANFENHSGRLGA 642
Cdd:pfam01044  355 KT----------------RDLRRQLRKAVVDHVSDSFLDTTTPLKLLIEAAKA-----GREENFEEKAQNFQEHANRLVE 413
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  643 TAEKAAAVGtANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSL 722
Cdd:pfam01044  414 VARLACSCS-NNKETVEAIRMAAAQVESLTPQVINAARILLHNPGSKAAQENMETFKNQWEDQVRRLTEAVDDITDTDDF 492
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  723 LDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAK 802
Cdd:pfam01044  493 LAVSEEHILEDVNKCVMAIQNADPQTLVATAGSIAGRANRVLLVAKAEMDNSEDPVYTERVKEAVDILSNTIPPMFAEAK 572
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  803 AVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPqepdfpppppdleqlrltdelappkpplpegevppprppppeekd 882
Cdd:pfam01044  573 EVAVNALDPGAAKSWEENNYEFLDAVRLVYDAVRP--------------------------------------------- 607
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  883 eefpeqkagevINQPMMMaaRQLHDEARKWSSKPGIPAAQVgiGVVAEANAADAVGFPFPSDMEDDYEPELLLMPS--NQ 960
Cdd:pfam01044  608 -----------IRQAVLM--NRSPPELPTDSEFELREDEPA--PPRPPPPVETEPPPRPPPPPETDREEMRRLFPEekAK 672
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  961 PVNQ--PILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGS--GTKRALIQCAKDIAKASDEVTRLAKEV 1036
Cdd:pfam01044  673 IAAQvqPFLAAAHKLHREVAKWDSKGNDIIALAKRMCMIMMEMTDFTRGKGplKTTMDVINAAKKIAEAGEEVTRLARQI 752
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911 1037 AKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKI 1116
Cdd:pfam01044  753 ARQCTDSRIKTDLLAYLERIPLYCTQLKILSKVKATMLGSGNELSVSGLDSAESLIQNAQNLMQSVVQTVKAAYAASTKI 832
                         1130      1140
                   ....*....|....*....|
gi 1679820911 1117 RTD--AGFTLRWVRKTPWYQ 1134
Cdd:pfam01044  833 RTDqvNSPRVRWKMKPPWKQ 852
 
Name Accession Description Interval E-value
Vinculin pfam01044
Vinculin family;
3-1134 0e+00

Vinculin family;


Pssm-ID: 460040  Cd Length: 852  Bit Score: 1041.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911    3 VFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDqiLKRDMPPAFIKVE 82
Cdd:pfam01044    1 EFRTKTVEKILEPLAQQVTTLVITHEPSEKDGGASPDLTAPVAAVSQAVSNLIEVGYDIANSSPD--LKQDMPPALERVE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911   83 NACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTK 162
Cdd:pfam01044   79 KTGQLMEQASREFASDPYSSPKRGKLIRGARGLLSAVSRLLILADEADVRKIIRVCKKVLDYLAVAEVAETMEDLVQFYK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  163 NLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKnsknqGIEEALKNRNFTVEKMSAEIN 242
Cdd:pfam01044  159 DLGPNMTKLNKMVDRRQQELTHQVHRDILAAARDTLKKLAPILITAMKIFVRHP-----GVEEARENRDYTAKQMSDAMN 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  243 EIIRVLQLTSWdedawaskdtEAMKRALASIDSKLNQAKGWLRDPnaspgdageqairQILDEAGKVGELCAGKERREIL 322
Cdd:pfam01044  234 EIIRVLQLTSY----------TVMKKALSGIGSELAAALDWLDDP-------------IIIDPATYIEERCRPSLEERIE 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  323 GTCKMLGQMTDQVADLRARGQgaspvamqkaqqvsqgldvltakvenaarkleamtnskqsiakkidaaqnwladpnggp 402
Cdd:pfam01044  291 SIISGAASMADSLCTRRNRGQ----------------------------------------------------------- 311
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  403 egeeqirgalaeaRKIAELCddpkerddilrslgeiaaltsklgdlrrqgkgdspearalakqvatalqnlqtktnrava 482
Cdd:pfam01044  312 -------------AIVAECN------------------------------------------------------------ 318
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  483 nsrpakaavhlegkieqaqrwidnptvddrGVGQAAIRGLVAEGHRLANVMMgpyrqDLLAKCDRVDQltaqladlaARG 562
Cdd:pfam01044  319 ------------------------------GAGRQALQDLLSEYMKLAGRKD-----DLDALCDAIDR---------MRK 354
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  563 EGespqaralasqlqdslKDLKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAppdapNREEVFDERAANFENHSGRLGA 642
Cdd:pfam01044  355 KT----------------RDLRRQLRKAVVDHVSDSFLDTTTPLKLLIEAAKA-----GREENFEEKAQNFQEHANRLVE 413
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  643 TAEKAAAVGtANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSL 722
Cdd:pfam01044  414 VARLACSCS-NNKETVEAIRMAAAQVESLTPQVINAARILLHNPGSKAAQENMETFKNQWEDQVRRLTEAVDDITDTDDF 492
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  723 LDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAK 802
Cdd:pfam01044  493 LAVSEEHILEDVNKCVMAIQNADPQTLVATAGSIAGRANRVLLVAKAEMDNSEDPVYTERVKEAVDILSNTIPPMFAEAK 572
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  803 AVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPqepdfpppppdleqlrltdelappkpplpegevppprppppeekd 882
Cdd:pfam01044  573 EVAVNALDPGAAKSWEENNYEFLDAVRLVYDAVRP--------------------------------------------- 607
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  883 eefpeqkagevINQPMMMaaRQLHDEARKWSSKPGIPAAQVgiGVVAEANAADAVGFPFPSDMEDDYEPELLLMPS--NQ 960
Cdd:pfam01044  608 -----------IRQAVLM--NRSPPELPTDSEFELREDEPA--PPRPPPPVETEPPPRPPPPPETDREEMRRLFPEekAK 672
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  961 PVNQ--PILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGS--GTKRALIQCAKDIAKASDEVTRLAKEV 1036
Cdd:pfam01044  673 IAAQvqPFLAAAHKLHREVAKWDSKGNDIIALAKRMCMIMMEMTDFTRGKGplKTTMDVINAAKKIAEAGEEVTRLARQI 752
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911 1037 AKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKI 1116
Cdd:pfam01044  753 ARQCTDSRIKTDLLAYLERIPLYCTQLKILSKVKATMLGSGNELSVSGLDSAESLIQNAQNLMQSVVQTVKAAYAASTKI 832
                         1130      1140
                   ....*....|....*....|
gi 1679820911 1117 RTD--AGFTLRWVRKTPWYQ 1134
Cdd:pfam01044  833 RTDqvNSPRVRWKMKPPWKQ 852
 
Name Accession Description Interval E-value
Vinculin pfam01044
Vinculin family;
3-1134 0e+00

Vinculin family;


Pssm-ID: 460040  Cd Length: 852  Bit Score: 1041.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911    3 VFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDqiLKRDMPPAFIKVE 82
Cdd:pfam01044    1 EFRTKTVEKILEPLAQQVTTLVITHEPSEKDGGASPDLTAPVAAVSQAVSNLIEVGYDIANSSPD--LKQDMPPALERVE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911   83 NACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTK 162
Cdd:pfam01044   79 KTGQLMEQASREFASDPYSSPKRGKLIRGARGLLSAVSRLLILADEADVRKIIRVCKKVLDYLAVAEVAETMEDLVQFYK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  163 NLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKnsknqGIEEALKNRNFTVEKMSAEIN 242
Cdd:pfam01044  159 DLGPNMTKLNKMVDRRQQELTHQVHRDILAAARDTLKKLAPILITAMKIFVRHP-----GVEEARENRDYTAKQMSDAMN 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  243 EIIRVLQLTSWdedawaskdtEAMKRALASIDSKLNQAKGWLRDPnaspgdageqairQILDEAGKVGELCAGKERREIL 322
Cdd:pfam01044  234 EIIRVLQLTSY----------TVMKKALSGIGSELAAALDWLDDP-------------IIIDPATYIEERCRPSLEERIE 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  323 GTCKMLGQMTDQVADLRARGQgaspvamqkaqqvsqgldvltakvenaarkleamtnskqsiakkidaaqnwladpnggp 402
Cdd:pfam01044  291 SIISGAASMADSLCTRRNRGQ----------------------------------------------------------- 311
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  403 egeeqirgalaeaRKIAELCddpkerddilrslgeiaaltsklgdlrrqgkgdspearalakqvatalqnlqtktnrava 482
Cdd:pfam01044  312 -------------AIVAECN------------------------------------------------------------ 318
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  483 nsrpakaavhlegkieqaqrwidnptvddrGVGQAAIRGLVAEGHRLANVMMgpyrqDLLAKCDRVDQltaqladlaARG 562
Cdd:pfam01044  319 ------------------------------GAGRQALQDLLSEYMKLAGRKD-----DLDALCDAIDR---------MRK 354
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  563 EGespqaralasqlqdslKDLKAQMQEAMTQEVSDVFSDTTTPIKLLAVAATAppdapNREEVFDERAANFENHSGRLGA 642
Cdd:pfam01044  355 KT----------------RDLRRQLRKAVVDHVSDSFLDTTTPLKLLIEAAKA-----GREENFEEKAQNFQEHANRLVE 413
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  643 TAEKAAAVGtANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSL 722
Cdd:pfam01044  414 VARLACSCS-NNKETVEAIRMAAAQVESLTPQVINAARILLHNPGSKAAQENMETFKNQWEDQVRRLTEAVDDITDTDDF 492
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  723 LDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAK 802
Cdd:pfam01044  493 LAVSEEHILEDVNKCVMAIQNADPQTLVATAGSIAGRANRVLLVAKAEMDNSEDPVYTERVKEAVDILSNTIPPMFAEAK 572
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  803 AVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPqepdfpppppdleqlrltdelappkpplpegevppprppppeekd 882
Cdd:pfam01044  573 EVAVNALDPGAAKSWEENNYEFLDAVRLVYDAVRP--------------------------------------------- 607
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  883 eefpeqkagevINQPMMMaaRQLHDEARKWSSKPGIPAAQVgiGVVAEANAADAVGFPFPSDMEDDYEPELLLMPS--NQ 960
Cdd:pfam01044  608 -----------IRQAVLM--NRSPPELPTDSEFELREDEPA--PPRPPPPVETEPPPRPPPPPETDREEMRRLFPEekAK 672
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911  961 PVNQ--PILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGS--GTKRALIQCAKDIAKASDEVTRLAKEV 1036
Cdd:pfam01044  673 IAAQvqPFLAAAHKLHREVAKWDSKGNDIIALAKRMCMIMMEMTDFTRGKGplKTTMDVINAAKKIAEAGEEVTRLARQI 752
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679820911 1037 AKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKI 1116
Cdd:pfam01044  753 ARQCTDSRIKTDLLAYLERIPLYCTQLKILSKVKATMLGSGNELSVSGLDSAESLIQNAQNLMQSVVQTVKAAYAASTKI 832
                         1130      1140
                   ....*....|....*....|
gi 1679820911 1117 RTD--AGFTLRWVRKTPWYQ 1134
Cdd:pfam01044  833 RTDqvNSPRVRWKMKPPWKQ 852
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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