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Conserved domains on  [gi|1624437681|ref|XP_028848410|]
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uridine-cytidine kinase-like 1 isoform X8 [Denticeps clupeoides]

Protein Classification

uridine-cytidine kinase( domain architecture ID 10113977)

uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine and cytidine as well as the pharmacological activation of several cytotoxic pyrimidine ribonucleoside analogues

CATH:  3.40.50.300
EC:  2.7.1.48
Gene Ontology:  GO:0044206|GO:0043771|GO:0005524|GO:0004849|GO:0044211
SCOP:  4003940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 95-294 4.14e-123

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


:

Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 357.63  E-value: 4.14e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKVLSAEEQALAASNdyNFDHPGAFDFELLVTTLRKLKQGKSVK 174
Cdd:cd02023     1 IIGIAGGSGSGKTTVAEEIIEQLGNPKVVIISQDSYYKDLSHEELEERKNN--NYDHPDAFDFDLLISHLQDLKNGKSVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 175 IPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYNKF 254
Cdd:cd02023    79 IPVYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKF 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1624437681 255 VKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQ 294
Cdd:cd02023   159 VKPMHEQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
313-488 4.93e-03

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 39.42  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 313 SRP--SACPSQGAPGFGPPESAAPPDPQCPGEHAAGPRPA----RHHQKQGDQPRrvhlllqtpdaPPDRTCPDLPALAA 386
Cdd:PRK14086  106 SEPelPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAypayQQRPEPGAWPR-----------AADDYGWQQQRLGF 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 387 lrcPDPARRGVRGAALPRQRDNRGVHFAGRGDHGAGpeggvQRRPHRQNPHPDQygfrraraalsaPAQRHQRRPRDthg 466
Cdd:PRK14086  175 ---PPRAPYASPASYAPEQERDREPYDAGRPEYDQR-----RRDYDHPRPDWDR------------PRRDRTDRPEP--- 231

                         170       180
                  ....*....|....*....|..
gi 1624437681 467 qhrlHGGSCHDGRTGPTGPRRP 488
Cdd:PRK14086  232 ----PPGAGHVHRGGPGPPERD 249
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 95-294 4.14e-123

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 357.63  E-value: 4.14e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKVLSAEEQALAASNdyNFDHPGAFDFELLVTTLRKLKQGKSVK 174
Cdd:cd02023     1 IIGIAGGSGSGKTTVAEEIIEQLGNPKVVIISQDSYYKDLSHEELEERKNN--NYDHPDAFDFDLLISHLQDLKNGKSVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 175 IPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYNKF 254
Cdd:cd02023    79 IPVYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKF 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1624437681 255 VKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQ 294
Cdd:cd02023   159 VKPMHEQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 89-298 7.13e-94

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 283.20  E-value: 7.13e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  89 QSKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYK---VLSAEEQALAasndyNFDHPGAFDFELLVTTLR 165
Cdd:PRK05480    2 MMKKPIIIGIAGGSGSGKTTVASTIYEELGDESIAVIPQDSYYKdqsHLSFEERVKT-----NYDHPDAFDHDLLIEHLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 166 KLKQGKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIE 245
Cdd:PRK05480   77 ALKAGKAIEIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLE 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624437681 246 GVIKQYNKFVKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQLEER 298
Cdd:PRK05480  157 SVINQYLSTVRPMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLEKN 209
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 90-296 2.07e-83

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 256.55  E-value: 2.07e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  90 SKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKvlSAEEQALAASNDYNFDHPGAFDFELLVTTLRKLKQ 169
Cdd:TIGR00235   3 KPKGIIIGIGGGSGSGKTTVARKIYEQLGKLEIVIISQDNYYK--DQSHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 170 GKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIK 249
Cdd:TIGR00235  81 GSPIDVPVYDYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRSLDSVID 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1624437681 250 QYNKFVKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQLE 296
Cdd:TIGR00235 161 QYRKTVRPMYEQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 89-293 1.22e-81

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 251.68  E-value: 1.22e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  89 QSKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKvlSAEEQALAASNDYNFDHPGAFDFELLVTTLRKLK 168
Cdd:COG0572     3 RSGKPRIIGIAGPSGSGKTTFARRLAEQLGADKVVVISLDDYYK--DREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 169 QGKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVI 248
Cdd:COG0572    81 AGESVELPVYDFATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTAESVI 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1624437681 249 KQYNKFVKPAFDQYIEPTMRLADIVVPRGGG-NMVAIDLIVQHVHS 293
Cdd:COG0572   161 EQYWATVRPGHEQYIEPTKEYADIVIPNGGPlNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 95-283 2.37e-66

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 212.26  E-value: 2.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDVPWV--------VLLSMDSFYKVLSAEEQALAASNDYNFDHPGAFDFELLVTTLRK 166
Cdd:pfam00485   1 VIGVAGSSGSGKTTVARRIVSIFGREGVpavgiegdSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 167 LKQGKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEG 246
Cdd:pfam00485  81 LKEGGSVDKPIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEG 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1624437681 247 VIKQYNkFVKPAFDQYIEPTMRLADIVVPRGGGNMVA 283
Cdd:pfam00485 161 VTDSIL-FRKPDYVNYIDPQFSYADLIIQRVPTNDTA 196
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 95-234 4.80e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681   95 VIGLCGGSASGKTTVANKIIEALDVP--WVVLLSMDSFYKVLSAEEQALAASNDYNFDHPGAfDFELLVTTLRKLKQGks 172
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPggGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGEL-RLRLALALARKLKPD-- 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1624437681  173 vkipvydftthgrqkdwknvygasVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLR 234
Cdd:smart00382  81 ------------------------VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLT 118
dnaA PRK14086
chromosomal replication initiator protein DnaA;
313-488 4.93e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.42  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 313 SRP--SACPSQGAPGFGPPESAAPPDPQCPGEHAAGPRPA----RHHQKQGDQPRrvhlllqtpdaPPDRTCPDLPALAA 386
Cdd:PRK14086  106 SEPelPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAypayQQRPEPGAWPR-----------AADDYGWQQQRLGF 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 387 lrcPDPARRGVRGAALPRQRDNRGVHFAGRGDHGAGpeggvQRRPHRQNPHPDQygfrraraalsaPAQRHQRRPRDthg 466
Cdd:PRK14086  175 ---PPRAPYASPASYAPEQERDREPYDAGRPEYDQR-----RRDYDHPRPDWDR------------PRRDRTDRPEP--- 231

                         170       180
                  ....*....|....*....|..
gi 1624437681 467 qhrlHGGSCHDGRTGPTGPRRP 488
Cdd:PRK14086  232 ----PPGAGHVHRGGPGPPERD 249
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 95-294 4.14e-123

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 357.63  E-value: 4.14e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKVLSAEEQALAASNdyNFDHPGAFDFELLVTTLRKLKQGKSVK 174
Cdd:cd02023     1 IIGIAGGSGSGKTTVAEEIIEQLGNPKVVIISQDSYYKDLSHEELEERKNN--NYDHPDAFDFDLLISHLQDLKNGKSVE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 175 IPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYNKF 254
Cdd:cd02023    79 IPVYDFKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVERGRDLESVINQYLKF 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1624437681 255 VKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQ 294
Cdd:cd02023   159 VKPMHEQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 89-298 7.13e-94

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 283.20  E-value: 7.13e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  89 QSKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYK---VLSAEEQALAasndyNFDHPGAFDFELLVTTLR 165
Cdd:PRK05480    2 MMKKPIIIGIAGGSGSGKTTVASTIYEELGDESIAVIPQDSYYKdqsHLSFEERVKT-----NYDHPDAFDHDLLIEHLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 166 KLKQGKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIE 245
Cdd:PRK05480   77 ALKAGKAIEIPVYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNERGRSLE 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1624437681 246 GVIKQYNKFVKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQLEER 298
Cdd:PRK05480  157 SVINQYLSTVRPMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLEKN 209
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 90-296 2.07e-83

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 256.55  E-value: 2.07e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  90 SKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKvlSAEEQALAASNDYNFDHPGAFDFELLVTTLRKLKQ 169
Cdd:TIGR00235   3 KPKGIIIGIGGGSGSGKTTVARKIYEQLGKLEIVIISQDNYYK--DQSHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 170 GKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIK 249
Cdd:TIGR00235  81 GSPIDVPVYDYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDINERGRSLDSVID 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1624437681 250 QYNKFVKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLIVQHVHSQLE 296
Cdd:TIGR00235 161 QYRKTVRPMYEQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 89-293 1.22e-81

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 251.68  E-value: 1.22e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  89 QSKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKvlSAEEQALAASNDYNFDHPGAFDFELLVTTLRKLK 168
Cdd:COG0572     3 RSGKPRIIGIAGPSGSGKTTFARRLAEQLGADKVVVISLDDYYK--DREHLPLDERGKPNFDHPEAFDLDLLNEHLEPLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 169 QGKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVI 248
Cdd:COG0572    81 AGESVELPVYDFATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEERGRTAESVI 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1624437681 249 KQYNKFVKPAFDQYIEPTMRLADIVVPRGGG-NMVAIDLIVQHVHS 293
Cdd:COG0572   161 EQYWATVRPGHEQYIEPTKEYADIVIPNGGPlNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 95-283 2.37e-66

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 212.26  E-value: 2.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDVPWV--------VLLSMDSFYKVLSAEEQALAASNDYNFDHPGAFDFELLVTTLRK 166
Cdd:pfam00485   1 VIGVAGSSGSGKTTVARRIVSIFGREGVpavgiegdSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 167 LKQGKSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEG 246
Cdd:pfam00485  81 LKEGGSVDKPIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMAERGHSLEG 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1624437681 247 VIKQYNkFVKPAFDQYIEPTMRLADIVVPRGGGNMVA 283
Cdd:pfam00485 161 VTDSIL-FRKPDYVNYIDPQFSYADLIIQRVPTNDTA 196
PTZ00301 PTZ00301
uridine kinase; Provisional
 95-287 3.72e-34

uridine kinase; Provisional


Pssm-ID: 140322 [Multi-domain]  Cd Length: 210  Bit Score: 127.81  E-value: 3.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDV---PWVV-LLSMDSFYKVLSAEEQALAASNDYnfDHPGAFDFELLVTTLRKLKQG 170
Cdd:PTZ00301    5 VIGISGASGSGKSSLSTNIVSELMAhcgPVSIgVICEDFYYRDQSNIPESERAYTNY--DHPKSLEHDLLTTHLRELKSG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 171 KSVKIPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQ 250
Cdd:PTZ00301   83 KTVQIPQYDYVHHTRSDTAVTMTPKSVLIVEGILLFTNAELRNEMDCLIFVDTPLDICLIRRAKRDMRERGRTFESVIEQ 162

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1624437681 251 YNKFVKPAFDQYIEPTMRLADIVVPRGGGNMVAIDLI 287
Cdd:PTZ00301  163 YEATVRPMYYAYVEPSKVYADIIVPSWKDNSVAVGVL 199
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 95-274 1.31e-29

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 114.32  E-value: 1.31e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDV--PWVVLLSMDSFYKVLSAEEQAlaasnDYNFDHPGAFDFELLVTTLRKLKQGKS 172
Cdd:cd02028     1 VVGIAGPSGSGKTTFAKKLSNQLRVngIGPVVISLDDYYVPRKTPRDE-----DGNYDFESILDLDLLNKNLHDLLNGKE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 173 VKIPVYDFTTHGRQKDWKNVYGAS-VIIFEGIMAFADKeLLRLLDMKIFVDT-DSDIRLVRRLRRDITERGRDIEGVIKQ 250
Cdd:cd02028    76 VELPIYDFRTGKRRGYRKLKLPPSgVVILEGIYALNER-LRSLLDIRVAVSGgVHLNRLLRRVVRDIQFRGYSAELTILM 154

                         170       180
                  ....*....|....*....|....
gi 1624437681 251 yNKFVkPAFDQYIEPTMRLADIVV 274
Cdd:cd02028   155 -WPSV-PSGEEFIIPPLQEAAIVM 176
PRK cd02026
Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or ...
 95-274 2.76e-24

Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH produced by the primary reactions of photosynthesis.


Pssm-ID: 238984 [Multi-domain]  Cd Length: 273  Bit Score: 102.03  E-value: 2.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKvLSAEEQALAASNDYnfdHPGAFDFELLVTTLRKLKQGKSVK 174
Cdd:cd02026     1 IIGVAGDSGCGKSTFLRRLTSLFGSDLVTVICLDDYHS-LDRKGRKETGITAL---DPRANNFDLMYEQLKALKEGQAIE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 175 IPVYDFTThGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYNKf 254
Cdd:cd02026    77 KPIYNHVT-GLIDPPELIKPTKIVVIEGLHPLYDERVRELLDFSVYLDISDEVKFAWKIQRDMAERGHSLEDVLASIEA- 154

                         170       180
                  ....*....|....*....|
gi 1624437681 255 VKPAFDQYIEPTMRLADIVV 274
Cdd:cd02026   155 RKPDFEAYIDPQKQYADVVI 174
PLN02318 PLN02318
phosphoribulokinase/uridine kinase
 95-274 1.48e-21

phosphoribulokinase/uridine kinase


Pssm-ID: 177952 [Multi-domain]  Cd Length: 656  Bit Score: 98.01  E-value: 1.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALdvPWVVLLSMDSF---YKVLsaeeqalaasnDYNFDHPGAFDFELLVTTLRKLKQGK 171
Cdd:PLN02318   67 LVGVAGPSGAGKTVFTEKVLNFM--PSIAVISMDNYndsSRII-----------DGNFDDPRLTDYDTLLDNIHDLKAGK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 172 SVKIPVYDFTTHGRQKDWK-NVYGASVIIFEGIMAFADKelLR-LLDMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIK 249
Cdd:PLN02318  134 SVQVPIYDFKSSSRVGYRTlEVPSSRIVIIEGIYALSEK--LRpLLDLRVSVTGGVHFDLVKRVLRDIQRAGQEPEEIIH 211

                         170       180
                  ....*....|....*....|....*
gi 1624437681 250 QYNKFVKPAFDQYIEPTMRLADIVV 274
Cdd:PLN02318  212 QISETVYPMYKAFIEPDLQTAHIKI 236
PRK07429 PRK07429
phosphoribulokinase; Provisional
 87-274 4.39e-20

phosphoribulokinase; Provisional


Pssm-ID: 180975  Cd Length: 327  Bit Score: 90.84  E-value: 4.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  87 GTQSKEAFVIGLCGGSASGKTTVANKIIEALDVPWVVLLSMDSFYKVLSAEEQ-----ALaasndynfdHPGAFDFELLV 161
Cdd:PRK07429    2 TSMPDRPVLLGVAGDSGCGKTTFLRGLADLLGEELVTVICTDDYHSYDRKQRKelgitAL---------DPRANNLDIMY 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 162 TTLRKLKQGKSVKIPVYDFTThGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITERG 241
Cdd:PRK07429   73 EHLKALKTGQPILKPIYNHET-GTFDPPEYIEPNKIVVVEGLHPLYDERVRELYDFKVYLDPPEEVKIAWKIKRDMAKRG 151

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1624437681 242 RDIEGVIKQYNKfVKPAFDQYIEPTMRLADIVV 274
Cdd:PRK07429  152 HTYEQVLAEIEA-REPDFEAYIRPQRQWADVVI 183
PLN02348 PLN02348
phosphoribulokinase
 151-274 1.10e-18

phosphoribulokinase


Pssm-ID: 215198  Cd Length: 395  Bit Score: 87.98  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 151 HPGAFDFELLVTTLRKLKQGKSVKIPVYDFTThGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLV 230
Cdd:PLN02348  120 DPRANNFDLMYEQVKALKEGKAVEKPIYNHVT-GLLDPPELIEPPKILVIEGLHPMYDERVRDLLDFSIYLDISDDVKFA 198

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1624437681 231 RRLRRDITERGRDIEGvIKQYNKFVKPAFDQYIEPTMRLADIVV 274
Cdd:PLN02348  199 WKIQRDMAERGHSLES-IKASIEARKPDFDAYIDPQKQYADVVI 241
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 95-232 3.42e-12

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 65.04  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALdvPWVVLLSMDSFYKvlSAEEQALAASNDYNFDHPGAFDFELLVTTLR-KLKQGKSV 173
Cdd:cd02024     1 IVGISGVTNSGKTTLAKLLQRIL--PNCCVIHQDDFFK--PEDEIPVDENGFKQWDVLEALDMEAMMSTLDyWRETGHFP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1624437681 174 K-------------IPVYDFTTHGRQKDWKNVYGASVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRR 232
Cdd:cd02024    77 KflrshgnendpekEFIEDAQIEETKADLLGAEDLHILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRR 148
CoaA COG1072
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ...
 94-235 1.41e-10

Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440690  Cd Length: 309  Bit Score: 62.23  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  94 FVIGLCGGSASGKTTVAnKIIEAL-----DVPWVVLLSMDSF-Y--KVLsaEEQALAasndynfDHPGA---FDFELLVT 162
Cdd:COG1072    87 FIIGIAGSVAVGKSTTA-RLLQALlsrwpEHPKVELVTTDGFlYpnAVL--ERRGLM-------DRKGFpesYDRRGLLR 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 163 TLRKLKQGKS-VKIPVYDFTTH---------GRQKDwknvygasVIIFEGIMAFADKELLR-----LLDMKIFVDTD-SD 226
Cdd:COG1072   157 FLARVKSGDPeVRAPVYSHLLYdivpgaivvVDQPD--------ILIVEGNNVLQDEPNPWlfvsdFFDFSIYVDADeED 228

                         170
                  ....*....|.
gi 1624437681 227 I--RLVRRLRR 235
Cdd:COG1072   229 LreWYVERFLK 239
PRK08233 PRK08233
hypothetical protein; Provisional
 91-302 2.44e-10

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 59.76  E-value: 2.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  91 KEAFVIGLCGGSASGKTTVANKIIEalDVPWVVLLSMDSFYKVLSAEE--QALAASNDYNfdhpgAFDFELLVTTLRKLK 168
Cdd:PRK08233    1 KKTKIITIAAVSGGGKTTLTERLTH--KLKNSKALYFDRYDFDNCPEDicKWIDKGANYS-----EWVLTPLIKDIQELI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 169 QGksvkipvydftthgRQKDWknvygasvIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLRRDITER-GRDIEGV 247
Cdd:PRK08233   74 AK--------------SNVDY--------IIVDYPFAYLNSEMRQFIDVTIFIDTPLDIAMARRILRDFKEDtGNEIHND 131

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1624437681 248 IKQYNKFVKPAFDQYIEPTMRLADIVVprgGGNMvAIDLIVQHVHSQLEERELSV 302
Cdd:PRK08233  132 LKHYLNYARPLYLEALHTVKPNADIVL---DGAL-SVEEIINQIEEELYRREVIV 182
PLN03046 PLN03046
D-glycerate 3-kinase; Provisional
 85-204 1.72e-07

D-glycerate 3-kinase; Provisional


Pssm-ID: 178608  Cd Length: 460  Bit Score: 53.38  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  85 EHGTQSKEA-----FVIGLCGGSASGKTTvankIIEALDVPWVV------LLSMDSFYkvLSAEEQA-LAASNDYNF--- 149
Cdd:PLN03046  199 EHRSKFKDGddippLVIGFSAPQGCGKTT----LVFALDYLFRVtgrksaTLSIDDFY--LTAEGQAeLRERNPGNAlle 272

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1624437681 150 --DHPGAFDFELLVTTLRKL----KQGKSVKIPVYDFTTHGRQKD------WKNVYGA-SVIIFEGIM 204
Cdd:PLN03046  273 lrGNAGSHDLQFSVETLEALskltKEGIKMKVPRYDKSAYSGRGDradpstWPEVEGPlEVILFEGWM 340
PanK cd02025
Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4 ...
 95-277 2.18e-06

Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in CoA biosynthesis.


Pssm-ID: 238983  Cd Length: 220  Bit Score: 48.46  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVAnKIIEAL-----DVPWVVLLSMDSF-YKVLSAEEQALAASNDYnfdhPGAFDFELLVTTLRKLK 168
Cdd:cd02025     1 IIGIAGSVAVGKSTTA-RVLQALlsrwpDHPNVELITTDGFlYPNKELIERGLMDRKGF----PESYDMEALLKFLKDIK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 169 QGKS-VKIPVYDFTTHGRQKDWK-NVYGASVIIFEGIMAFADKELLR-----LLDMKIFVDTD-SDIR--LVRRLRRDIT 238
Cdd:cd02025    76 SGKKnVKIPVYSHLTYDVIPGEKqTVDQPDILIIEGLNVLQTGQNPRlfvsdFFDFSIYVDADeDDIEkwYIKRFLKLRE 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1624437681 239 ERGRDIEGVIKQYNKFV----------------KPAFDQYIEPTMRLADIVVPRG 277
Cdd:cd02025   156 TAFSDPDSYFHRYAKMSeeeaiafarevwkninLKNLRENILPTRNRADLILEKG 210
PRK09270 PRK09270
nucleoside triphosphate hydrolase domain-containing protein; Reviewed
 94-235 1.02e-05

nucleoside triphosphate hydrolase domain-containing protein; Reviewed


Pssm-ID: 236442  Cd Length: 229  Bit Score: 46.85  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  94 FVIGLCGGSASGKTTVANKIIEALD----VPWVVlLSMDSFY---KVLsaEEQALAASNdynfdhpGA---FDFELLVTT 163
Cdd:PRK09270   34 TIVGIAGPPGAGKSTLAEFLEALLQqdgeLPAIQ-VPMDGFHldnAVL--DAHGLRPRK-------GApetFDVAGLAAL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 164 LRKLKQGKS-VKIPVYDftthgRQKDwKNVYGASVI-------IFEGIMAFAD----KELLRLLDMKIFVDTDSDIrLVR 231
Cdd:PRK09270  104 LRRLRAGDDeVYWPVFD-----RSLE-DPVADAIVVpptarlvIVEGNYLLLDeepwRRLAGLFDFTIFLDAPAEV-LRE 176


                  ....
gi 1624437681 232 RLRR 235
Cdd:PRK09270  177 RLVA 180
PRK06696 PRK06696
uridine kinase; Validated
 96-274 7.20e-05

uridine kinase; Validated


Pssm-ID: 180660  Cd Length: 223  Bit Score: 44.20  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  96 IGLCGGSASGKTTVANKI---IEALDVPwVVLLSMDSFYKV---------LSAEeqalaasnDYNFDhpgAFDFELLVT- 162
Cdd:PRK06696   25 VAIDGITASGKTTFADELaeeIKKRGRP-VIRASIDDFHNPrviryrrgrESAE--------GYYED---AYDYTALRRl 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 163 TLRKLKQGKS--VKIPVYDFTTHGRQKD-WKNVYGASVIIFEGIMAFADkELLRLLDMKIFVDTDSDIRLVRRLRRDITE 239
Cdd:PRK06696   93 LLDPLGPNGDrqYRTASHDLKTDIPVHNpPLLAAPNAVLIVDGTFLLRP-ELRDLWDYKIFLDTDFEVSRRRGAKRDTEA 171

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1624437681 240 RGRDIEgVIKQYNKFVKPAFDQYIE---PtMRLADIVV 274
Cdd:PRK06696  172 FGSYEE-AEKMYLARYHPAQKLYIAeanP-KERADVVI 207
CoaE COG0237
Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the ...
 94-122 2.46e-03

Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440007  Cd Length: 193  Bit Score: 39.28  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*....
gi 1624437681  94 FVIGLCGGSASGKTTVAnKIIEALDVPWV 122
Cdd:COG0237     2 LIIGLTGGIGSGKSTVA-RMFAELGAPVI 29
CPT pfam07931
Chloramphenicol phosphotransferase-like protein; The members of this family are all similar to ...
 95-154 3.24e-03

Chloramphenicol phosphotransferase-like protein; The members of this family are all similar to chloramphenicol 3-O phosphotransferase (CPT) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group to the C-3 hydroxyl group of Cm, CPT inactivates this potentially lethal metabolite.


Pssm-ID: 400334  Cd Length: 172  Bit Score: 38.59  E-value: 3.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  95 VIGLCGGSASGKTTVANKIIEALDVPWVVlLSMDSFYKVLSAEEQALAASNDYNFDHPGA 154
Cdd:pfam07931   3 IILLNGGSSSGKSSIARALQDVLDGPWMH-FGVDAFVEAMPPKRQNSGGGLEWSTDGPGP 61
AAA_18 pfam13238
AAA domain;
96-252 3.71e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 37.41  E-value: 3.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681  96 IGLCGGSASGKTTVAnKIIEALDVPWVVLLSMdsfykvlsAEEQALAASNDYNFDHPGAFDFELLVTTLRKLKQgksvki 175
Cdd:pfam13238   1 ILITGTPGVGKTTLA-KELSKRLGFGDNVRDL--------ALENGLVLGDDPETRESKRLDEDKLDRLLDLLEE------ 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1624437681 176 pvydftthgrqkdWKNVYGASVIIFEGIMAFADKELLRLLdMKIFVDTDSDIRLVRRLRRDITERGRDIEGVIKQYN 252
Cdd:pfam13238  66 -------------NAALEEGGNLIIDGHLAELEPERAKDL-VGIVLRASPEELLERLEKRGYEEAKIKENEEAEILG 128
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 95-234 4.80e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 37.74  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681   95 VIGLCGGSASGKTTVANKIIEALDVP--WVVLLSMDSFYKVLSAEEQALAASNDYNFDHPGAfDFELLVTTLRKLKQGks 172
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPggGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGEL-RLRLALALARKLKPD-- 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1624437681  173 vkipvydftthgrqkdwknvygasVIIFEGIMAFADKELLRLLDMKIFVDTDSDIRLVRRLR 234
Cdd:smart00382  81 ------------------------VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLT 118
dnaA PRK14086
chromosomal replication initiator protein DnaA;
313-488 4.93e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.42  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 313 SRP--SACPSQGAPGFGPPESAAPPDPQCPGEHAAGPRPA----RHHQKQGDQPRrvhlllqtpdaPPDRTCPDLPALAA 386
Cdd:PRK14086  106 SEPelPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAypayQQRPEPGAWPR-----------AADDYGWQQQRLGF 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624437681 387 lrcPDPARRGVRGAALPRQRDNRGVHFAGRGDHGAGpeggvQRRPHRQNPHPDQygfrraraalsaPAQRHQRRPRDthg 466
Cdd:PRK14086  175 ---PPRAPYASPASYAPEQERDREPYDAGRPEYDQR-----RRDYDHPRPDWDR------------PRRDRTDRPEP--- 231

                         170       180
                  ....*....|....*....|..
gi 1624437681 467 qhrlHGGSCHDGRTGPTGPRRP 488
Cdd:PRK14086  232 ----PPGAGHVHRGGPGPPERD 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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