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Conserved domains on  [gi|1622958373|ref|XP_028707968|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1 [Macaca mulatta]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 59-338 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


:

Pssm-ID: 467708  Cd Length: 280  Bit Score: 574.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  59 CTCTHCIGQRKLSVWFDERFNQTVQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVG 138
Cdd:cd23980     1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23980    81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 219 SATTTGTISHTYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23980   161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622958373 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23980   241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 59-338 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 574.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  59 CTCTHCIGQRKLSVWFDERFNQTVQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVG 138
Cdd:cd23980     1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23980    81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 219 SATTTGTISHTYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23980   161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622958373 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23980   241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 85-333 1.67e-88

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 266.01  E-value: 1.67e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  85 LLTAQNALLEDdtyrwWLRLQREKKP-NNLNDTIKELFRVVPgnvdpmleKRSVGCRRCAVVGNSGNLRESSYGPEIDRH 163
Cdd:pfam00777   1 FLTKENFPLGE-----WIRYSEWWLPfTVTEELLELLPKVSP--------FDNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 164 DFVLRMNKAPTAGFEADVGTKTTHHLVYPES-----FRELGD------NVSMILVPFKTIDLEWVVSATTTGTISH---- 228
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESaidskYGNLGFshprdpFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 229 TYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHG---RYPSTGILSVIFSMHVCDEVDLYGFGA--DSKGNWHHYWEN 303
Cdd:pfam00777 148 LYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDN 227

                         250       260       270
                  ....*....|....*....|....*....|
gi 1622958373 304 NPSAgAFRKTGVHDADFESNVTATLASINK 333
Cdd:pfam00777 228 VLMK-KGGFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 59-338 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 574.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  59 CTCTHCIGQRKLSVWFDERFNQTVQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVG 138
Cdd:cd23980     1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNVDPLLEKRLVS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23980    81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 219 SATTTGTISHTYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23980   161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622958373 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23980   241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 61-338 1.40e-168

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 469.84  E-value: 1.40e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  61 CTHCIGQRKLSVWFDERFNQTVQPLLTAQNALLEDDTYRWWLRLQREKKpNNLNDTIKELFRVVPGNvDPMLEKRSVGCR 140
Cdd:cd23966     1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQSSKN-SDLREVLEKLFQVVPGE-NPYRTRDPNRCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 141 RCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSA 220
Cdd:cd23966    79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 221 TTTGTISHTYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWHHY 300
Cdd:cd23966   159 LTTGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHY 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1622958373 301 WENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23966   239 WEKNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 59-338 7.66e-135

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 384.61  E-value: 7.66e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  59 CTCTHCIGQRKLSVWFDERFNQTVQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNvDPMLEKRSVG 138
Cdd:cd23979     1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGE-NPYRSWDPSR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVV 218
Cdd:cd23979    80 CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWIT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 219 SATTTGTISHTYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH 298
Cdd:cd23979   160 SALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWH 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622958373 299 HYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23979   240 HYWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 85-333 1.67e-88

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 266.01  E-value: 1.67e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  85 LLTAQNALLEDdtyrwWLRLQREKKP-NNLNDTIKELFRVVPgnvdpmleKRSVGCRRCAVVGNSGNLRESSYGPEIDRH 163
Cdd:pfam00777   1 FLTKENFPLGE-----WIRYSEWWLPfTVTEELLELLPKVSP--------FDNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 164 DFVLRMNKAPTAGFEADVGTKTTHHLVYPES-----FRELGD------NVSMILVPFKTIDLEWVVSATTTGTISH---- 228
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESaidskYGNLGFshprdpFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 229 TYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHG---RYPSTGILSVIFSMHVCDEVDLYGFGA--DSKGNWHHYWEN 303
Cdd:pfam00777 148 LYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDN 227

                         250       260       270
                  ....*....|....*....|....*....|
gi 1622958373 304 NPSAgAFRKTGVHDADFESNVTATLASINK 333
Cdd:pfam00777 228 VLMK-KGGFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 71-338 2.76e-56

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 184.77  E-value: 2.76e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  71 SVWFDERFNQTVQPLLTAqnallEDDTYRWWLRLQREKKPN---NLN-DTIKELFRVVPG-NVDPMLEKRS--VGCRRCA 143
Cdd:cd23964    12 SPWFRERFIPDIKVLLDS-----EDFNPEEYNRLSHYKLPFgwgGLNrEVVERLLRNLNLtSSRYMFVLRGgrPRCIRCA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 144 VVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRE-------LGDNVSMILVPFKTIDLEW 216
Cdd:cd23964    87 VVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNsllkhvpQDKDTKYLFIPFKIRDYDY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 217 VVSATTTGTI------SHTYVPVPAKiRVKQDKILIYHPAFIKYVFDNWLQGH-GRYPSTGILSVIFSMHVCDEVDLYGF 289
Cdd:cd23964   167 LDAVLSGKPVpdgcdkGKRPPPLFGP-KLNATNVRLLHPDFIRYLFNRWLNSStSYRPTTGALMLLTALHTCDQVSVYGF 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1622958373 290 GADSKGNWHHYweNNPSAGAFRKTGVHDADFESNVTATLASINKIRIFK 338
Cdd:cd23964   246 GYDPRFSLHYY--DKTFVKFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 142-324 4.25e-54

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 176.01  E-value: 4.25e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 142 CAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKtiDLEWVVSAT 221
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLP--LEEEVVLIL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 222 TTGTISHTYVPVPAKIRVKQDKILIYHPA--FIKYVFDNWLQGH------GRYPSTGILSVIFSMHVCDEVDLYGFGADS 293
Cdd:cd19952    79 SRAAAADFKRLKRRKKRHDNAVLLLTDPApdLLSYVRKRLEKLGlksffgGNAPSSGLLAVLLALQLCDSVDLYGFGVDS 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1622958373 294 ---KGNWHHYWENnpsAGAFRKTGVHDADFESNV 324
Cdd:cd19952   159 ghaPKVPYHYYDL---VEAEEGTAVHSFDLEAEL 189
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 138-322 5.69e-47

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 157.84  E-value: 5.69e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 138 GCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES-FR---ELGDNVSMILVPFKTID 213
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESaFRdpeEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 214 LEW---VVSATTTGTISHTYVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQ------GHGRYPSTGILSVIFSMHVCDEV 284
Cdd:cd23967    81 LLWlqaVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGlpmngkQGKNVPTTGIIAIVMALHYCDEV 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1622958373 285 DLYGFGADSK--GNWHHYWENNPSAGAFRKTGvHDADFES 322
Cdd:cd23967   161 DIAGFGYDPSdpNAPLHYYDSLTMKAIKRSWT-HNVTKEK 199
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 139-303 6.59e-37

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 131.71  E-value: 6.59e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES--FRELGDNVS---MILVPFKTID 213
Cdd:cd23982     2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESaqFDPGIENDPdtlLVLVPFKPLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 214 LEWVVSATTTGTISHT--YVPVPAKIRVKQDKILIYHPAFIKYVFDNWLQ-----GHGRYPSTGILSVIFSMHVCDEVDL 286
Cdd:cd23982    82 FYWLYEILSNEKRVRKgfWKQPPRIWDANPKQIRILNPYYTYVAATKLLQvpgqrKKKQKPTTGLLAITLALHLCDEVHI 161

                         170       180
                  ....*....|....*....|
gi 1622958373 287 YGFGADSKGN---WHHYWEN 303
Cdd:cd23982   162 AGFGYPDNGNsnqPIHYYNQ 181
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 139-303 4.59e-34

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 124.09  E-value: 4.59e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESF----RELGDNVSMILVPFKTIDL 214
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIfsdpSHYDPNTTVVLIPFKPHDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 215 EWVVSATTTGTISHT--YVPVPAKIRVKQDKILIYHPAFIKYVFDNWL--------QGHGRYPSTGILSVIFSMHVCDEV 284
Cdd:cd23984    82 RWLLDLLMGKKVSAKgfWKKPALNLIYKPNQIRILNPFILRIAAYELLhfpkrfpkEKKPKHPTTGIIAITLALHICNEV 161

                         170       180
                  ....*....|....*....|.
gi 1622958373 285 DLYGFGAD--SKGNWHHYWEN 303
Cdd:cd23984   162 HIAGFKYDfsNLNSTLHYYGN 182
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 138-321 2.83e-32

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 119.84  E-value: 2.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 138 GCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE----SFRELGDNVSMILVPFKTID 213
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEgapkSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 214 LEWVVSATTTGTIS-----HTYVPVPAKIRVKQDKILIYHPAFIK---YVFDNWLQGHGRY-------PSTGILSVIFSM 278
Cdd:cd23983    81 FAWLKAMVKKEPLSfwsrlFFWKEVADSIPLKPSQFRILNPLIIKetaLDILQYPEPQSRLwgwdknvPTLGVTAVVLAT 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1622958373 279 HVCDEVDLYGFGAD--SKGNWHHYWENNPSAgAFRKTGVHDADFE 321
Cdd:cd23983   161 HLCDEVSLAGFGYDlsQPHAPLHYYDSVCMA-AMNTQTMHNVTKE 204
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 76-305 4.49e-30

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 115.44  E-value: 4.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  76 ERFNQTVQPLLTAQNALLEDDTYRwwlrLQREKKPNNLNDTIKELFRvvpgNVDPMLEKRSvgcRRCAVVGNSGNLRESS 155
Cdd:cd23963    11 ERLLNTRKLFLTQKNTPLGDVLYY----SYFKKKTFKITKSLYELLP----KTSPFSHKRY---KTCAVVGNSGILLGSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 156 YGPEIDRHDFVLRMNKAPTAGFEADVGTKT--------------------THHLVYPESFRELGDnvSMILVP--FKTID 213
Cdd:cd23963    80 CGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsilkrrynslkknRDRDKFLNRLKEYNG--SILWYPkfSFKSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 214 LEWVVSATTTgtishtyvpvpAKIRVKQDKILIYHPAFIKYVFDNW-LQGHGRYPSTGILSVIFSMHVCDEVDLYGF--- 289
Cdd:cd23963   158 TNLLLKAARA-----------LKKNGLNLTVVYSNPEHFLAVQKFWkRRGLEKRPSTGLYLVSLALTFCDEIHLYGFwpf 226

                         250
                  ....*....|....*...
gi 1622958373 290 GADSKGNW--HHYWENNP 305
Cdd:cd23963   227 PTDPNGRPvpYHYYDDLS 244
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 139-303 3.33e-29

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 111.55  E-value: 3.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE----SFRELGDNVSMILVPFKTIDL 214
Cdd:cd23981     2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEgaiqKPEQYEKDSLFVLAGFKWQDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 215 EWV--------VSATTTGTIS-HTYVP-VPAKIRVkQDKILIYHPAF--IKYVFDNWLQGHGRYPSTGILSVIFSMHVCD 282
Cdd:cd23981    82 KWLkyivykekVSASDGFWKSvATRVPrEPHEIRI-LNPYFIQEAAFsfIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                         170       180
                  ....*....|....*....|...
gi 1622958373 283 EVDLYGFGAD--SKGNWHHYWEN 303
Cdd:cd23981   161 EVAVAGFGYDmnTPNAPLHYYET 183
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 101-339 2.80e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 105.99  E-value: 2.80e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 101 WLRLQREKKP---NNLNDT-IKELFRVVPGNVDPML----EKRSVGCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKA 172
Cdd:cd23973    37 WDRLEHFNPPfgfMGLNYTlVKEVVELIPKPKEQQLlalsPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 173 PTAGFEADVGTKTTHHLVYPES-------FRELG-------DNVSMILVPFKTIDLEWVVSATTTGTISH--TYVPVPAK 236
Cdd:cd23973   117 VIKGYEEDVGTRTSFYVHTAHSitsslmiLQKRGfknipqdKDIKYILFPEGPRDYQWLEALLKNKTIPSgaYYGRRPRS 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 237 I---RVKQDKILIYHPAFIKYVFDNWLQG---HGRY-----PSTGILSVIFSMHVCDEVDLYGF-GADSKGNWHHYWENN 304
Cdd:cd23973   197 YfsgDFTEDKYLVLHPDFLRYVKNRFLRSktlKGKYwaiyrPTTGAFLLLTALHLCDTVSAYGFiTEDYRKYPDHYYDKK 276

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1622958373 305 PSAGAFrkTGVHDADFESNVTATLASINKIRIFKG 339
Cdd:cd23973   277 KTKLVF--YINHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 61-338 9.88e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 104.52  E-value: 9.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373  61 CTHCIGQR-KLSVWFDERFNQTVqPLLTAQNALLEDDtyrwWLRLQREKKPNN---------------LNDTI-KELF-- 121
Cdd:cd23972     1 CPHSLHLRiQRDPHFRGLFNFDI-PVLLWGQHFTPAL----WDRLSQRKVPYGwkglshqvvastlslLNDSAnAKLFfp 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 122 RVVPGnvdpmlekrsvGCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHH----------LVy 191
Cdd:cd23972    76 RDTPG-----------KCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvntmknsLI- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 192 peSFRELG-------DNVSMILVPFKTIDLEWVVSATTTgtishtyVPVPA--------------KIRVKQDKILiyHPA 250
Cdd:cd23972   144 --SYWNLGftrtpqgQDLQYIFIPSDIRDYVMLRSAILG-------VPVPEgldkgdrphkyfgpEASAKKFKLL--HPD 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 251 FIKYVFDNWLQ--------GHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWH-HYWENNPSAGAFRKTgvHDADFE 321
Cdd:cd23972   213 FISYLTDRFLKskllnthyGHLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSdHYYERKKKPLVFYAN--HDMLLE 290

                         330
                  ....*....|....*..
gi 1622958373 322 SNVTATLASINKIRIFK 338
Cdd:cd23972   291 AALWRRLHKAGILQLYQ 307
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 136-340 3.52e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 102.35  E-value: 3.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 136 SVGCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTT-----HHLVYPESFRELGD----NVSMIL 206
Cdd:cd23968    42 TKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTlrlinSQILSKPEFNFLTDplyrNVTLLV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 207 ---VPFKTIDLEWVVSAtttgtiSHTYVP--VPAKIRVKQDKILIYHPAFIKYVFDnWLQ------GHGRYPSTGILSVI 275
Cdd:cd23968   122 wdpSSYNVNLEKWYKKP------DFDFFPnyIKYRRRHPEEPFYLIDPRFLWRLWD-ILQeytpekIKPNPPSSGFIGIV 194

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622958373 276 FSMHVCDEVDLYGFgADSKGNWH--HYWEN----NPSAGAFrktgvHDADFESNVTATLASINKIRIF-KGR 340
Cdd:cd23968   195 LMLHLCDWVDVYEY-VPSVRQTDrcHYYDVekdlACTLGAW-----HPLAAEKLLVRHLNVGSDDDIFrKGR 260
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 139-302 4.08e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 95.70  E-value: 4.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLV-----------YPESFRELGDNVSMILV 207
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVshtsvplllrnQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 208 PFKTIDLEwvVSATTTGTISHTYVPVPakiRVKQDKILIYHPAFIKYVFDNWLQGH----GRYPSTGILSVIFSMHVCDE 283
Cdd:cd23977    81 PERNMDRD--GGGKTYRALLTLAKMYP---HLQVYTLTEEKMAYCDGVFQNETGKNrmksGSFLSTGWFTMILALELCEE 155

                         170       180
                  ....*....|....*....|....*.
gi 1622958373 284 VDLYGFGADS--KGNWH-----HYWE 302
Cdd:cd23977   156 ILVYGMVSDSycRNKNHssvpyHYYE 181
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 139-288 1.16e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 94.23  E-value: 1.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMIL--VPFKTIDLEW 216
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAILLLagTRAPTVVVFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 217 VVSATTTGTIShTYVPVPAKIRVKQDKILIYHPAFIKY-----VFDN-----------WLqghgrypSTGILSVIFSMHV 280
Cdd:cd23965    81 GPETKMNKDGA-GKYNLLRSLSKKYPDVEFYSLTPEKMdyadeLFEKetgksriksgtWL-------STGWFTMLLALDV 152


                  ....*...
gi 1622958373 281 CDEVDLYG 288
Cdd:cd23965   153 CDEIKVYG 160
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 129-304 3.00e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 95.20  E-value: 3.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 129 DPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE-------SFRELGDN 201
Cdd:cd23974    74 WWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNtlmnslrAYAGVGFN 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 202 -------VSMILVPFKTIDLEWVVSATTtgtisHTYVPV-------PAK---IRVKQDKILIYHPAFIKYVFDNWLQ--- 261
Cdd:cd23974   154 gppqskeTRYIFLPDHDRDYLLVKAALT-----HTPIDRgrdkskrPSKyfgKDVTAEKFKIYHPDFIRYLRNRFLWspi 228

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622958373 262 ---GHGRY--PSTGILSVIFSMHVCDEVDLYGFGADSKGNWH-HYWENN 304
Cdd:cd23974   229 lntKQRDIyrPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSdHYYDKT 277
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 103-307 4.42e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 94.02  E-value: 4.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 103 RLQREKKPNNLNDTIKELFRVVPgNVDPMLEKRSvgcRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVG 182
Cdd:cd23969    32 RMHYEIDRHKTVNITQDLYQLLP-EVSPLKGKHF---RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 183 TK----TTHHLVYPESF----------------RELGDnvSMILVP-FKTIDLEWVVSATTTgTISHTYVPVpakirvkq 241
Cdd:cd23969   108 TKsnltTMNPSVIPHAYgdlvnatdkekfverlRQLGD--SILWIPaFVSKGGEEHVQWTNE-IILKHKLNV-------- 176

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622958373 242 dKILIYHPAFIKYVFDNWLQG--HGRYPSTGILSVIFSMHVCDEVDLYG---FGADSKGN--WHHYWENNPSA 307
Cdd:cd23969   177 -KTAYPPLRLNHAIRGYWLTTkfRIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRavKYHYYDNRKYL 248
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 141-317 3.32e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 91.55  E-value: 3.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 141 RCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAgFEADVGTKTthHLVYPesfrelgdNVSMILVPFKTidLEW---- 216
Cdd:cd23971    66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT--NLVTA--------NPSILREKFHN--LKKrrrp 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 217 -VVSATTTGtisHTYVPVPA---------KIRVK--------QDKILIYHPAFIKYVFDNWL-QG-HGRYPSTGILSVIF 276
Cdd:cd23971   133 fVERMKVYG---NALLLLPAfsytsntepSLRALytledfgsPQKVLFFNPEYLRNLSRYWKsKGlKARRLSTGLMLVSA 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1622958373 277 SMHVCDEVDLYGF---GADSKGNW--HHYWENNPSagafrKTGVHD 317
Cdd:cd23971   210 ALELCENVHLYGFwpfSTDLDGNPisHHYYDNVLP-----KKGVHA 250
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 140-303 4.07e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 91.30  E-value: 4.07e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 140 RRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMI---------LVPFK 210
Cdd:cd23970    69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIqdrnnfflsLKKLD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 211 TIDLeWV------VSATTTGTISHTYVPVPAKIRVKqdkiLIYHPAFIKYVFDNWLQGHG--RYPSTGILSVIFSMHVCD 282
Cdd:cd23970   149 GAIL-WIpafffhTSATVTRTLVDFFVEHRGQLKVQ----LAWPGNIMQHVNRYWKTKHLspKRLSTGILMYTLASAICE 223

                         170       180
                  ....*....|....*....|....*.
gi 1622958373 283 EVDLYGF---GADSKGNW--HHYWEN 303
Cdd:cd23970   224 EIHLYGFwpfGFDPTGTPlpYHYYDK 249
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 118-316 5.90e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 90.58  E-value: 5.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 118 KELFRVVPGNvDPMlekRSVGCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAG-FEADVGTKTthHLVYPesfr 196
Cdd:cd23991    47 ENIFRMFPKS-QPF---RGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKT--NLVTA---- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 197 elgdNVSMILVPFKTIDLEWVVSATTTGTISHTYVPVPA------------------KIRVKQdKILIYHPAFIKYVFDN 258
Cdd:cd23991   117 ----NPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAfsyrsntalsfkvyytleDFKAKQ-KVIFFHPIYLKHLAQF 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622958373 259 WL-QGHGRYP-STGILSVIFSMHVCDEVDLYGFGADSKGN-----WHHYWENNPSagafrKTGVH 316
Cdd:cd23991   192 WRsKGVQVYRlSTGLMITSAALELCEEVKLYGFWPFSKNTegkpiSHHYYDNQLP-----KPGFH 251
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 128-303 8.86e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 87.70  E-value: 8.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 128 VDPMLEKRSvgcRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPE-------SFRELGD 200
Cdd:cd23988    56 VSPMKNRRF---KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafgGFRNESD 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 201 NVSMILVPFKTID-LEWVVSATTTGTISHTYVpVPAKIRVKQDKILIYHPA--FIKYVFDNWLQG--HGRYPSTGILSVI 275
Cdd:cd23988   133 REKFVHRLSMLNDsVLWIPAFMVKGGEKHVEW-VNALILKNKLKVRTAYPSlrLIHAVRGYWLTNkvNIKRPSTGLLMYT 211

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622958373 276 FSMHVCDEVDLYG---FGADSKGN--WHHYWEN 303
Cdd:cd23988   212 LATRFCDEIHLYGfwpFPKDANGNpvKYHYYDD 244
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 140-310 2.06e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 86.42  E-value: 2.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 140 RRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAP-TAGFEADVGTKTthHLVYPesfrelgdNVSMILVPFKTIDLEWVV 218
Cdd:cd23989    64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT--QLVTA--------NPSIIDKRFQNLLWSRKS 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 219 SATTTGTISHTYVPVPA---------KIRVKQ--------DKILIYHPAFIKYVFDNWLQG--HGRYPSTGILSVIFSMH 279
Cdd:cd23989   134 FVESMKVYGRSYIYMPAfsmktgtdpSLRVYYtladvganQTVLFANPNFLRNVGKFWKSKgvHAKRLSTGLFLVSAALG 213

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1622958373 280 VCDEVDLYGF-----GADSKGNWHHYWENNPSAGAF 310
Cdd:cd23989   214 LCEEVTIYGFwpfsvDLDERTISHHYYDNVLPDSGF 249
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 140-289 2.46e-19

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 86.30  E-value: 2.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 140 RRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTT-----HHLVYPESFRELGDNV--SMILV----- 207
Cdd:cd23985    46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTirlinSQLVTTEKHKFLKDSLynEGILIvwdpa 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 208 PFKTIDLEWVVSatTTGTISHTYvpvpAKIRVKQDKILIY--HPAFIKYVFDNWLQGHGRY-----PSTGILSVIFSMHV 280
Cdd:cd23985   126 PYHSDIPEWYKN--PDYNFFENY----KTYRRLNPNQPFYilHPQMQWELWDIIQENSPEEiqpnpPSSGMLGIILMMTL 199


                  ....*....
gi 1622958373 281 CDEVDLYGF 289
Cdd:cd23985   200 CDQVDVYEF 208
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 103-303 5.86e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 76.80  E-value: 5.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 103 RLQREKKPNNLNDTIKELFRVVPgnvDPMLEKRSvGCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAP-TAGFEADV 181
Cdd:cd23990    32 KLKYEVDTSGIYHINSEIFKMFP---KDMPYSRS-QFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 182 GTKTTHHLVYPESFRELGDNVSMILVPFKTIdLEWVVSATTTGTISHTYVPVPAKIRVK--------QDKILIYHPAFIK 253
Cdd:cd23990   108 GVKTDVVTINPSIITERFHKLEKWRRPFYEV-LQVYENASVVLPAFYNTRNTDVSIRVKyvlddfesQQAVYYFHPQYLL 186

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622958373 254 YVFDNWL-QG-HGRYPSTGILSVIFSMHVCDEVDLYGFGA---DSKGNW--HHYWEN 303
Cdd:cd23990   187 NVSRFWLrQGvRAKRISSGLMLVTAALELCEEVHLYGFWAfpmNPSGIFitHHYYDN 243
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 138-289 1.86e-15

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 75.26  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 138 GCRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTT-------------HHLVYPESFRELgdnvsm 204
Cdd:cd23986    48 GFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnpnHHFIDSSLYKDV------ 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 205 ILV-----PFKTIDLEWVVSATTtgtisHTYVP-VPAKIRVKQDKILIYHPAFIKYVFDnWLQGHGRY------PSTGIL 272
Cdd:cd23986   122 ILVawdpaPYSANLHKWYKKPDY-----NLFTPyVQYRKRNPNQPFYILHPKFIWQLWD-IIQENTQEkiqpnpPSSGFI 195

                         170
                  ....*....|....*..
gi 1622958373 273 SVIFSMHVCDEVDLYGF 289
Cdd:cd23986   196 GILIMMSMCREVHVYEY 212
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 118-289 5.79e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 73.82  E-value: 5.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 118 KELFRVVPgNVDPMLEKRSvgcRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYP----E 193
Cdd:cd23987    47 QNLYELLP-RTSPLKNKHF---KTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPsvvqR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 194 SFRELGD--------------NVSMILVPFKTID-----LEWVVSATTTGTIShtyvpvpakIRVKQDKILIYHPafiky 254
Cdd:cd23987   123 AFEDLVNetwkekflqrlqslNGSILWIPAFMAKggeerVEWVNDLILKHHIN---------VRTAYPSLRLLHA----- 188

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622958373 255 VFDNWLQG--HGRYPSTGILSVIFSMHVCDEVDLYGF 289
Cdd:cd23987   189 VRGYWLTNkvHIKRPTTGLLMYTLATRFCNRIHLYGF 225
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 139-302 1.67e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 71.89  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPES-----------FRELGDNVSMILV 207
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSvplllknpdyfFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 208 PFKTI--DLEWVVSATTTGTIShTYvpVPAKIRVKQDKILIYHPA-FIKYVFDNWLQGhGRYPSTGILSVIFSMHVCDEV 284
Cdd:cd23975    81 PFRNMrkDGKGIVYNMLKKAVE-SY--PQAKIYVTTEKRMSYCDTvFKKETGKDRVQS-GSYLSTGWFTLILAMDACYGI 156

                         170       180
                  ....*....|....*....|....*
gi 1622958373 285 DLYGFGADS-------KGNWHHYWE 302
Cdd:cd23975   157 HVYGMINDTycktegyRKVPYHYYE 181
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 139-288 2.84e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 71.04  E-value: 2.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTT-----HHLVY-----PESFRELGDNVSMIL-- 206
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTlrvvaHSSVYrvlrrPQEFLNRTPETTLIFwg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 207 ------VPFKTIDLEWVVSATTTGTISHTYVPVPAKIRvkqdkiliyhpafikyVFDNWLQGH-GR-------YPSTGIL 272
Cdd:cd23978    81 ppnkmqKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMR----------------QFDDLFRGEtGRdrkkshsWLSTGWF 144

                         170
                  ....*....|....*.
gi 1622958373 273 SVIFSMHVCDEVDLYG 288
Cdd:cd23978   145 TMVIAVELCDNVHVYG 160
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 139-288 1.01e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 58.34  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 139 CRRCAVVGNSGNLRESSYGPEIDRHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMIL-VPFKTIDLEWV 217
Cdd:cd23976    15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELLnVSQGTVFIFWG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622958373 218 VSATTTG----------TISHTYVPVPAKIRVKQDKILIYHPAFIK------YVFDNWLqghgrypSTGILSVIFSMHVC 281
Cdd:cd23976    95 PSNYMRRdgkglvynnlQLMNQILPKLKVYTITRHKMLQFDELFKRetgkdrKISNTWL-------STGWFTMIIALELC 167


                  ....*..
gi 1622958373 282 DEVDLYG 288
Cdd:cd23976   168 DRINVYG 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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