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Conserved domains on  [gi|1622957880|ref|XP_028707909|]
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neurexin 3 isoform X24 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
286-417 3.07e-34

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 128.23  E-value: 3.07e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   286 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957880   364 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 417
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
903-1031 8.34e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.77  E-value: 8.34e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  903 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 982
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957880  983 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1031
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
474-623 2.84e-30

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 2.84e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   474 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 553
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957880   554 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 623
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.37e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 3.37e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957880  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
712-846 1.64e-21

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.63  E-value: 1.64e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   712 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 790
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   791 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 846
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1095-1274 6.81e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.56  E-value: 6.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1095 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1174
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1175 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1254
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                          170       180
                   ....*....|....*....|
gi 1622957880 1255 GGKDKGRLFQGQLSGLYYDG 1274
Cdd:cd00110    124 GGLPEDLKSPGLPVSPGFVG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
651-684 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.52e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957880  651 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 684
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 1.88e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957880  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
4.1m super family cl02555
putative band 4.1 homologues' binding motif;
1417-1435 2.81e-03

putative band 4.1 homologues' binding motif;


The actual alignment was detected with superfamily member smart00294:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 2.81e-03
                            10
                    ....*....|....*....
gi 1622957880  1417 MYKYRNRDEGSYQVDETRN 1435
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1397-1453 4.73e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 4.73e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957880 1397 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1453
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
286-417 3.07e-34

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 128.23  E-value: 3.07e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   286 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957880   364 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 417
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
262-414 7.18e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 127.92  E-value: 7.18e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  262 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 339
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622957880  340 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 414
Cdd:cd00110     76 PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
903-1031 8.34e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.77  E-value: 8.34e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  903 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 982
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957880  983 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1031
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
291-414 2.76e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 122.53  E-value: 2.76e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  291 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRQVTISVDGILTTT 369
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1622957880  370 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 414
Cdd:pfam02210   79 SLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
876-1029 7.07e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.14  E-value: 7.07e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  876 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 953
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957880  954 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1029
Cdd:cd00110     78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
474-623 2.84e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 2.84e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   474 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 553
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957880   554 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 623
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
898-1031 3.18e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 3.18e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   898 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 976
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957880   977 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1031
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.37e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 3.37e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957880  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
452-621 5.97e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 113.67  E-value: 5.97e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  452 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 530
Cdd:cd00110      1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  531 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 609
Cdd:cd00110     68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                          170
                   ....*....|..
gi 1622957880  610 GYVGCIRDLFID 621
Cdd:cd00110    140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 8.42e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 109.74  E-value: 8.42e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880    50 DLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957880   129 G-QSGELQPQRPYMDVVSDLFLGGVPADIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
479-623 1.63e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  479 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 558
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957880  559 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 623
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.59e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.19  E-value: 1.59e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   55 FKTNVSTGLLLYLDDGGiCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957880  134 LQPQRPY-MDVVSDLFLGGVPADirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
712-846 1.64e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.63  E-value: 1.64e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   712 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 790
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   791 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 846
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1095-1274 6.81e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.56  E-value: 6.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1095 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1174
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1175 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1254
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                          170       180
                   ....*....|....*....|
gi 1622957880 1255 GGKDKGRLFQGQLSGLYYDG 1274
Cdd:cd00110    124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1126-1274 1.81e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 85.55  E-value: 1.81e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1126 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1205
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957880 1206 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1274
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
1121-1274 3.53e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.08  E-value: 3.53e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  1121 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1200
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  1201 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 1270
Cdd:smart00282   80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                    ....
gi 1622957880  1271 YYDG 1274
Cdd:smart00282  128 KVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
717-846 7.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.31  E-value: 7.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  717 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 796
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957880  797 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 846
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
690-845 6.60e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.30  E-value: 6.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  690 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 769
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  770 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 842
Cdd:cd00110     72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                   ...
gi 1622957880  843 MFN 845
Cdd:cd00110    149 KVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
651-684 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.52e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957880  651 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 684
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 1.88e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957880  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
651-682 8.78e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 8.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622957880  651 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 682
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-684 1.95e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.95e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1622957880   651 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 684
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1417-1435 2.81e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 2.81e-03
                            10
                    ....*....|....*....
gi 1622957880  1417 MYKYRNRDEGSYQVDETRN 1435
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1397-1453 4.73e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 4.73e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957880 1397 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1453
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 8.40e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 8.40e-03
                           10        20
                   ....*....|....*....|....*....
gi 1622957880  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
286-417 3.07e-34

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 128.23  E-value: 3.07e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   286 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVD 363
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1622957880   364 GILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 417
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
262-414 7.18e-34

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 127.92  E-value: 7.18e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  262 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 339
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622957880  340 KFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 414
Cdd:cd00110     76 PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
903-1031 8.34e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.77  E-value: 8.34e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  903 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 982
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957880  983 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1031
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
291-414 2.76e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 122.53  E-value: 2.76e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  291 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRQVTISVDGILTTT 369
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1622957880  370 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 414
Cdd:pfam02210   79 SLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
876-1029 7.07e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.14  E-value: 7.07e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  876 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 953
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957880  954 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1029
Cdd:cd00110     78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
474-623 2.84e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 2.84e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   474 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 553
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957880   554 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 623
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
898-1031 3.18e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 3.18e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   898 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 976
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957880   977 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1031
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.37e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.44  E-value: 3.37e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957880  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
452-621 5.97e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 113.67  E-value: 5.97e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  452 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 530
Cdd:cd00110      1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  531 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 609
Cdd:cd00110     68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                          170
                   ....*....|..
gi 1622957880  610 GYVGCIRDLFID 621
Cdd:cd00110    140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 8.42e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 109.74  E-value: 8.42e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880    50 DLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957880   129 G-QSGELQPQRPYMDVVSDLFLGGVPADIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
479-623 1.63e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  479 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 558
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957880  559 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 623
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.59e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.19  E-value: 1.59e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   55 FKTNVSTGLLLYLDDGGiCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957880  134 LQPQRPY-MDVVSDLFLGGVPADirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
903-1031 3.12e-22

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 93.92  E-value: 3.12e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  903 FKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSdrPLNDNQWHNVVITRDNSNThSLKVD---TK 978
Cdd:pfam00054    1 FRTTEPSGLLLYNgTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD--KLNDGKWHSVELERNGRSG-TLSVDgeaRP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622957880  979 VVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKlvASRDGFQGCLASVDLNGR 1031
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGLPSLGVKKRRL--AISPSFDGCIRDVIVNGK 128
LamG smart00282
Laminin G domain;
712-846 1.64e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.63  E-value: 1.64e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   712 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 790
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   791 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 846
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1095-1274 6.81e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.56  E-value: 6.81e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1095 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1174
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1175 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1254
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                          170       180
                   ....*....|....*....|
gi 1622957880 1255 GGKDKGRLFQGQLSGLYYDG 1274
Cdd:cd00110    124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_1 pfam00054
Laminin G domain;
291-416 3.75e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 87.76  E-value: 3.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  291 FKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGAfeaIVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTT 368
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRLEVSYDLGSGA---AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1622957880  369 TGYTQEDYTMLGS-DDFFYVGGSPSTADLP-GSPVSNNFMGCLKEVVYKN 416
Cdd:pfam00054   78 TGESPLGATTDLDvDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNG 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1126-1274 1.81e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 85.55  E-value: 1.81e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1126 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1205
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957880 1206 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1274
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
479-623 2.32e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 85.45  E-value: 2.32e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  479 FRTTEPNGLILFThgkpqerkdarsQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQkKANDGEWYHVDIQRDGRSG 558
Cdd:pfam00054    1 FRTTEPSGLLLYN------------GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSG 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957880  559 TISVNSRRTPFTAS--GESEILDLEGDMYLGGLPEnragliLPTELWTAMLNYGYVGCIRDLFIDGR 623
Cdd:pfam00054   68 TLSVDGEARPTGESplGATTDLDVDGPLYVGGLPS------LGVKKRRLAISPSFDGCIRDVIVNGK 128
LamG smart00282
Laminin G domain;
1121-1274 3.53e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.08  E-value: 3.53e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  1121 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1200
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  1201 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 1270
Cdd:smart00282   80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                    ....
gi 1622957880  1271 YYDG 1274
Cdd:smart00282  128 KVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
717-846 7.13e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.31  E-value: 7.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  717 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 796
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957880  797 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 846
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
690-845 6.60e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.30  E-value: 6.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  690 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 769
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  770 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 842
Cdd:cd00110     72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                   ...
gi 1622957880  843 MFN 845
Cdd:cd00110    149 KVN 151
Laminin_G_1 pfam00054
Laminin G domain;
724-846 3.25e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.25e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  724 GLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD-DVAE 802
Cdd:pfam00054    8 GLLLYNGTQTERDFLALELRDGRLEVSYDL---------GSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGeARPT 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957880  803 GTMVgdHTRLEFHNIETGIM-------TEKRYISVVPSSFIGHLQSLMFNG 846
Cdd:pfam00054   79 GESP--LGATTDLDVDGPLYvgglpslGVKKRRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
55-183 3.48e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880   55 FKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGEL 134
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622957880  135 QPQRPYM--DVVSDLFLGGVPADI---RPSALTldgvqamPGFKGLILDLKYGN 183
Cdd:pfam00054   81 SPLGATTdlDVDGPLYVGGLPSLGvkkRRLAIS-------PSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
1126-1212 8.23e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 8.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880 1126 FSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEErTPVNDGKYHVVRFTRNGGNATLQVD-NWPVN 1204
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGAAVVRSG-DKLNDGKWHSVELERNGRSGTLSVDgEARPT 78

                   ....*...
gi 1622957880 1205 EHYPTGNT 1212
Cdd:pfam00054   79 GESPLGAT 86
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
651-684 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 1.52e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957880  651 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 684
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.88e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 1.88e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957880  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
651-682 8.78e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 8.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622957880  651 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 682
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
283-395 4.59e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 42.37  E-value: 4.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957880  283 SSDEITLSFktW------QRNGLILHTGKSADYVNLAL-KDGAVSLVINLGSGAFEAIVepVNGKFNDNAWHDVKVTRNL 355
Cdd:pfam13385   15 PTSDFTVSA--WvkpdslPGWARAIISSSGGGGYSLGLdGDGRLRFAVNGGNGGWDTVT--SGASVPLGQWTHVAVTYDG 90
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1622957880  356 RQVTISVDGILTTTGyTQEDYTMLGSDDFFYVGGSPSTAD 395
Cdd:pfam13385   91 GTLRLYVNGVLVGSS-TLTGGPPPGTGGPLYIGRSPGGDD 129
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
652-684 1.09e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 1.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622957880  652 DSYPCKNNAVCKDGWNRFICDCTgTGYWG-RTCE 684
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCP-PGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
651-684 1.95e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.95e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1622957880   651 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 684
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1417-1435 2.81e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 2.81e-03
                            10
                    ....*....|....*....
gi 1622957880  1417 MYKYRNRDEGSYQVDETRN 1435
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1397-1453 4.73e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 4.73e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957880 1397 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1453
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 8.40e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 8.40e-03
                           10        20
                   ....*....|....*....|....*....
gi 1622957880  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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