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Conserved domains on  [gi|1622957838|ref|XP_028707886|]
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neurexin 3 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
907-1035 4.53e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.53e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  907 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 986
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957838  987 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1035
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
282-421 8.02e-32

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 8.02e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   282 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 359
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622957838   360 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 421
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
478-627 2.39e-30

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.39e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   478 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 557
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957838   558 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 627
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.10e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.82  E-value: 3.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957838  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
716-850 1.29e-21

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.40  E-value: 1.29e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   716 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 794
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   795 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 850
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1108-1287 5.97e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.94  E-value: 5.97e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1108 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1187
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1188 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1267
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                          170       180
                   ....*....|....*....|
gi 1622957838 1268 GGKDKGRLFQGQLSGLYYDG 1287
Cdd:cd00110    124 GGLPEDLKSPGLPVSPGFVG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
655-688 9.87e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 9.87e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957838  655 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 688
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.34e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957838  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
4.1m super family cl02555
putative band 4.1 homologues' binding motif;
1638-1656 3.23e-03

putative band 4.1 homologues' binding motif;


The actual alignment was detected with superfamily member smart00294:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 3.23e-03
                            10
                    ....*....|....*....
gi 1622957838  1638 MYKYRNRDEGSYQVDETRN 1656
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan super family cl20212
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1618-1674 5.45e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


The actual alignment was detected with superfamily member pfam01034:

Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 5.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957838 1618 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1674
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
907-1035 4.53e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.53e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  907 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 986
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957838  987 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1035
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
880-1033 5.67e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 5.67e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  880 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 957
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957838  958 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1033
Cdd:cd00110     78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
282-421 8.02e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 8.02e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   282 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 359
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622957838   360 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 421
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
258-418 2.27e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.99  E-value: 2.27e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  258 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 335
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  336 KFNDNAWHDVKVTRNLRQhsgighamVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 415
Cdd:cd00110     76 PLNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRD 147

                   ...
gi 1622957838  416 VVY 418
Cdd:cd00110    148 LKV 150
LamG smart00282
Laminin G domain;
478-627 2.39e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.39e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   478 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 557
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957838   558 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 627
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
287-418 5.21e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.98  E-value: 5.21e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  287 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRqhsgighaMVTIS 365
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGN--------TLTLS 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622957838  366 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 418
Cdd:pfam02210   71 VDGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG smart00282
Laminin G domain;
902-1035 2.38e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.36  E-value: 2.38e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   902 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 980
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957838   981 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1035
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.10e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.82  E-value: 3.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957838  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
456-625 5.71e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  456 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 534
Cdd:cd00110      1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  535 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 613
Cdd:cd00110     68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                          170
                   ....*....|..
gi 1622957838  614 GYVGCIRDLFID 625
Cdd:cd00110    140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 6.61e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.12  E-value: 6.61e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838    50 DLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957838   129 G-QSGELQPQRPYMDVVSDLFLGGVPADIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
483-627 1.00e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.00e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  483 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 562
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957838  563 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 627
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.01e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.96  E-value: 1.01e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   55 FKTNVSTGLLLYLDDGGiCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957838  134 LQPQRPY-MDVVSDLFLGGVPADirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
716-850 1.29e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.40  E-value: 1.29e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   716 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 794
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   795 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 850
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1108-1287 5.97e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.94  E-value: 5.97e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1108 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1187
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1188 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1267
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                          170       180
                   ....*....|....*....|
gi 1622957838 1268 GGKDKGRLFQGQLSGLYYDG 1287
Cdd:cd00110    124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1139-1287 1.18e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 1.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1139 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1218
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957838 1219 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1287
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
1134-1287 2.86e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.47  E-value: 2.86e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  1134 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1213
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  1214 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 1283
Cdd:smart00282   80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                    ....
gi 1622957838  1284 YYDG 1287
Cdd:smart00282  128 KVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
721-850 5.18e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 5.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  721 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 800
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957838  801 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 850
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
694-849 6.20e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.69  E-value: 6.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  694 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 773
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  774 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 846
Cdd:cd00110     72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                   ...
gi 1622957838  847 MFN 849
Cdd:cd00110    149 KVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
655-688 9.87e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 9.87e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957838  655 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 688
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.34e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957838  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
655-686 6.18e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 6.18e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622957838  655 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 686
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
655-688 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1622957838   655 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 688
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1638-1656 3.23e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 3.23e-03
                            10
                    ....*....|....*....
gi 1622957838  1638 MYKYRNRDEGSYQVDETRN 1656
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1618-1674 5.45e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 5.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957838 1618 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1674
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 6.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|....*....
gi 1622957838  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
907-1035 4.53e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 127.54  E-value: 4.53e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  907 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNsNTHSLKVDTKVVTQ 986
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLL-SSGKNLNDGQWHSVRVERNG-NTLTLSVDGQTVVS 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957838  987 VINGAKN--LDLKGDLYMAGLaqgMYSNLPKLVASRDGFQGCLASVDLNGR 1035
Cdd:pfam02210   79 SLPPGESllLNLNGPLYLGGL---PPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
880-1033 5.67e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 122.53  E-value: 5.67e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  880 PVTFkTKSSYLSLATLQA-YTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgnSDRPL 957
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLVLS--SKTPL 77
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957838  958 NDNQWHNVVITRDNSNTHsLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMysnLPKLVASRDGFQGCLASVDLN 1033
Cdd:cd00110     78 NDGQWHSVSVERNGRSVT-LSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDL---KSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
282-421 8.02e-32

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 121.29  E-value: 8.02e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   282 EITLSFKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGafEAIVEPVNGKFNDNAWHDVKVTRNLRQhsgigh 359
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRS------ 72
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622957838   360 amVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNN 421
Cdd:smart00282   73 --VTLSVDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
258-418 2.27e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.99  E-value: 2.27e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  258 VATFRGSEYLCYDLSQNPIQSSSdeITLSFKTWQRNGLILHTG--KSADYVNLALKDGAVSLVINLGSGafEAIVEPVNg 335
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLS--ISFSFRTTSPNGLLLYAGsqNGGDFLALELEDGRLVLRYDLGSG--SLVLSSKT- 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  336 KFNDNAWHDVKVTRNLRQhsgighamVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 415
Cdd:cd00110     76 PLNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRD 147

                   ...
gi 1622957838  416 VVY 418
Cdd:cd00110    148 LKV 150
LamG smart00282
Laminin G domain;
478-627 2.39e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 117.06  E-value: 2.39e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   478 SISFDFRTTEPNGLILFTHGKPQerkdarsqkntkVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQR 557
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG------------GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVER 68
                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622957838   558 DGRSGTISVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNYGYVGCIRDLFIDGR 627
Cdd:smart00282   69 NGRSVTLSVDgGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV-------TPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
287-418 5.21e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.98  E-value: 5.21e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  287 FKTWQRNGLILHTG-KSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNgkFNDNAWHDVKVTRNLRqhsgighaMVTIS 365
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKN--LNDGQWHSVRVERNGN--------TLTLS 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622957838  366 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVY 418
Cdd:pfam02210   71 VDGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG smart00282
Laminin G domain;
902-1035 2.38e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.36  E-value: 2.38e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   902 HLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKgNSDRPLNDNQWHNVVITRDNSNTHsLKVD 980
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSGPARLT-SDPTPLNDGQWHRVAVERNGRSVT-LSVD 78
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957838   981 -TKVVTQVINGAK-NLDLKGDLYMAGLAQgmySNLPKLVASRDGFQGCLASVDLNGR 1035
Cdd:smart00282   79 gGNRVSGESPGGLtILNLDGPLYLGGLPE---DLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
35-181 3.10e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.82  E-value: 3.10e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   35 NQWARYLRWDA-STRSDLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLM 113
Cdd:cd00110      7 SSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVS 86
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957838  114 VSRDRLRTVLMLDGEGQ-SGELQPQRPYMDVVSDLFLGGVPADIRPSALTLdgvqaMPGFKGLILDLKY 181
Cdd:cd00110     87 VERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-----SPGFVGCIRDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
456-625 5.71e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 114.05  E-value: 5.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  456 PINFETPeAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQErkdarsqkntkvDFFAVELLDGNLYLLLDMGSG 534
Cdd:cd00110      1 GVSFSGS-SYVRLPTLpAPRTRLSISFSFRTTSPNGLLLYAGSQNGG------------DFLALELEDGRLVLRYDLGSG 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  535 TIKVKATQKKaNDGEWYHVDIQRDGRSGTISVNSRRT-PFTASGESEILDLEGDMYLGGLPENRAGLILPTelwtamlNY 613
Cdd:cd00110     68 SLVLSSKTPL-NDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-------SP 139
                          170
                   ....*....|..
gi 1622957838  614 GYVGCIRDLFID 625
Cdd:cd00110    140 GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
50-183 6.61e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.12  E-value: 6.61e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838    50 DLSFQFKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGE 128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSdPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957838   129 G-QSGELQPQRPYMDVVSDLFLGGVPADIRPSALTLDgvqamPGFKGLILDLKYGN 183
Cdd:smart00282   81 NrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNG 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
483-627 1.00e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.00e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  483 FRTTEPNGLILFTHGKPQerkdarsqkntkvDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSG 562
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-------------DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957838  563 TISVNSRRT-PFTASGESEILDLEGDMYLGGLPEnraglilPTELWTAMLNYGYVGCIRDLFIDGR 627
Cdd:pfam02210   68 TLSVDGQTVvSSLPPGESLLLNLNGPLYLGGLPP-------LLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
55-183 1.01e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 100.96  E-value: 1.01e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   55 FKTNVSTGLLLYLDDGGiCDFLCLSLVDGRVQLRFSMDCAETAVLS-NKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGE 133
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG-SDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957838  134 LQPQRPY-MDVVSDLFLGGVPADirpsaLTLDGVQAMPGFKGLILDLKYGN 183
Cdd:pfam02210   80 LPPGESLlLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
907-1035 3.65e-22

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 93.92  E-value: 3.65e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  907 FKTTSPDGFILFN-SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSdrPLNDNQWHNVVITRDNSNThSLKVD---TK 982
Cdd:pfam00054    1 FRTTEPSGLLLYNgTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD--KLNDGKWHSVELERNGRSG-TLSVDgeaRP 77
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622957838  983 VVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKlvASRDGFQGCLASVDLNGR 1035
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGLPSLGVKKRRL--AISPSFDGCIRDVIVNGK 128
LamG smart00282
Laminin G domain;
716-850 1.29e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 92.40  E-value: 1.29e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   716 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCirincnsskGPETLYAGQ-KLNDNEWHTVRVVRRGK 794
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---------GPARLTSDPtPLNDGQWHRVAVERNGR 71
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   795 SLKLTVDD-DVAEGTMVGDHTRLEFH-NIETG--IMTEKRYISVVPSSFIGHLQSLMFNG 850
Cdd:smart00282   72 SVTLSVDGgNRVSGESPGGLTILNLDgPLYLGglPEDLKLPPLPVTPGFRGCIRNLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
1108-1287 5.97e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 90.94  E-value: 5.97e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1108 TYIFGKSGGLILYTWPAndrpSTRSDRLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEEr 1187
Cdd:cd00110      1 GVSFSGSSYVRLPTLPA----PRTRLSISFSFRTTSPNGLLLYAGSQNG-GDFLALELEDGRLVLRYDLGSGSLVLSSK- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1188 TPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHyptgntdnerfqmvkqkipfkynrpveewlqEKGRQLTIFNTQAQIAI 1267
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVES-------------------------------GSPGGSALLNLDGPLYL 123
                          170       180
                   ....*....|....*....|
gi 1622957838 1268 GGKDKGRLFQGQLSGLYYDG 1287
Cdd:cd00110    124 GGLPEDLKSPGLPVSPGFVG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
1139-1287 1.18e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 1.18e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1139 FSTTVKDGILvrIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 1218
Cdd:pfam02210    1 FRTRQPNGLL--LYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957838 1219 HYPTGNTDnerfqmvkqkipfkynrpveewlqekgrqltIFNTQAQIAIGGKDKGRL---------FQGQLSGLYYDG 1287
Cdd:pfam02210   79 SLPPGESL-------------------------------LLNLNGPLYLGGLPPLLLlpalpvragFVGCIRDVRVNG 125
LamG smart00282
Laminin G domain;
1134-1287 2.86e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.47  E-value: 2.86e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  1134 RLAVGFSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 1213
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG-GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDG 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  1214 -WPVNEHYPTGntdnerfqmvkqkipfkynrpveewlqekgrqLTIFNTQAQIAIGGKDKGRL---------FQGQLSGL 1283
Cdd:smart00282   80 gNRVSGESPGG--------------------------------LTILNLDGPLYLGGLPEDLKlpplpvtpgFRGCIRNL 127

                    ....
gi 1622957838  1284 YYDG 1287
Cdd:smart00282  128 KVNG 131
Laminin_G_1 pfam00054
Laminin G domain;
483-627 2.93e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 85.45  E-value: 2.93e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  483 FRTTEPNGLILFThgkpqerkdarsQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQkKANDGEWYHVDIQRDGRSG 562
Cdd:pfam00054    1 FRTTEPSGLLLYN------------GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSG 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957838  563 TISVNSRRTPFTAS--GESEILDLEGDMYLGGLPEnragliLPTELWTAMLNYGYVGCIRDLFIDGR 627
Cdd:pfam00054   68 TLSVDGEARPTGESplGATTDLDVDGPLYVGGLPS------LGVKKRRLAISPSFDGCIRDVIVNGK 128
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
721-850 5.18e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 81.70  E-value: 5.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  721 FMSQRAYGLLVATTSRDSaDTLRLELDGGRVKLMVNLdcirincnSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 800
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDL--------GSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957838  801 DDDVAEGTMvgDHTRLEFHNIETGI------MTEKRYISVVPSSFIGHLQSLMFNG 850
Cdd:pfam02210   72 DGQTVVSSL--PPGESLLLNLNGPLylgglpPLLLLPALPVRAGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
287-420 1.56e-17

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 80.44  E-value: 1.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  287 FKTWQRNGLILHTGKSA--DYVNLALKDGAVSLVINLGSGAfeaIVEPVNGKFNDNAWHDVKVTRNLRQhsgighamVTI 364
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRLEVSYDLGSGA---AVVRSGDKLNDGKWHSVELERNGRS--------GTL 69
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957838  365 SVDGILTTTGYTQEDYTMLGS-DDFFYVGGSPSTADLP-GSPVSNNFMGCLKEVVYKN 420
Cdd:pfam00054   70 SVDGEARPTGESPLGATTDLDvDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNG 127
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
694-849 6.20e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 76.69  E-value: 6.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  694 LSYDGSMYMKIIMPMVMHTEaEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETL 773
Cdd:cd00110      2 VSFSGSSYVRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDL---------GSGSLVL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  774 YAGQKLNDNEWHTVRVVRRGKSLKLTVDDD-VAEGTMVGDHTRLefhNIETGI------MTEKRYISVVPSSFIGHLQSL 846
Cdd:cd00110     72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGErVVESGSPGGSALL---NLDGPLylgglpEDLKSPGLPVSPGFVGCIRDL 148

                   ...
gi 1622957838  847 MFN 849
Cdd:cd00110    149 KVN 151
Laminin_G_1 pfam00054
Laminin G domain;
728-850 3.77e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 3.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838  728 GLLVATTSRDSADTLRLELDGGRVKLMVNLdcirincnsSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD-DVAE 806
Cdd:pfam00054    8 GLLLYNGTQTERDFLALELRDGRLEVSYDL---------GSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGeARPT 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622957838  807 GTMVgdHTRLEFHNIETGIM-------TEKRYISVVPSSFIGHLQSLMFNG 850
Cdd:pfam00054   79 GESP--LGATTDLDVDGPLYvgglpslGVKKRRLAISPSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
55-183 4.15e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 4.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838   55 FKTNVSTGLLLYLDDGGICDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGEL 134
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622957838  135 QPQRPYM--DVVSDLFLGGVPADI---RPSALTldgvqamPGFKGLILDLKYGN 183
Cdd:pfam00054   81 SPLGATTdlDVDGPLYVGGLPSLGvkkRRLAIS-------PSFDGCIRDVIVNG 127
Laminin_G_1 pfam00054
Laminin G domain;
1139-1225 9.44e-07

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 9.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957838 1139 FSTTVKDGILVRIDSAPGlGDFLQLHIEQGKIGVVFNIGTVDISIKEErTPVNDGKYHVVRFTRNGGNATLQVD-NWPVN 1217
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE-RDFLALELRDGRLEVSYDLGSGAAVVRSG-DKLNDGKWHSVELERNGRSGTLSVDgEARPT 78

                   ....*...
gi 1622957838 1218 EHYPTGNT 1225
Cdd:pfam00054   79 GESPLGAT 86
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
655-688 9.87e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 9.87e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622957838  655 CDSY-PCKNNAVCKDGWNRFICDCTgTGYWGRTCE 688
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
202-232 1.34e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 1.34e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622957838  202 CGERPCENGGICFLLDGHPTCDCStTGYGGK 232
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
655-686 6.18e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 6.18e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622957838  655 CDSYPCKNNAVCKDGWNRFICDCTgTGYWGRT 686
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
656-688 7.30e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 7.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622957838  656 DSYPCKNNAVCKDGWNRFICDCTgTGYWG-RTCE 688
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCP-PGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
655-688 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1622957838   655 CDSY-PCKNNAVCKDGWNRFICDCtGTGYW-GRTCE 688
Cdd:smart00179    5 CASGnPCQNGGTCVNTVGSYRCEC-PPGYTdGRNCE 39
4.1m smart00294
putative band 4.1 homologues' binding motif;
1638-1656 3.23e-03

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 36.35  E-value: 3.23e-03
                            10
                    ....*....|....*....
gi 1622957838  1638 MYKYRNRDEGSYQVDETRN 1656
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
Syndecan pfam01034
Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are ...
1618-1674 5.45e-03

Syndecan domain; Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.


Pssm-ID: 460035  Cd Length: 63  Bit Score: 36.99  E-value: 5.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957838 1618 GMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRnyisnsaQSNGTLMKEKQQ 1674
Cdd:pfam01034   11 AVIGGGVVGLLFAVLLVMFLVYRMKKKDEGSYALDEPK-------QANNYYTKAPTK 60
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
206-234 6.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|....*....
gi 1622957838  206 PCENGGICFLLDGHPTCDCStTGYGGKLC 234
Cdd:cd00054     10 PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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