|
Name |
Accession |
Description |
Interval |
E-value |
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
656-1142 |
0e+00 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 778.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 656 KIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIPATY 735
Cdd:TIGR00614 1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 736 LTGDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASNRLISTLEnlyERKLLARFVIDEAHCVSQWGHDFRQDYKRMNM 815
Cdd:TIGR00614 81 LNSAQTKEQQLNVLTDL--KDGKIKLLYVTPEKISASNRLLQTLE---ERKGITLIAVDEAHCISQWGHDFRPDYKALGS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 816 LRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPkKVAFDCLEWIRKHYPYDSGIIYCL 895
Cdd:TIGR00614 156 LKQKFPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTP-KILEDLLRFIRKEFEGKSGIIYCP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 896 SRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWInQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQE 975
Cdd:TIGR00614 235 SRKKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQ-RDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 976 SGRAGRDGEISHCLLFYTYHDVTRLKRLIIMEKDGNhhtRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCK 1055
Cdd:TIGR00614 314 SGRAGRDGLPSECHLFYAPADMNRLRRLLMEEPDGN---FRTYKLKLYEMMEYCLNSSTCRRLILLSYFGEKGFNKSFCI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1056 KHPDVSCDNCCKTKDYKTRDVTDDVKSIIRFVQEHSSSQGMRNvkhvgpsGRFTMNMLVDIFLGSKSAKIQSGIFGKGSA 1135
Cdd:TIGR00614 391 MGTEKCCDNCCKRLDYKTKDVTDKVYDFGPQAQKALSAVGRLN-------QKFGMGYPVDFLRGSNSQKIRDGGFRKHSL 463
|
....*..
gi 1622957628 1136 YSRHNAE 1142
Cdd:TIGR00614 464 YGRGKDE 470
|
|
| BLM_N |
pfam16202 |
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate ... |
1-367 |
0e+00 |
|
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate Bloom syndrome proteins. The exact function is not known.
Pssm-ID: 465064 Cd Length: 370 Bit Score: 577.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1 MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPPPDT 80
Cdd:pfam16202 1 MAAVPQNNLQEQLERHSARKLNNKLSLSKPKSSGFTFKKKTSSGNDVSVTSVSVAKTPVLSDKDVNVTEAFSFSEPLPHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 81 TNQQ-RVKDFFKNAPAGQQTQRVGSKPLLPDFLQTPKEVLCTTQNTPTVKKSQNTALKKLEFSSSPDSFRTINDWDDMDD 159
Cdd:pfam16202 81 TNQQtRINDFFKNAPAGQQTKRAGSKPLLPDSSQTPQEVSCTTQVTPAVKKPPDAVFKKLEFSSSFDSFISLNDWDDMDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 160 FDTSRTSKAFVTPPQSHFVRVSTAQKSKKAKRNFFKAQLYTTNTVKADLPPSFSESEQIDLTKEQKDDSEWLSSDVICID 239
Cdd:pfam16202 161 FDTSGNSKAFVTPPRNHFVRVSTAQKSKKSKRNFSKAQLSKANTVKADLTPSSGESKQVDLTKEQLDDSEWLSSDVICID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 240 DGPIDEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDIDFVPPSPEE--ISASSSSSKC 317
Cdd:pfam16202 241 DDPISEELINEDTQESHSLKTHLGDERDNSEKKKHLEETELHSVEKSPCVELNEDDYDIDFVPPSPEEevISSSSSSLKC 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1622957628 318 LSMLKDLDTSDRKEDVLSTSKDLLSKPEKMSTQEPNPETSTDCDARQINL 367
Cdd:pfam16202 321 FSMLKDLDTSDKEKDGLSTSEDLLSKPEKMTTQQPDQETSTDCDARQISL 370
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
653-1149 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 558.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 653 EMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIP 732
Cdd:COG0514 4 DALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAAGIR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 733 ATYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEkicasnRLIS--TLENLYERKLlARFVIDEAHCVSQWGHDFRQDY 810
Cdd:COG0514 84 AAFLNSSLSAEERREVLRALRAGE--LKLLYVAPE------RLLNprFLELLRRLKI-SLFAIDEAHCISQWGHDFRPDY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 811 KRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHYPyDSG 890
Cdd:COG0514 155 RRLGELRERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKPPDDKLAQLLDFLKEHPG-GSG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 891 IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGcQVICATIAFGMGIDKPDVRFVIHASLPKSME 970
Cdd:COG0514 234 IVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEV-DVIVATIAFGMGIDKPDVRFVIHYDLPKSIE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 971 GYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLiIMEKDGNHHTRETHFNNLYSMVHYCEnITECRRIQLLAYFGENGFN 1050
Cdd:COG0514 313 AYYQEIGRAGRDGLPAEALLLYGPEDVAIQRFF-IEQSPPDEERKRVERAKLDAMLAYAE-TTGCRRQFLLRYFGEELAE 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1051 PdfCKKhpdvsCDNCCKTKdyKTRDVTDDVKSIIRFvqehsssqgmrnVKHVGPsgRFTMNMLVDIFLGSKSAKIQS--- 1127
Cdd:COG0514 391 P--CGN-----CDNCLGPP--ETFDGTEAAQKALSC------------VYRTGQ--RFGAGHVIDVLRGSKNEKIRQfgh 447
|
490 500
....*....|....*....|....*
gi 1622957628 1128 ---GIFGKGSAYSRHNAERLFKKLI 1149
Cdd:COG0514 448 dklSTYGIGKDLSDKEWRSVIRQLL 472
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
642-1332 |
5.54e-152 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 492.87 E-value: 5.54e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 642 RFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVD 721
Cdd:PLN03137 436 KWSSRNFPWTKKLEVNNKKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQD 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 722 QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQ 801
Cdd:PLN03137 516 QIMNLLQANIPAASLSAGMEWAEQLEILQELSSEYSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAHCVSQ 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 802 WGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKkvafdCLE-- 879
Cdd:PLN03137 596 WGHDFRPDYQGLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTKK-----CLEdi 670
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 880 --WIRKHYPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDV 957
Cdd:PLN03137 671 dkFIKENHFDECGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQW-SKDEINIICATVAFGMGINKPDV 749
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 958 RFVIHASLPKSMEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLII--------MEKDGNHHTR-----ETHFNNLYS 1024
Cdd:PLN03137 750 RFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSDYIRVKHMISqggveqspMAMGYNRMASsgrilETNTENLLR 829
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1025 MVHYCENITECRRIQLLAYFGENgFNPDFCKKhpdvSCDNCCKTKDYKTRDVTDDVKSIIRFvqehsssqgmrnVKHVGP 1104
Cdd:PLN03137 830 MVSYCENEVDCRRFLQLVHFGEK-FDSTNCKK----TCDNCSSSKSLIDKDVTEIARQLVEL------------VKLTGE 892
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1105 sgRFTMNMLVDIFLGSKSAKIQS------GIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGN--KA 1176
Cdd:PLN03137 893 --RFSSAHILEVYRGSLNQYVKKhrhetlSLHGAGKHLSKGEASRILHYLVTEDILAEDVKKSDLYGSVSSLLKVNesKA 970
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1177 QTVLNGNLKV--DFMETENSSSVKKQKALVAKVSQRE------EMVKKCLGEL----------------TEVCKSLGKvf 1232
Cdd:PLN03137 971 YKLFSGGQTIimRFPSSVKASKPSKFEATPAKGPLTSgkqstlPMATPAQPPVdlnlsailytalrklrTALVKEAGD-- 1048
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1233 GVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVI----SVLQKY--SEWTSPAEDNSPGmslSGSR-- 1304
Cdd:PLN03137 1049 GVMAYHIFGNATLQQISKRIPRTKEELLEINGLGKAKVSKYGDRLLetieSTINEYykTDKNSSSSNDSPD---SGKRrr 1125
|
730 740 750
....*....|....*....|....*....|.
gi 1622957628 1305 --GPGRSTAEELDEEISVS-SHYFTSKTRNE 1332
Cdd:PLN03137 1126 deNINPNVAEDDDFTKSTSqSKKKTVKNKNK 1156
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
650-857 |
1.04e-147 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 446.97 E-value: 1.04e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 650 HTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSL 729
Cdd:cd18016 1 HSKEMMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 730 DIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQD 809
Cdd:cd18016 81 DIPATYLTGDKTDAEATKIYLQLSKKDPIIKLLYVTPEKISASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRPD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1622957628 810 YKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 857
Cdd:cd18016 161 YKRLNMLRQKFPSVPMMALTATATPRVQKDILNQLKMLRPQVFTMSFN 208
|
|
| BDHCT_assoc |
pfam16204 |
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom ... |
424-646 |
4.67e-130 |
|
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom syndrome-associated DEAD-box helicases in higher eukaryotes. It lies between the BDHCT, and DEAD-box families, pfam08072 and pfam00270.
Pssm-ID: 465065 Cd Length: 223 Bit Score: 400.72 E-value: 4.67e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 424 GSVWRCRPDSLDGPVEGDSCSAGNSMKELNFSHLPSNSVSPGDYLLTTTLGKTGFSATRENLFERPSFNTPLQKSFVSSN 503
Cdd:pfam16204 1 GSVWRCRPDSLGSPVKGDSCPTGNSVKELNFPHLPSNSLSTGECLLTTTPGKTGFSATTKNLSERPLFSSHLQKSFVSSN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 504 WAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWENIMHNLAASKSSTAAY 583
Cdd:pfam16204 81 WAETPRTEKRNESSYFPGNVLTSTAVKDQNKHTASVNDLEREIQASCDIDNFDIDDFDDDDDWENIMHNLAASKSSTAAY 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622957628 584 QPIKEGRPIKSVSERLSSAKTNCLPVASTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSL 646
Cdd:pfam16204 161 QPIKEGGPVKSVSERISSAKTNCLPVASTAQNKNFSESIQNYTDKSAQNLASRNLKHEHFQSL 223
|
|
| DpdF |
NF041063 |
protein DpdF; |
671-1003 |
1.00e-48 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 187.81 E-value: 1.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALL---GEDCFILMPTGGGKSLCYQLPACVSP---GVTIVISPLRSLIVDQVQKLTSL-------DIPATYLT 737
Cdd:NF041063 145 QREAVRAALLappGSTLIVNLPTGSGKSLVAQAPALLASrqgGLTLVVVPTVALAIDQERRARELlrragpdLGGPLAWH 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 738 GDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASnrLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLR 817
Cdd:NF041063 225 GGLSAEERAAIRQRI--RDGTQRILFTSPESLTGS--LRPALFDAAEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAGLR 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 818 QKFPSVP-------VMALTATanprvqkdiLTQ-----LKIL-----RPQVFSMSFNRHNLKYYVLPKKPKKVAFDC-LE 879
Cdd:NF041063 301 RSLLRLApsgrpfrTLLLSAT---------LTEstldtLETLfgppgPFIVVSAVQLRPEPAYWVAKCDSEEERRERvLE 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 880 WIRkHYPYDSgIIYCLSRRECDTMADTLQRDGLAALA-YHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVR 958
Cdd:NF041063 372 ALR-HLPRPL-ILYVTKVEDAEAWLQRLRAAGFRRVAlFHGDTPDAERERLIEQW-RENELDIVVATSAFGLGMDKSDVR 448
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1622957628 959 FVIHASLPKSMEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRL 1003
Cdd:NF041063 449 TVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDLDIAKSL 493
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
668-840 |
2.92e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 118.11 E-value: 2.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 668 RTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPAC------VSPGVTIVISPLRSLIVDQVQKLTSLDIPATY-----L 736
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGKGLGLkvaslL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 737 TGDKTDSEATNIylqlsKKdpiIKLLYVTPEKICASNRLISTLENLyerKLLarfVIDEAHCVSQWGhdFRQDYKRmnML 816
Cdd:pfam00270 81 GGDSRKEQLEKL-----KG---PDILVGTPGRLLDLLQERKLLKNL---KLL---VLDEAHRLLDMG--FGPDLEE--IL 142
|
170 180
....*....|....*....|....
gi 1622957628 817 RQKFPSVPVMALTATAnPRVQKDI 840
Cdd:pfam00270 143 RRLPKKRQILLLSATL-PRNLEDL 165
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
660-840 |
4.06e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.72 E-value: 4.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 660 KKFGLHNFRTNQLEAINAALLGE-DCFILMPTGGGKSLCYQLPA-----CVSPGVTIVISPLRSLIVDQVQKLTSL---- 729
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPAlealkRGKGGRVLVLVPTRELAEQWAEELKKLgpsl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 730 -DIPATYLTGDKTDSEATNIylqlskKDPIIKLLYVTPEKIcasnrLISTLENLYERKLLARFVIDEAHCVSQWGhdFRQ 808
Cdd:smart00487 82 gLKVVGLYGGDSKREQLRKL------ESGKTDILVTTPGRL-----LDLLENDKLSLSNVDLVILDEAHRLLDGG--FGD 148
|
170 180 190
....*....|....*....|....*....|..
gi 1622957628 809 DYKRmnMLRQKFPSVPVMALTATANPRVQKDI 840
Cdd:smart00487 149 QLEK--LLKLLPKNVQLLLLSATPPEEIENLL 178
|
|
| BDHCT |
pfam08072 |
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily. |
371-411 |
6.12e-20 |
|
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily.
Pssm-ID: 462356 Cd Length: 41 Bit Score: 84.25 E-value: 6.12e-20
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1622957628 371 LIHVMDHICKLIDNIPADKLKLLDCGNELLQQRNIRRKLLT 411
Cdd:pfam08072 1 LYSVMEEICKLVDTIPIHELKALSCGNELLQQRDIRRKLLA 41
|
|
| HRDC |
smart00341 |
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ... |
1212-1291 |
8.43e-20 |
|
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Pssm-ID: 128635 [Multi-domain] Cd Length: 81 Bit Score: 85.04 E-value: 8.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1212 EMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPA 1291
Cdd:smart00341 2 ERQLRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDSPSEA 81
|
|
| HRDC |
pfam00570 |
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ... |
1215-1281 |
2.19e-11 |
|
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Pssm-ID: 425755 [Multi-domain] Cd Length: 68 Bit Score: 60.63 E-value: 2.19e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957628 1215 KKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVL 1281
Cdd:pfam00570 2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
656-1142 |
0e+00 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 778.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 656 KIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIPATY 735
Cdd:TIGR00614 1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 736 LTGDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASNRLISTLEnlyERKLLARFVIDEAHCVSQWGHDFRQDYKRMNM 815
Cdd:TIGR00614 81 LNSAQTKEQQLNVLTDL--KDGKIKLLYVTPEKISASNRLLQTLE---ERKGITLIAVDEAHCISQWGHDFRPDYKALGS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 816 LRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPkKVAFDCLEWIRKHYPYDSGIIYCL 895
Cdd:TIGR00614 156 LKQKFPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTP-KILEDLLRFIRKEFEGKSGIIYCP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 896 SRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWInQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQE 975
Cdd:TIGR00614 235 SRKKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQ-RDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 976 SGRAGRDGEISHCLLFYTYHDVTRLKRLIIMEKDGNhhtRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCK 1055
Cdd:TIGR00614 314 SGRAGRDGLPSECHLFYAPADMNRLRRLLMEEPDGN---FRTYKLKLYEMMEYCLNSSTCRRLILLSYFGEKGFNKSFCI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1056 KHPDVSCDNCCKTKDYKTRDVTDDVKSIIRFVQEHSSSQGMRNvkhvgpsGRFTMNMLVDIFLGSKSAKIQSGIFGKGSA 1135
Cdd:TIGR00614 391 MGTEKCCDNCCKRLDYKTKDVTDKVYDFGPQAQKALSAVGRLN-------QKFGMGYPVDFLRGSNSQKIRDGGFRKHSL 463
|
....*..
gi 1622957628 1136 YSRHNAE 1142
Cdd:TIGR00614 464 YGRGKDE 470
|
|
| BLM_N |
pfam16202 |
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate ... |
1-367 |
0e+00 |
|
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate Bloom syndrome proteins. The exact function is not known.
Pssm-ID: 465064 Cd Length: 370 Bit Score: 577.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1 MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPPPDT 80
Cdd:pfam16202 1 MAAVPQNNLQEQLERHSARKLNNKLSLSKPKSSGFTFKKKTSSGNDVSVTSVSVAKTPVLSDKDVNVTEAFSFSEPLPHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 81 TNQQ-RVKDFFKNAPAGQQTQRVGSKPLLPDFLQTPKEVLCTTQNTPTVKKSQNTALKKLEFSSSPDSFRTINDWDDMDD 159
Cdd:pfam16202 81 TNQQtRINDFFKNAPAGQQTKRAGSKPLLPDSSQTPQEVSCTTQVTPAVKKPPDAVFKKLEFSSSFDSFISLNDWDDMDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 160 FDTSRTSKAFVTPPQSHFVRVSTAQKSKKAKRNFFKAQLYTTNTVKADLPPSFSESEQIDLTKEQKDDSEWLSSDVICID 239
Cdd:pfam16202 161 FDTSGNSKAFVTPPRNHFVRVSTAQKSKKSKRNFSKAQLSKANTVKADLTPSSGESKQVDLTKEQLDDSEWLSSDVICID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 240 DGPIDEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDIDFVPPSPEE--ISASSSSSKC 317
Cdd:pfam16202 241 DDPISEELINEDTQESHSLKTHLGDERDNSEKKKHLEETELHSVEKSPCVELNEDDYDIDFVPPSPEEevISSSSSSLKC 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1622957628 318 LSMLKDLDTSDRKEDVLSTSKDLLSKPEKMSTQEPNPETSTDCDARQINL 367
Cdd:pfam16202 321 FSMLKDLDTSDKEKDGLSTSEDLLSKPEKMTTQQPDQETSTDCDARQISL 370
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
653-1149 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 558.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 653 EMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIP 732
Cdd:COG0514 4 DALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAAGIR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 733 ATYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEkicasnRLIS--TLENLYERKLlARFVIDEAHCVSQWGHDFRQDY 810
Cdd:COG0514 84 AAFLNSSLSAEERREVLRALRAGE--LKLLYVAPE------RLLNprFLELLRRLKI-SLFAIDEAHCISQWGHDFRPDY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 811 KRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHYPyDSG 890
Cdd:COG0514 155 RRLGELRERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKPPDDKLAQLLDFLKEHPG-GSG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 891 IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGcQVICATIAFGMGIDKPDVRFVIHASLPKSME 970
Cdd:COG0514 234 IVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEV-DVIVATIAFGMGIDKPDVRFVIHYDLPKSIE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 971 GYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLiIMEKDGNHHTRETHFNNLYSMVHYCEnITECRRIQLLAYFGENGFN 1050
Cdd:COG0514 313 AYYQEIGRAGRDGLPAEALLLYGPEDVAIQRFF-IEQSPPDEERKRVERAKLDAMLAYAE-TTGCRRQFLLRYFGEELAE 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1051 PdfCKKhpdvsCDNCCKTKdyKTRDVTDDVKSIIRFvqehsssqgmrnVKHVGPsgRFTMNMLVDIFLGSKSAKIQS--- 1127
Cdd:COG0514 391 P--CGN-----CDNCLGPP--ETFDGTEAAQKALSC------------VYRTGQ--RFGAGHVIDVLRGSKNEKIRQfgh 447
|
490 500
....*....|....*....|....*
gi 1622957628 1128 ---GIFGKGSAYSRHNAERLFKKLI 1149
Cdd:COG0514 448 dklSTYGIGKDLSDKEWRSVIRQLL 472
|
|
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
654-1284 |
8.68e-155 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 481.11 E-value: 8.68e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 654 MMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIPA 733
Cdd:TIGR01389 1 AQQVLKRTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAAGVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 734 TYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEKicasnrlistLENLYERKLLAR-----FVIDEAHCVSQWGHDFRQ 808
Cdd:TIGR01389 81 AYLNSTLSAKEQQDIEKALVNGE--LKLLYVAPER----------LEQDYFLNMLQRipialVAVDEAHCVSQWGHDFRP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 809 DYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVafDCLEWIRKHYPyD 888
Cdd:TIGR01389 149 EYQRLGSLAERFPQVPRIALTATADAETRQDIRELLRLADANEFITSFDRPNLRFSVVKKNNKQK--FLLDYLKKHRG-Q 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 889 SGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGcQVICATIAFGMGIDKPDVRFVIHASLPKS 968
Cdd:TIGR01389 226 SGIIYASSRKKVEELAERLESQGISALAYHAGLSNKVRAENQEDFLYDDV-KVMVATNAFGMGIDKPNVRFVIHYDMPGN 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 969 MEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLI-IMEKDGNHHTRETHfnNLYSMVHYCENITeCRRIQLLAYFGEN 1047
Cdd:TIGR01389 305 LESYYQEAGRAGRDGLPAEAILLYSPADIALLKRRIeQSEADDDYKQIERE--KLRAMIAYCETQT-CRRAYILRYFGEN 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1048 GFNPdfCKKhpdvsCDNCckTKDYKTRDVTDDVKSIIrfvqehsssqgmRNVKHVGpsGRFTMNMLVDIFLGSKSAKI-- 1125
Cdd:TIGR01389 382 EVEP--CGN-----CDNC--LDPPKSYDATVEAQKAL------------SCVYRMG--QRFGVGYIIEVLRGSKNDKIlq 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1126 ----QSGIFGKGSAYSRHNAERLFKKLILDKildedlYINANDQAIAYVMLGNKAQTVLNGnlkvdfmETENSSSVKKQK 1201
Cdd:TIGR01389 439 kghdQLSTYGIGKDYTQKEWRSLIDQLIAEG------LLTENDEIYIGLQLTEAARKVLKN-------EVEVLLRPFKVV 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1202 ALVAKVSQRE--EMVKKCLGE-LTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVI 1278
Cdd:TIGR01389 506 AKEKTRVQKNlsVGVDNALFEaLRELRKEQADEQNVPPYVIFSDSTLREMAEKRPATLNALLKIKGVGQNKLDRYGEAFL 585
|
....*.
gi 1622957628 1279 SVLQKY 1284
Cdd:TIGR01389 586 EVIREY 591
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
642-1332 |
5.54e-152 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 492.87 E-value: 5.54e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 642 RFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVD 721
Cdd:PLN03137 436 KWSSRNFPWTKKLEVNNKKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQD 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 722 QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQ 801
Cdd:PLN03137 516 QIMNLLQANIPAASLSAGMEWAEQLEILQELSSEYSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAHCVSQ 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 802 WGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKkvafdCLE-- 879
Cdd:PLN03137 596 WGHDFRPDYQGLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTKK-----CLEdi 670
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 880 --WIRKHYPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDV 957
Cdd:PLN03137 671 dkFIKENHFDECGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQW-SKDEINIICATVAFGMGINKPDV 749
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 958 RFVIHASLPKSMEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLII--------MEKDGNHHTR-----ETHFNNLYS 1024
Cdd:PLN03137 750 RFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSDYIRVKHMISqggveqspMAMGYNRMASsgrilETNTENLLR 829
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1025 MVHYCENITECRRIQLLAYFGENgFNPDFCKKhpdvSCDNCCKTKDYKTRDVTDDVKSIIRFvqehsssqgmrnVKHVGP 1104
Cdd:PLN03137 830 MVSYCENEVDCRRFLQLVHFGEK-FDSTNCKK----TCDNCSSSKSLIDKDVTEIARQLVEL------------VKLTGE 892
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1105 sgRFTMNMLVDIFLGSKSAKIQS------GIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGN--KA 1176
Cdd:PLN03137 893 --RFSSAHILEVYRGSLNQYVKKhrhetlSLHGAGKHLSKGEASRILHYLVTEDILAEDVKKSDLYGSVSSLLKVNesKA 970
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1177 QTVLNGNLKV--DFMETENSSSVKKQKALVAKVSQRE------EMVKKCLGEL----------------TEVCKSLGKvf 1232
Cdd:PLN03137 971 YKLFSGGQTIimRFPSSVKASKPSKFEATPAKGPLTSgkqstlPMATPAQPPVdlnlsailytalrklrTALVKEAGD-- 1048
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1233 GVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVI----SVLQKY--SEWTSPAEDNSPGmslSGSR-- 1304
Cdd:PLN03137 1049 GVMAYHIFGNATLQQISKRIPRTKEELLEINGLGKAKVSKYGDRLLetieSTINEYykTDKNSSSSNDSPD---SGKRrr 1125
|
730 740 750
....*....|....*....|....*....|.
gi 1622957628 1305 --GPGRSTAEELDEEISVS-SHYFTSKTRNE 1332
Cdd:PLN03137 1126 deNINPNVAEDDDFTKSTSqSKKKTVKNKNK 1156
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
650-857 |
1.04e-147 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 446.97 E-value: 1.04e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 650 HTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSL 729
Cdd:cd18016 1 HSKEMMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 730 DIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQD 809
Cdd:cd18016 81 DIPATYLTGDKTDAEATKIYLQLSKKDPIIKLLYVTPEKISASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRPD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1622957628 810 YKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 857
Cdd:cd18016 161 YKRLNMLRQKFPSVPMMALTATATPRVQKDILNQLKMLRPQVFTMSFN 208
|
|
| BDHCT_assoc |
pfam16204 |
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom ... |
424-646 |
4.67e-130 |
|
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom syndrome-associated DEAD-box helicases in higher eukaryotes. It lies between the BDHCT, and DEAD-box families, pfam08072 and pfam00270.
Pssm-ID: 465065 Cd Length: 223 Bit Score: 400.72 E-value: 4.67e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 424 GSVWRCRPDSLDGPVEGDSCSAGNSMKELNFSHLPSNSVSPGDYLLTTTLGKTGFSATRENLFERPSFNTPLQKSFVSSN 503
Cdd:pfam16204 1 GSVWRCRPDSLGSPVKGDSCPTGNSVKELNFPHLPSNSLSTGECLLTTTPGKTGFSATTKNLSERPLFSSHLQKSFVSSN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 504 WAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWENIMHNLAASKSSTAAY 583
Cdd:pfam16204 81 WAETPRTEKRNESSYFPGNVLTSTAVKDQNKHTASVNDLEREIQASCDIDNFDIDDFDDDDDWENIMHNLAASKSSTAAY 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622957628 584 QPIKEGRPIKSVSERLSSAKTNCLPVASTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSL 646
Cdd:pfam16204 161 QPIKEGGPVKSVSERISSAKTNCLPVASTAQNKNFSESIQNYTDKSAQNLASRNLKHEHFQSL 223
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
655-1284 |
5.99e-120 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 388.30 E-value: 5.99e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 655 MKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIPAT 734
Cdd:PRK11057 14 KQVLQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQVDQLLANGVAAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 735 YLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEKICASNrlisTLENLYERKlLARFVIDEAHCVSQWGHDFRQDYKRMN 814
Cdd:PRK11057 94 CLNSTQTREQQLEVMAGCRTGQ--IKLLYIAPERLMMDN----FLEHLAHWN-PALLAVDEAHCISQWGHDFRPEYAALG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 815 MLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPK-KPKKVAFDCLEWIRKHypydSGIIY 893
Cdd:PRK11057 167 QLRQRFPTLPFMALTATADDTTRQDIVRLLGLNDPLIQISSFDRPNIRYTLVEKfKPLDQLMRYVQEQRGK----SGIIY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 894 CLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYY 973
Cdd:PRK11057 243 CNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAF-QRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 974 QESGRAGRDGEISHCLLFYTYHDVTRLKRLIIMEKDGNHHTRETHfnNLYSMVHYCENITeCRRIQLLAYFGENGFNPdf 1053
Cdd:PRK11057 322 QETGRAGRDGLPAEAMLFYDPADMAWLRRCLEEKPAGQQQDIERH--KLNAMGAFAEAQT-CRRLVLLNYFGEGRQEP-- 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1054 ckkhpdvsCDNCcktkdyktrDVTDDVKSiiRFVQEHSSSQGMRNVKHVGPsgRFTMNMLVDIFLGSKSAKIQS------ 1127
Cdd:PRK11057 397 --------CGNC---------DICLDPPK--QYDGLEDAQKALSCIYRVNQ--RFGMGYVVEVLRGANNQRIRDyghdkl 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1128 GIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQaiayvmLGNKAQTVLNG--NLKVDFMETENSSSVKKQKalva 1205
Cdd:PRK11057 456 KVYGIGRDKSHEHWVSVIRQLIHLGLVTQNIAQHSALQ------LTEAARPVLRGevSLQLAVPRIVALKPRAMQK---- 525
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622957628 1206 kvSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKY 1284
Cdd:PRK11057 526 --SFGGNYDRKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALIRAH 602
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
656-857 |
8.85e-97 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 308.69 E-value: 8.85e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 656 KIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIPATY 735
Cdd:cd17920 2 QILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 736 LTGDKTDSEATNIYLQLskKDPIIKLLYVTPEKIcASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNM 815
Cdd:cd17920 82 LNSTLSPEEKREVLLRI--KNGQYKLLYVTPERL-LSPDFLELLQRLPERKRLALIVVDEAHCVSQWGHDFRPDYLRLGR 158
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1622957628 816 LRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 857
Cdd:cd17920 159 LRRALPGVPILALTATATPEVREDILKRLGLRNPVIFRASFD 200
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
649-857 |
2.31e-83 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 271.55 E-value: 2.31e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 649 PHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTS 728
Cdd:cd18015 1 PWSGKVKDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 729 LDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQ 808
Cdd:cd18015 81 LGISATMLNASSSKEHVKWVHAALTDKNSELKLLYVTPEKIAKSKRFMSKLEKAYNAGRLARIAIDEVHCCSQWGHDFRP 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1622957628 809 DYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 857
Cdd:cd18015 161 DYKKLGILKRQFPNVPILGLTATATSKVLKDVQKILCIQKCLTFTASFN 209
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
858-992 |
7.65e-78 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 252.90 E-value: 7.65e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 858 RHNLKYYVLPKKPKKVAFDCLEWIRKHYPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINqD 937
Cdd:cd18794 1 RPNLFYSVRPKDKKDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLR-D 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1622957628 938 GCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAGRDGEISHCLLFY 992
Cdd:cd18794 80 KIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
655-857 |
1.00e-61 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 209.42 E-value: 1.00e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 655 MKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACV----SPGVTIVISPLRSLIVDQVQKLTSLd 730
Cdd:cd18018 1 LKLLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLlrrrGPGLTLVVSPLIALMKDQVDALPRA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 731 IPATYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEKICASnrliSTLENLYERKLLARFVIDEAHCVSQWGHDFRQDY 810
Cdd:cd18018 80 IKAAALNSSLTREERRRILEKLRAGE--VKILYVSPERLVNE----SFRELLRQTPPISLLVVDEAHCISEWSHNFRPDY 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1622957628 811 KRM-NMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 857
Cdd:cd18018 154 LRLcRVLRELLGAPPVLALTATATKRVVEDIASHLGIPESGVVRGPLY 201
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
656-849 |
5.76e-61 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 207.71 E-value: 5.76e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 656 KIFHKKFGLHNFRTN-QLEAINAALLGE-DCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIPA 733
Cdd:cd18014 2 STLKKVFGHSDFKSPlQEKATMAVVKGNkDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKTLKIRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 734 TYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKiCASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRM 813
Cdd:cd18014 82 DSLNSKLSAQERKRIIADLESEKPQTKFLYITPEM-AATSSFQPLLSSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRL 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 1622957628 814 NMLRQKFPSVPVMALTATANPRVQKDILTQLKILRP 849
Cdd:cd18014 161 GALRSRYGHVPWVALTATATPQVQEDIFAQLRLKKP 196
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
662-857 |
4.18e-50 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 175.73 E-value: 4.18e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 662 FGLHNFRTNQLEAINAAL-LGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPLRSLIVDQVQKLTSLDIPATYLTGDK 740
Cdd:cd18017 8 FGHSSFRPVQWKVIRSVLeERRDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMSNIPACFLGSAQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 741 TDSEATNIylqlskKDPIIKLLYVTPEKICASNRLISTLENlyERKLLArfvIDEAHCVSQWGHDFRQDYKRMNMLRQKF 820
Cdd:cd18017 88 SQNVLDDI------KMGKIRVIYVTPEFVSKGLELLQQLRN--GITLIA---IDEAHCVSQWGHDFRSSYRHLGSIRNRL 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 1622957628 821 PSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 857
Cdd:cd18017 157 PNVPIVALTATATPSVRDDIIKNLNLRNPQITCTSFD 193
|
|
| DpdF |
NF041063 |
protein DpdF; |
671-1003 |
1.00e-48 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 187.81 E-value: 1.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALL---GEDCFILMPTGGGKSLCYQLPACVSP---GVTIVISPLRSLIVDQVQKLTSL-------DIPATYLT 737
Cdd:NF041063 145 QREAVRAALLappGSTLIVNLPTGSGKSLVAQAPALLASrqgGLTLVVVPTVALAIDQERRARELlrragpdLGGPLAWH 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 738 GDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASnrLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLR 817
Cdd:NF041063 225 GGLSAEERAAIRQRI--RDGTQRILFTSPESLTGS--LRPALFDAAEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAGLR 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 818 QKFPSVP-------VMALTATanprvqkdiLTQ-----LKIL-----RPQVFSMSFNRHNLKYYVLPKKPKKVAFDC-LE 879
Cdd:NF041063 301 RSLLRLApsgrpfrTLLLSAT---------LTEstldtLETLfgppgPFIVVSAVQLRPEPAYWVAKCDSEEERRERvLE 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 880 WIRkHYPYDSgIIYCLSRRECDTMADTLQRDGLAALA-YHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVR 958
Cdd:NF041063 372 ALR-HLPRPL-ILYVTKVEDAEAWLQRLRAAGFRRVAlFHGDTPDAERERLIEQW-RENELDIVVATSAFGLGMDKSDVR 448
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1622957628 959 FVIHASLPKSMEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRL 1003
Cdd:NF041063 449 TVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDLDIAKSL 493
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
668-840 |
2.92e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 118.11 E-value: 2.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 668 RTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPAC------VSPGVTIVISPLRSLIVDQVQKLTSLDIPATY-----L 736
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGKGLGLkvaslL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 737 TGDKTDSEATNIylqlsKKdpiIKLLYVTPEKICASNRLISTLENLyerKLLarfVIDEAHCVSQWGhdFRQDYKRmnML 816
Cdd:pfam00270 81 GGDSRKEQLEKL-----KG---PDILVGTPGRLLDLLQERKLLKNL---KLL---VLDEAHRLLDMG--FGPDLEE--IL 142
|
170 180
....*....|....*....|....
gi 1622957628 817 RQKFPSVPVMALTATAnPRVQKDI 840
Cdd:pfam00270 143 RRLPKKRQILLLSATL-PRNLEDL 165
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
660-840 |
4.06e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.72 E-value: 4.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 660 KKFGLHNFRTNQLEAINAALLGE-DCFILMPTGGGKSLCYQLPA-----CVSPGVTIVISPLRSLIVDQVQKLTSL---- 729
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPAlealkRGKGGRVLVLVPTRELAEQWAEELKKLgpsl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 730 -DIPATYLTGDKTDSEATNIylqlskKDPIIKLLYVTPEKIcasnrLISTLENLYERKLLARFVIDEAHCVSQWGhdFRQ 808
Cdd:smart00487 82 gLKVVGLYGGDSKREQLRKL------ESGKTDILVTTPGRL-----LDLLENDKLSLSNVDLVILDEAHRLLDGG--FGD 148
|
170 180 190
....*....|....*....|....*....|..
gi 1622957628 809 DYKRmnMLRQKFPSVPVMALTATANPRVQKDI 840
Cdd:smart00487 149 QLEK--LLKLLPKNVQLLLLSATPPEEIENLL 178
|
|
| RecQ_Zn_bind |
pfam16124 |
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ. |
994-1066 |
6.28e-22 |
|
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
Pssm-ID: 465031 [Multi-domain] Cd Length: 66 Bit Score: 90.43 E-value: 6.28e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622957628 994 YHDVTRLKRLIiMEKDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENgFNPDFCKKhpdvsCDNCC 1066
Cdd:pfam16124 1 YQDVVRLRFLI-EQSEADEERKEVELQKLQAMVAYCENTTDCRRKQLLRYFGEE-FDSEPCGN-----CDNCL 66
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
901-983 |
4.89e-20 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 85.73 E-value: 4.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 901 DTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAG 980
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKF-NNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
...
gi 1622957628 981 RDG 983
Cdd:smart00490 80 RAG 82
|
|
| BDHCT |
pfam08072 |
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily. |
371-411 |
6.12e-20 |
|
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily.
Pssm-ID: 462356 Cd Length: 41 Bit Score: 84.25 E-value: 6.12e-20
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1622957628 371 LIHVMDHICKLIDNIPADKLKLLDCGNELLQQRNIRRKLLT 411
Cdd:pfam08072 1 LYSVMEEICKLVDTIPIHELKALSCGNELLQQRDIRRKLLA 41
|
|
| HRDC |
smart00341 |
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ... |
1212-1291 |
8.43e-20 |
|
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Pssm-ID: 128635 [Multi-domain] Cd Length: 81 Bit Score: 85.04 E-value: 8.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1212 EMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPA 1291
Cdd:smart00341 2 ERQLRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDSPSEA 81
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
875-983 |
3.88e-17 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 78.41 E-value: 3.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 875 FDCLEWIRKHYPYDSGIIYCLSRRECDTMAdTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDK 954
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEAEL-LLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDVLVATDVAERGLDL 80
|
90 100
....*....|....*....|....*....
gi 1622957628 955 PDVRFVIHASLPKSMEGYYQESGRAGRDG 983
Cdd:pfam00271 81 PDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
671-1003 |
7.87e-16 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 81.73 E-value: 7.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALLGEDCFILMPTGGGKSLCYQLPAC--VSPGV-----TIVISPLRSL---IVDQVQKLTS-LDIPATYLTGd 739
Cdd:COG0513 29 QAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLqrLDPSRprapqALILAPTRELalqVAEELRKLAKyLGLRVATVYG- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 740 ktdseATNIYLQ---LSKKDPIIkllyV-TPekicasNRLIstleNLYERKLLA-----RFVIDEAhcvsqwghD----- 805
Cdd:COG0513 108 -----GVSIGRQiraLKRGVDIV----VaTP------GRLL----DLIERGALDlsgveTLVLDEA--------Drmldm 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 806 -FRQDYKR-MNML---RQkfpsvpVMALTATANPRVQKdiLTQlKILR-PQVfsMSFNRHNLK------YYVLPKKPKKv 873
Cdd:COG0513 161 gFIEDIERiLKLLpkeRQ------TLLFSATMPPEIRK--LAK-RYLKnPVR--IEVAPENATaetieqRYYLVDKRDK- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 874 aFDCLEWIRKHYPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWinQDG-CQVICAT-IAfGMG 951
Cdd:COG0513 229 -LELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAF--RNGkIRVLVATdVA-ARG 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1622957628 952 IDKPDVRFVIHASLPKSMEGYYQESG---RAGRDGEishCLLFYTYHDVTRLKRL 1003
Cdd:COG0513 305 IDIDDVSHVINYDLPEDPEDYVHRIGrtgRAGAEGT---AISLVTPDERRLLRAI 356
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
681-831 |
1.04e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 75.52 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 681 GEDCFILMPTGGGKSLCYQLPA-CVS---PGVTIVISPLRSLIVDQ---VQKLTSLDIPATYLTGDKTDSEATNIYLQLS 753
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAAlLLLlkkGKKVLVLVPTKALALQTaerLRELFGPGIRVAVLVGGSSAEEREKNKLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622957628 754 kkdpiiKLLYVTPEKIcasNRLISTLENLYERKlLARFVIDEAHCVSQWGHDFRQDYKRmnMLRQKFPSVPVMALTAT 831
Cdd:cd00046 81 ------DIIIATPDML---LNLLLREDRLFLKD-LKLIIVDEAHALLIDSRGALILDLA--VRKAGLKNAQVILLSAT 146
|
|
| RQC |
smart00956 |
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ... |
1075-1180 |
1.19e-15 |
|
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 214936 [Multi-domain] Cd Length: 92 Bit Score: 73.66 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1075 DVTDDVKSIIRFVQEHSssqgmrnvkhvgpsGRFTMNMLVDIFLGSKSAKI------QSGIFGKGSAYSRHNAERLFKKL 1148
Cdd:smart00956 1 DVTEEAQKLLSCVYRTG--------------QRFGAGHVIDVLRGSKNKKIrqkghdRLSTFGIGKDLSKKEWRRLIRQL 66
|
90 100 110
....*....|....*....|....*....|..
gi 1622957628 1149 ILDKILDEDlyinanDQAIAYVMLGNKAQTVL 1180
Cdd:smart00956 67 IAEGYLRED------GGRYPYLKLTEKARPVL 92
|
|
| RQC |
pfam09382 |
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ... |
1071-1186 |
3.02e-15 |
|
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 462780 [Multi-domain] Cd Length: 108 Bit Score: 72.96 E-value: 3.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 1071 YKTRDVTDDVKSIIRFVQEhsssqgMRnvkhvgpsGRFTMNMLVDIFLGSKSAKI------QSGIFGKGSAYSRHNAERL 1144
Cdd:pfam09382 2 PETVDVTEEAQKILSCVYR------TG--------QRFGAGHLIDVLRGSKNKKIrqlghdKLSTFGIGKDLSKKEWRRI 67
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1622957628 1145 FKKLILDKILDEDLyinandQAIAYVMLGNKAQTVLNGNLKV 1186
Cdd:pfam09382 68 IRQLIAEGYLEVDI------EFYSVLKLTPKAREVLKGEEKV 103
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
661-997 |
6.03e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 79.68 E-value: 6.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 661 KFGLHNFrtnQLEAINAALL----GEDCFIL-MPTGGGKS-----LCYQLPAcvsPGVTIVISPLRSLiVDQ-VQKLTSL 729
Cdd:COG1061 78 SFELRPY---QQEALEALLAalerGGGRGLVvAPTGTGKTvlalaLAAELLR---GKRVLVLVPRREL-LEQwAEELRRF 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 730 DiPATYLTGDKTDSEAtniylqlskkdPIIkllyvtpekicasnrlISTLENLYERKLLARF-------VIDEAHcvsqw 802
Cdd:COG1061 151 L-GDPLAGGGKKDSDA-----------PIT----------------VATYQSLARRAHLDELgdrfglvIIDEAH----- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 803 gHDFRQDYKRmnmLRQKFPSVPVMALTATANPRVQKDILTQL----------------KILRPQVF---SMSFNRHNLKY 863
Cdd:COG1061 198 -HAGAPSYRR---ILEAFPAAYRLGLTATPFRSDGREILLFLfdgivyeyslkeaiedGYLAPPEYygiRVDLTDERAEY 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 864 YVL------------PKKPKKVAfdclEWIRKHYPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQ 931
Cdd:COG1061 274 DALserlrealaadaERKDKILR----ELLREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILE 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622957628 932 kWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAGRDGEISHCLLFYTYHDV 997
Cdd:COG1061 350 -AFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYDFVGN 414
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
660-986 |
4.27e-14 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 77.57 E-value: 4.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 660 KKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPA----CVSPGVT-IVISPLRSLIVDQVQKLTSL----- 729
Cdd:COG1205 50 KKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVlealLEDPGATaLYLYPTKALARDQLRRLRELaealg 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 730 -DI-PATYlTGDkTDSEAtniylqlskKDPIIK---LLYVTPEKICAS-----NRLISTLENLyerkllaRF-VIDEAHC 798
Cdd:COG1205 130 lGVrVATY-DGD-TPPEE---------RRWIREhpdIVLTNPDMLHYGllphhTRWARFFRNL-------RYvVIDEAHT 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 799 ---V--SQWGHDFRqdykRMNMLRQKFPSVPVMALT-AT-ANPrvqKDILTQLkILRP-QVFSMSFNRHNLKYYVL---P 867
Cdd:COG1205 192 yrgVfgSHVANVLR----RLRRICRHYGSDPQFILAsATiGNP---AEHAERL-TGRPvTVVDEDGSPRGERTFVLwnpP 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 868 KKPKKVAFDCL--------EWIRKHYpydSGIIYCLSRRECDTMADTLQR------DGLAALAYHAGLSDSARDEVQQKW 933
Cdd:COG1205 264 LVDDGIRRSALaeaarllaDLVREGL---RTLVFTRSRRGAELLARYARRalrepdLADRVAAYRAGYLPEERREIERGL 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1622957628 934 inQDG-CQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAGRDGEIS 986
Cdd:COG1205 341 --RSGeLLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDS 392
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
862-992 |
4.94e-14 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 70.23 E-value: 4.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 862 KYYVLPKKPKKVAfdCLEWIRKHYPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDgCQV 941
Cdd:cd18787 4 LYVVVEEEEKKLL--LLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGK-VRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1622957628 942 ICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQESGRAGRDGEISHCLLFY 992
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
642-981 |
2.06e-12 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 71.46 E-value: 2.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 642 RFQSLSFPHTKEMMKifhkKFGLHNFRTNQLEAINAALLGEDCFIL-MPTGGGKSLCYQLPAC--VSPGVTIV-ISPLRS 717
Cdd:COG1204 2 KVAELPLEKVIEFLK----ERGIEELYPPQAEALEAGLLEGKNLVVsAPTASGKTLIAELAILkaLLNGGKALyIVPLRA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 718 LIvDQV-----QKLTSLDIPATYLTGDKTDSEAtniylQLSKKDPIIkllyVTPEKicasnrLISTLENlyERKLLARF- 791
Cdd:COG1204 78 LA-SEKyrefkRDFEELGIKVGVSTGDYDSDDE-----WLGRYDILV----ATPEK------LDSLLRN--GPSWLRDVd 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 792 --VIDEAHCVsqwghdfrQDYKR---MNM----LRQKFPSVPVMALTAT-ANPrvqKDILTQLKI-----------LRPQ 850
Cdd:COG1204 140 lvVVDEAHLI--------DDESRgptLEVllarLRRLNPEAQIVALSATiGNA---EEIAEWLDAelvksdwrpvpLNEG 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 851 VFSMSFNRHNLKYYVLPKKPKKVAFDCLEwirkhypyDSG--IIYCLSRRECDTMAD----------------------- 905
Cdd:COG1204 209 VLYDGVLRFDDGSRRSKDPTLALALDLLE--------EGGqvLVFVSSRRDAESLAKkladelkrrltpeereeleelae 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 906 --------TLQRDGLAAL-----AYH-AGLSDSARDEVQQkWInQDG-CQVICAT--IAfgMGIDKPdVRFVIHASL--- 965
Cdd:COG1204 281 ellevseeTHTNEKLADClekgvAFHhAGLPSELRRLVED-AF-REGlIKVLVATptLA--AGVNLP-ARRVIIRDTkrg 355
|
410 420
....*....|....*....|
gi 1622957628 966 ----PKSMEgYYQESGRAGR 981
Cdd:COG1204 356 gmvpIPVLE-FKQMAGRAGR 374
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
671-991 |
1.49e-11 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 68.66 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALLGEDCFILMPTGGGKSLCYQLP---ACVS----------PGVTIVISPLRSLIVdQVQ---KLTSLDIP-- 732
Cdd:PLN00206 148 QMQAIPAALSGRSLLVSADTGSGKTASFLVPiisRCCTirsghpseqrNPLAMVLTPTRELCV-QVEdqaKVLGKGLPfk 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 733 -ATYLTGDKTDSeatniylQLSKKDPIIKLLYVTPekicasNRLISTL-ENLYERKLLARFVIDEAHCVSQWGhdFRQdy 810
Cdd:PLN00206 227 tALVVGGDAMPQ-------QLYRIQQGVELIVGTP------GRLIDLLsKHDIELDNVSVLVLDEVDCMLERG--FRD-- 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 811 kRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKilrpQVFSMSF---NR-----HNLKYYVLPKKPKKVAFDCLEwIR 882
Cdd:PLN00206 290 -QVMQIFQALSQPQVLLFSATVSPEVEKFASSLAK----DIILISIgnpNRpnkavKQLAIWVETKQKKQKLFDILK-SK 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 883 KHY-PydSGIIYCLSRRECDTMADTLQR-DGLAALAYHAGLSDSARDEVQQKWINQDgCQVICATIAFGMGIDKPDVRFV 960
Cdd:PLN00206 364 QHFkP--PAVVFVSSRLGADLLANAITVvTGLKALSIHGEKSMKERREVMKSFLVGE-VPVIVATGVLGRGVDLLRVRQV 440
|
330 340 350
....*....|....*....|....*....|.
gi 1622957628 961 IHASLPKSMEGYYQESGRAGRDGEISHCLLF 991
Cdd:PLN00206 441 IIFDMPNTIKEYIHQIGRASRMGEKGTAIVF 471
|
|
| HRDC |
pfam00570 |
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ... |
1215-1281 |
2.19e-11 |
|
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Pssm-ID: 425755 [Multi-domain] Cd Length: 68 Bit Score: 60.63 E-value: 2.19e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622957628 1215 KKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVL 1281
Cdd:pfam00570 2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
671-797 |
2.13e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 61.45 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALLGEDCFILMPTGGGKSLCYQLP----ACVSPGVT-IVISPLRSLIVDQVQKLTSL------DI-PATYlTG 738
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPileaLLRDPGSRaLYLYPTKALAQDQLRSLRELleqlglGIrVATY-DG 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622957628 739 DKTDSEATNIYLQLSkkdpiiKLLYVTPEKICAS-----NRLISTLENLyerkllaRF-VIDEAH 797
Cdd:cd17923 84 DTPREERRAIIRNPP------RILLTNPDMLHYAllphhDRWARFLRNL-------RYvVLDEAH 135
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
891-984 |
2.13e-09 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 57.27 E-value: 2.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 891 IIYCLSRRECDTMA----DTLQRDGLAA---LAYHAGLSDSARDEVQQKWINQDGCQVIcATIAFGMGIDKPDVRFVIHA 963
Cdd:cd18797 39 IVFCRSRKLAELLLrylkARLVEEGPLAskvASYRAGYLAEDRREIEAELFNGELLGVV-ATNALELGIDIGGLDAVVLA 117
|
90 100
....*....|....*....|.
gi 1622957628 964 SLPKSMEGYYQESGRAGRDGE 984
Cdd:cd18797 118 GYPGSLASLWQQAGRAGRRGK 138
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
681-797 |
2.18e-09 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 57.98 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 681 GEDCFILMPTGGGKSLCYQLPACVS------PGVTIV-ISPLRSLIVDQVQKLT------SLDIPATYLTGDKTDSEATn 747
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSladepeKGVQVLyISPLKALINDQERRLEepldeiDLEIPVAVRHGDTSQSEKA- 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1622957628 748 iylQLSKKDPIIklLYVTPEKICA---SNRLISTLENLyerkllaRFVI-DEAH 797
Cdd:cd17922 80 ---KQLKNPPGI--LITTPESLELllvNKKLRELFAGL-------RYVVvDEIH 121
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
887-998 |
4.44e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 51.55 E-value: 4.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 887 YDSGIIYCLSRRECDTMADTLQrdglaalayhaglsdsardevqqkwinqdgcqVICATIAFGMGIDKPDVRFVIHASLP 966
Cdd:cd18785 3 VVKIIVFTNSIEHAEEIASSLE--------------------------------ILVATNVLGEGIDVPSLDTVIFFDPP 50
|
90 100 110
....*....|....*....|....*....|..
gi 1622957628 967 KSMEGYYQESGRAGRDGEIShcllfYTYHDVT 998
Cdd:cd18785 51 SSAASYIQRVGRAGRGGKDE-----GEVILFV 77
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
671-1002 |
6.92e-08 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 57.09 E-value: 6.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALLGEDCFILMPTGGGKSLCYQLPACV--------SPG---VTIVISPLRSLiVDQvqkltsldIPATYLT-G 738
Cdd:PTZ00110 157 QVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVhinaqpllRYGdgpIVLVLAPTREL-AEQ--------IREQCNKfG 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 739 DKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLE-NLYERKLLARFVIDEAHCVSQWGHDFrQDYKRMNMLR 817
Cdd:PTZ00110 228 ASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLEsNVTNLRRVTYLVLDEADRMLDMGFEP-QIRKIVSQIR 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 818 qkfPSVPVMALTATANPRVQK---DILTQLKIlRPQVFSMSFNR-HNLK--YYVLPKKPKKVAfdcLEWIRKHYPYDSG- 890
Cdd:PTZ00110 307 ---PDRQTLMWSATWPKEVQSlarDLCKEEPV-HVNVGSLDLTAcHNIKqeVFVVEEHEKRGK---LKMLLQRIMRDGDk 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 891 -IIYCLSRRECDTMADTLQRDGLAALAYHAglsDSARDEvqQKWINQD----GCQVICATIAFGMGIDKPDVRFVIHASL 965
Cdd:PTZ00110 380 iLIFVETKKGADFLTKELRLDGWPALCIHG---DKKQEE--RTWVLNEfktgKSPIMIATDVASRGLDVKDVKYVINFDF 454
|
330 340 350
....*....|....*....|....*....|....*..
gi 1622957628 966 PKSMEGYYQESGRAGRDGEISHCLLFYTyHDVTRLKR 1002
Cdd:PTZ00110 455 PNQIEDYVHRIGRTGRAGAKGASYTFLT-PDKYRLAR 490
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
671-836 |
1.36e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 53.03 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALLGEDCFIL-MPTGGGKSLCYQLPA----CVSPGVTIVISPLRSLiVDQV-----QKLTSLDIPATYLTGDK 740
Cdd:cd17921 6 QREALRALYLSGDSVLVsAPTSSGKTLIAELAIlralATSGGKAVYIAPTRAL-VNQKeadlrERFGPLGKNVGLLTGDP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 741 TDSeatniYLQLSKKDPIIkllyVTPEKICAsnrLISTLENLYERKLLArFVIDEAHCVSqwghdfrqDYKR-------M 813
Cdd:cd17921 85 SVN-----KLLLAEADILV----ATPEKLDL---LLRNGGERLIQDVRL-VVVDEAHLIG--------DGERgvvlellL 143
|
170 180
....*....|....*....|....
gi 1622957628 814 NMLRQKFPSVPVMALTAT-ANPRV 836
Cdd:cd17921 144 SRLLRINKNARFVGLSATlPNAED 167
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
891-1013 |
1.85e-07 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 55.67 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 891 IIYCLSRRECDTMADTLqrdGLAALAYHAGLSDSARDEVQQKWINQDgCQVICATIAFGMGIDKPDVRfVIHASLPK--- 967
Cdd:COG1202 431 IIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKVERRFADQE-LAAVVTTAALAAGVDFPASQ-VIFDSLAMgie 505
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1622957628 968 --SMEGYYQESGRAGRDGeishcllfytYHDvtRLKRLIIMEKDGNHH 1013
Cdd:COG1202 506 wlSVQEFHQMLGRAGRPD----------YHD--RGKVYLLVEPGKSYH 541
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
666-855 |
3.17e-07 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 52.36 E-value: 3.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 666 NFRTNQLEAINAALLGEDCFIL-MPTGGGKSLCYQL--------PACVSPG--VTIVISPLRSLIVDQV----QKLTSLD 730
Cdd:cd18023 1 YFNRIQSEVFPDLLYSDKNFVVsAPTGSGKTVLFELailrllkeRNPLPWGnrKVVYIAPIKALCSEKYddwkEKFGPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 731 IPATYLTGDkTDSEATNiylQLSKKDPIIkllyVTPEKICASNRLISTLENLYErkLLARFVIDEAHCVSQW-GHDFRQD 809
Cdd:cd18023 81 LSCAELTGD-TEMDDTF---EIQDADIIL----TTPEKWDSMTRRWRDNGNLVQ--LVALVLIDEVHIIKENrGATLEVV 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1622957628 810 YKRMNML-------RQKFPSVPVMALTATAnPRVQkDILTQLKILRPQVFSMS 855
Cdd:cd18023 151 VSRMKTLsssselrGSTVRPMRFVAVSATI-PNIE-DLAEWLGDNPAGCFSFG 201
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
878-983 |
3.63e-07 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 51.01 E-value: 3.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 878 LEWIRKHYPYDSGIIYCLSRRECDTMADTLQrdGLAalAYHAGLSDSARDEV----QQKWInqdgcQVICATIAFGMGID 953
Cdd:cd18795 34 LLKIETVSEGKPVLVFCSSRKECEKTAKDLA--GIA--FHHAGLTREDRELVeelfREGLI-----KVLVATSTLAAGVN 104
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1622957628 954 KPdVRFVIHASLPK----------SMEgYYQESGRAGRDG 983
Cdd:cd18795 105 LP-ARTVIIKGTQRydgkgyrelsPLE-YLQMIGRAGRPG 142
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
891-1003 |
4.91e-07 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 53.68 E-value: 4.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 891 IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSME 970
Cdd:PTZ00424 271 IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREF-RSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPE 349
|
90 100 110
....*....|....*....|....*....|...
gi 1622957628 971 GYYQESGRAGRDGEISHCLLFYTYHDVTRLKRL 1003
Cdd:PTZ00424 350 NYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEI 382
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
877-991 |
1.72e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 46.10 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 877 CLEWIRKHypyDSGIIYCLSRRECDTMADTL------QRDGLAALAYHAGLSDSARDEVQQKWinQDG-CQVICATIAFG 949
Cdd:cd18796 31 VIFLLERH---KSTLVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAAL--KRGdLKVVVATSSLE 105
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1622957628 950 MGIDKPDVRFVIHASLPKSMEGYYQESGRAG-RDGEISHCLLF 991
Cdd:cd18796 106 LGIDIGDVDLVIQIGSPKSVARLLQRLGRSGhRPGAASKGRLV 148
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
671-834 |
2.51e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 43.48 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALL-GEDCFILMPTGGGKSLCYQL---PACVSPGVTIVISPLRSLIVDQV---QKLTSLDIPATYLTGDkTDS 743
Cdd:cd18028 6 QAEAVRAGLLkGENLLISIPTASGKTLIAEMamvNTLLEGGKALYLVPLRALASEKYeefKKLEEIGLKVGISTGD-YDE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 744 EATNiylqLSKKDPIIkllyVTPEKICASNRLISTLENlyerkLLARFVIDEAHCVSqwghdfrqDYKR-------MNML 816
Cdd:cd18028 85 DDEW----LGDYDIIV----ATYEKFDSLLRHSPSWLR-----DVGVVVVDEIHLIS--------DEERgptlesiVARL 143
|
170
....*....|....*....
gi 1622957628 817 RQKFPSVPVMALTATA-NP 834
Cdd:cd18028 144 RRLNPNTQIIGLSATIgNP 162
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
884-991 |
5.05e-04 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 41.01 E-value: 5.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 884 HYPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDE--VQQKWINQDGCQVICATIAFGMGIDKPDVRFVI 961
Cdd:cd18799 3 KYVEIKTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGDeaLILLFFGELKPPILVTVDLLTTGVDIPEVDNVV 82
|
90 100 110
....*....|....*....|....*....|.
gi 1622957628 962 HASLPKSMEGYYQESGRAGR-DGEISHCLLF 991
Cdd:cd18799 83 FLRPTESRTLFLQMLGRGLRlHEGKDFFTIL 113
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
667-831 |
6.81e-04 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 42.42 E-value: 6.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 667 FRTNQLEAINAALLGEDCFILMPTGGGKS-----LC----YQLPaCVSPGVTIVISPLRSLIVDQVQKL-TSLDIPAtYL 736
Cdd:cd17927 3 PRNYQLELAQPALKGKNTIICLPTGSGKTfvavlICehhlKKFP-AGRKGKVVFLANKVPLVEQQKEVFrKHFERPG-YK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 737 TGDKTDSEATNIYLQLSKKDPiiKLLYVTPEkICASNRLISTLENLYERKLLarfVIDEAHCVSQwGHDFRQDYKRmnML 816
Cdd:cd17927 81 VTGLSGDTSENVSVEQIVESS--DVIIVTPQ-ILVNDLKSGTIVSLSDFSLL---VFDECHNTTK-NHPYNEIMFR--YL 151
|
170
....*....|....*....
gi 1622957628 817 RQKFPSV---P-VMALTAT 831
Cdd:cd17927 152 DQKLGSSgplPqILGLTAS 170
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
887-991 |
1.27e-03 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 43.30 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 887 YDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWinQDG-CQVICATIAFGMGIDKPDVRFVIHASL 965
Cdd:PRK11634 245 FDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERL--KDGrLDILIATDVAARGLDVERISLVVNYDI 322
|
90 100
....*....|....*....|....*.
gi 1622957628 966 PKSMEGYYQESGRAGRDGEISHCLLF 991
Cdd:PRK11634 323 PMDSESYVHRIGRTGRAGRAGRALLF 348
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
671-838 |
2.81e-03 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 40.50 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALLGEDCFILMPTGGGKSLCYQLPACV-----------SPGVtIVISPLRSL---IVDQVQKLTS-LDIPATY 735
Cdd:cd00268 17 QAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEkllpepkkkgrGPQA-LVLAPTRELamqIAEVARKLGKgTGLKVAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 736 LTGdktdseATNIYLQLSKKDPIIKLLYVTPEkicasnRListLENLYERKLLAR----FVIDEAhcvsqwghD------ 805
Cdd:cd00268 96 IYG------GAPIKKQIEALKKGPDIVVGTPG------RL---LDLIERGKLDLSnvkyLVLDEA--------Drmldmg 152
|
170 180 190
....*....|....*....|....*....|....*..
gi 1622957628 806 FRQD----YKRMNMLRQkfpsvpVMALTATANPRVQK 838
Cdd:cd00268 153 FEEDvekiLSALPKDRQ------TLLFSATLPEEVKE 183
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
683-835 |
4.76e-03 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 39.66 E-value: 4.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 683 DCFILM--PTGGGKSLCYQLPAC----VSPGVTIV-ISPLRSLIVDQVQ----KLT-SLDIPATYLTGDKT-DSEAtniy 749
Cdd:cd18022 17 DNNVLLgaPTGSGKTIAAELAMFrafnKYPGSKVVyIAPLKALVRERVDdwkkRFEeKLGKKVVELTGDVTpDMKA---- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 750 lqLSKKDPIIkllyVTPEKICASNRLISTLENLYERKLLarfVIDEAHCV-SQWGHDFRQDYKRMNML-RQKFPSVPVMA 827
Cdd:cd18022 93 --LADADIII----TTPEKWDGISRSWQTREYVQQVSLI---IIDEIHLLgSDRGPVLEVIVSRMNYIsSQTEKPVRLVG 163
|
....*....
gi 1622957628 828 L-TATANPR 835
Cdd:cd18022 164 LsTALANAG 172
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
671-848 |
5.38e-03 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 39.87 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 671 QLEAINAALLGEDCFILMPTGGGKSLCYQLP-----------ACVSPGVT-IVISPLRSLiVDQVQK-LTSL------DI 731
Cdd:cd17961 21 QSKAIPLALEGKDILARARTGSGKTAAYALPiiqkilkakaeSGEEQGTRaLILVPTREL-AQQVSKvLEQLtaycrkDV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 732 PATYLTGDKTDSEATNIylqLSKKDPIIkllyV-TPEKI---CASNRLI--STLENLyerkllarfVIDEAHCVSQWGHD 805
Cdd:cd17961 100 RVVNLSASSSDSVQRAL---LAEKPDIV----VsTPARLlshLESGSLLllSTLKYL---------VIDEADLVLSYGYE 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1622957628 806 frqdyKRMNMLRQKFPSVPVMALT-ATANPRVQKdiLTQLkILR 848
Cdd:cd17961 164 -----EDLKSLLSYLPKNYQTFLMsATLSEDVEA--LKKL-VLH 199
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
656-738 |
7.51e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 40.68 E-value: 7.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622957628 656 KIFHKKFGLHNFRTNQLEAINA---ALL-GEDCFILMPTGGGKSLCYQLPA---CVSPGVTIVIS----PLRSLIVDQ-- 722
Cdd:COG1199 4 GLLALAFPGFEPRPGQREMAEAvarALAeGRHLLIEAGTGTGKTLAYLVPAllaARETGKKVVIStatkALQEQLVEKdl 83
|
90
....*....|....*...
gi 1622957628 723 --VQKLTSLDIPATYLTG 738
Cdd:COG1199 84 plLRKALGLPLRVALLKG 101
|
|
| |
