BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  46 NWQATKASLKERFAFLFNSELLSDVRFVLGKGRGTAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 125
Cdd:cd18346     1 NWQATKSSLKERFAFLFNNELLSDVRFVVGKGRPRGPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622954436 126 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 178
Cdd:cd18346    81 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.

                          10        20
                  ....*....|....*....|.
gi 1622954436 332 NRFQQVESRWGYSGTS-DRIR 351
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIR 21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  46 NWQATKASLKERFAFLFNSELLSDVRFVLGKGRGTAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 125
Cdd:cd18346     1 NWQATKSSLKERFAFLFNNELLSDVRFVVGKGRPRGPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622954436 126 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 178
Cdd:cd18346    81 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  61 LFNSELLSDVRFVLGKgrgtaaaggpQRIPAHRFVLAAGSAVFDAMFNGGMAT-TSAEIELPDVEPAAFLALLRFLYSDE 139
Cdd:pfam00651   4 LREQGELCDVTLVVGD----------KEFRAHKAVLAACSPYFKALFSGQESEsSVSEITLDDVSPEDFEALLEFMYTGK 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622954436 140 VqIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHL 174
Cdd:pfam00651  74 L-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  186 ARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIR-ESRLFGAVVRWAEAECQRQqlpvtfgnkQ 264
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHDPEKR---------R 78

                           90       100
                   ....*....|....*....|.
gi 1622954436  265 KVLGKALSLIRFPLMTIEEFA 285
Cdd:smart00875  79 EHLPELLEHVRLPLLSPDYLL 99

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  88 RIPAHRFVLAAGSAVFDAMFNGGMATTsaEIELP-DVEpaAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHC 166
Cdd:PHA03098   22 IIKVHKIILSSSSEYFKKMFKNNFKEN--EINLNiDYD--SFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLC 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436 167 VEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSI-RESRLFGAVVR 245
Cdd:PHA03098   98 INYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVsSEDVVLEIIIK 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436 246 WAEAECQrqqlpvtfgNKQKVLGKALSLIRFPLMTIEEFAAgpaqsgilsdrevvnLFLHFTVNPKPRVEYIDRPRCCLR 325
Cdd:PHA03098  178 WLTSKKN---------NKYKDICLILKVLRITFLSEEGIKK---------------LKRWKLRIKKKKIVFNKRCIKIIY 233

                  ....*...
gi 1622954436 326 gkECCINR 333
Cdd:PHA03098  234 --SKKYNL 239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  46 NWQATKASLKERFAFLFNSELLSDVRFVLGKGRGTAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 125
Cdd:cd18346     1 NWQATKSSLKERFAFLFNNELLSDVRFVVGKGRPRGPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622954436 126 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 178
Cdd:cd18346    81 AAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436 174 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 253
Cdd:cd18522     1 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 80

                          90       100
                  ....*....|....*....|....*..
gi 1622954436 254 QQLPVTFGNKQKVLGKALSLIRFPLMT 280
Cdd:cd18522    81 QQLPVTSENKQKVLGKALSLIRFPLMT 107

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436 174 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 253
Cdd:cd18487     1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                          90
                  ....*....|....*
gi 1622954436 254 QQLPVTFGNKQKVLG 268
Cdd:cd18487    81 QGLSVTPENQRKVLG 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  61 LFNSELLSDVRFVLGKgrgtaaAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEV 140
Cdd:cd18282     1 MFNNELMADVHFIVGP------PGGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIPDVEPAAFLNLLRYLYCDEI 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622954436 141 QIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHL 174
Cdd:cd18282    75 DLEPDTVLATLYAAKKYLVPHLARACVQFLETSL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  47 WQATKASLKERFAFLFNSELLSDVRFVLGkgrgtaAAGGPQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELPDVEPA 126
Cdd:cd18348     1 WQGLYPTIRERNAVMFNNDLMADIHFVVG------PPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPA 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622954436 127 AFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADNAFMLL 183
Cdd:cd18348    75 AFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436 174 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 253
Cdd:cd18525     1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKR 80

                          90
                  ....*....|....*
gi 1622954436 254 QQLPVTFGNKQKVLG 268
Cdd:cd18525    81 QGLPPTARNKRNVLG 95

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  61 LFNSELLSDVRFVLGKgrgtaaaggpQRIPAHRFVLAAGSAVFDAMFNGGMAT-TSAEIELPDVEPAAFLALLRFLYSDE 139
Cdd:pfam00651   4 LREQGELCDVTLVVGD----------KEFRAHKAVLAACSPYFKALFSGQESEsSVSEITLDDVSPEDFEALLEFMYTGK 73

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622954436 140 VqIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHL 174
Cdd:pfam00651  74 L-ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  54 LKERFAFLFNSELLSDVRFVLGKGRgtaaaggpQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELP--DVEPAAFLAL 131
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPER--------QEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlsDIEPEVFRAV 72

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622954436 132 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 170
Cdd:cd18294    73 LEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436   69 DVRFVLGKgrgtaaaggpQRIPAHRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETV 147
Cdd:smart00225   1 DVTLVVGG----------KKFHAHKAVLAAHSPYFKALFSSDFKeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENV 70

                           90       100
                   ....*....|....*....|....*..
gi 1622954436  148 MTTLYTAKKYAVPALEAHCVEFLTKHL 174
Cdd:smart00225  71 EELLELADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  89 IPAHRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCV 167
Cdd:cd18237    33 IKAHRVVLAAASHFFHLMFTSNMTeSKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCV 112

                          90
                  ....*....|.
gi 1622954436 168 EFLTKHLRADN 178
Cdd:cd18237   113 DFLKEQLDASN 123

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  60 FLFNSELLSDVRFVLgkgrgtaaAGGPqrIPAHRFVLAAGSAVFDAMFNGGMATTSA-EIELPDVEPAAFLALLRFLYSD 138
Cdd:cd18300     2 LFLNKGLFSDVTFIV--------EDGT--IPAHKALLVARCDVMAAMFGGNFRESSAkEVELPGVSKETFLALLEYLYTD 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1622954436 139 EVQIGPE-TVMTTLYTAKKYAVPALEAHCVEFLTKHL 174
Cdd:cd18300    72 QAPILEDgDCVGLIVLANRLCLPRLVALCEQYIVKEL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  85 GPQRIPAHRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 163
Cdd:cd18238    23 GEKSIHCHRLVLACVSPYFRAMFTSEMAeSKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVA 102

                          90
                  ....*....|....*.
gi 1622954436 164 AHCVEFLTKHLRADNA 179
Cdd:cd18238   103 KACCEFMKDHLHPSNC 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  89 IPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCV 167
Cdd:cd18235    33 IPAHRVVLASCSPYFHAMFTGDLSESRANrVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACC 112

                  ....*..
gi 1622954436 168 EFLTKHL 174
Cdd:cd18235   113 DFLQSQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  61 LFNSELLSDVRFVLGKgrgtaaaggpQRIPAHRFVLAAGSAVFDamfNGGMATTSaEIELPDVEPAAFLALLRFLYSDEV 140
Cdd:cd18303    12 LFDKELYSDITIKLAD----------KSIPAHKFVLAARSEKWS---NENLASTN-ELDLSDISYEVVLALLRWLYTDEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622954436 141 QIGPETV--MTTLYTAKKYAVPALEAHCVEFLTKHLRADN 178
Cdd:cd18303    78 DLTLDDEflLELMKAAKRFQLTDLVERCERALMSSVNVDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  85 GPQRIPAHRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 163
Cdd:cd18247    27 GDQKFSAHRIVLAATIPYFHAMFTHDMVeSKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSVK 106

                  ....*....
gi 1622954436 164 AHCVEFLTK 172
Cdd:cd18247   107 DACCEFLKE 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  88 RIPAHRFVLAAGSAVFDAMFNGGMATTSAE------IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPA 161
Cdd:cd18296    28 RFPCHKAFFCGRSDYFKALLRDHFAESEENngsipvVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPG 107

                          90
                  ....*....|...
gi 1622954436 162 LEAHCVEFLTKHL 174
Cdd:cd18296   108 LKRLCGTVLAQSL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  67 LSDVRFVLGkGRgtaaaggpqRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPE 145
Cdd:cd18259    32 LSDVTLLVG-GR---------EFPCHRSVLALCSHYFNAMFTGDFVESiSARVEIKDVDPAVMESLIDFAYTGKLTINQG 101

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622954436 146 TVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 178
Cdd:cd18259   102 NVEALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  87 QRIPAHRFVLAAGSAVFDAMFNGGMATTS-AEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAH 165
Cdd:cd18240    27 VEFPAHRNILCACSPYFRALFTNGWNETEkKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKA 106

                          90
                  ....*....|...
gi 1622954436 166 CVEFLTKHLRADN 178
Cdd:cd18240   107 CCDFLEDQLCPEN 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  58 FAFLFNSELLSDVRF-VLGkgrgtaaaggpQRIPAHRFVLAAGSAVFDAMFNGGMAT-TSAEIELPDVEPAAFLALLRFL 135
Cdd:cd18280     5 FGALLESEEGADVTFnVDG-----------EKFRAHKLVLAARSPVFRSMLFGPMREeNEGEIVIEDVEPPVFKALLHFI 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622954436 136 YSDEVqigPETVMTTLYTAKKYAVPaleahcvefLTKHlradnafmLLTQARLFDEPQLASLC 198
Cdd:cd18280    74 YKDEL---PDDVEPAGSDSSSLDTT---------MAQH--------LLAAADRYALERLRLLC 116

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  63 NSELLSDVRFVLgKGRgtaaaggpqRIPAHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQ 141
Cdd:cd18352     9 NNATLSDVTFLV-EGR---------RFYAHRIALLASSDAFRAMFDGGYREKEARdIEIPNIRWEVFELMMRFIYTGSVD 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1622954436 142 IGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 178
Cdd:cd18352    79 ITNDIAKDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  85 GPQRIPAHRFVLAAGSAVFDAMFNGGMATTSA-EIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 163
Cdd:cd18269    35 GDKEFPCHRLVLAACSPYFRAMFLSDLEESKKkEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIF 114

                          90
                  ....*....|....*
gi 1622954436 164 AHCVEFLTKHLRADN 178
Cdd:cd18269   115 TVCVSYLQKRLSLSN 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  85 GPQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 163
Cdd:cd18336    27 GNLKIPAHRLVLSAVSDYFAAMFtNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVI 106

                          90
                  ....*....|....*
gi 1622954436 164 AHCVEFLTKHLRADN 178
Cdd:cd18336   107 DVCCNFLMKQLHPSN 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622954436  54 LKERFAFLFNSELLSDVRFVLGKgrgtaaaggpQRIPAHRFVLAAGSAVFDAMFNGGMA-TTSAEIELPDVEPAAFLALL 132
Cdd:cd18279     5 LAEDLGNLWENSRFTDCCLCVGG----------QEFQAHKAILAARSPVFSAMFEHEMEeSKKNRVEINDVDPEVFKEMM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622954436 133 RFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 178
Cdd:cd18279    75 RFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622954436  87 QRIPAHRFVLAAGSAVFDAMFNGGMATTS-AEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKY 157
Cdd:cd01165     8 EKFHVNKELLAQSSEYFRALFRGGFRESGqAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79