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Conserved domains on  [gi|1622947901|ref|XP_028705685|]
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proton-coupled amino acid transporter 1 isoform X3 [Macaca mulatta]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
47-388 2.00e-58

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 195.60  E-value: 2.00e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901  47 TTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLVIGIVAVHCMGILVKCaHHFCRRLNKSFVDYGDTVmygles 126
Cdd:pfam01490   3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRC-SKEVPVTGKRNKSYGDLG------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 127 spcswLRNHAHWGRHVVDFFLIVTQLGFCCVYFVFLADNFKQVIEaangttNNCHnnetvilTPTMDSRLYMLSFLPFLV 206
Cdd:pfam01490  76 -----YRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFD------SFFD-------TCPISLVYFIIIFGLIFI 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 207 LLVFIRNLRALSVFSLLANITMLVSLIMIYQFIVQRIP-DPSHLPLVAPW-----KTYPLFFGTAIFAFEGIGMVLPLEN 280
Cdd:pfam01490 138 PLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPIQN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 281 KMKDPRKFPL---ILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPN-CWLYQSVKLLYSIGIFFTYALQFYVPAE 356
Cdd:pfam01490 218 EMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPIRQ 297
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1622947901 357 II--------IPFFVSRAPEHCELVVDLFVRTVLVCLTYF 388
Cdd:pfam01490 298 IVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYL 337
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
47-388 2.00e-58

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 195.60  E-value: 2.00e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901  47 TTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLVIGIVAVHCMGILVKCaHHFCRRLNKSFVDYGDTVmygles 126
Cdd:pfam01490   3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRC-SKEVPVTGKRNKSYGDLG------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 127 spcswLRNHAHWGRHVVDFFLIVTQLGFCCVYFVFLADNFKQVIEaangttNNCHnnetvilTPTMDSRLYMLSFLPFLV 206
Cdd:pfam01490  76 -----YRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFD------SFFD-------TCPISLVYFIIIFGLIFI 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 207 LLVFIRNLRALSVFSLLANITMLVSLIMIYQFIVQRIP-DPSHLPLVAPW-----KTYPLFFGTAIFAFEGIGMVLPLEN 280
Cdd:pfam01490 138 PLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPIQN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 281 KMKDPRKFPL---ILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPN-CWLYQSVKLLYSIGIFFTYALQFYVPAE 356
Cdd:pfam01490 218 EMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPIRQ 297
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1622947901 357 II--------IPFFVSRAPEHCELVVDLFVRTVLVCLTYF 388
Cdd:pfam01490 298 IVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYL 337
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
197-304 1.28e-05

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 47.20  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 197 YMLSFLP---------FLVLLVFIRNLRALSVFSLLANITMLVSLIMIYQFIVQRIP--DPSHL-PLVAPWKTYPLFFGT 264
Cdd:COG0531   115 YLSSLFPaggsvlialVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVVGLFafDPANFtPFLPAGGGLSGVLAA 194
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622947901 265 ---AIFAFEGIGMVLPLENKMKDPRK-FPLILYLGMVIVTILYI 304
Cdd:COG0531   195 lalAFFAFTGFEAIANLAEEAKNPKRnIPRAIILSLLIVGVLYI 238
PTZ00206 PTZ00206
amino acid transporter; Provisional
61-324 2.35e-03

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 39.85  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901  61 IGTGLLGLPLAVKNAGIVMGPISLLVIGIVAVHCMGILVKCAHhfcrRLNKSFVDYGDTVMYGlesspcswlrnhaHWGR 140
Cdd:PTZ00206   74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAAD----KTNIRTYEGVARVLLG-------------PWGS 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 141 HVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMdsrlymlsFLPFLVLLVFIRNLRALSVF 220
Cdd:PTZ00206  137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLTSLM--------WLCFMLPLVIPRHIDSLRYV 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 221 SLLANITMLVSLIMIyqfIVQRIPD--PSHLPLVAPWK---TYPLFFGTAIFAFEGIGM--------VLPLENKM----K 283
Cdd:PTZ00206  209 STIAVSFMVYLVIVI---VVHSCMNglPENIKNVSVGKddnAEIILFNSGNRAIEGLGVfifayvfqITAYEVYMdmtnR 285
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1622947901 284 DPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITL 324
Cdd:PTZ00206  286 SVGKFVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLL 326
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
47-388 2.00e-58

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 195.60  E-value: 2.00e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901  47 TTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLVIGIVAVHCMGILVKCaHHFCRRLNKSFVDYGDTVmygles 126
Cdd:pfam01490   3 ISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRC-SKEVPVTGKRNKSYGDLG------ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 127 spcswLRNHAHWGRHVVDFFLIVTQLGFCCVYFVFLADNFKQVIEaangttNNCHnnetvilTPTMDSRLYMLSFLPFLV 206
Cdd:pfam01490  76 -----YRLLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFD------SFFD-------TCPISLVYFIIIFGLIFI 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 207 LLVFIRNLRALSVFSLLANITMLVSLIMIYQFIVQRIP-DPSHLPLVAPW-----KTYPLFFGTAIFAFEGIGMVLPLEN 280
Cdd:pfam01490 138 PLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVlTAQGVGHLGSKtniklAGTFLAIGIIVFAFEGHAVLLPIQN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 281 KMKDPRKFPL---ILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPN-CWLYQSVKLLYSIGIFFTYALQFYVPAE 356
Cdd:pfam01490 218 EMKNPSKFKAmtkILLTAIIIATVLYILIGLVGYLAFGDNVKGNILLNLPKsAWLIDIANLLLVLHVILSFPLQLFPIRQ 297
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1622947901 357 II--------IPFFVSRAPEHCELVVDLFVRTVLVCLTYF 388
Cdd:pfam01490 298 IVenllfrkeAPFGASGKNNPKSKLLRVVIRSGLVVITYL 337
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
197-304 1.28e-05

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 47.20  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 197 YMLSFLP---------FLVLLVFIRNLRALSVFSLLANITMLVSLIMIYQFIVQRIP--DPSHL-PLVAPWKTYPLFFGT 264
Cdd:COG0531   115 YLSSLFPaggsvlialVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVVGLFafDPANFtPFLPAGGGLSGVLAA 194
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622947901 265 ---AIFAFEGIGMVLPLENKMKDPRK-FPLILYLGMVIVTILYI 304
Cdd:COG0531   195 lalAFFAFTGFEAIANLAEEAKNPKRnIPRAIILSLLIVGVLYI 238
PTZ00206 PTZ00206
amino acid transporter; Provisional
61-324 2.35e-03

amino acid transporter; Provisional


Pssm-ID: 240313  Cd Length: 467  Bit Score: 39.85  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901  61 IGTGLLGLPLAVKNAGIVMGPISLLVIGIVAVHCMGILVKCAHhfcrRLNKSFVDYGDTVMYGlesspcswlrnhaHWGR 140
Cdd:PTZ00206   74 VGAGIVGLPSAANSSGLVMAMIYLIIITAMTIFSIYALGVAAD----KTNIRTYEGVARVLLG-------------PWGS 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 141 HVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNCHNNETVILTPTMdsrlymlsFLPFLVLLVFIRNLRALSVF 220
Cdd:PTZ00206  137 YYVAATRAFHGFSACVAYVISVGDILSATLKGTNAPDFLKQKSGNRLLTSLM--------WLCFMLPLVIPRHIDSLRYV 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622947901 221 SLLANITMLVSLIMIyqfIVQRIPD--PSHLPLVAPWK---TYPLFFGTAIFAFEGIGM--------VLPLENKM----K 283
Cdd:PTZ00206  209 STIAVSFMVYLVIVI---VVHSCMNglPENIKNVSVGKddnAEIILFNSGNRAIEGLGVfifayvfqITAYEVYMdmtnR 285
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1622947901 284 DPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITL 324
Cdd:PTZ00206  286 SVGKFVLASTIAMGMCFTMYVLTAFFGYMDFGRNVTGSVLL 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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