NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622946061|ref|XP_028705446|]
View 

peptidyl-glycine alpha-amidating monooxygenase isoform X12 [Macaca mulatta]

Protein Classification

peptidyl-glycine alpha-amidating monooxygenase( domain architecture ID 10471209)

peptidyl-glycine alpha-amidating monooxygenase is a bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 394-701 2.53e-150

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 443.63  E-value: 2.53e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 394 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 473
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 474 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 553
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 554 SPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 632
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946061 633 GLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 701
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 197-343 2.37e-62

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 461021  Cd Length: 157  Bit Score: 207.10  E-value: 2.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 197 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 265
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 266 LP--QAFYPVEHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDTFRTIP 343
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 60-169 9.20e-27

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.80  E-value: 9.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061  60 LDIRMPGV-IPKQSDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 132
Cdd:pfam01082   1 FDLLNPNVtVPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622946061 133 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 169
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 394-701 2.53e-150

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 443.63  E-value: 2.53e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 394 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 473
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 474 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 553
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 554 SPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 632
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946061 633 GLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 701
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 197-343 2.37e-62

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 207.10  E-value: 2.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 197 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 265
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 266 LP--QAFYPVEHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDTFRTIP 343
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 60-169 9.20e-27

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.80  E-value: 9.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061  60 LDIRMPGV-IPKQSDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 132
Cdd:pfam01082   1 FDLLNPNVtVPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622946061 133 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 169
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
451-707 1.21e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 78.14  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 451 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPI-LILGrsmqPGSDQNhfcqPTD 529
Cdd:COG4257    38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 530 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGEFitqwgeeSSGSSPLPGQFtvPHSLALVPhLGQLCVADRENARIQCFKTD 608
Cdd:COG4257   107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 609 TKEFVREIKHSSFGRNVfaisyipGLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVRKHFdmPHDIVASEDGTVY 688
Cdd:COG4257   175 TGTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVW 245

                         250
                  ....*....|....*....
gi 1622946061 689 IGDAHTNTVWKFTLTEKVE 707
Cdd:COG4257   246 FAESGANRIVRFDPDTELT 264
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 577-605 8.86e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.38  E-value: 8.86e-04
                          10        20
                  ....*....|....*....|....*....
gi 1622946061 577 FTVPHSLALVPhLGQLCVADRENARIQCF 605
Cdd:pfam01436   1 FNRPHGVAVDS-NGDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 394-701 2.53e-150

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 443.63  E-value: 2.53e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 394 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 473
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 474 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 553
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 554 SPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 632
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDED-GRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946061 633 GLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVR---KHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 701
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGkapGQFQNPHDIAVDSGGDIYVGELGPNRVQKFV 300
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 197-343 2.37e-62

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 207.10  E-value: 2.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 197 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 265
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 266 LP--QAFYPVEHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDTFRTIP 343
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 409-700 3.54e-45

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 163.64  E-value: 3.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 409 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPNNAAVLQ--SSGKNL--FYLPHGLSIDKDG 484
Cdd:cd05819    11 QGIAVDSSGNIYVADTGNN------------------------RIQVFDPDGNFITSfgSFGSGDgqFNEPAGVAVDSDG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 485 NYWVTDVALHQVFKLDPNNKEgpILILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGEFITQWG 564
Cdd:cd05819    67 NLYVADTGNHRIQKFDPDGNF--LASFGGS---GDGDGEFNGPRGIAVDS-SGNIYVAD-TGNHRIQKFDPDGEFLTTFG 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 565 EESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTkEFVREIKHSSFGRNVFaiSYIPGLLFAVNGKPHF 644
Cdd:cd05819   140 SGGSG----PGQFNGPTGVAVDSD-GNIYVADTGNHRIQVFDPDG-NFLTTFGSTGTGPGQF--NYPTGIAVDSDGNIYV 211

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622946061 645 GDQEPVQGFVMNFSSGEIIDI--FKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKF 700
Cdd:cd05819   212 ADSGNNRVQVFDPDGAGFGGNgnFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 467-701 9.80e-30

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 119.60  E-value: 9.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 467 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPILILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 546
Cdd:cd14955   104 SGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSG--TFITKWGSF---GSGDGQFNSPTGIAVD-SAGNVYVADTG- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 547 NSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCFKTDTkEFVreikhSSFGrnvf 626
Cdd:cd14955   177 NNRIQKFTSTGTFLTKWGSEGSG----DGQFNAPYGIA-VDSAGNVYVADTGNNRIQKFDSSG-TFI-----TKWG---- 241

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622946061 627 aiSYIPGllfavngkphfgdqepvqgfvmnfsSGEiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 701
Cdd:cd14955   242 --SEGSG-------------------------DGQ-----------FNSPSGIAVDSAGNVYVADSGNNRIQKFA 278
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 60-169 9.20e-27

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 105.80  E-value: 9.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061  60 LDIRMPGV-IPKQSDTYFCMSMRLP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 132
Cdd:pfam01082   1 FDLLNPNVtVPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622946061 133 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 169
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 472-608 1.20e-26

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 110.45  E-value: 1.20e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 472 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpilILGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIV 551
Cdd:cd14956   106 FNAPRGVAVDADGNLYVADFGNQRIQKFDPDGS-----FLRQWGGTGIEPGSFNYPRGVAVDPD-GTLYVADTY-NDRIQ 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946061 552 QFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPhLGQLCVADRENARIQCFKTD 608
Cdd:cd14956   179 VFDNDGAFLRKWGGRGTG----PGQFNYPYGIAIDP-DGNVFVADFGNNRIQKFTAD 230
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 451-700 1.58e-25

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 106.98  E-value: 1.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 451 DTILVIDPNNAAVL--------------QSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPILILGRsmq 516
Cdd:cd14956    24 DNVYVADARNGRIQvfdkdgtflrrfgtTGDGPGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTLTGE--LQTIGGS--- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 517 PGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVAD 596
Cdd:cd14956    99 SGSGPGQFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGSFLRQWGGTGIE----PGSFNYPRGVAVDPD-GTLYVAD 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 597 RENARIQCFKTDTKeFVREI-KHSSFG---RNVFAISYIP-GLLFAVNgkphFGDQEpVQGFVMNfssGEIIDIF--KPV 669
Cdd:cd14956   172 TYNDRIQVFDNDGA-FLRKWgGRGTGPgqfNYPYGIAIDPdGNVFVAD----FGNNR-IQKFTAD---GTFLTSWgsPGT 242

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1622946061 670 RKH-FDMPHDIVASEDGTVYIGDAHTNTVWKF 700
Cdd:cd14956   243 GPGqFKNPWGVVVDADGTVYVADSNNNRVQRF 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 407-605 1.60e-23

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 101.50  E-value: 1.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 407 QVSGVALDPKNNLvifhrgdHVWD-GNS----FDSKFVY------------QQIGLGPIEEDT---ILVIDPNNAAV--L 464
Cdd:cd14955    64 SPTGIAVDSDGNV-------YVADtGNHriqkFDSTGTFltkwgssgsgdgQFNSPSGIAVDSagnVYVTDSGNNRIqkF 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 465 QSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPILILGRsmqPGSDQNHFCQPTDVAV 532
Cdd:cd14955   137 DSSGTFItkwgsfgsgdgqFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTG--TFLTKWGS---EGSGDGQFNAPYGIAV 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622946061 533 DpGTGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCF 605
Cdd:cd14955   212 D-SAGNVYVADTG-NNRIQKFDSSGTFITKWGSEGSG----DGQFNSPSGIA-VDSAGNVYVADSGNNRIQKF 277
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 467-703 5.42e-23

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 99.96  E-value: 5.42e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 467 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPILILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 546
Cdd:cd14955    10 SGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDST---GTFLTKWGS--SGSGDGQFYSPTGIAVD-SDGNVYVADTG- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 547 NSRIVQFSPSGEFITQWGEESSGSsplpGQFTVPHSLAlVPHLGQLCVADRENARIQcfktdtkefvreiKHSSFGrnvf 626
Cdd:cd14955    83 NHRIQKFDSTGTFLTKWGSSGSGD----GQFNSPSGIA-VDSAGNVYVTDSGNNRIQ-------------KFDSSG---- 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946061 627 aisyipgllfavngkphfgdqepvqGFVMNFSSGEIIDifkpvrKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 703
Cdd:cd14955   141 -------------------------TFITKWGSFGSGD------GQFNSPTGIAVDSAGNVYVADTGNNRIQKFTST 186
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 385-605 8.95e-20

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 90.30  E-value: 8.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 385 VLDQDFHMEEALDWPGVYLL--------PGQVS---GVALDPKNNLVIFHRGDH---VWDGN-SFDSKFVYQQIGLGPIE 449
Cdd:cd14954    86 VADKDNHRIQVFDLNGRFLLkfgergtkNGQFNypwGVAVDSEGRIYVSDTRNHrvqVFDSDgQFIRKFGFEGAGPGQLD 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 450 EdtilvidpnnaavlqssgknlfylPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPILILGrsmQPGSDQNHFCQPTD 529
Cdd:cd14954   166 S------------------------PRGVAVNPDGNIVVSDFNNHRLQVFDPDGQ--FLRFFG---SEGSGNGQFKRPRG 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622946061 530 VAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCF 605
Cdd:cd14954   217 VAVDDE-GNIIVADSG-NHRVQVFSPDGEFLCSFGTEGNG----EGQFDRPSGVAVTPD-GRIVVVDRGNHRIQVF 285
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 468-623 1.89e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 89.18  E-value: 1.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 468 GKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPILILGRSMQpgsdqnhFCQPTDVAVDPGTGAIYVSDGYcN 547
Cdd:cd14962    52 GPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGK--FLRAIGAGAL-------FKRPTGIAVDPAGKRLYVVDTL-A 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622946061 548 SRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVReikhsSFGR 623
Cdd:cd14962   122 HKVKVFDLDGRLLFDIGKRGSG----PGEFNLPTDLAVDRD-GNLYVTDTMNFRVQIFDADGK-FLR-----SFGE 186
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 405-605 3.17e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 88.49  E-value: 3.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 405 PGQ---VSGVALDPKNNLVIfhrgdhvwdgnsfdSKFVYQQIglgpieedtiLVIDPNNAAVLQSSGKNL----FYLPHG 477
Cdd:cd14956   103 PGQfnaPRGVAVDADGNLYV--------------ADFGNQRI----------QKFDPDGSFLRQWGGTGIepgsFNYPRG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 478 LSIDKDGNYWVTDVALH--QVFkldpNNKEGPILILGrsmQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSP 555
Cdd:cd14956   159 VAVDPDGTLYVADTYNDriQVF----DNDGAFLRKWG---GRGTGPGQFNYPYGIAIDP-DGNVFVADFG-NNRIQKFTA 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622946061 556 SGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCF 605
Cdd:cd14956   230 DGTFLTSWGSPGTG----PGQFKNPWGVV-VDADGTVYVADSNNNRVQRF 274
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 466-701 7.50e-19

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 87.71  E-value: 7.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 466 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGP-ILILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVS 542
Cdd:cd14957    11 GSGNGQFNTPRGIAVDSAGNIYVADTGNNriQVF-----TSSGVySYSIGSG---GTGSGQFNSPYGIAVD-SNGNIYVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 543 DgYCNSRIVQFSPSGEFITQWGeeSSGSSplPGQFTVPHSLALVPHlGQLCVADRENARIQCFkTDTKEFVREIKHSSFG 622
Cdd:cd14957    82 D-TDNNRIQVFNSSGVYQYSIG--TGGSG--DGQFNGPYGIAVDSN-GNIYVADTGNHRIQVF-TSSGTFSYSIGSGGTG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 623 RNVFaiSYIPGLLFAVNGKPHFGDQ--EPVQGFVmnfSSGEIIDIF---KPVRKHFDMPHDIVASEDGTVYIGDAHTNTV 697
Cdd:cd14957   155 PGQF--NGPQGIAVDSDGNIYVADTgnHRIQVFT---SSGTFQYTFgssGSGPGQFSDPYGIAVDSDGNIYVADTGNHRI 229


                  ....
gi 1622946061 698 WKFT 701
Cdd:cd14957   230 QVFT 233
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 472-703 1.53e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 86.57  E-value: 1.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 472 FYLPHGLSIDKDGNYWVTDVALH--QVFKLDPNNKegpililGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDgYCNSR 549
Cdd:cd14956    12 FKDPRGIAVDADDNVYVADARNGriQVFDKDGTFL-------RRFGTTGDGPGQFGRPRGLAVDKD-GWLYVAD-YWGDR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 550 IVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKeFVREIkhssfgrnvfais 629
Cdd:cd14956    83 IQVFTLTGELQTIGGSSGSG----PGQFNAPRGVAVDAD-GNLYVADFGNQRIQKFDPDGS-FLRQW------------- 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622946061 630 yipgllfavnGKPhfgDQEPVQgfvmnfssgeiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFTLT 703
Cdd:cd14956   144 ----------GGT---GIEPGS---------------------FNYPRGVAVDPDGTLYVADTYNDRIQVFDND 183
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 448-691 3.24e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 85.42  E-value: 3.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 448 IEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVA--LHQVFkldpnNKEGPILil 511
Cdd:cd14963    17 VSDGRIYVADTNNhrVQVFDYEGKFKksfggpgtgpgeFKYPYGIAVDSDGNIYVADLYngRIQVF-----DPDGKFL-- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 512 gRSMQPGSDQNHFCQPTDVAVDPGTgaIYVSD-GYcnSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlG 590
Cdd:cd14963    90 -KYFPEKKDRVKLISPAGLAIDDGK--LYVSDvKK--HKVIVFDLEGKLLLEFGKPGSE----PGELSYPNGIAVDED-G 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 591 QLCVADRENARIQCFKTDTKeFVREIKHSSFGRNVFA----ISYIP-GLLFAVNGKPHFgdqepVQGFVMNFSSGEIIDI 665
Cdd:cd14963   160 NIYVADSGNGRIQVFDKNGK-FIKELNGSPDGKSGFVnprgIAVDPdGNLYVVDNLSHR-----VYVFDEQGKELFTFGG 233

                         250       260
                  ....*....|....*....|....*.
gi 1622946061 666 FKPVRKHFDMPHDIVASEDGTVYIGD 691
Cdd:cd14963   234 RGKDDGQFNLPNGLFIDDDGRLYVTD 259
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 466-605 8.09e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 81.54  E-value: 8.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 466 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpNNKEGPILILGrsmQPGSDQNHFCQPTDVAVDpGTGAIYVSD 543
Cdd:cd14957   152 GTGPGQFNGPQGIAVDSDGNIYVADTGNHriQVF----TSSGTFQYTFG---SSGSGPGQFSDPYGIAVD-SDGNIYVAD 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622946061 544 gYCNSRIVQFSPSGEFITQWGeeSSGSSplPGQFTVPHSLAlVPHLGQLCVADRENARIQCF 605
Cdd:cd14957   224 -TGNHRIQVFTSSGAYQYSIG--TSGSG--NGQFNYPYGIA-VDNDGKIYVADSNNNRIQVF 279
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 466-697 8.46e-16

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 78.46  E-value: 8.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 466 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpNNKEGPILILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSD 543
Cdd:cd14957    58 GTGSGQFNSPYGIAVDSNGNIYVADTDNNriQVF----NSSGVYQYSIGTG---GSGDGQFNGPYGIAVDS-NGNIYVAD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 544 GYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQCFkTDTKEFVREIKHSSFGr 623
Cdd:cd14957   130 TG-NHRIQVFTSSGTFSYSIGSGGTG----PGQFNGPQGIAVDSD-GNIYVADTGNHRIQVF-TSSGTFQYTFGSSGSG- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 624 nvfaisyiPGLLF-----AV--NGKPHFGDQ--EPVQGFVmnfSSGEI---IDIFKPVRKHFDMPHDIVASEDGTVYIGD 691
Cdd:cd14957   202 --------PGQFSdpygiAVdsDGNIYVADTgnHRIQVFT---SSGAYqysIGTSGSGNGQFNYPYGIAVDNDGKIYVAD 270


                  ....*.
gi 1622946061 692 AHTNTV 697
Cdd:cd14957   271 SNNNRI 276
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
451-707 1.21e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 78.14  E-value: 1.21e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 451 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPI-LILGrsmqPGSDQNhfcqPTD 529
Cdd:COG4257    38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 530 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGEFitqwgeeSSGSSPLPGQFtvPHSLALVPhLGQLCVADRENARIQCFKTD 608
Cdd:COG4257   107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 609 TKEFVREIKHSSFGRNVfaisyipGLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVRKHFdmPHDIVASEDGTVY 688
Cdd:COG4257   175 TGTLTEYALPTPGAGPR-------GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGAR--PYGVAVDGDGRVW 245

                         250
                  ....*....|....*....
gi 1622946061 689 IGDAHTNTVWKFTLTEKVE 707
Cdd:COG4257   246 FAESGANRIVRFDPDTELT 264
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 518-705 1.96e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 77.33  E-value: 1.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 518 GSDQNHFCQPTDVAVDPGTgaIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADR 597
Cdd:cd14963     3 GPFGDPLNKPMGVAVSDGR--IYVADTN-NHRVQVFDYEGKFKKSFGGPGTG----PGEFKYPYGIAVDSD-GNIYVADL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 598 ENARIQCFKTDTKeFVReikhsSFGRNVFAISYI-PGLLFAVNGKPHFGDQEPVQGFVMNFSSGEIIDIFKPVRK--HFD 674
Cdd:cd14963    75 YNGRIQVFDPDGK-FLK-----YFPEKKDRVKLIsPAGLAIDDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEpgELS 148

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1622946061 675 MPHDIVASEDGTVYIGDAHTNTVWKFTLTEK 705
Cdd:cd14963   149 YPNGIAVDEDGNIYVADSGNGRIQVFDKNGK 179
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 472-614 2.05e-14

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 74.51  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 472 FYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILI-LGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYcNS 548
Cdd:cd14954    23 LCRPWGVAVDKDGRIIVADRSNNrvQVF-----DPDGKFLRkFGSY---GSRDGQFDRPAGVAVN-SRGRIIVADKD-NH 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622946061 549 RIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLAlVPHLGQLCVADRENARIQCFKTDTKeFVR 614
Cdd:cd14954    93 RIQVFDLNGRFLLKFGERGTK----NGQFNYPWGVA-VDSEGRIYVSDTRNHRVQVFDSDGQ-FIR 152
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 444-697 3.97e-14

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 73.74  E-value: 3.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 444 GLGPIEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkegpil 509
Cdd:cd14954    28 GVAVDKDGRIIVADRSNnrVQVFDPDGKFLrkfgsygsrdgqFDRPAGVAVNSRGRIIVADKDNHRIQVFDLN------- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 510 ilGRSM----QPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGEESsgssPLPGQFTVPHSLAl 585
Cdd:cd14954   101 --GRFLlkfgERGTKNGQFNYPWGVAVDSE-GRIYVSDTR-NHRVQVFDSDGQFIRKFGFEG----AGPGQLDSPRGVA- 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 586 VPHLGQLCVADRENARIQCFKTDTKeFVREIKHSSFGRNVFAISYipGLlfAVngkphfgDQEpvqGFVMNFSSGEI-ID 664
Cdd:cd14954   172 VNPDGNIVVSDFNNHRLQVFDPDGQ-FLRFFGSEGSGNGQFKRPR--GV--AV-------DDE---GNIIVADSGNHrVQ 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1622946061 665 IFKP----VRK---------HFDMPHDIVASEDGTVYIGDAHTNTV 697
Cdd:cd14954   237 VFSPdgefLCSfgtegngegQFDRPSGVAVTPDGRIVVVDRGNHRI 282
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
475-708 7.33e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 72.74  E-value: 7.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 475 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEgpililGRSMQPGSdqnhFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFS 554
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGE------FTEYPLGG----GSGPHGIAVDP-DGNLWFTDNG-NNRIGRID 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 555 PSGEFITQWgeessgssPLPGQFTVPHSLALVPHlGQLCVADRENARIQCFKTDTKEfVREIKHSSFGRNVFAISYIPG- 633
Cdd:COG4257    87 PKTGEITTF--------ALPGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDPATGE-VTEFPLPTGGAGPYGIAVDPDg 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622946061 634 -LLFAVNGKPHFGdqepvqgfVMNFSSGEiIDIFKPVRKhFDMPHDIVASEDGTVYIGDAHTNTVWKF-TLTEKVEH 708
Cdd:COG4257   157 nLWVTDFGANAIG--------RIDPDTGT-LTEYALPTP-GAGPRGLAVDPDGNLWVADTGSGRIGRFdPKTGTVTE 223
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 409-602 9.31e-14

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 73.33  E-value: 9.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 409 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPN-------------------NAAvlqssgk 469
Cdd:cd14953    26 SGVAVDAAGNLYVADRGNH------------------------RIRKITPDgvvttvagtgtagfadgggAAA------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 470 nLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPIL------ILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSD 543
Cdd:cd14953    75 -QFNTPSGVAVDAAGNLYVADTGNHRIRKITPD---GVVStlagtgTAGFSDDGGATAAQFNYPTGVAVDA-AGNLYVAD 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622946061 544 GYcNSRIVQFSPSGEFITQWGEESSGSSPL-PG---QFTVPHSLALVPHlGQLCVADRENARI 602
Cdd:cd14953   150 TG-NHRIRKITPDGVVTTVAGTGGAGYAGDgPAtaaQFNNPTGVAVDAA-GNLYVADRGNHRI 210
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 517-701 1.69e-13

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 71.91  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 517 PGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGeeSSGSSplPGQFTVPHSLAlVPHLGQLCVAD 596
Cdd:cd14957    10 NGSGNGQFNTPRGIAVDSA-GNIYVADTG-NNRIQVFTSSGVYSYSIG--SGGTG--SGQFNSPYGIA-VDSNGNIYVAD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 597 RENARIQCFkTDTKEFVREIKHSSFGRNVFaiSYIPGLLFAVNGKPHFGDQ--EPVQGFVmnfSSGEI---IDIFKPVRK 671
Cdd:cd14957    83 TDNNRIQVF-NSSGVYQYSIGTGGSGDGQF--NGPYGIAVDSNGNIYVADTgnHRIQVFT---SSGTFsysIGSGGTGPG 156

                         170       180       190
                  ....*....|....*....|....*....|
gi 1622946061 672 HFDMPHDIVASEDGTVYIGDAHTNTVWKFT 701
Cdd:cd14957   157 QFNGPQGIAVDSDGNIYVADTGNHRIQVFT 186
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 453-606 3.76e-13

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 70.84  E-value: 3.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 453 ILVIDPNNAAVL--QSSGKNLFYL-------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpilILGRSMQPGSDQNH 523
Cdd:cd14960    77 IIIADYDNKWVSifSPDGKFKSKIgagklmgPKGVAVDRNGHIIVVDNKACCVFIFQPNGK-----LVTRFGSRGNGDRQ 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 524 FCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPHSLALVPHlGQLCVADRENARIQ 603
Cdd:cd14960   152 FAGPHFAAVNN-NNEIIVTD-FHNHSVKVFNAEGEFLFKFGSNGEG----NGQFNAPTGVAVDSN-GNIIVADWGNSRIQ 224


                  ...
gi 1622946061 604 CFK 606
Cdd:cd14960   225 VFD 227
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
395-609 5.41e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 69.34  E-value: 5.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 395 ALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYqqigLGPIEEDTILVIDPNNAAVLQS--SGKNlf 472
Cdd:COG3391    38 AAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY----VANSGSGRVSVIDLATGKVVATipVGGG-- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 473 ylPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpiliLGRSMQPGSdqnhfcQPTDVAVDPGTGAIYVSDGYCN--SR 549
Cdd:COG3391   112 --PRGLAVDPDGGRlYVADSGNGRVSVIDTATGK-----VVATIPVGA------GPHGIAVDPDGKRLYVANSGSNtvSV 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622946061 550 IVQ-FSP-SGEFITQWgeessgssPLPGQftvPHSLALVPHLGQLCVADREN-------ARIQCFKTDT 609
Cdd:COG3391   179 IVSvIDTaTGKVVATI--------PVGGG---PVGVAVSPDGRRLYVANRGSntsnggsNTVSVIDLAT 236
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 399-605 1.06e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 69.24  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 399 PGVYLLPgqvSGVALDPKNNLVI---FHRGDHVWD--GNsFDSKFVYQQIGLGP-------IEEDTILVID--PNNAAVL 464
Cdd:cd14963    52 PGEFKYP---YGIAVDSDGNIYVadlYNGRIQVFDpdGK-FLKYFPEKKDRVKLispaglaIDDGKLYVSDvkKHKVIVF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 465 QSSGKNLFYL------------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPILIL-GRSMQPGSdqnhFCQPTDVA 531
Cdd:cd14963   128 DLEGKLLLEFgkpgsepgelsyPNGIAVDEDGNIYVADSGNGRIQVFDKNGK--FIKELnGSPDGKSG----FVNPRGIA 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622946061 532 VDPgTGAIYVSDGYCNsRIVQFSPSGEFITQWGeeSSGSSPlpGQFTVPHSLALVPHlGQLCVADRENARIQCF 605
Cdd:cd14963   202 VDP-DGNLYVVDNLSH-RVYVFDEQGKELFTFG--GRGKDD--GQFNLPNGLFIDDD-GRLYVTDRENNRVAVY 268
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 397-609 1.99e-12

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 68.46  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 397 DWPGVYLLPgqvSGVALDPKNNLVIFHrgdhvwDGNS----FDSK-FVYQQIGlgPIEEDTILVIDPNNAAV-------- 463
Cdd:cd14961     5 GWPGTLNNP---TGVAVTPTGRVVVAD------DGNKriqvFDSDgNCLQQFG--PKGDAGQDIRYPLDVAVtpdghivv 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 464 ----------------LQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILILGRSmqpgsdQNHFCQP 527
Cdd:cd14961    74 tdagdrsvkvfsfdgrLKLFVRKSFSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFKLGILKKGQKL------CSQLCRP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 528 TDVAVDPgTGAIYVSD-------GYCNSRIVQFSPSGEFITQWGeeSSGSSPLPGQFTVPHSLAlVPHLGQLCVADRENA 600
Cdd:cd14961   148 RFVAVSR-LGAVAVTEhlfangtRSSSTRVKVFSSGGQLLGQID--SFGLNLVFPSLICASGVA-FDSEGNVIVADTGSG 223


                  ....*....
gi 1622946061 601 RIQCFKTDT 609
Cdd:cd14961   224 AILCLGKPE 232
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 409-602 1.55e-11

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 66.40  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 409 SGVALDPKNNLVIFHRGDHVwdgnsfdskfvyqqiglgpieedtILVIDPN--------NAAVLQSSGKN----LFYLPH 476
Cdd:cd14953   135 TGVAVDAAGNLYVADTGNHR------------------------IRKITPDgvvttvagTGGAGYAGDGPataaQFNNPT 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 477 GLSIDKDGNYWVTDVALHQVFKLDPNnkeGPIL-ILGRSMQPGSDQNH-----FCQPTDVAVDpGTGAIYVSDgYCNSRI 550
Cdd:cd14953   191 GVAVDAAGNLYVADRGNHRIRKITPD---GVVTtVAGTGTAGFSGDGGataaqLNNPTGVAVD-AAGNLYVAD-SGNHRI 265

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622946061 551 VQFSPSGEFIT----QWGEESSGSSPLPGQFTVPHSLALVPHlGQLCVADRENARI 602
Cdd:cd14953   266 RKITPAGVVTTvaggGAGFSGDGGPATSAQFNNPTGVAVDAA-GNLYVADTGNNRI 320
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 502-605 3.36e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 61.79  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 502 NNKEGPILILGRSmqpGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGssplPGQFTVPH 581
Cdd:cd14954     4 RAKGRPLLSFGKE---GSKDGELCRPWGVAVDKD-GRIIVADRS-NNRVQVFDPDGKFLRKFGSYGSR----DGQFDRPA 74

                          90       100
                  ....*....|....*....|....
gi 1622946061 582 SLAlVPHLGQLCVADRENARIQCF 605
Cdd:cd14954    75 GVA-VNSRGRIIVADKDNHRIQVF 97
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 472-701 1.40e-09

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 60.62  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 472 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPILILGRSMQPGSD-----QNHFCQPTDVAVDPGtGAIYVSDGYc 546
Cdd:cd14953    22 FNSPSGVAVDAAGNLYVADRGNHRIRKITPD---GVVTTVAGTGTAGFAdgggaAAQFNTPSGVAVDAA-GNLYVADTG- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 547 NSRIVQFSPSGEFITQWGEESSGSSPLPG----QFTVPHSLALVPHlGQLCVADRENARIQcfKTDTKEFVReikhssfg 622
Cdd:cd14953    97 NHRIRKITPDGVVSTLAGTGTAGFSDDGGataaQFNYPTGVAVDAA-GNLYVADTGNHRIR--KITPDGVVT-------- 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622946061 623 rnVFAISYIPGllFAVNGkphfgdqepvqgfvmnfssgeiidifKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFT 701
Cdd:cd14953   166 --TVAGTGGAG--YAGDG--------------------------PATAAQFNNPTGVAVDAAGNLYVADRGNHRIRKIT 214
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 475-602 4.96e-09

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 57.99  E-value: 4.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 475 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILilgrsmqPGSDQNhfcQPTDVAVDpGTGAIYVSDGYcNSRIVQFS 554
Cdd:cd14952    12 PGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQTVL-------PFTGLY---QPQGVAVD-AAGTVYVTDFG-NNRVLKLA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622946061 555 PSgefitqwgeeSSGSSPLPgqFT---VPHSLAlVPHLGQLCVADRENARI 602
Cdd:cd14952    80 AG----------STTQTVLP--FTglnDPTGVA-VDAAGNVYVADTGNNRV 117
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 518-691 6.73e-09

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 57.67  E-value: 6.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 518 GSDQNHFCQPTDVAVDpGTGAIYVSDGYcNSRIVQFSPSGEFITQWGEESSGSsplpGQFTVPHSLALVPHLGQLCVADR 597
Cdd:cd14959    15 GSGEGQFNSPSGFCLG-EDEDILVADTN-NHRIQVFDKEGEFKFQFGIPGKRD----GQLWYPNKVAVCRVTGRYVVTDR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 598 --ENARIQCFkTDTKEFVREikhssfgrnvFAISYI--PGLLfAVNGKPHFGDQEPVQGFVMNFS-SGEIIDIFKpVRKH 672
Cdd:cd14959    89 gnPRHRMQIF-TKRGQFVRK----------FGARYLqhVRGL-TVDAAGHIIVVESKVMRVFIFDeSGNVLKWFD-CSKY 155

                         170
                  ....*....|....*....
gi 1622946061 673 FDMPHDIVASeDGTVYIGD 691
Cdd:cd14959   156 LEEPSDVAVN-DNEIYICD 173
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 475-715 1.46e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 56.83  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 475 PHGLSIDKDGNYWVTDVALHQVFKLD-PNNKEGPIlilgrsmQPGSDqNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQF 553
Cdd:cd14962    14 PYGVAADGRGRIYVADTGRGAVFVFDlPNGKVFVI-------GNAGP-NRFVSPIGVAIDAN-GNLYVSDAE-LGKVFVF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 554 SPSGEFITQWGEessgssplPGQFTVPHSLALVPHLGQLCVADRENARIQCFKTDTKEfvreikhssfgrnVFAIsyipg 633
Cdd:cd14962    84 DRDGKFLRAIGA--------GALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL-------------LFDI----- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 634 llfavnGKPHFGDQEpvqgfvmnfssgeiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKvEHRSVKK 713
Cdd:cd14962   138 ------GKRGSGPGE------------------------FNLPTDLAVDRDGNLYVTDTMNFRVQIFDADGK-FLRSFGE 186


                  ..
gi 1622946061 714 AG 715
Cdd:cd14962   187 RG 188
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 409-555 1.96e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 56.44  E-value: 1.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 409 SGVALDPKNNLV-IFHRGDH---VWDGnsfDSKFVYQ--QIGLGPIE-----------EDTILVIDPNNA--AVLQSSGK 469
Cdd:cd14962   103 TGIAVDPAGKRLyVVDTLAHkvkVFDL---DGRLLFDigKRGSGPGEfnlptdlavdrDGNLYVTDTMNFrvQIFDADGK 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 470 NL------------FYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILI-LGrsmQPGSDQNHFCQPTDVAVDp 534
Cdd:cd14962   180 FLrsfgergdgpgsFARPKGIAVDSEGNIYVVDAAFDnvQIF-----NPEGELLLtVG---GPGSGPGEFYLPSGIAID- 250

                         170       180
                  ....*....|....*....|.
gi 1622946061 535 GTGAIYVSDGYcNSRIVQFSP 555
Cdd:cd14962   251 KDDRIYVVDQF-NRRIQVFQY 270
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 467-560 2.76e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 53.04  E-value: 2.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 467 SGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILilgrsMQ---PGSDQNHFCQPTDVAVDPGTGAIYV 541
Cdd:cd14959    16 SGEGQFNSPSGFCLGEDEDILVADTNNHriQVF-----DKEGEFK-----FQfgiPGKRDGQLWYPNKVAVCRVTGRYVV 85

                          90       100
                  ....*....|....*....|
gi 1622946061 542 SD-GYCNSRIVQFSPSGEFI 560
Cdd:cd14959    86 TDrGNPRHRMQIFTKRGQFV 105
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 475-602 3.05e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 52.60  E-value: 3.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 475 PHGLSIDKDGNYWVTDVALHQVFKLDPnnkegpililGRSMQ---PGSDQNHfcqPTDVAVDPGtGAIYVSDGYcNSRIV 551
Cdd:cd14952    96 PTGVAVDAAGNVYVADTGNNRVLKLAA----------GSNTQtvlPFTGLSN---PDGVAVDGA-GNVYVTDTG-NNRVL 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622946061 552 QFsPSGefitqwgeeSSGSSPLPgqFT---VPHSLAlVPHLGQLCVADRENARI 602
Cdd:cd14952   161 KL-AAG---------STTQTVLP--FTglnSPSGVA-VDTAGNVYVTDHGNNRV 201
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 475-552 4.52e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 51.82  E-value: 4.52e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622946061 475 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPILilgrsmqPGSDQNHfcqPTDVAVDPgTGAIYVSDgYCNSRIVQ 552
Cdd:cd14952   180 PSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTVL-------PFTGLNG---PLGVAVDA-AGNVYVAD-RGNDRVVK 245
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
539-697 5.30e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.62  E-value: 5.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 539 IYVSDGYcNSRIVQFSP-SGEFITQWgeeSSGSSPlpgqftvpHSLALVPHLGQLCVADRENARIQCFKTDTKEFVREIK 617
Cdd:COG3391    82 LYVANSG-SGRVSVIDLaTGKVVATI---PVGGGP--------RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIP 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 618 hssFGRNVFAISYIP--GLLFAVNgkphFGDQEpVQGFV--MNFSSGEIIDIFKPvrkhFDMPHDIVASEDG-TVYIGDA 692
Cdd:COG3391   150 ---VGAGPHGIAVDPdgKRLYVAN----SGSNT-VSVIVsvIDTATGKVVATIPV----GGGPVGVAVSPDGrRLYVANR 217


                  ....*
gi 1622946061 693 HTNTV 697
Cdd:COG3391   218 GSNTS 222
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 453-606 1.36e-06

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 50.81  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 453 ILVIDPNNAAVL--QSSGK------------NLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILILGRSMQ 516
Cdd:cd14960   119 IIVVDNKACCVFifQPNGKlvtrfgsrgngdRQFAGPHFAAVNNNNEIIVTDFHNHsvKVF-----NAEGEFLFKFGSNG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 517 PGSDQnhFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGEFITQWGeesSGSSPLPGqftvPHSLALVPHlGQLCVAD 596
Cdd:cd14960   194 EGNGQ--FNAPTGVAVDS-NGNIIVAD-WGNSRIQVFDSSGSFLSYIN---TSADPLYG----PQGLALTSD-GHVVVAD 261

                         170
                  ....*....|
gi 1622946061 597 RENAriqCFK 606
Cdd:cd14960   262 SGNH---CFK 268
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 465-554 3.09e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 49.96  E-value: 3.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 465 QSSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPILilgRSM-QPGSDQNHFCQPTDVAVDpGTGAIYV 541
Cdd:cd14957   198 SGSGPGQFSDPYGIAVDSDGNIYVADTGNHriQVF-----TSSGAYQ---YSIgTSGSGNGQFNYPYGIAVD-NDGKIYV 268

                          90
                  ....*....|...
gi 1622946061 542 SDGYcNSRIVQFS 554
Cdd:cd14957   269 ADSN-NNRIQVFN 280
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
529-700 3.81e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.92  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 529 DVAVDPGTGAIYVSDGYCNSRIVQFSPSGEFITQWGEESSGSSPLPGQFTVPHSLALVPHLGQ-LCVADRENARIQCFKT 607
Cdd:COG3391    18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 608 DTKEFVREIKHSSFGRNVfAISYIPGLLFAVNGKPHFgdqepVQgfVMNFSSGEIIDIFKPvrkhFDMPHDIVASEDG-T 686
Cdd:COG3391    98 ATGKVVATIPVGGGPRGL-AVDPDGGRLYVADSGNGR-----VS--VIDTATGKVVATIPV----GAGPHGIAVDPDGkR 165

                         170
                  ....*....|....
gi 1622946061 687 VYIGDAHTNTVWKF 700
Cdd:COG3391   166 LYVANSGSNTVSVI 179
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 518-691 5.69e-06

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 48.81  E-value: 5.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 518 GSDQNHFCQPTDVAVDPgTGAIYVSD-GycNSRIVQFSPSGEFITQWGEESSGSsplpGQFTVPHSLALVPHlGQLCVAD 596
Cdd:cd14961     4 GGWPGTLNNPTGVAVTP-TGRVVVADdG--NKRIQVFDSDGNCLQQFGPKGDAG----QDIRYPLDVAVTPD-GHIVVTD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 597 RENARIqcfktdtKEFVREIKHSSFGRNVFAISYipGLlfAVNGKPHF--GDQEpvQG----FVMNFSSGEIIDIFKpVR 670
Cdd:cd14961    76 AGDRSV-------KVFSFDGRLKLFVRKSFSLPW--GV--AVNPSGEIlvTDSE--AGklfvLTVDFKLGILKKGQK-LC 141

                         170       180
                  ....*....|....*....|.
gi 1622946061 671 KHFDMPHDIVASEDGTVYIGD 691
Cdd:cd14961   142 SQLCRPRFVAVSRLGAVAVTE 162
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 559-701 2.29e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 47.19  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 559 FITQWGEESSGSsplpGQFTVPHSLAlVPHLGQLCVADRENARIQCFKTDtkefvreikhssfgrnvfaisyipGLLFAV 638
Cdd:cd14955     1 FVTQWGSYGSGD----GQFNSPSGIA-VDSAGNVYVADTGNNRIQKFDST------------------------GTFLTK 51

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622946061 639 NGKPHFGDqepvqgfvmnfssGEiidifkpvrkhFDMPHDIVASEDGTVYIGDAHTNTVWKFT 701
Cdd:cd14955    52 WGSSGSGD-------------GQ-----------FYSPTGIAVDSDGNVYVADTGNHRIQKFD 90
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 448-608 2.35e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 46.81  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 448 IEEDTILVIDPNNAAV---LQSSGknlfyLPHGLSIDKDGNYWVTDvALHQVFKLDPNNKEgPILILGRSMQPGSdqnhf 524
Cdd:COG3386    26 IPGGRIHRYDPDGGAVevfAEPSG-----RPNGLAFDPDGRLLVAD-HGRGLVRFDPADGE-VTVLADEYGKPLN----- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 525 cQPTDVAVDPGtGAIYVSD---GYCNSRIVQFSPSGEFitqwgeessgsSPLPGQFTVPHSLALVPHLGQLCVADRENAR 601
Cdd:COG3386    94 -RPNDGVVDPD-GRLYFTDmgeYLPTGALYRVDPDGSL-----------RVLADGLTFPNGIAFSPDGRTLYVADTGAGR 160


                  ....*..
gi 1622946061 602 IQCFKTD 608
Cdd:COG3386   161 IYRFDLD 167
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 577-605 8.86e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.38  E-value: 8.86e-04
                          10        20
                  ....*....|....*....|....*....
gi 1622946061 577 FTVPHSLALVPhLGQLCVADRENARIQCF 605
Cdd:pfam01436   1 FNRPHGVAVDS-NGDIYVADSENHRVQVF 28
MALA cd12811
Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia ...
 527-632 2.26e-03

Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia sympodialis allergen Mala s 1 which is localized in the cell wall and exposed on the cell surface. It can elicit specific IgE and T-cell activity in patients with atopic eczema (AE), a chronic inflammatory disease. Mala s 1 does not show any significant sequence homology to characterized proteins. However, its structure is a beta-propeller which is a novel fold among allergens.


Pssm-ID: 411995 [Multi-domain]  Cd Length: 304  Bit Score: 41.08  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622946061 527 PTDVAVDPgTGAIYVSDGYCNSrIVQFSPSGEFITQWGEESSGSSPLPGqFTvphSLALVPHLGQLCVADRENARIQCFK 606
Cdd:cd12811   123 FQDSAQDS-DGNSYVVGALPPA-IAKVSPDGKTVTPWFLEAPNGSTRPG-YT---GIAYIPEDNVLLASGGEPGQLTRFD 196

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622946061 607 TD----TKEFVReIKHSSFGRNVFAIsYIP 632
Cdd:cd12811   197 LSsatpTPIPVK-ISGENFGGLDDGE-KLP 224
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 524-553 2.66e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.84  E-value: 2.66e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1622946061 524 FCQPTDVAVDPGtGAIYVSDgYCNSRIVQF 553
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVAD-SENHRVQVF 28
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 673-700 3.87e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 3.87e-03
                          10        20
                  ....*....|....*....|....*...
gi 1622946061 673 FDMPHDIVASEDGTVYIGDAHTNTVWKF 700
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH